“Pauci-Hemosiderotic” Fibrolipomatous Tumor: A Mimicker of Various Lipomatous Lesions

2020 ◽  
pp. 106689692093079
Author(s):  
C. Y. Pang ◽  
Edmund Wong ◽  
J. W. Liao ◽  
John K. C. Chan ◽  
Wah Cheuk
Keyword(s):  
Soft Tissue Tumor ◽  
Left Wrist ◽  
Diagnostic Pitfall ◽  
Spindle Cells ◽  
Hemosiderin Deposition ◽  
Dorsum Of Foot ◽  
The Rich ◽  
Diagnostic Clue ◽  
Hemosiderin Deposits

Hemosiderotic fibrolipomatous tumor is a rare soft tissue tumor that preferentially affects the dorsum of foot, shows recurrent t(1;10) translocation targeting TGFBR3 and OGA ( MGEA5) genes, and has a high recurrence potential. Hemosiderin deposits, mature adipocytes, and interspersed spindle cells are the 3 cardinal morphologic features of this tumor. We describe a “pauci-hemosiderotic” example involving the left wrist of a 45-year-old female, posing a diagnostic pitfall. The tumor comprised mature adipose tissue traversed by variably thick fibrous septa containing short fascicles of spindle cells. Prominent small- to medium-sized blood vessels were present, often with perivascular fibrosis or aggregates of foamy histiocytes, sometimes associated with red cell extravasation. Hemosiderin was not conspicuous, but fine deposits could be found focally on careful search and with the aid of Perls stain. The diagnosis was further confirmed by diffuse expression of CD34 and presence of OGA translocation by fluorescence in situ hybridization. Pathologists should be aware that hemosiderin deposition can be scanty and focal in hemosiderotic fibrolipomatous, but the rich vasculature with a “damaged” appearance is a useful diagnostic clue.

Mammary-type Myofibroblastoma with Leiomyomatous Differentiation: A Rare Variant with Potential Pitfalls

2021 ◽  
pp. 106689692110313
Author(s):  
Alexander M. Strait ◽  
Julia A. Bridge ◽  
Anthony J. Iafrate ◽  
Marilyn M. Li ◽  
Feng Xu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Transcriptome Sequencing ◽  
Smooth Muscle Actin ◽  
The Body ◽  
Muscle Actin ◽  
Mature Adipose Tissue ◽  
Spindle Cells ◽  
Whole Transcriptome Sequencing ◽  
Whole Transcriptome

Myofibroblastoma is a rare, benign stromal tumor with a diverse morphologic spectrum. Mammary-type myofibroblastoma (MTMF) is the extra-mammary counterpart of this neoplasm and its occurrence throughout the body has become increasingly recognized. Similar morphologic variations of MTMF have now been described which mirror those seen in the breast. We describe a case of intra-abdominal MTMF composed of short fascicles of eosinophilic spindle cells admixed with mature adipose tissue. The spindle cells stained diffusely positive for CD34, desmin, smooth muscle actin, and h-caldesmon by immunohistochemistry. Concurrent loss of RB1 (13q14) and 13q34 loci were confirmed by fluorescence in situ hybridization whereas anchored multiplex PCR and whole transcriptome sequencing did not reveal any pathognomonic fusions suggesting an alternative diagnosis. To the best of our knowledge this is the first documented case of leiomyomatous variant of MTMF.

The utility of fluorescence in situ hybridization (FISH) in determining DNA damage-inducible transcript 3 (DDIT3) amplification in dedifferentiated liposarcomas – an important diagnostic pitfall

2021 ◽  
pp. 153555
Author(s):  
Olga Kuczkiewicz-Siemion ◽  
Piotr Wiśniewski ◽  
Agnieszka Dansonka-Mieszkowska ◽  
Magdalena Grabowska-Kierył ◽  
Katarzyna Olszewska ◽  
...  
Keyword(s):  
Dna Damage ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Diagnostic Pitfall

scholarly journals A Leaf Point Documents Hunting with Spears in the Middle Paleolithic at Hohle Fels, Germany

2021 ◽  
Vol 2021 (30) ◽  
Author(s):  
Veerle Rots ◽  
Justin Coppe ◽  
Nicholas Conard
Keyword(s):  
Life History ◽  
Evolutionary Development ◽  
Functional Study ◽  
Middle Paleolithic ◽  
Projectile Technology ◽  
Excellent Preservation ◽  
The Rich ◽  
Pointed End ◽  
The University

