Neutrophil Functions in Lead-Exposed Workers

1990 ◽  
Vol 9 (4) ◽  
pp. 231-233 ◽  
Author(s):  
A. Bergeret ◽  
E. pouget ◽  
R. Tedone ◽  
T. Meygret ◽  
R. Cadot ◽  
...  
Keyword(s):  
Blood Lead ◽  
Ethnic Origin ◽  
Drug Intake ◽  
Smoking Habits ◽  
Blood Lead Levels ◽  
Exposed Workers ◽  
Clinical Consequences ◽  
Lead Levels

Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemiluminescence was found to be slightly but not significantly altered in exposed workers. In contrast, chemotaxis using the agarose technique was significantly depressed. These results are in agreement with previous in-vitro findings. A further assessment of clinical consequences is warranted.

Influence of VDR and HFE polymorphisms on blood lead levels of occupationally exposed workers

2020 ◽  
pp. 096032712097545
Author(s):  
Monica Shirley Mani ◽  
Amitha Puranik ◽  
Shama Prasada Kabekkodu ◽  
Manjunath B Joshi ◽  
Herman Sunil Dsouza
Keyword(s):  
Blood Lead ◽  
Negative Influence ◽  
Positive Influence ◽  
Health Concern ◽  
Blood Lead Levels ◽  
Lead Metabolism ◽  
Alad Activity ◽  
Exposed Workers ◽  
Occupationally Exposed ◽  
Lead Levels

Lead is a ubiquitous heavy metal toxin of significant public health concern. Every individual varies in their response to lead’s toxic effects due to underlying genetic variations in lead metabolizing enzymes or proteins distributed in the population. Earlier studies, including our lab, have attributed the influence of ALAD (δ-Aminolevulinate dehydratase) polymorphism on blood lead retention and ALAD activity. The present study aimed to investigate the influence of VDR (Vitamin D receptor) and HFE (Hemochromatosis) polymorphisms in modulating blood lead levels (BLLs) of occupationally exposed workers. 164 lead-exposed subjects involved in lead alloy manufacturing and battery breaking and recycling processes and 160 unexposed controls with BLLs below 10 µg/dL recruited in the study. Blood lead levels, along with a battery of biochemical assays and genotyping, were performed. Regression analysis revealed a negative influence of BLLs on ALAD activity ( p < 0.0001) and a positive influence on smokeless tobacco use ( p < 0.001) in lead-exposed subjects. A predicted haplotype of the three VDR polymorphisms computed from genotyping data revealed that T-A-A haplotype increased the BLLs by 0.93 units ( p ≤ 0.05) and C-C-A haplotype decreased the BLLs by 7.25 units ( p ≤ 0.05). Further analysis revealed that the wild-type CC genotype of HFE H63D presented a higher median BLL, indicating that variant C allele may have a role in increasing the concentration of lead. Hence, the polymorphism of genes associated with lead metabolism might aid in predicting genetic predisposition to lead and its associated effects.

scholarly journals Assessment of Thyroid Function and Oxidative Stress State in Foundry Workers Exposed to Lead

2020 ◽  
Vol 10 (27) ◽  
pp. 200903 ◽  
Author(s):  
Yosri A. Fahim ◽  
Nevin E. Sharaf ◽  
Ibrahim W. Hasani ◽  
Eman A. Ragab ◽  
Heba K. Abdelhakim
Keyword(s):  
Oxidative Stress ◽  
Thyroid Function ◽  
Blood Lead ◽  
Research Centre ◽  
Blood Lead Levels ◽  
Control Group ◽  
Exposed Workers ◽  
Occupationally Exposed ◽  
Lead Levels ◽  
Foundry Workers

Background. Exposure to lead (Pb) has been associated with endocrine, hematological, gastrointestinal, renal and neurological problems in humans. However, effects on the thyroid gland are controversial. Objectives. The aim of the present study was to assess thyroid function in foundry workers occupationally exposed to Pb and the mechanism of oxidative-antioxidant imbalance. Methods. Thyroid function parameters and markers of oxidative stress were examined in 59 adult males who had been occupationally exposed to Pb. The results were then compared to those of 28 male subjects who had no history of Pb exposure or thyroid abnormalities and served as a control group. Results. Mean blood lead levels (16.5±1.74 μg/dl) were significantly higher among the exposed workers compared to those of the control group (12.8±1.16 μg/dl, (p <0.001)). The exposed group had significantly increased free triiodothyronine (FT3), free thyroxine (FT4) and significantly decreased thyroid stimulating hormone (TSH) (1.77±0.44 μIU/ml), whereas the control group had a TSH level of 2.61±0.94 μIU/ml (p< 0.0001). A state of oxidative stress was indicated by the significant increase in mean levels of malondialdehyde (MDA) and significant decrease in glutathione (GSH) (p < 0.0001). There was a significant positive correlation (r=0.358, p <0.05) between blood lead levels (BLL) and duration of employment, while BLL showed a significant negative correlation with TSH (r =−0.486, p <0.001), and GSH (r =−0.336, p <0.05). Of the occupationally exposed workers, 32.76% had elevated thyroid hormones. The results showed a significant positive relationship between GSH and TSH (β coefficient=0.274, p < 0.05), MDA with FT3 (β coefficient=0.355, p < 0.05) and FT4 (β coefficient = 0.491, p < 0.0001) among exposed workers. Conclusions. Workers exposed to Pb dust proved to be at risk for hyperthyroidism, which was found to have a significant role in oxidative–antioxidant imbalance present among workers with increasing duration of exposure. Participant Consent. Obtained Ethics Approval. This study was approved by the Ethical Committee of the National Research Centre in Egypt (NRC) under the registration number 15225. Competing Interests. The authors declare no competing financial interests.

