Should heparin-binding protein levels be routinely monitored in patients with severe sepsis and septic shock?

ObjectivesOur aim was to assess the release level of heparin-binding protein (HBP) in sepsis and septic shock under theThird International Consensus Definitions for Sepsis and Septic Shock(Sepsis-3).DesignProspective cohort study.SettingA general teaching hospital in China.ParticipantsAdult infected patients with suspected sepsis and people who underwent physical examination were included. According to the health status and severity of illness, the research subjects were divided into healthy, local infection, sepsis non-shock and septic shock under Sepsis-3 definitions.Main outcome measuresPlasma levels of HBP, procalcitonin (PCT), C reactive protein (CRP) and complete blood count were detected in all subjects. Single-factor analysis of variance was used to compare the biomarker levels of multiple groups. A receiver operating characteristic (ROC) curve was used to assess the diagnostic capacity of each marker.ResultsHBP levels were significantly higher in patients with sepsis non-shock than in those with local infections (median 49.7ng/mL vs 11.8 ng/mL, p<0.01) at enrolment. Moreover, HBP levels in patients with septic shock were significantly higher than in patients with sepsis without shock (median 153.8ng/mL vs 49.7 ng/mL, p<0.01). The area under the ROC curve (AUC) of HBP (cut-off ≥28.1 ng/mL) was 0.893 for sepsis which was higher than those of PCT (0.856) for a cut-off ≥2.05 ng/mL and of CRP (0.699) for a cut-off ≥151.9 mg/L. Moreover, AUC of HBP (cut-off ≥103.5 ng/mL) was 0.760 for septic shock which was higher than the ROC curve of sequential [sepsis-related] organ failure assessment (SOFA) Score (0.656) for a cut-off ≥5.5. However, there was no significant difference between 28-d survivors (n=56) and 28-d non-survivors (n=37) with sepsis in terms of HBP value (p=0.182).ConclusionsA high level of HBP in plasma is associated with sepsis, which might be a useful diagnostic marker in patients with suspected sepsis.

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Heart-type fatty acid–binding protein as a prognostic factor in patients with severe sepsis and septic shock

The American Journal of Emergency Medicine ◽

10.1016/j.ajem.2012.02.005 ◽

2012 ◽

Vol 30 (9) ◽

pp. 1749-1755 ◽

Cited By ~ 16

Author(s):

You Hwan Jo ◽

Kyuseok Kim ◽

Jae Hyuk Lee ◽

Joong Eui Rhee ◽

Jin Hee Lee ◽

...

Keyword(s):

Septic Shock ◽

Severe Sepsis ◽

Fatty Acid ◽

Prognostic Factor ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Fatty Acid Binding ◽

Acid Binding Protein ◽

Sepsis And Septic Shock

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Heparin-binding protein improves prediction of severe sepsis in the emergency department

Critical Care ◽

10.1186/cc12904 ◽

2013 ◽

Vol 17 (Suppl 4) ◽

pp. P3 ◽

Cited By ~ 1

Author(s):

Adam Linder ◽

Ryan Arnold ◽

Marco Zindovic ◽

Igor Zindovic ◽

Anna Lange-Jendeberg ◽

...

Keyword(s):

Emergency Department ◽

Severe Sepsis ◽

Binding Protein ◽

Heparin Binding ◽

Heparin Binding Protein

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Differences of heparin binding protein levels in preeclampsian and non preeclampsian women

International Journal of Health Sciences ◽

10.29332/ijhs.v5n2.1199 ◽

2021 ◽

Vol 5 (2) ◽

Author(s):

Nurrahma Layuk ◽

Sitti Wahyuni ◽

Sharvianty Arifuddin

Keyword(s):

Urinary Tract ◽

Pregnant Women ◽

Urinary Tract Infections ◽

Binding Protein ◽

Sampling Technique ◽

Heparin Binding ◽

Cross Sectional ◽

Protein Levels ◽

Heparin Binding Protein ◽

Tract Infections

This study aims to the incidence of preeclampsia and determine differences in heparin-binding protein levels in preeclamptic and non-preeclamptic mothers and determine the relationship between urinary tract infections in pregnancy. The research design was cross-sectional on 65 respondents with an accidental sampling technique. The research data were obtained from a questionnaire containing a list of questions given to respondents, measurement of middle urine samples to measure nitrite, leukocytes urine using dipstick method, and to determine heparin binding protein (HBP) levels using the ELISA method in the Hasanuddin University RSP Research Laboratory. The results of the study found there was a difference in the levels of heparin-binding protein in pregnant women without preeclampsia, namely 1.90±0.22 Ng/ml and HBP levels in pregnant women preeclampsia ie 2.39±0.3 Ng/ml. That there was no significant relationship between urinary tract infections (UTI) and the incidence of preeclampsia with p= 0.074. The conclusion in this study is that the levels of heparin-binding protein differ in preeclamptic and non-preeclamptic mothers, the increase in HBP levels in preeclampsia is due to inflammation, the cause is not through UTI. There is no association between urinary tract infections in pregnant women and the incidence of preeclampsia.

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Evaluation and comparison of serum procalcitonin and heparin-binding protein levels as biomarkers of bacterial infection in cats

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x20959973 ◽

2020 ◽

pp. 1098612X2095997

Author(s):

Jae-Geum Cho ◽

Ye-In Oh ◽

Kun-Ho Song ◽

Kyoung-Won Seo

Keyword(s):

Bacterial Infection ◽

Absolute Neutrophil Count ◽

Neutrophil Count ◽

Bacterial Infections ◽

Binding Protein ◽

High Sensitivity ◽

Heparin Binding ◽

Protein Levels ◽

Heparin Binding Protein ◽

Valuable Marker

Objectives Although bacterial infection can lead to sepsis and high mortality, early and easy diagnosis of sepsis can improve survival. In cats, the diagnosis of systemic bacterial infection is quite challenging, and, usually, non-specific markers for inflammation are employed. In humans, procalcitonin, heparin-binding protein and absolute neutrophil count are biomarkers that are studied in bacterial infections and sepsis owing to their high sensitivity and specificity. Methods A total of 56 cats were categorised into 16 healthy cats and 40 bacterially infected cats, diagnosed by various examinations. In all cats, serum procalcitonin and heparin-binding protein levels were measured using ELISA and an absolute neutrophil count was performed. Results The median values of procalcitonin levels and absolute neutrophil count were significantly higher in the infection group than in the normal group, but heparin-binding protein levels were not. A procalcitonin level >366 pg/ml was a better biomarker of bacterial infection than heparin-binding protein and absolute neutrophil count (sensitivity: 67.5%; specificity: 93.8%). Procalcitonin was not correlated with heparin-binding protein ( r = 0.213, P = 0.115) and absolute neutrophil count ( r = 0.393, P = 0.003). Conclusions and relevance High procalcitonin levels in cats were associated with bacterial infection. Hence, procalcitonin could be a valuable marker for diagnosing bacterial infections in cats.

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