During the 2020 season at Hohle Fels Cave in the Ach Valley of southwestern Germany the excavation team from the University of Tübingen recovered a bifacial leaf point in archaeological horizon (AH) X. This horizon is the fifth deepest of the Middle Paleolithic horizons at the site and is located roughly 120 cm beneath the base of the rich Aurignacian layers of the cave. The new leaf point, or Blattspitze in German, is the first artifact of its kind found in situ in the Swabian caves since Gustav Riek’s excavation at Haldenstein Cave near the source of the Lone River recovered two leaf points in excellent preservation in 1936. The new find allowed our team to conduct the first techno-functional study of a freshly recovered leaf point from the European Middle Paleolithic. This study demonstrates that the leaf point was hafted at the less pointy end of the artifact. The leaf point bears clear damage to the pointed end of the artifact that occurred during a hunting episode. A Neanderthal knapper further damaged the tool during an attempt to resharpen and rejuvenate the tool. This damage was likely the reason the knapper discarded the leaf point at Hohle Fels. This result and a re-examination of the two leaf points from Haldenstein Cave indicate that late Neanderthals used Blattspitzen for hunting large game. The current results do not explicitly prove that spears with hafted leaf points were always thrown or used as thrusting spears, and one can easily imagine scenarios in which a weapon of this kind could be used in both ways. Ideally, the ongoing excavation at Hohle Fels will recover more leaf points, which will give us the opportunity to document the technological variability of this kind of tool with regard to their manufacture, function and life history. We also view the current research at Hohle Fels as an excellent opportunity to gain a better and more strongly contextualized understanding of the technological system linking lithic, botanical and osseous technologies during this phase of the Middle Paleolithic. This paper also considers the place that hafted leaf points have within the broader evolutionary development of hunting and projectile technology.

Primary Pleural Synovial Sarcoma

2003 ◽  
Vol 127 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Siok Bian Ng ◽  
Qasim Ahmed ◽  
Sim Leng Tien ◽  
Christina Sivaswaren ◽  
Lai Ching Lau
Keyword(s):  
Young Adults ◽  
In Situ Hybridization ◽  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Fluorescent In Situ Hybridization ◽  
Soft Tissue Tumor ◽  
Differential Diagnoses ◽  
Positive Staining ◽  
Rare Occurrence

Abstract Synovial sarcoma (SS) is an uncommon soft tissue tumor that occurs primarily in the extremities of young adults, especially in the periarticular region. In this report, we describe the rare occurrence of primary SS of the pleura in a 15-year-old boy. Histologically, the tumor demonstrated monophasic morphologic findings and showed positive staining with vimentin and Bcl-2 and focally for cytokeratin CK7. Fluorescent in situ hybridization identified t(X;18) translocation. The patient developed recurrences 20 months following resection of the tumor. The literature on this uncommon entity is reviewed, and its histogenesis, differential diagnoses, and cytologic features are also discussed.

scholarly journals Augmented Reality Storytelling – Narrative Design and Reconstruction of a Historical Event in situ

2019 ◽  
Vol 13 (12) ◽  
pp. 196 ◽  
Author(s):  
Gunnar Liestoel
Keyword(s):  
Augmented Reality ◽  
Early Morning ◽  
Media Representations ◽  
Background Information ◽  
Historical Event ◽  
Visual Medium ◽  
Narrative Design ◽  
Online Tracking ◽  
The Rich

<p class="0abstract"><span lang="EN-GB">How may we best utilize mobile augmented reality for storytelling when reconstructing historical events onlocation? In this article we present a series of narrative design considerations when developing an augmented reality application recreating the assault on Omaha Beach in the early morning on D-Day. To what extent may we select existing genre conventions from, for example, documentary film, and adapt them to a location–based audio–visual medium like AR? How can we best combine sequence and access, the narrative flow of an unfolding historical event with the availability of background information, in order to enrich the experience of the story, but without distorting its coherence? To what extent may we draw from existing and well known media representations of the Omaha Beach landing? How was the battle documented with contemporary means? We present the rich documentation of photos, films, drawings, paintings, maps, action reports, official reports, etc., and discuss how these have been employed to create the published AR situated simulation. We also describe and discuss the testing and evaluation of the application on location with visitors, as well as online tracking of its current use.</span></p>

scholarly journals Herpetological phylogeographic analyses support a Miocene focal point of Himalayan uplift and biological diversification

2020 ◽  
Author(s):  
Wei Xu ◽  
Wen-Jie Dong ◽  
Ting-Ting Fu ◽  
Wei Gao ◽  
Chen-Qi Lu ◽  
...  
Keyword(s):  
Middle Miocene ◽  
Focal Point ◽  
Himalayan Region ◽  
The World ◽  
Early Paleocene ◽  
The Rich ◽  
Source Of Information ◽  
The Himalaya ◽  
Exact Timing

