Postmortem Changes and Pharmacokinetics: Review of the Literature and Case Report

1992 ◽  
Vol 26 (4) ◽  
pp. 510-514 ◽  
Author(s):  
Michele F. Shepherd ◽  
Kathleen D. Lake ◽  
Melissa A. Kamps
Keyword(s):  
Human Body ◽  
English Language ◽  
Molecular Size ◽  
Data Sources ◽  
Postmortem Changes ◽  
Sequence Of Events ◽  
English Language Journal ◽  
Drug Concentrations ◽  
Pertinent Data ◽  
The Impact

OBJECTIVE: To review the mechanisms and sequence of events that occur during ischemia and cell death and following death of the human body. The impact of these postmortem events on the distribution and pharmacokinetic behavior of drugs is described. The case study presented illustrates a possible situation where such postmortem changes could have affected the pharmacokinetics of procainamide. DATA SOURCES: English-language journal articles and reference texts identified from pertinent data sources. DATA SYNTHESIS: Postmortem changes in the human body begin at the cellular level with the onset of ischemia. As the length of time of ischemia increases and death ensues, more changes occur and lead to deterioration in tissue and organ function. These changes may affect the pharmacokinetic and distribution behavior of certain drugs. Drugs particularly affected are those whose distribution is dependent on molecular size, lipophilicity, pH, energy-dependent transport, and tissue binding. Such drugs include the tricyclic antidepressants, digoxin, and cimetidine. Other drugs with similar characteristics, such as procainamide, may also demonstrate like changes in distribution and pharmacokinetics. CONCLUSIONS: When measuring drug concentrations after death, it is important to consider the phenomenon of postmortem redistribution. Postmortem drug concentrations may not be a true reflection of antemortem concentrations and as a result, wrong conclusions could be made about the cause of death. More studies characterizing the postmortem distribution and pharmacokinetic characteristics of specific drugs are necessary.

Hypoglycemia Secondary to Trimethoprim/Sulfamethoxazole Administration in a Renal Transplant Patient

1993 ◽  
Vol 27 (3) ◽  
pp. 304-306 ◽  
Author(s):  
Jeffrey A. Johnson ◽  
Joanne E. Kappel ◽  
M. Nabi Sharif
Keyword(s):  
Renal Transplant ◽  
English Language ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Data Sources ◽  
High Dose ◽  
Hypoglycemic Episode ◽  
Medline Search ◽  
English Language Journal ◽  
Pertinent Data

OBJECTIVE: To report a case of trimethoprim/sulfamethoxazole (TMP/SMX)-induced hypoglycemia in an immunosuppressed renal transplant patient. DATA SOURCES: English-language journal articles and reference texts identified via a MEDLINE search and a bibliographic review of pertinent data sources. DATA SYNTHESIS: Hypoglycemia resulting from the combination of sulfonylureas and sulfonamides is a recognized drug interaction. Hypoglycemia induced by sulfonamides alone may be encountered less frequently. Previously reported cases of TMP/SMX-induced hypoglycemia postulated that the sulfonamide mimics hypoglycemic sulfonylurea agents and stimulates pancreatic islet cells to secrete insulin. We report a case of hypoglycemia following the administration of high-dose TMP/SMX in a renal transplant patient. Elevated C-peptide concentrations following the hypoglycemic episode indicate that hypoglycemia resulted from increased endogenous insulin secretion. CONCLUSIONS: Hypoglycemia has been a rarely encountered result of TMP/SMX use. Patients receiving TMP/SMX, particularly those with impaired renal function and those receiving high doses, should be monitored closely for hypoglycemia.

A Review of Cyclic Antidepressant-Induced Blood Dyscrasias

1992 ◽  
Vol 26 (3) ◽  
pp. 378-383 ◽  
Author(s):  
Edward A. Hartshorn ◽  
Gary M. Levin ◽  
C. Lindsay DeVane
Keyword(s):  
English Language ◽  
Human Subjects ◽  
Onset Time ◽  
Data Sources ◽  
Letters To The Editor ◽  
Data Synthesis ◽  
Chemical Structures ◽  
Study Selection ◽  
Pertinent Data

