Intrapleural Administration of Fibres Induces Mesothelioma in Rats in the same Relative Order of Hazard as Occurs in Man after Exposure

1992 ◽  
Vol 11 (6) ◽  
pp. 530-534 ◽  
Author(s):  
P. Carthew ◽  
R.J. Hill ◽  
R.E. Edwards ◽  
P.N. Lee
Keyword(s):  
Dose Response ◽  
Relative Sensitivity ◽  
Route Of Administration ◽  
Published Data ◽  
Relative Order ◽  
Response Data ◽  
Effect Level ◽  
Dose Responses ◽  
The Relationship ◽  
Intrapleural Administration

1 The dose—response data for the induction of mesothelioma, in rats, by the intrapleural administration of the fibrous zeolite, erionite, has been compared to the published data for the crocidolite and chrysotile forms of asbestos. Erionite is more than two orders of magnitude more carcinogenic than either of the two forms of asbestos examined. 2 The relative sensitivity of the intrapleural and intraperitoneal routes of injection were also examined. The sensitivity of the intraperitoneal over the intrapleural route of administration was considerably greater for all the forms of asbestos examined but not for erionite. 3 The relationship for different fibres, between the number of fibres required to give animals mesothelioma, at the 50% or 10% observable tumour effect level (OTEL) was examined, and a ranking of relative carcinogenicity was made. 4 This showed that the data derived from the dose responses obtained by the intrapleural administration of fibres to rats ranked the relative carcinogenicity of erionite, crocidolite and chrysotile in accord with the known clinical mesothelioma induction in man after exposure to these fibres. Examination of the carcinogenicity ranking from data derived from intraperitoneal injections of fibres was not in accord with the known clinical mesothelioma induction in man for the various asbestos types examined.

The guinea pig tracheobronchial spiral strip: responses to selected agonists

1978 ◽  
Vol 56 (5) ◽  
pp. 823-827 ◽  
Author(s):  
C. J. Hanna ◽  
S. H. Roth
Keyword(s):  
Regression Analysis ◽  
Guinea Pig ◽  
Dose Response ◽  
Effective Concentration ◽  
Relative Order ◽  
Response Curves ◽  
Response Data ◽  
Significant Difference ◽  
Dose Dependent

The guinea pig tracheal spiral strip is a useful preparation for studying bronchoconstrictor and bronchodilator compounds. Employing a simple and rapid modification of this technique, experiments were performed in vitro to quantitate the effects of selected bronchospastic agents on guinea pig tracheobronchial smooth muscle. Three sections of the main airways were prepared from each animal: an upper tracheal, a lower tracheal, and a bronchial segment. The dose-dependent contractile responses of the three tissue segments were determined for carbachol, acetylcholine, histamine, 5-hydroxytryptamine, and bradykinin, Differences were observed amongst the agonists in magnitudes of contraction, effective concentration ranges, and slopes of dose–response curves. ED25, ED50, and ED75, values were calculated from regression analysis of dose–response data. The relative order for these agents to produce maximum contractions was found to be carbachol [Formula: see text] acetylcholine > histamine > 5-hydroxytryptamine > bradykinin. Furthermore, it was found that there was no significant difference between the three tissue segments in their responses to the various agonists.

Extrapolation of Laboratory pH Dose–Response Data to Fluctuating Environments: Comparisons with a Null Model

1989 ◽  
Vol 46 (9) ◽  
pp. 1499-1509
Author(s):  
James W. Haefner ◽  
Linda C. Abbott
Keyword(s):  
Monte Carlo ◽  
Dose Response ◽  
Survival Rates ◽  
Null Model ◽  
Simulated Data ◽  
Parameter Estimates ◽  
Published Data ◽  
Response Data ◽  
Laboratory Conditions ◽  
Fluctuating Environments

A simple model was developed to extrapolate laboratory dose–response data to randomly varying conditions. We fit published data of dose–response experiments for the effects of low pH stress on survival rates of stream macro-invertebrates to a modification of the Weibull distribution. Using the resulting parameter estimates and Monte Carlo simulation, we compared the values obtained in constant laboratory conditions with the expected survival rates obtained in fluctuating environments. For each of three species, we performed 108 Monte Carlo experiments in a full factorial design that varied the mean pH, the standard deviation of pH fluctuations, the distribution from which pH values were drawn, the distributions of runs of constant pH, and the presence of episodic events. Fluctuating environments decreased the survival rates of resistant species, but increased survivorship of sensitive species. No one exposure duration under laboratory conditions could consistently be extrapolated to the suite of variable environments we examined. Probit analyses performed on the observed and simulated data indicated that LC-50s of different observed exposure durations were similar to each other and to the LC-50s of the simulated data assuming an exposure of 24 h. Based on these results, we recommend that toxicity studies incorporate temporal variability directly by using varying dose levels in laboratory tests.

