The protective effects of ω-3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats

Strawberries and blueberries are two of the most commonly consumed berries. Berries, in general, are characterized by their highly nutritive compounds, including minerals, vitamins, fatty acids, and dietary fiber, as well as their high content and wide diversity of bioactive compounds, such as phenolic compounds and organic acids. These bioactive compounds have been associated with protective effects against chronic diseases, such as cardiovascular disease, cancer, Alzheimer’s and other disorders. In this paper 16 human intervention studies investigating the beneficial health effects of dietary strawberry or blueberry consumption on inflammation, cardiovascular disease or cognitive function and mental health are reviewed.

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Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities

International Journal of Molecular Sciences ◽

10.3390/ijms20184402 ◽

2019 ◽

Vol 20 (18) ◽

pp. 4402 ◽

Cited By ~ 3

Author(s):

Arzu Ulu ◽

Prakash K. Sahoo ◽

Ana G. Yuil-Valdes ◽

Maheswari Mukherjee ◽

Matthew Van Ormer ◽

...

Keyword(s):

Fatty Acids ◽

Smooth Muscle ◽

Vascular Smooth Muscle ◽

Placental Tissue ◽

Cell Types ◽

Extravillous Trophoblast ◽

Protective Effects ◽

Omega 3 Fatty Acids ◽

Omega 3

Omega-3 fatty acids are important to pregnancy and neonatal development and health. One mechanism by which omega-3 fatty acids exert their protective effects is through serving as substrates for the generation of specialized pro-resolving lipid mediators (SPM) that potently limit and resolve inflammatory processes. We recently identified that SPM levels are increased in maternal blood at delivery as compared to umbilical cord blood, suggesting the placenta as a potential site of action for maternal SPM. To explore this hypothesis, we obtained human placental samples and stained for the SPM resolvin D2 (RvD2) receptor GPR18 via immunohistochemistry. In so doing, we identified GPR18 expression in placental vascular smooth muscle and extravillous trophoblasts of the placental tissues. Using in vitro culturing, we confirmed expression of GPR18 in these cell types and further identified that stimulation with RvD2 led to significantly altered responsiveness (cytoskeletal changes and pro-inflammatory cytokine production) to lipopolysaccharide inflammatory stimulation in human umbilical artery smooth muscle cells and placental trophoblasts. Taken together, these findings establish a role for SPM actions in human placental tissue.

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Protective Effects of Diets Supplemented with Omega-3 Polyunsaturated Fatty Acids and Calcium Against Colorectal Tumor Formation

Digestive Diseases and Sciences ◽

10.1007/s10620-007-0107-8 ◽

2007 ◽

Vol 53 (8) ◽

pp. 2177-2182 ◽

Cited By ~ 12

Author(s):

Levent Kenar ◽

Turan Karayilanoglu ◽

Ahmet Aydin ◽

Muhittin Serdar ◽

Songul Kose ◽

...

Keyword(s):

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Tumor Formation ◽

Colorectal Tumor ◽

Protective Effects ◽

Omega 3

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Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level

Nutrients ◽

10.3390/nu11071616 ◽

2019 ◽

Vol 11 (7) ◽

pp. 1616 ◽

Cited By ~ 3

Author(s):

Hanane Moussa ◽

Molière Nguile-Makao ◽

Karine Robitaille ◽

Marie-Hélène Guertin ◽

Janie Allaire ◽

...

Keyword(s):

Prostate Cancer ◽

Fatty Acids ◽

Active Surveillance ◽

Experimental Studies ◽

Low Risk ◽

Prostate Tissue ◽

High Grade ◽

Protective Effects ◽

Omega 3 Fatty Acids ◽

Omega 3

Dietary omega-3 fatty acids (ω3), particularly long-chain ω3 (LCω3), have protective effects against prostate cancer (PCa) in experimental studies. Observational studies are conflicting, possibly because of the biomarker used. This study aimed at evaluating associations between grade reclassification and ω3 levels assessed in prostatic tissue, red blood cells (RBC), and diet. We conducted a validation cross-sectional study nested within a phase II clinical trial. We identified 157 men diagnosed with low-risk PCa who underwent a first active surveillance repeat prostate biopsy session. Fatty acid (FA) intake was assessed using a food frequency questionnaire and their levels measured in prostate tissue and RBC. Associations were evaluated using logistic regression. At first repeat biopsy session, 39 (25%) men had high-grade PCa (grade group ≥2). We found that high LCω3-eicosapentaenoic acid (EPA) level in prostate tissue (odds ratio (OR) 0.25; 95% (confidence interval (CI) 0.08–0.79; p-trend = 0.03) was associated with lower odds of high-grade PCa. Similar results were observed for LCω3 dietary intake (OR 0.30; 95% CI 0.11-0.83; p-trend = 0.02) but no association for RBC. LCω3-EPA levels in the target prostate tissue are inversely associated with high-grade PCa in men with low-risk PCa, supporting that prostate tissue FA, but not RBC FA, is a reliable biomarker of PCa risk.

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Histopathologic investigation of the protective effects of omega-3 fatty acids against boric acid-induced injury in kidney and testis tissue

Dicle Medical Journal / Dicle Tip Dergisi ◽

10.5798/diclemedj.0921.2014.02.0436 ◽

2014 ◽

Vol 41 (2) ◽

pp. 385-390

Author(s):

Ahmet Nacar ◽

Keyword(s):

Fatty Acids ◽

Boric Acid ◽

Protective Effects ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Testis Tissue

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Protective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in rats

Toxicology and Industrial Health ◽

10.1177/0748233710389852 ◽

2011 ◽

Vol 27 (6) ◽

pp. 489-495 ◽

Cited By ~ 12

Author(s):

Ismail Zararsiz ◽

Sedat Meydan ◽

Mustafa Sarsilmaz ◽

Ahmet Songur ◽

Oguz Aslan Ozen ◽

...

Keyword(s):

Fatty Acids ◽

Essential Fatty Acids ◽

Protective Effects ◽

Omega 3 ◽

Cerebellar Damage

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Gastrointestinal Bleeding After High Intake of Omega-3 Fatty Acids, Cortisone and Antibiotic Therapy: A Case Study

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.2013-0204 ◽

2014 ◽

Vol 24 (3) ◽

pp. 253-257 ◽

Cited By ~ 4

Author(s):

Paraskevi Detopoulou ◽

Vasilios Papamikos

Keyword(s):

Fatty Acids ◽

Previous History ◽

High Dose ◽

Present Observation ◽

Protective Effects ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Animal Data ◽

Gastrointestinal Problems ◽

Amateur Athlete

Omega-3 fatty acids exert a plethora of physiological actions including triglycerides lowering, reduction of inflammatory indices, immunomodulation, anti- thrombotic effects and possibly promotion of exercise performance. Their use is widespread and for commonly ingested doses their side- effects are minimal. We report a case of a 60y amateur athlete who consumed about 20 g omega-3 fatty acids daily from supplements and natural sources for a year. After the intake of cortisone and antibiotics he presented duodenum ulcer and bleeding although he had no previous history of gastrointestinal problems. Although several animal data support gastro-protective effects of omega-3 fatty acids in the present case they were not able to prevent ulcer generation. The present observation may be explained by (i) the high dose of omega-3 fatty acids and their effect on bleeding, (ii) the fact that cortisone increases their oxidation and may render them proinflammatory, (iii) other antithrombotic microconstituents included in the consumed cod-oil and/or the diet of the subject and (iv) the differences in the coagulation and fibrinolytic systems of well- trained subjects. Further studies are needed to substantiate any possible interaction of cortisone and omega-3 fatty acids in wide ranges of intake.

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