Use of Sodium Hypochlorite for Skin Antisepsis Before Inserting a Peripheral Venous Catheter

2014 ◽  
Vol 17 (3) ◽  
pp. 330-333 ◽  
Author(s):  
Cristiana Forni ◽  
Tania Sabattini ◽  
Fabio D’Alessandro ◽  
Ambra Fiorani ◽  
Simonetta Gamberini ◽  
...  
Keyword(s):  
Pilot Study ◽  
Sodium Hypochlorite ◽  
Povidone Iodine ◽  
Experimental Studies ◽  
Venous Catheter ◽  
Contamination Rate ◽  
Peripheral Venous Catheter ◽  
Skin Antisepsis ◽  
Skin Decontamination

Although it can be prevented, catheter-related bacteremia is common and dangerous. The antiseptics most widely used during insertion of peripheral venous catheters (PVCs) include povidone iodine, alcohol, and chlorhexidine. Another widely used antiseptic is a solution of 0.057 g sodium hypochlorite. This pilot study explored the contamination rate of the PVC tip inserted after skin decontamination with sodium hypochlorite. Culture analysis of the tips of the PVCs inserted into the 42 participants showed 7 (16.7%) colonized catheters. The results of this pilot study suggest taking into serious consideration the assessment of this antiseptic in randomized experimental studies.

scholarly journals Sodium hypochlorite in antisepsis of children’s and new-born babies’ skin prior to insertion of peripheral venous catheter

2014 ◽  
Vol 3 (6) ◽  
pp. 97 ◽  
Author(s):  
Paolo Chiari ◽  
Domenica Gazineo ◽  
Olimpia Pezzullo ◽  
Veronica Ricciardi ◽  
Lucia Caso ◽  
...  
Keyword(s):  
Pilot Study ◽  
Sodium Hypochlorite ◽  
Bacterial Contamination ◽  
Venous Catheter ◽  
Peripheral Venous Catheter ◽  
New Born ◽  
Explorative Study ◽  
Contamination Levels ◽  
Positive Results

Antisepsis of the skin of children to whom a peripheral venous catheter (PVC) is to be attached is an important factor in reducing catheter related infections. No data are available on the effectiveness of sodium hypochlorite. Explorative study of children and new-born babies treated in hospital to ascertain bacterial contamination levels of PVC tips as surrogate infection indicator. In a sample of 51 children and 52 new-born babies, catheter tips were found contaminated for 7.8% of the children and 3.8% of the new-born babies. The positive results of this pilot study suggest that serious consideration should be given to assessing Amukine Med 0.05% for use with PVCs. 

scholarly journals Comparison of alcohol, povidone-iodine and octenidine dihydrochloride as skin disinfectants to reduce bacterial count prior to peripheral venous catheter insertions in newborn infants

2011 ◽  
Vol 51 (5) ◽  
pp. 277 ◽  
Author(s):  
Lily Rundjan ◽  
Rinawati Rohsiswatmo ◽  
Sarah Rafika ◽  
Enty Enty ◽  
Lucky H. Moehario
Keyword(s):  
Povidone Iodine ◽  
Newborn Infants ◽  
Bloodstream Infections ◽  
Venous Catheter ◽  
Bacterial Count ◽  
Peripheral Venous Catheter ◽  
Skin Bacteria ◽  
Skin Disinfection ◽  
Octenidine Dihydrochloride ◽  
Before And After