OBJECTIVE: To review the literature for cases of blood dyscrasias associated with cyclic antidepressants. Several types of blood dyscrasias are discussed. DATA SOURCES: All references were selected through the use of MEDLINE. Indexing terms were blood, abnormalities, dyscrasias, antidepressants, agranulocytosis, and eosinophilia. The only constraints were English language and human subjects. STUDY SELECTION: All cases were included except for letters to the editor of various journals when pertinent data such as doses and additional medications were omitted. DATA SYNTHESIS: The review provides a table listing the different blood dyscrasias and the drug the patient was receiving. The table also includes time of onset, time to recovery, and several symptoms for each patient. CONCLUSIONS: Common symptoms of various blood dyscrasias are discussed. The chemical structures of the antidepressants are related to phenothiazines, which are also implicated in causing blood dyscrasias. Recommendations for treatment of both the dyscrasia and depression are discussed.

On Raising the International Dissemination of German Research

2004 ◽  
Vol 51 (4) ◽  
pp. 319-328 ◽  
Author(s):  
Andreas Dinkel ◽  
Hendrik Berth ◽  
Ada Borkenhagen ◽  
Elmar Brähler
Keyword(s):  
Experimental Psychology ◽  
English Language ◽  
German Language ◽  
Psychology Research ◽  
Change Publication ◽  
English Language Journal ◽  
German Research ◽  
German Speaking ◽  
Publication Language ◽  
The Impact

Abstract. It has been proposed that German basic psychology journals should change publication language to English in order to facilitate access to research from German-speaking countries. However, to truly increase the dissemination of German research, it seems crucial to progress towards an internationalization of authors and readers. We applied bibliometric analysis to investigate the impact of the transition to English on the rate of foreign authors publishing in Zeitschrift für Experimentelle Psychologie/Experimental Psychology, as well as possible associated changes in citation patterns. There was an increase in the rate of articles published by foreign authors from 14.6 and 8.7 per cent, respectively, for the last biannual periods as German-language journal, to 52.7 per cent in the first biannual period as English-language journal. Regarding citations patterns, the clearest changes emerged for domestic authors. The results illustrate possible consequences of a transition to English as publication language, and reveal that Experimental Psychology has successfully established certain prerequisites for an increase of the international dissemination of German psychology research.

Understanding interorganizational network evolution

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Harini K.N. ◽  
Manoj T. Thomas
Keyword(s):  
English Language ◽  
Research Work ◽  
Network Evolution ◽  
Interorganizational Network ◽  
Research Attention ◽  
Content Type ◽  
English Language Journal ◽  
Research Questions ◽  
Environmental Causes ◽  
The Impact

Purpose The purpose of this paper is to provide an overview of the available insights regarding interorganizational network evolution. The research questions being addressed are as follows: What is the nature of interorganizational network evolution? And what causes interorganizational network evolution? The review hence focuses on the nature of interorganizational network evolution (at the ego-network level and whole-network level) and the causes of interorganizational network evolution (firm-related causes and environmental causes). This paper highlights relevant gaps in the existing literature on interorganizational network evolution while outlining a research agenda by identifying key research questions and issues requiring further scholarly contributions to stimulate research in this field. Design/methodology/approach An extensive review of scholarly peer-reviewed English language journal articles was conducted in the subject areas of economics, sociology, business and management (including entrepreneurship) while excluding articles in the domain areas of computer science that dealt with computer networks and the health field that addressed neural networks to obtain articles on interorganizational network evolution for the period 1970-2019. Various journal databases such as EBSCO, ScienceDirect (Elsevier), Emerald, JSTOR and ABI/INFORM and Ebook Central on ProQuest were used to extract relevant articles using specific keywords. Findings To better understand this phenomenon of interorganizational network evolution, there is a need for future studies to focus on the less researched areas such as the “nature of evolution” of EINR1, EINR3 and EINR4 and the “causes of evolution” of FRC3, FRC5, FRC7 and FRC8. Further, over the years, in comparison to the evolution of interorganizational network relationships (EINR), fewer works have considered the evolution of overall interorganizational network structure (EINS). The research studies on environmental causes (EC) have been less in number in comparison to firm related causes (FRC), and this could be an area for further research. Also, studies on interorganizational network evolution have not examined the impact of FRC1 on EINR 3 and only a few studies have examined the impact of FRC1 on EINR1 and EINR4. Less attention has been given to the impact of FRC2 on EINR1, EINR3, EINR4 and EINS. Additionally, the impact of FRC3 on EINR1, EINR3 and EINS needs more in-depth examination. The impact of FRC4 on EINR4; FRC5 on EINR1, EINR2 and EINR4; FRC6 on EINR1 and EINS; and FRC7 and FRC8 on all forms of “nature of interorganizational network evolution” requires more research work. Finally, the impact of EC on EINR3 and EINR4 is also a less researched stream in the literature needing more scholarly contribution to better understand the phenomenon under consideration in this study. Some of the least explored theoretical lenses and relevant questions that can be addressed using these lenses to advance research on network evolution have also been discussed. Originality/value The main contribution of this paper is that it provides a comprehensive literature review, collating the dispersed knowledge on interorganizational network evolution – nature of evolution and causes of evolution, identifying areas that require further research attention for the development of this domain.