Abstract The Himalaya are among the youngest and highest mountains in the world, but the exact timing of their uplift and origins of their biodiversity are still in debate. The Himalayan region is a relatively small area but with exceptional diversity and endemism. One common hypothesis to explain the rich montane diversity is uplift-driven diversification–that orogeny creates conditions favoring rapid in situ speciation of resident lineages. We test this hypothesis in the Himalayan region using amphibians and reptiles, two environmental sensitive vertebrate groups. In addition, analysis of diversification of the herpetofauna provides an independent source of information to test competing geological hypotheses of Himalayan orogenesis. We conclude that the origins of the Himalayan herpetofauna date to the early Paleocene, but that diversification of most groups was concentrated in the Miocene. There was an increase in both rates and modes of diversification during the early to middle Miocene, together with regional interchange (dispersal) between the Himalaya and adjacent regions. Our analyses support a recently proposed stepwise geological model of Himalayan uplift beginning in the Paleocene, with a subsequent rapid increase of uplifting during the Miocene, finally give rise to the intensification of the modern South Asia Monsoon.

Amelanotic Malignant Melanoma of the Male Urethra: A Potential Diagnostic Pitfall

2020 ◽  
Vol 28 (5) ◽  
pp. 510-513
Author(s):  
Alessandro Caputo ◽  
Alfonso Califano ◽  
Marco Fabiano ◽  
Vincenzo Altieri ◽  
Pio Zeppa ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Common Disease ◽  
High Grade ◽  
Male Urethra ◽  
Unusual Site ◽  
Diagnostic Pitfall ◽  
Melanoma In Situ ◽  
Amelanotic Malignant Melanoma ◽  
Histological Characteristics

A rare disease in an unusual site can closely mimic a typical presentation of a common disease, sometimes with devastating consequences. We present a case of primary amelanotic malignant melanoma of the urethra in a male, with clinical and histological characteristics that could have led to a mistaken diagnosis of high-grade urothelial carcinoma. Amelanotic mucosal melanoma should be suspected in all cases of high-grade mucosal tumors with practically any appearance (epithelioid, sarcomatoid, anaplastic, mixed). Morphological hints pointing toward melanoma—such as the presence of sparse melanin pigment or melanoma in situ—should be sought, and if absent, an immunohistochemical panel comprising S100 and HMB45 should be performed.

Microglandular Adenosis: A Possible Non-Obligate Precursor to Breast Carcinoma With Potential to Either Luminal-Type or Basal-Type Differentiation

2019 ◽  
Vol 27 (7) ◽  
pp. 781-787 ◽  
Author(s):  
Alexander T. Damron ◽  
Katrina Korhonen ◽  
Samantha Zuckerman ◽  
Julia Tchou ◽  
Kimberly L. Dumoff ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Invasive Carcinoma ◽  
Case Reports ◽  
Unique Case ◽  
Diagnostic Pitfall ◽  
In Situ Carcinoma ◽  
Luminal Type ◽  
Basal Type ◽  
Microglandular Adenosis

Microglandular adenosis (MGA) of the breast is exceedingly rare, with only a few case reports and series published to date. Previous studies have elegantly demonstrated the progression of benign MGA to atypical MGA to MGA-in situ carcinoma to invasive carcinoma and therefore suggest MGA as a possible non-obligate precursor lesion to a subset of breast carcinomas. Immunohistochemically, MGA is negative for estrogen receptor (ER), progesterone receptor (PR), and HER2-neu oncoprotein expression, and carcinomas arising in the setting of MGA are often reported to be triple negative. In this article, we present a unique case of an ER+/PR+/HER2− invasive carcinoma associated with MGA and atypical MGA. Our case highlights the diagnostic pitfall of MGA and suggests that MGA is a heterogeneous group of lesions with potential for either luminal-type or basal-type differentiation during progression to breast carcinoma.

A mini review of in situ near-ambient pressure XPS studies on non-noble, late transition metal catalysts

2019 ◽  
Vol 9 (15) ◽  
pp. 3851-3867 ◽  
Author(s):  
Liping Zhong ◽  
Dingkai Chen ◽  
Spyridon Zafeiratos
Keyword(s):  
Ambient Pressure ◽  
Transition Metal Catalysts ◽  
Catalytic Reactions ◽  
Late Transition Metal ◽  
Heterogeneous Catalytic ◽  
Ambient Pressure Xps ◽  
The Rich ◽  
Late Transition ◽  
Near Ambient Pressure Xps

The rich surface chemistry of Fe, Co, Ni and Cu during heterogeneous catalytic reactions from the perspective of NAP-XPS studies.

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