AbstractBackground Vascular access may increase the risk of bloodstream infections, especially in newborn infants with weak immune systems and requiring invasive supportive care. Skin disinfection prior to peripheral venous catheter insertion lowers the risk of infection. However, antiseptics chosen for this task should be effective and safe for newborn infants.Objective To compare the effectiveness of 70% alcohol (BD alcohol swabs ®), 10% povidone-iodine (Pharma-RSUPNCM), and octenidine (Octenisept ®) as antiseptics for reducing skin bacteria for pre-invasive procedures in neonates.Methods Infants aged less than 28 days, regardless of gestational age, at the Neonatal Unit of Cipto Mangunkusumo Hospital (RSUPNCM) were included in our study. Infants were divided into three groups, each tested with different skin antiseptics (alcohol, povidone-iodine or octenidine). Skin swabs were performed before and after application of skin antiseptic, followed by inoculation onto blood agar plates. Colony-forming units were counted after 18 hours of incubation at 37ºC.Results Ninety subjects were divided into 3 groups of 30, each group using either 70% alcohol swabs, 10% povidone-iodine, or octenidine as skin antiseptic. Skin swabs were taken before and after antiseptic application and drying, as well as 5 minutes after application. The mean reductions in CFU/cm2 (%) after antiseptic application (and fully dried) were 97.54% for povidone-iodine, 97.52% for octenidine, and 89.07% for alcohol. There were no significant differences in mean CFU reductions among the three antiseptics groups (P=0.299). Furthermore, 5 minutes after application, there were still no significant differences in the three antiseptic groups (P=0.289).Conclusions Although octenidine showed a significant bacterial count reduction after application, it was not significantly different from those of alcohol or povidone-iodine. [Paediatr Indones. 2011;51:277-81].

Blood Culture Contamination Rates after Skin Antisepsis with Chlorhexidine Gluconate versus Povidone-Iodine in a Pediatric Emergency Department

2010 ◽  
Vol 31 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Lauren Marlowe ◽  
Rakesh D. Mistry ◽  
Susan Coffin ◽  
Kateri H. Leckerman ◽  
Karin L. McGowan ◽  
...  
Keyword(s):  
Emergency Department ◽  
Blood Culture ◽  
Peripheral Blood ◽  
Povidone Iodine ◽  
Chlorhexidine Gluconate ◽  
Series Data ◽  
Control Group ◽  
Contamination Rate ◽  
Peripheral Blood Culture ◽  
Skin Antisepsis

Objective.To determine blood culture contamination rates after skin antisepsis with Chlorhexidine, compared with povidone-iodine.Design.Retrospective, quasi-experimental study.Setting.Emergency department of a tertiary care children's hospital.Patients.Children aged 2-36 months with peripheral blood culture results from February 2004 to June 2008. Control patients were children younger than 2 months with peripheral blood culture results.Methods.Blood culture contamination rates were compared using segmented regression analysis of time-series data among 3 patient groups: (1) patients aged 2-36 months during the 26-month preintervention period, in which 10% povidone-iodine was used for skin antisepsis before blood culture; (2) patients aged 2-36 months during the 26-month postintervention period, in which 3% Chlorhexidine gluconate was used; and (3) patients younger than 2 months not exposed to the Chlorhexidine intervention (ie, the control group).Results.Results from 11,595 eligible blood cultures were reviewed (4,942 from the preintervention group, 4,274 from the postintervention group, and 2,379 from the control group). For children aged 2-36 months, the blood culture contamination rate decreased from 24.81 to 17.19 contaminated cultures per 1,000 cultures (P< .05) after implementation of Chlorhexidine. This decrease of 7.62 contaminated cultures per 1,000 cultures (95% confidence interval, —0.781 to —15.16) represented a 30% relative decrease from the preintervention period and was sustained over the entire postintervention period. No change in contamination rate was observed in the control group (P= .337).Conclusion.Skin antisepsis with Chlorhexidine significantly reduces the blood culture contamination rate among young children, as compared with povidone-iodine.