scholarly journals Matching and integration of data about Russian research organizations from multilingual data sources

2021 ◽  
Author(s):  
Zinaida Vladimirovna Apanovich
Keyword(s):  
Geographical Distribution ◽  
English Language ◽  
Data Sources ◽  
Scientific Publications ◽  
Data Matching ◽  
Research Organizations ◽  
Geographic Factor ◽  
Multilingual Data ◽  
The Impact ◽  
Russian Research

Information about research organizations is an important attribute that enables identifying authors of scientific publications, as well as analyzing the geographical distribution of publications and assessing the impact on the citation of publications associated with a geographic factor. Unfortunately, information on national research-related organizations is often incomplete or distorted in international databases. This applies, in particular, to Russian research organizations represented in English-language databases. The paper presents experiments on data matching and integration about Russian research organizations in multilingual data sources. Data sources such as GRID, Wikipedia, Wikidata and eLIBRARY.ru are considered.

The Impact of Anglicizing Former German-Language Psychology Journals on Authorship and Citation Frequencies

2012 ◽  
Vol 17 (3) ◽  
pp. 190-198 ◽  
Author(s):  
Günter Krampen ◽  
Thomas Huckert ◽  
Gabriel Schui
Keyword(s):  
Side Effects ◽  
English Language ◽  
General Trend ◽  
Native Language ◽  
Impact Factors ◽  
German Language ◽  
Journal Articles ◽  
Number Of Citations ◽  
The Impact ◽  
Number Of Authors

Exemplary for other than English-language psychology journals, the impact of recent Anglicization of five former German-language psychology journals on (1) authorship (nationality, i.e., native language, and number of authors, i.e., single or multiple authorships), (2) formal characteristics of the journal (number of articles per volume and length of articles), and (3) number of citations of the articles in other journal articles, the language of the citing publications, and the impact factors (IF) is analyzed. Scientometric data on these variables are gathered for all articles published in the four years before anglicizing and in the four years after anglicizing the same journal. Results reveal rather quick changes: Citations per year since original articles’ publication increase significantly, and the IF of the journals go up markedly. Frequencies of citing in German-language journals decrease, citing in English-language journals increase significantly after the Anglicization of former German-language psychology journals, and there is a general trend of increasing citations in other languages as well. Side effects of anglicizing former German-language psychology journals include the publication of shorter papers, their availability to a more international authorship, and a slight, but significant increase in multiple authorships.

Strategi Peningkatan Kompetensi Berbicara Bahasa Inggris Siswa Smk Negeri 1 Pacitan Tahun Pelajaran 2012/2013

2017 ◽  
Vol 1 (1) ◽  
pp. 43-51
Author(s):  
Asroji Asroji
Keyword(s):  
English Language ◽  
Language Instruction ◽  
Final Report ◽  
Computer Engineering ◽  
Project Report ◽  
Engineering Software ◽  
Final Project ◽  
Network Computer ◽  
Sequence Of Events ◽  
English Speaking

