MicroRNA-204-5p Inhibits Ovarian Cancer Cell Proliferation by Down-Regulating USP47

Ovarian cancer (OC) is the most lethal gynecologic cancer, and the incidence of OC has risen steadily worldwide. Numerous microRNAs (miRNAs) have been found to be involved in the progression of OC. miR-204-5p is down-regulated and functions as a tumor suppressor in various types of human malignant tumors. However, the biological roles and molecular mechanisms of miR-204-5p in OC still remain unclear. In this study, the aberrant down-regulation of miR-204-5p was detected in OC tissues. We also observed that miR-204-5p overexpression represses OC cell proliferation. Ubiquitin-specific peptidase 47 (USP47) is verified as the functional target of miR-204-5p, through which it plays an important biological role in OC. Our results uncover new functions and mechanisms for miR-204-5p in the progression of OC, and provide a potential therapeutic target for the treatment of OC.

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Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target

Translational Oncology ◽

10.1016/j.tranon.2014.04.008 ◽

2014 ◽

Vol 7 (3) ◽

pp. 410-419 ◽

Cited By ~ 20

Author(s):

Rémi Longuespée ◽

Frédéric Couture ◽

Christine Levesque ◽

Anna Kwiatkowska ◽

Roxane Desjardins ◽

...

Keyword(s):

Ovarian Cancer ◽

Cell Proliferation ◽

Tumor Progression ◽

Cancer Cell ◽

Therapeutic Target ◽

Ovarian Cancer Cell ◽

Cancer Cell Proliferation ◽

Proprotein Convertases

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ELNCRNA1, A LONG NONCODING RNA TRANSCRIPTIONALLY INDUCED BY OESTROGEN, PROMOTES EPITHELIAL OVARIAN CANCER CELL PROLIFERATION

10.26226/morressier.599bdc7ad462b80296ca15fa ◽

2017 ◽

Author(s):

junjun qiu

Keyword(s):

Ovarian Cancer ◽

Cell Proliferation ◽

Epithelial Ovarian Cancer ◽

Cancer Cell ◽

Long Noncoding Rna ◽

Noncoding Rna ◽

Ovarian Cancer Cell ◽

Cancer Cell Proliferation ◽

Epithelial Ovarian Cancer Cell

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Small Molecule Targeting of Oxysterol-Binding Protein (OSBP)-Related Protein 4 and OSBP Inhibits Ovarian Cancer Cell Proliferation in Monolayer and Spheroid Cell Models

ACS Pharmacology & Translational Science ◽

10.1021/acsptsci.0c00207 ◽

2021 ◽

Vol 4 (2) ◽

pp. 744-756

Author(s):

Ryan C. Bensen ◽

Gokhan Gunay ◽

Matthew C. Finneran ◽

Isha Jhingan ◽

Handan Acar ◽

...

Keyword(s):

Ovarian Cancer ◽

Cell Proliferation ◽

Cancer Cell ◽

Small Molecule ◽

Ovarian Cancer Cell ◽

Binding Protein ◽

Cancer Cell Proliferation ◽

Related Protein ◽

Cell Models ◽

Oxysterol Binding Protein

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Evaluation of MACF1-regulatory non-coding RNA as a potential therapeutic target in Colorectal Cancer

QJM ◽

10.1093/qjmed/hcab088.011 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Rowaida Mohammed Reda M. M Aboushahba ◽

Fayda Ibrahim Abdel Motaleb ◽

Ahmed Abdel Aziz Abou-Zeid ◽

Enas Samir Nabil ◽

Dalia Abdel-Wahab Mohamed ◽

...

Keyword(s):

Colorectal Cancer ◽

Cell Proliferation ◽

Wnt Signaling ◽

Cell Line ◽

Signaling Pathway ◽

Therapeutic Target ◽

Molecular Mechanisms ◽

Wnt Signaling Pathway ◽

Control Group ◽

Potential Therapeutic Target

ABSTRACT Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths world-wide. There is an increasing need for the identification of novel biomarkers/targets for early diagnosis and for the development of novel chemopreventive and therapeutic agents for CRC. Recently, MACF1 gene has emerged as a potential therapeutic target in cancer as it involved in processes critical for tumor cell proliferation, invasion and metastasis. It is suggested that MACF1 may function in cancers through Wnt signaling. MiR-34a is a well-known tumor suppressor miRNA.miR-34a targets MACF1 gene as a part of the wnt signaling pathway. In this study, 40 colonic tissues were collected from CRC patients (20) and control subjects (20). miR-34a-5p was assessed by real time PCR in all study groups. The results showed highly significant decrease (P < 0.01) in miR-34a relative expression in the CRC group (median RQ 0.13) when compared to the benign group (median RQ 5.3) and the healthy control group (median RQ 19.63). miR-34a mimic and inhibitor were transfected in CaCo-2 cell line and proliferation was assessed. The transfection of the cell line with miR-34a mimic decreased cell proliferation. Our study suggests that miR-34a-5p targets MACF1 gene as a part of the wnt signaling pathway leading to the involvement in the molecular mechanisms of CRC development and progression.

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