Dose-response assessment by a fuzzy linear-regression method

2001 ◽  
Vol 43 (2) ◽  
pp. 133-140 ◽  
Author(s):  
Y. W. Lee ◽  
S. Y. Chung ◽  
I. Bogardi ◽  
M. F. Dahab ◽  
S. E. Oh
Keyword(s):  
Linear Regression ◽  
Dose Response ◽  
Health Effect ◽  
Response Assessment ◽  
Exposure Dose ◽  
Linear Regression Method ◽  
Fuzzy Linear Regression ◽  
Response Data ◽  
Nitrate Dose ◽  
The Relationship

Regression analysis has been used to characterize the relationship between an exposure dose and the incidence of an adverse health effect such as cancer. However, the regression rarely describes the true relationship due to uncertainties in dose-response data and relationships. Therefore, a method is developed to perform dose-response assessments by a fuzzy linear regression which explicitly exhibit these uncertainties. This method is applied to define the relationship between a particular nitrate dose to humans and its corresponding cancer risk.

scholarly journals The relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose–response meta-analysis by the EURRECA Network

2012 ◽  
Vol 108 (11) ◽  
pp. 1962-1971 ◽  
Author(s):  
Nicola M. Lowe ◽  
Marisol Warthon Medina ◽  
Anna-Louise Stammers ◽  
Sujata Patel ◽  
Olga W. Souverein ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Best Practice ◽  
Meta Analysis ◽  
Population Characteristics ◽  
Cochrane Library ◽  
Published Data ◽  
Quantitative Evidence ◽  
Core Content ◽  
The Relationship

Dietary Zn recommendations vary widely across Europe due to the heterogeneity of approaches used by expert panels. Under the EURopean micronutrient RECommendations Aligned (EURRECA) consortium a protocol was designed to systematically review and undertake meta-analyses of research data to create a database that includes ‘best practice’ guidelines which can be used as a resource by future panels when setting micronutrient recommendations. As part of this process, the objective of the present study was to undertake a systematic review and meta-analysis of previously published data describing the relationship between Zn intake and status in adults. Searches were performed of literature published up to February 2010 using MEDLINE, Embase and the Cochrane Library. Data extracted included population characteristics, dose of Zn, duration of study, dietary intake of Zn, and mean concentration of Zn in plasma or serum at the end of the intervention period. An intake–status regression coefficient ($\circ {>\beta }$) was estimated for each individual study, and pooled meta-analysis undertaken. The overall pooled $\circ {>\beta }$ for Zn supplementation on serum/plasma Zn concentrations from randomised controlled trials and observational studies was 0·08 (95 % CI 0·05, 0·11; P < 0·0001; I2 84·5 %). An overall $\circ {>\beta }$ of 0·08 means that for every doubling in Zn intake, the difference in Zn serum or plasma concentration is $2^{ \circ {>\beta }}$ (20·08 = 1·06), which is 6 %. Whether the dose–response relationship, as provided in the present paper, could be used as either qualitative or quantitative evidence to substantiate the daily Zn intake dose necessary to achieve normal or optimal levels of biomarkers for Zn status remains a matter of discussion.

scholarly journals Intraspecific Latitudinal Variation in Nest Orientation Among Ground-Nesting Passerines: A Study Using Published Data

The Condor ◽  
2007 ◽  
Vol 109 (2) ◽  
pp. 441-446 ◽  
Author(s):  
Niall H.K. Burton
Keyword(s):  
Early Morning ◽  
Published Data ◽  
Nest Entrance ◽  
Clear Trend ◽  
European Species ◽  
Statistical Comparison ◽  
Species Comparisons ◽  
Nest Microclimate ◽  
The Relationship ◽  
Ground Nesting

Abstract The relationship between nest entrance orientation and latitude among ground-nesting passerines was reviewed using published information. Data were collated for seven North American and European species. Pooling within-species comparisons, there was a clear trend from a preference for north-facing nests at lower latitudes to eastward- or southward-facing nests farther north. Orientations differed significantly in eight of 12 cases for which statistical comparison was possible, means differing in the expected direction in six of these cases. These results highlight how the influence of solar radiation on nest microclimate typically delineates preferred nest orientation in these species, i.e., at lower latitudes, the need for shade results in a preference for northward orientations; at mid latitudes, eastward orientations predominate, reflecting a probable balance between the benefits of warmth in the early morning and shade in the afternoon; while at high latitudes, nests may be oriented southward to gain warmth throughout the day.

scholarly journals Weighted mixed-effects dose–response models for tables of correlated contrasts

2021 ◽  
Vol 21 (2) ◽  
pp. 320-347
Author(s):  
Nicola Orsini
Keyword(s):  
Dose Response ◽  
Response Pattern ◽  
Mixed Effects ◽  
Data Generation ◽  
Measures Of Association ◽  
Response Models ◽  
Response Data ◽  
Hazard Ratios ◽  
Health Related ◽  
Generation Mechanisms

Recognizing a dose–response pattern based on heterogeneous tables of contrasts is hard. Specification of a statistical model that can consider the possible dose–response data-generating mechanism, including its variation across studies, is crucial for statistical inference. The aim of this article is to increase the understanding of mixed-effects dose–response models suitable for tables of correlated estimates. One can use the command drmeta with additive (mean difference) and multiplicative (odds ratios, hazard ratios) measures of association. The postestimation command drmeta_graph greatly facilitates the visualization of predicted average and study-specific dose–response relationships. I illustrate applications of the drmeta command with regression splines in experimental and observational data based on nonlinear and random-effects data-generation mechanisms that can be encountered in health-related sciences.

