Evaluation and comparison of serum procalcitonin and heparin-binding protein levels as biomarkers of bacterial infection in cats

2020 ◽  
pp. 1098612X2095997
Author(s):  
Jae-Geum Cho ◽  
Ye-In Oh ◽  
Kun-Ho Song ◽  
Kyoung-Won Seo
Keyword(s):  
Bacterial Infection ◽  
Absolute Neutrophil Count ◽  
Neutrophil Count ◽  
Bacterial Infections ◽  
Binding Protein ◽  
High Sensitivity ◽  
Heparin Binding ◽  
Protein Levels ◽  
Heparin Binding Protein ◽  
Valuable Marker

Objectives Although bacterial infection can lead to sepsis and high mortality, early and easy diagnosis of sepsis can improve survival. In cats, the diagnosis of systemic bacterial infection is quite challenging, and, usually, non-specific markers for inflammation are employed. In humans, procalcitonin, heparin-binding protein and absolute neutrophil count are biomarkers that are studied in bacterial infections and sepsis owing to their high sensitivity and specificity. Methods A total of 56 cats were categorised into 16 healthy cats and 40 bacterially infected cats, diagnosed by various examinations. In all cats, serum procalcitonin and heparin-binding protein levels were measured using ELISA and an absolute neutrophil count was performed. Results The median values of procalcitonin levels and absolute neutrophil count were significantly higher in the infection group than in the normal group, but heparin-binding protein levels were not. A procalcitonin level >366 pg/ml was a better biomarker of bacterial infection than heparin-binding protein and absolute neutrophil count (sensitivity: 67.5%; specificity: 93.8%). Procalcitonin was not correlated with heparin-binding protein ( r = 0.213, P = 0.115) and absolute neutrophil count ( r = 0.393, P = 0.003). Conclusions and relevance High procalcitonin levels in cats were associated with bacterial infection. Hence, procalcitonin could be a valuable marker for diagnosing bacterial infections in cats.

scholarly journals Differences of heparin binding protein levels in preeclampsian and non preeclampsian women

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Nurrahma Layuk ◽  
Sitti Wahyuni ◽  
Sharvianty Arifuddin
Keyword(s):  
Urinary Tract ◽  
Pregnant Women ◽  
Urinary Tract Infections ◽  
Binding Protein ◽  
Sampling Technique ◽  
Heparin Binding ◽  
Cross Sectional ◽  
Protein Levels ◽  
Heparin Binding Protein ◽  
Tract Infections

This study aims to the incidence of preeclampsia and determine differences in heparin-binding protein levels in preeclamptic and non-preeclamptic mothers and determine the relationship between urinary tract infections in pregnancy. The research design was cross-sectional on 65 respondents with an accidental sampling technique. The research data were obtained from a questionnaire containing a list of questions given to respondents, measurement of middle urine samples to measure nitrite, leukocytes urine using dipstick method, and to determine heparin binding protein (HBP) levels using the ELISA method in the Hasanuddin University RSP Research Laboratory. The results of the study found there was a difference in the levels of heparin-binding protein in pregnant women without preeclampsia, namely 1.90±0.22 Ng/ml and HBP levels in pregnant women preeclampsia ie 2.39±0.3 Ng/ml. That there was no significant relationship between urinary tract infections (UTI) and the incidence of preeclampsia with p= 0.074. The conclusion in this study is that the levels of heparin-binding protein differ in preeclamptic and non-preeclamptic mothers, the increase in HBP levels in preeclampsia is due to inflammation, the cause is not through UTI. There is no association between urinary tract infections in pregnant women and the incidence of preeclampsia.

scholarly journals Roles of Heparin-Binding Protein in Bacterial Infections

2010 ◽  
Vol 2 (5) ◽  
pp. 431-438 ◽  
Author(s):  
Adam Linder ◽  
Oliver Soehnlein ◽  
Per Åkesson
Keyword(s):  
Bacterial Infections ◽  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein

