scholarly journals UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769220 ◽  
Author(s):  
Harsimran Sidhu ◽  
Neena Capalash
Keyword(s):  
Dna Methylation ◽  
Cancer Cells ◽  
Cancer Diagnosis ◽  
Growth Arrest ◽  
Cancer Therapeutics ◽  
Molecular Target ◽  
Compelling Evidence ◽  
Diagnosis And Prognosis ◽  
Ability To Act ◽  
Potential Biomarker

UHRF1 is a master regulator of epigenome as it coordinates DNA methylation and histone modifications. Compelling evidence suggests a strong link between UHRF1 overexpression and tumorigenesis, substantiating its ability to act as a potential biomarker for cancer diagnosis and prognosis. UHRF1 also mediates repair of damaged DNA that makes cancer cells resistant toward cytocidal drugs. Hence, understanding the molecular mechanism of UHRF1 regulation would help in developing cancer therapeutics. Natural compounds have shown applicability to downregulate UHRF1 leading to growth arrest and apoptosis in cancer cells.

scholarly journals Biomechanical Properties of Cancer Cells

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 887
Author(s):  
Gaël Runel ◽  
Noémie Lopez-Ramirez ◽  
Julien Chlasta ◽  
Ingrid Masse
Keyword(s):  
Cancer Cells ◽  
Cancer Diagnosis ◽  
Crucial Role ◽  
Biomechanical Properties ◽  
Supplementary Information ◽  
Cancer Cell Growth ◽  
Diagnosis And Prognosis ◽  
Surrounding Environment ◽  
Surrounding Extracellular Matrix

Since the crucial role of the microenvironment has been highlighted, many studies have been focused on the role of biomechanics in cancer cell growth and the invasion of the surrounding environment. Despite the search in recent years for molecular biomarkers to try to classify and stratify cancers, much effort needs to be made to take account of morphological and nanomechanical parameters that could provide supplementary information concerning tissue complexity adaptation during cancer development. The biomechanical properties of cancer cells and their surrounding extracellular matrix have actually been proposed as promising biomarkers for cancer diagnosis and prognosis. The present review first describes the main methods used to study the mechanical properties of cancer cells. Then, we address the nanomechanical description of cultured cancer cells and the crucial role of the cytoskeleton for biomechanics linked with cell morphology. Finally, we depict how studying interaction of tumor cells with their surrounding microenvironment is crucial to integrating biomechanical properties in our understanding of tumor growth and local invasion.

Ultra-sensitive MicroRNA-21 detection based on multiple cascaded strand displacement amplification and CRISPR/Cpf1 (MC-SDA/CRISPR/Cpf1)

2021 ◽  
Author(s):  
Xiaolong Chen ◽  
Yuanyi Deng ◽  
Gaihua Cao ◽  
Yifan Xiong ◽  
Danqun Huo ◽  
...  
Keyword(s):  
Cancer Diagnosis ◽  
Analytical Method ◽  
Strand Displacement ◽  
Strand Displacement Amplification ◽  
Diagnosis And Prognosis ◽  
Potential Biomarker ◽  
Cancer Diagnosis And Prognosis

MicroRNA-21 (miR-21) has been considered as a potential biomarker for cancer diagnosis and prognosis due to its highly expressed in tumors. Here, an analytical method which integrates the multiple cascaded...

scholarly journals Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy

2021 ◽  
Vol 8 ◽  
Author(s):  
Jenniffer Linares ◽  
Juan A. Marín-Jiménez ◽  
Jordi Badia-Ramentol ◽  
Alexandre Calon
Keyword(s):  
Cancer Cells ◽  
Cancer Progression ◽  
Cancer Diagnosis ◽  
Response To Treatment ◽  
Cancer Associated Fibroblasts ◽  
Epithelial Cancer ◽  
Diagnosis And Prognosis ◽  
Secreted Factors ◽  
Druggable Targets ◽  
Lines Of Evidence

Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology.

scholarly journals Matrix Metalloproteinase 11 is a Potential Biomarker in Bladder Cancer Diagnosis and Prognosis

2020 ◽  
Vol Volume 13 ◽  
pp. 9059-9069
Author(s):  
Chen Chen ◽  
Xiaoping Liu ◽  
Jiazhi Jiang ◽  
Shenjuan Li ◽  
Gang Wang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Diagnosis ◽  
Diagnosis And Prognosis ◽  
Potential Biomarker ◽  
P Matrix ◽  
Cancer Diagnosis And Prognosis

Biodegradable nanoparticle-assisted and multiplexed imaging of asymmetric RNA expressions in live cells for precise cancer diagnosis and prognosis

Nanoscale ◽  
2020 ◽  
Vol 12 (47) ◽  
pp. 24100-24106
Author(s):  
Xia Li ◽  
Fang Yang ◽  
Chunfang Gan ◽  
Ruo Yuan ◽  
Yun Xiang
Keyword(s):  
Cancer Cells ◽  
Cancer Diagnosis ◽  
Live Cells ◽  
Diagnosis And Prognosis ◽  
Multiplexed Imaging ◽  
Biodegradable Nanoparticle ◽  
Cancer Diagnosis And Prognosis

Simultaneous and amplified imaging of asymmetrically expressed RNAs in live cancer cells by the biodegradable ZnO/DNAzyme nanoparticle probe.

scholarly journals RNAM EXPRESSION AND DNA METHYLATION OF DKK2 GENE IN COLORECTAL CÂNCER

2021 ◽  
Vol 58 (1) ◽  
pp. 55-60
Author(s):  
Ronaldo Eliezer MAMELLI ◽  
Aledson Vitor FELIPE ◽  
Tiago Donizetti SILVA ◽  
Vanessa HINZ ◽  
Nora Manoukian FORONES
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Overall Survival ◽  
Cancer Diagnosis ◽  
Promoter Methylation ◽  
Cpg Islands ◽  
Polymerase Chain Reaction Analysis ◽  
Diagnosis And Prognosis ◽  
Melting Analysis ◽  
Cancer Tissues

ABSTRACT BACKGROUND: Colorectal cancer is the third most common neoplasm in the world. Methylation of tumor related genes in CpG islands can cause gene silencing and been involved in the development of cancer. The potential role of DKK2 as a biomarker for early diagnosis of colorectal cancer remains unclear. OBJECTIVE: The aim of the study was to evaluate the profile of methylation and RNAm expression of DKK2 as potential predictors of colorectal cancer diagnosis and prognosis. METHODS: Expression of mRNAs encoding DKK2 in 35 colorectal cancer tissues was quantified using real-time polymerase chain reaction analysis. The DNA methylation was studied by high resolution melting analysis. The general characteristics of the patients were collected. DKK2 methylation and expression were compared to clinical, pathological aspects and overall survival. RESULTS: Among the 35 patients studied, 18 were male, 10 were on right colon and 25 on left colon. Among the 20 patients with high hypermethylation, 15 of them had mRNA low expression of DKK2. There was no significant association between DKK2 promoter methylation and mRNA DKK2 expression and clinical or pathological features. DKK2 promoter methylation (P=0.154) and DKK2 RNA expression (P=0.345) did not show significant correlation with overall survival. CONCLUSION: DKK2 promoter methylation and DKK2 RNA status appear to be biomarkers of cancer diagnosis but not predictors of prognosis.

Sign in / Sign up

Export Citation Format

Share Document