Archiving of Food Samples from Restaurants and Caterers—Quantitative Profiling of Outbreaks of Foodborne Salmonellosis in Japan

2004 ◽  
Vol 67 (9) ◽  
pp. 2024-2032 ◽  
Author(s):  
FUMIKO KASUGA ◽  
MASAMITSU HIROTA ◽  
MASAMICHI WADA ◽  
TOSHIHIKO YUNOKAWA ◽  
HAJIME TOYOFUKU ◽  
...  
Keyword(s):  
Dose Response ◽  
Storage System ◽  
Epidemiological Data ◽  
Food Samples ◽  
Food Storage ◽  
Disease Rate ◽  
Data Sets ◽  
Response Data ◽  
Quantitative Profiling

The Ministry of Health, Labor and Welfare (former MHW) of Japan issued a Directive in 1997 advising restaurants and caterers to freeze portions of both raw food and cooked dishes for at least 2 weeks. This system has been useful for determining vehicle foods at outbreaks. Enumeration of bacteria in samples of stored food provide data about pathogen concentrations in the implicated food. Data on Salmonella concentrations in vehicle foods associated with salmonellosis outbreaks were collected in Japan between 1989 and 1998. The 39 outbreaks that occurred during this period were categorized by the settings where the outbreaks took place, and epidemiological data from each outbreak were summarized. Characteristics of outbreak groups were analyzed and compared. The effect of new food-storage system on determination of bacterial concentration was evaluated. Freezing and nonfreezing conditions prior to microbial examination were compared in the dose-response relationship. Data from outbreaks in which implicated foods had been kept frozen suggested apparent correlation between the Salmonella dose ingested and the disease rate. Combined with results of epidemiological investigation, quantitative data from the ingested pathogen could provide complete dose-response data sets.

Underestimation of Dose - Response Relationship with Particular Reference to the Relationship between the Dietary Intake of Mercury and its Concentration in Blood

1988 ◽  
Vol 7 (2) ◽  
pp. 129-132 ◽  
Author(s):  
J.C. Sherlock ◽  
M.J. Quinn
Keyword(s):  
Linear Regression ◽  
Dietary Intake ◽  
Dose Response ◽  
Mercury Concentration ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Blood Mercury ◽  
Relationship Of ◽  
The Relationship ◽  
Blood Mercury Concentration

Wide discrepancies have been observed between controlled and uncontrolled intake studies of the relationship of blood mercury concentration to intake of mercury. The probable reason for the apparent discrepancies is that the within-subject variation of mercury intake in the uncontrolled studies was almost certainly considerably larger than the within-subject variation in blood mercury concentration; in these circumstances, the apparent slope obtained from a linear regression of blood mercury on intake will invariably be much smaller than the true slope. Studies of the exposure or intake of any substance should therefore include a consideration of the likely within-subject variation in the exposure or intake relative to that in the effect.

Nonclinical Core Competencies and Effects of Interprofessional Teamwork in Disaster and Emergency Response Training and Practice: A Pilot Study

2013 ◽  
Vol 7 (4) ◽  
pp. 395-402 ◽  
Author(s):  
Jennifer Peller ◽  
Brian Schwartz ◽  
Simon Kitto
Keyword(s):  
Cognitive Skills ◽  
Disaster Response ◽  
Interprofessional Collaboration ◽  
Core Competencies ◽  
Evidence Base ◽  
Response Data ◽  
Competency Training ◽  
Interprofessional Teamwork ◽  
The Relationship ◽  
Depth Interviews

AbstractObjectiveTo define and delineate the nontechnical core competencies required for disaster response, Disaster Medical Assistance Team (DMAT) members were interviewed regarding their perspectives and experiences in disaster management. Also explored was the relationship between nontechnical competencies and interprofessional collaboration.MethodsIn-depth interviews were conducted with 10 Canadian DMAT members to explore how they viewed nontechnical core competencies and how their experiences influenced their perceptions toward interprofessonalism in disaster response. Data were examined using thematic analysis.ResultsNontechnical core competencies were categorized under austere skills, interpersonal skills, and cognitive skills. Research participants defined interprofessionalism and discussed the importance of specific nontechnical core competencies to interprofessional collaboration.ConclusionsThe findings of this study established a connection between nontechnical core competencies and interprofessional collaboration in DMAT activities. It also provided preliminary insights into the importance of context in developing an evidence base for competency training in disaster response and management. (Disaster Med Public Health Preparedness. 2013;0:1–8)

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