scholarly journals Apoptosis mediated chemosensitization of tumor cells to 5-fluorouracil on supplementation of fish oil in experimental colon carcinoma

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769501 ◽  
Author(s):  
Isha Rani ◽  
Bhoomika Sharma ◽  
Sandeep Kumar ◽  
Satinder Kaur ◽  
Navneet Agnihotri
Keyword(s):  
Fatty Acids ◽  
Dna Damage ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Tumor Cells ◽  
Apoptotic Index ◽  
Apoptotic Pathway ◽  
Apoptotic Effect ◽  
Underlying Mechanisms ◽  
Apoptotic Pathways

5-Fluorouracil has been considered as a cornerstone therapy for colorectal cancer; however, it suffers from low therapeutic response rate and severe side effects. Therefore, there is an urgent need to increase the clinical efficacy of 5-fluorouracil. Recently, fish oil rich in n-3 polyunsaturated fatty acids has been reported to chemosensitize tumor cells to anti-cancer drugs. This study is designed to understand the underlying mechanisms of synergistic effect of fish oil and 5-fluorouracil by evaluation of tumor cell–associated markers such as apoptosis and DNA damage. The colon cancer was developed by administration of N,N-dimethylhydrazine dihydrochloride and dextran sulfate sodium salt. Further these animals were treated with 5-fluorouracil, fish oil, or a combination of both. In carcinogen-treated animals, a decrease in DNA damage and apoptotic index was observed. There was also a decrease in the expression of Fas, FasL, caspase 8, and Bax, and an increase in Bcl-2. In contrast, administration of 5-fluorouracil and fish oil as an adjuvant increased both DNA damage and apoptotic index by activation of both extrinsic and intrinsic apoptotic pathways as compared to the other groups. The increased pro-apoptotic effect by synergism of 5-fluorouracil and fish oil may be attributed to the incorporation of n-3 polyunsaturated fatty acids in membrane, which alters membrane fluidity in cancer cells. In conclusion, this study highlights that the induction of apoptotic pathway by fish oil may increase the susceptibility of tumors to chemotherapeutic regimens.

Protective Effect of Supplementation of Fish Oil with Highn−3 Polyunsaturated Fatty Acids against Oxidative Stress-Induced DNA Damage of Rat Liver in Vivo

2003 ◽  
Vol 51 (20) ◽  
pp. 6073-6079 ◽  
Author(s):  
Kiyomi Kikugawa ◽  
Yoshinobu Yasuhara ◽  
Ken Ando ◽  
Keiko Koyama ◽  
Kazuyuki Hiramoto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Dna Damage ◽  
Polyunsaturated Fatty Acids ◽  
Protective Effect ◽  
Fish Oil ◽  
Rat Liver

scholarly journals Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187934 ◽  
Author(s):  
Chiemi Sakai ◽  
Mari Ishida ◽  
Hideo Ohba ◽  
Hiromitsu Yamashita ◽  
Hitomi Uchida ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Dna Damage ◽  
Endothelial Cells ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Omega 3

Effects of Fish Oil with a High Content of n-3 Polyunsaturated Fatty Acids on Mouse Gut Microbiota

2014 ◽  
Vol 45 (3) ◽  
pp. 195-202 ◽  
Author(s):  
Hai-Ning Yu ◽  
Jing Zhu ◽  
Wen-sheng Pan ◽  
Sheng-Rong Shen ◽  
Wei-Guang Shan ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Mouse Gut Microbiota

Enzymatic enrichment of polyunsaturated fatty acids using novel lipase preparations modified by combination of immobilization and fish oil treatment

2011 ◽  
Vol 102 (14) ◽  
pp. 7154-7158 ◽  
Author(s):  
Jinyong Yan ◽  
Sanxiong Liu ◽  
Jiang Hu ◽  
Xiaohua Gui ◽  
Guilong Wang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil

scholarly journals Fish Oil Increases the Duodenal Flow of Long Chain Polyunsaturated Fatty Acids and trans-11 18:1 and Decreases 18:0 in Steers via Changes in the Rumen Bacterial Community

2008 ◽  
Vol 138 (5) ◽  
pp. 889-896 ◽  
Author(s):  
Eun J. Kim ◽  
Sharon A. Huws ◽  
Michael R. F. Lee ◽  
Jeff D. Wood ◽  
Stefan M. Muetzel ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bacterial Community ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Long Chain

scholarly journals Antioxidative Behavior of Phospholipids for Polyunsaturated Fatty Acids of Fish Oil

1992 ◽  
Vol 41 (2) ◽  
pp. 130-135 ◽  
Author(s):  
Setsuko HARA ◽  
Norio OKADA ◽  
Hidehiko HIBINO ◽  
Yoichiro TOTANI
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil

scholarly journals Development of farmed fish: a nutritionally necessary alternative to meat

1999 ◽  
Vol 58 (2) ◽  
pp. 377-383 ◽  
Author(s):  
J. R. Sargent ◽  
A. G. J. Tacon
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Marine Fish ◽  
Vegetable Oils ◽  
Linseed Oil ◽  
Partial Replacement ◽  
Farmed Fish ◽  
Alternative Source ◽  
Fish Feeds

The projected stagnation in the catch from global fisheries and the continuing expansion of aquaculture is considered against the background that fishmeal and fish oil are major feed stocks for farmed salmon and trout, and also for marine fish. The dietary requirement of these farmed fish for high-quality protein, rich in essential amino acids, can be met by sources other than fishmeal. However, the highly-polyunsaturated fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) present in high concentrations in fish oil are essential dietary constituents for marine fish and highly-desirable dietary constituents for salmonids. Currently, there is no feasible alternative source to fish oil for these nutrients in fish feeds. Vegetable oils rich in linoleic acid (18:2n-6) can partially substitute for 20:5n-3 and 22:6n-3 in salmonid and marinefish feeds. However, this is nutritionally undesirable for human nutrition because the healthpromoting effects of fish-derived 20:5n-3 and 22:6n-3 reflect a very high intake of 18:2n-6 relative to linolenic acid (18:3n-3) in Western diets. If partial replacement of fish oils in fish feeds with vegetable oils becomes necessary in future, it is argued that 18:3n-3-rich oils, such as linseed oil, are the oils of choice because they are much more acceptable lrom a human nutritional perspective, especially given the innate ability of freshwater fish, including salmonids, to convert dietary 18:3n-3 to 20:5n-3 and 22:6n-3. In the meantime, a more judicious use of increasinglyexpensive fish oil in aquaculture is recommended. High priorities in the future development of aquaculture are considered to be genetic improvement of farmed fish stocks with enhanced abilities to convert C18 to C20 and C22n-3 polyunsaturated fatty acids, enhanced development of primary production of 20:5n-3 and 22:6n-3 by single-cell marine organisms, and continuing development of new species.

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