A Bilayer Hyaluronic Acid Wound Dressing to Promote Wound Healing in Diabetic Ulcer

2009 ◽  
Vol 24 (5) ◽  
pp. 424-443 ◽  
Author(s):  
Yung-Kai Lin ◽  
Yasuhiro Matsumoto ◽  
Yoshimitsu Kuroyanagi ◽  
Shizuko Kagawa
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Wound Dressing ◽  
Diabetic Ulcer ◽  
Promote Wound Healing

scholarly journals Preparation of Foam Dressings Based on Gelatin, Hyaluronic Acid, and Carboxymethyl Chitosan Containing Fibroblast Growth Factor-7 for Dermal Regeneration

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3279
Author(s):  
Longhao Jin ◽  
Sun-Jung Yoon ◽  
Dae Hoon Lee ◽  
Yun Chang Pyun ◽  
Woo Youp Kim ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Hyaluronic Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Wound Dressing ◽  
Transmission Rate ◽  
Carboxymethyl Chitosan ◽  
Amide Bond ◽  
Fibroblast Growth

Wound recovery close to the function of the native skin is the goal of wound healing. In this study, we prepared foam dressings (FDs; 2-GHC-FD-1–9, 5-GHC-FD-1–9, and 10-GHC-FD-1–9) composed of various concentrations of gelatin, hyaluronic acid, and carboxymethyl chitosan, which are chemically interconnected through amide bond formation, for evaluating wound healing. Tensile and cell proliferation tests showed that 2-GHC-FD-1–9 are suitable for wound dressing. For further evaluation, three types of FDs, 2-GHC-FD-1, 2-GHC-FD-4, and 2-GHC-FD-8 were chosen. The results of animal intradermal reactivity, water vapor transmission rate, and absorption rate of the three FDs indicated that 2-GHC-FD-8 is the most appropriate scaffold for wound healing. For wound healing acceleration, various concentrations of fibroblast growth factor-7 (FGF-7) was soaked in 2-GHC-FD-8 (2-GHC-FD-8/F1-6) and evaluated by using scanning electron microscopy, cell proliferation, release behavior, and in vivo animal tests. The FDs showed interconnected porous structures, increased cell proliferation until 8.0 × 10−11 M, controlled release with initial burst within 1 h, and sustained release for 48 h. The results of the animal test showed an appropriate concentration of FGF-7 for wound healing. In addition, 2-GHC-FD-8 is a suitable scaffold for wound healing. Therefore, we suggest that 2-GHC-FD-8/F3 is a useful wound dressing for accelerating wound healing.

Collagen-based wound dressing: Effects of hyaluronic acid and firponectin on wound healing

Biomaterials ◽  
1986 ◽  
Vol 7 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Charles J. Doillon ◽  
Frederick H. Silver
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Wound Dressing

scholarly journals Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Composite Nanosilver (AgNPs) - Based Dressing Vs. Traditional Dressing: A Prospective Randomized Control Study

2021 ◽  
Vol 15 (6) ◽  
pp. 2043-2047
Author(s):  
Ehsan A. Yahia ◽  
Ayman E. El- Sharkawey ◽  
Magda M. Bayoumi
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Wound Dressing ◽  
Diabetic Ulcer ◽  
Nano Silver ◽  
Randomized Control Study ◽  
The Third ◽  
Prospective Randomized Control Study ◽  
Randomized Control ◽  
Control Study

Background: The wound dressings perform a crucial role in cutaneous wounds management due to their ability to protect wounds and promote dermal and epidermal tissue regeneration. Aim: the aim was to evaluate the effectiveness of using hydrogel/nano silver-based dressing vs. traditional dressing on diabetic foot wound healing. Methods: Sixty patients with type-2 diabetes hospitalized for diabetic foot wound treatment were recruited from selected Surgical departments. A prospective randomized control study was carried, and the results showed that the percentage of a reduction rate of the ulcer by the third week of the treatment as in the hydrogel/nano silver-based dressing group was higher (15.11%) than traditional wound dressing group (33.44%). Moreover, the mean ulcers size "sq mm" in the hydrogel/nano silver-based dressing group recognized a faster healing rate (15.11 ± 7.89), and considerably lesser in comparison to the traditional by the third week (21.65 ± 8.4). Conclusion: The hydrogel/nanosilver-based dressing showed better results than traditional dressing in managing diabetic ulcer foot. Keywords: Diabetes, Wound, Diabetic ulcer, Wound dressing, Nanomedicine, Nano-silver.