scholarly journals Fast Hemoglobin in Lead Poisoning

Blood ◽  
1966 ◽  
Vol 28 (3) ◽  
pp. 377-386 ◽  
Author(s):  
SAMUEL CHARACHE ◽  
DAVID J. WEATHERALL
Keyword(s):  
Lead Poisoning ◽  
Molecular Species ◽  
Hypochromic Anemia ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Oxidized Glutathione ◽  
Elevated Blood ◽  
Lead Levels ◽  
Elevated Blood Lead Levels

Abstract 1. An electrophoretically fast hemoglobin was found in approximately 40 per cent of preschool children with elevated blood lead levels. 2. Fast hemoglobin was found more often in lead-poisoned patients with hypochromic anemia than in patients with normochromic red cells. 3. Fast hemoglobin differed from hemoglobins produced in vitro by incubation with chromate or oxidized glutathione. It had electrophoretic properties similar to that found in a few patients receiving tolbutamide. 4. Fast hemoglobin could not be differentiated from normal hemoglobin A3 by any technic utilized. 5. Both lead and A3 hemoglobins were heterogeneous molecular species. 6. The mechanisms leading to the production of hemoglobin A3 and lead hemoglobin remain unknown.

scholarly journals Induction of myeloperoxidase deficiency in granulocytes in lead- intoxicated dogs

Blood ◽  
1979 ◽  
Vol 53 (4) ◽  
pp. 588-593 ◽  
Author(s):  
KC Caldwell ◽  
L Taddeini ◽  
RL Woodburn ◽  
GL Anderson ◽  
M Lobell
Keyword(s):  
Enzyme Activity ◽  
Lead Poisoning ◽  
Clinical Signs ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Red Cell ◽  
Lead Levels ◽  
Red Cell Membranes

Abstract Lead interferes with heme synthesis in erythrocytes and has a deleterious effect on red cell membranes. We measured myeloperoxidase (MPO) enzyme activity in the granulocytes of dogs fed increasing quantities of lead. Concurrently, iodination capability and in vitro bactericidal activity were measured. Blood lead levels were monitored. Three of 4 dogs poisoned with lead developed significant decreases in MPO enzyme activity in their granulocytes. The decline in MPO activity correlated with cumulative lead toxicity as judged by blood lead levels and clinical signs of lead poisoning. Iodination ability in all 4 dogs decreased with cumulative lead toxicity. After discontinuation of lead administration, recovery of granulocyte MPO activity preceded recovery of iodination ability. This observation suggests the possibility of separate effects of lead on iodination ability and MPO activity. Moderate impairment of bactericidal capacity developed in 3 of 4 dogs with severe lead poisoning. Clinical infections were not observed during the course of the study.

scholarly journals Blood Lead Levels and Cause-Specific Mortality of Inorganic Lead-Exposed Workers in South Korea

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140360 ◽  
Author(s):  
Min-Gi Kim ◽  
Jae-Hong Ryoo ◽  
Se-Jin Chang ◽  
Chun-Bae Kim ◽  
Jong-Ku Park ◽  
...  
Keyword(s):  
South Korea ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Inorganic Lead ◽  
Specific Mortality ◽  
Exposed Workers ◽  
Lead Levels

Association of glutathione S-transferase genes (GSTM1 AND GSTT1) with blood lead levels in occupationally lead-exposed workers

2019 ◽  
Vol 34 (1) ◽  
pp. S78-S79
Author(s):  
Himani ◽  
Sudip Datta ◽  
Jamal Akhtar Ansari ◽  
Dilutpal Sharma ◽  
Abbas Ali Mahdi
Keyword(s):  
Blood Lead ◽  
Blood Lead Levels ◽  
Glutathione S Transferase ◽  
Exposed Workers ◽  
Lead Levels
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