The heparin-binding protein interactome in pancreatic diseases

Pancreatology ◽  
2013 ◽  
Vol 13 (6) ◽  
pp. 598-604 ◽  
Author(s):  
Q.M. Nunes ◽  
V. Mournetas ◽  
B. Lane ◽  
R. Sutton ◽  
D.G. Fernig ◽  
...  
Keyword(s):  
Binding Protein ◽  
Heparin Binding ◽  
Pancreatic Diseases ◽  
Heparin Binding Protein ◽  
Protein Interactome

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

2001 ◽  
Vol 7 (10) ◽  
pp. 1123-1127 ◽  
Author(s):  
Narinder Gautam ◽  
A. Maria Olofsson ◽  
Heiko Herwald ◽  
Lars F. Iversen ◽  
Evy Lundgren-Åkerlund ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Binding Protein ◽  
Heparin Binding ◽  
Missing Link ◽  
Heparin Binding Protein

Human C21orf63 is a Heparin-binding Protein

2009 ◽  
Vol 146 (3) ◽  
pp. 369-373 ◽  
Author(s):  
Kanae Mitsunaga ◽  
Jun Harada-Itadani ◽  
Toshihide Shikanai ◽  
Hiroaki Tateno ◽  
Yuzuru Ikehara ◽  
...  
Keyword(s):  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein

Heparin Binding Protein for The Early Diagnosis and Prognosis Of Sepsis In The Emergency Department

Shock ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Konstantinos Katsaros ◽  
Georgios Renieris ◽  
Asimina Safarika ◽  
Evangelia-Maria Adami ◽  
Theologia Gkavogianni ◽  
...  
Keyword(s):  
Emergency Department ◽  
Early Diagnosis ◽  
Binding Protein ◽  
Heparin Binding ◽  
Diagnosis And Prognosis ◽  
Heparin Binding Protein

Dynamic Changes in Heparin-binding Protein as a Prognostic Biomarker in Patients with Sepsis

2020 ◽  
Author(s):  
Qing-Li Dou ◽  
Jiang-Ping Liu ◽  
Wen-Wu Zhang ◽  
Hoi Sin Tong ◽  
Ya-Nan Gu ◽  
...  
Keyword(s):  
Predictive Accuracy ◽  
Binding Protein ◽  
Care Center ◽  
Dynamic Change ◽  
Tertiary Care ◽  
Heparin Binding ◽  
Dynamic Changes ◽  
Multicenter Studies ◽  
Absolute Level ◽  
Heparin Binding Protein

Abstract BACKGROUNDWe aimed to investigate the prognostic value of dynamic changes in heparin-binding protein (HBP) within the first 48 hours of hospital admission in sepsis patients.MethodsWe conducted a prospective observational study in the emergency intensive care unit of a tertiary care center. Patients who met SEPSIS-3 criteria were prospectively enrolled from August 2019 to January 2020. Serum levels of HBP were measured at admission, 24 hours, and 48 hours. Dynamic change in HBP was calculated as a percentage change between admission and 24 hours, and between admission and 48 hours. Accuracies of absolute level of HBP, dynamic change of HBP, and other biomarkers were compared with ROC analysis.ResultsA total of 245 patients were enrolled. After excluding patients not fulfilling the eligibility criteria and those died before 48 hours of admission, 185 patients were included for final analysis, of which 117 had sepsis, 68(36.76%) had septic shock, and 48(30%) died in the hospital. Day 1-HBP was correlated with procalcitonin (r2=0.21, p=0.004). Of all predictors of 30-day mortality, HBP clearance within 48 hours had the highest predictive accuracy (AUC: 0.82), followed by Day 1-HBP (AUC: 0.79), PCT (AUC: 0.75) and HBPc-24(AUC: 0.6). HBPc-48 > -17.14% had an independent impact on 30-day survival after adjusting for age, gender, shock status, and requirement of mechanical ventilation support.ConclusionsHBPc-48 can predict survival in critically ill patients with sepsis and can assist clinicians with risk stratification of these patients. Future multicenter studies are necessary to assess the generalizability of these findings.

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