Wound Healing and Anti-inflammatory Effects of Topical Hyaluronic Acid Injection in Surgical-Site Infection Caused by Staphylococcus aureus

2017 ◽  
Vol 16 (3) ◽  
pp. 202-207 ◽  
Author(s):  
Jin Hyung Park ◽  
Eon Ju Park ◽  
Hyung Suk Yi
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Hyaluronic Acid ◽  
Surgical Site Infection ◽  
Bacterial Count ◽  
Control Group ◽  
Site Infection ◽  
Promote Wound Healing ◽  
Gross Pathology ◽  
Anti Inflammatory

Surgical-site infection (SSI) is a common postoperative complication, primarily caused by Staphylococcus aureus. S aureus produces hyaluronidase which degrades hyaluronic acid (HA). HA prevents bacterial proliferation and has anti-inflammatory effects to promote wound healing. We evaluated the effect of HA injection with systemic antibiotics for prevention and treatment of SSIs caused by S aureus. An open wound was created on the dorsum of 40 rats. The wound bed was sutured with S aureus inoculated thread. The test group was injected with HA (HA group), and the control group received a subcutaneous injection of normal saline (NS group). All groups were then treated with intraperitoneal cefazolin injection. The sutures were removed 2 days after the procedure. Gross pathology, bacterial count, and wound histology were assessed at days 2, 4, 6, and 8 postprocedure. The HA group showed a significant reduction in the wound area compared with the control group on gross pathology (at days 8 postprocedure, 36.54% ± 6.12% vs 50.59% ± 5.50%, P < .001). The HA group showed significantly better wound healing than the control group on histological analysis, including assessment of abscess, neutrophilic infiltration, and necrosis (4.2 ± 1.2 vs 11.5 ± 2.1, P < .001). The HA group showed a lower bacterial count compared with the NS group, but the result was not significant statistically (at days 6 postprocedure, 5.11 ± 0.31 vs 5.91 ± 0.35 logCFU/mL, P = .706). In conclusion, immediate local injection of HA in wounds can reduce SSI occurrence and promote wound healing in an animal model.

A propolis enriched polyurethane-hyaluronic acid nanofibrous wound dressing with remarkable antibacterial and wound healing activities

2020 ◽  
Vol 149 ◽  
pp. 467-476 ◽  
Author(s):  
Asghar Eskandarinia ◽  
Amirhosein Kefayat ◽  
Mosayeb Gharakhloo ◽  
Maria Agheb ◽  
Darioush Khodabakhshi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Wound Dressing

Dually crosslinked self-healing hydrogels originating from cell-enhanced effect

2017 ◽  
Vol 5 (21) ◽  
pp. 3816-3822 ◽  
Author(s):  
Chen Xu ◽  
Qing Li ◽  
Xin-Ting Hu ◽  
Cai-Feng Wang ◽  
Su Chen
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Simple Cell ◽  
Self Healing ◽  
Promote Wound Healing

A new simple cell-loaded route is developed to facilely prepare self-healing and biocompatible dually crosslinked hydrogels. This bio-hydrogel can be used as wound dressing in in vivo experiments to promote wound healing, showing potential in biomedical applications.

Multifunctional green antibacterial rapid hemostasis composite wound dressing for wound healing

2021 ◽  
Author(s):  
Wencheng Liang ◽  
Qiaohui Lu ◽  
Fan Yu ◽  
Junyong Zhang ◽  
Chuang Xiao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Excessive Bleeding ◽  
Promote Wound Healing

Rapid hemostasis and antibacterial were essential for novel wound dressing to promote wound healing. Especially, timely and rapid hemostasis could be benefit to reduce the mortality caused by excessive bleeding...

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