This study was conducted based on the facts about the lack of maximal outcomes of learning English in almost all levels of education, especially in vocational school. Although English has been studied for many years, but the majority of students can not master English well, especially speaking. Many factors cause this phenomenon, and all parties should concern to work together to formulatebetter system and process of English learning at vocational school.The research was conducted at SMK Negeri 1 Pacitan, by taking the students of class XII as subjects research. The sample of this research consists of 94 students of Business Travel and Tourism,Network Computer Engineering, and Engineering Software classes. This research uses descriptive qualitative method. It is used to describe the students’ speaking competence, particularlyin presenting final task report. This research also identifies the internal and external functions to formulate a strategy to improve the students’s speaking competence. The results showed that based on the analysis of English speaking competency of SMK Negeri 1 Pacitan students, it can be concluded as follows: a). Based on the students absorption analysis of presenting final project report, shows that English competency level of students is in the category of “pretty”, with evidence of the studentsvalue average in presenting final project report is more than the passing grade value (7.50),it is 79.5. While the number of student, who passed the presentation test,is 66 students.So it can be obtained the percentage level of mastery learning students on the presentation test of final report is only 70.21%, and it is categorized “less”, because the percentage of students who passed this exam is still under 75%. b). While the analysis of the questionnaire can be scribed that the average overall score of 3.44 speaking competence components are categorized “pretty”, and it can be concluded that the level of competence of English speaking students generally categorized “enough”. Based on the level ofstudents’ English speaking competence , it can be formulated the strategies to increase its competence. They are: a). Maximizing the use of English as a language instruction and reducing the use of Indonesian, especially in the learning process, to improve English language competency, so that students can have the ability to explain the sequence of events and the students can pass the exam well. b). Having more English presentation activitiesin other topics to encourage the students’ bravery and self-confidence in speaking English, so that students have good Englishcompetence as preparation to getjobs or to continue their study at university.c). Having more exercise of using body language to improve the mastery of speech, and smooth attitude, so that students have good English competence,and they are able to compete in the global world in obtaining employment. d). And maximizing the use of school’s facilities by using various methods of learning, and focusing on the students’ center method to improve the studentsEnglish competency so that they are able to compete for educational scholarships in this country and abroad.

Vulnerability of medical students and professionals to extreme work stress: A select review of the literature

2018 ◽  
Vol 14 (2) ◽  
pp. 181-187
Author(s):  
Maciej Walkiewicz ◽  
Małgorzata Tartas
Keyword(s):  
Medical Students ◽  
Work Stress ◽  
English Language ◽  
Psychological Intervention ◽  
Medical Professionals ◽  
Extreme Stress ◽  
Online Databases ◽  
Medical Career ◽  
Medical University ◽  
The Impact

The goal of the paper is to describe the extent to which medical students and professionals are vulnerable to extreme stress. A select review of existing literature on this area has been undertaken, using the English-language online databases EBSCO, Medline and PubMed. The search has identified 36 citations relating to 6324 medical students and 28,285 medical staff (physicians, residents, nurses). The review indicates that merely beginning medical studies is a risk factor for stress, and that medical professionals, who are vulnerable to extreme work stress, say that they do not receive enough support from their co-workers. They are also often notably impulsive, introverted, neurotic and perfectionist, with low emotional intelligence and agreeableness, as well as low and external locus of control. Additionally, from longitudinal studies we have been able to identify psychological factors underpinning admission to a medical university that may be useful for predicting future stress in medical career. The results of this study may be taken into account when organizing psychological intervention programs targeted at educating future medical professionals. It seems that early identification of people at risk could reduce the impact of stress related to medical career and enhance the somatic and mental health of medical professionals.

Publication of a scientific article in for an english-language journal. Part 2

2019 ◽  
Vol 23 (5) ◽  
pp. 116-121
Author(s):  
A. I. Nevorotin ◽  
I. V. Awsiewitsch ◽  
I. M. Sukhanov
Keyword(s):  
Detailed Analysis ◽  
English Language ◽  
Scientific Literature ◽  
Scientific Article ◽  
Scientific Journals ◽  
English Language Journal ◽  
The Matrix ◽  
Syntactic Relations

This article is the continuation of analysis and discussion from the book by Professor AI Nevorotin "Matrix phraseological collection: a manual for writing a scientific article in English". The Matrix phraseological collection is a kind of catalog of text samples. The samples were from articles selected from the leading English-language scientific journals and were systematized in such away that when writing an article in English, a Russian researchers are able easy to find examples suitable for his/her own work. Furthermore, the selected samples can be transformed accordingly saving the semantic and syntactic relations between the elements and, finally, be inserted into the text. The second part of this work is devoted to the detailed analysis of the English scientific literature and also the section "Legality of the provisions of the problem".

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