Skin antisepsis with 0.05% sodium hypochlorite before central venous catheter insertion in neonates: A 2-year single-center experience

2018 ◽  
Vol 46 (2) ◽  
pp. 169-172 ◽  
Author(s):  
Matilde Ciccia ◽  
Roksana Chakrokh ◽  
Dario Molinazzi ◽  
Angela Zanni ◽  
Patrizia Farruggia ◽  
...  
Keyword(s):  
Central Venous Catheter ◽  
Sodium Hypochlorite ◽  
Venous Catheter ◽  
Catheter Insertion ◽  
Central Venous Catheter Insertion ◽  
Single Center ◽  
Central Venous ◽  
Single Center Experience ◽  
Skin Antisepsis

Povidone Iodine and Skin Disinfection before Initiation of Epidural Anesthesia 

1998 ◽  
Vol 88 (3) ◽  
pp. 668-672 ◽  
Author(s):  
David J. Birnbach ◽  
Deborah J. Stein ◽  
Odessa Murray ◽  
Daniel M. Thys ◽  
Emilia M. Sordillo
Keyword(s):  
Spinal Anesthesia ◽  
Bacterial Contamination ◽  
Microbial Contamination ◽  
Povidone Iodine ◽  
Multiple Use ◽  
Skin Disinfection ◽  
Skin Antisepsis ◽  
Single Use ◽  
Microbial Contaminants ◽  
Skin Decontamination

Background Povidone iodine (PI) solution is used commonly for skin disinfection before epidural and spinal anesthesia. Although there have been reports indicating the presence of microbial contaminants in PI solution, none have evaluated the prevalence of PI contamination. The aims of this study were to assess the frequency of bacterial contamination of previously opened bottles of PI solution and to compare the effectiveness of new and previously opened bottles of PI solution for skin disinfection. Methods Twenty previously opened and ten previously unopened multiple-use bottles of PI solution were evaluated for microbial contamination. In addition, final swabs and PI solution used for skin disinfection in 80 patients undergoing elective epidural analgesia were evaluated. Results The inside of the bottle cap or the PI solution from 40% of the multiple-use PI bottles in use were contaminated. There was no growth from any previously unused PI bottles. Povidone iodine from newly opened bottles provided more effective skin decontamination than did solution from previously opened bottles. Conclusions Multiple-use PI bottles in normal use may become contaminated by bacteria. In addition, PI solution from previously opened bottles was less effective than PI from previously unopened bottles. Based on these findings, if PI solution is chosen for skin antisepsis before initiation of epidural and spinal anesthesia, only single-use containers should be used.

scholarly journals Mucosa plication reinforced colorectal anastomosis and trans-anal vacuum drainage: a pilot study with preliminary results

2021 ◽  
Author(s):  
Alexander Ferko ◽  
Juraj Váňa ◽  
Marek Adámik ◽  
Adam Švec ◽  
Michal Žáček ◽  
...  
Keyword(s):  
Pilot Study ◽  
Povidone Iodine ◽  
Anal Verge ◽  
Colorectal Anastomosis ◽  
Stapled Anastomosis ◽  
Neoadjuvant Radiotherapy ◽  
Lower Upper ◽  
Registration Number ◽  
The Mean ◽  
Diversion Rate

AbstractDehiscence of colorectal anastomosis is a serious complication that is associated with increased mortality, impaired functional and oncological outcomes. The hypothesis was that anastomosis reinforcement and vacuum trans-anal drainage could eliminate some risk factors, such as mechanically stapled anastomosis instability and local infection. Patients with rectal cancer within 10 cm of the anal verge and low anterior resection with double-stapled technique were included consecutively. A stapler anastomosis was supplemented by trans-anal reinforcement and vacuum drainage using a povidone-iodine-soaked sponge. Modified reinforcement using a circular mucosa plication was developed and used. Patients were followed up by postoperative endoscopy and outcomes were acute leak rate, morbidity, and diversion rate. The procedure was successfully completed in 52 from 54 patients during time period January 2019–October 2020. The mean age of patients was 61 years (lower–upper quartiles 54–69 years). There were 38/52 (73%) males and 14/52 (27%) females; the neoadjuvant radiotherapy was indicated in a group of patients in 24/52 (46%). The mean level of anastomosis was 3.8 cm (lower–upper quartiles 3.00–4.88 cm). The overall morbidity was 32.6% (17/52) and Clavien–Dindo complications ≥ 3 grade appeared in 3/52 (5.7%) patients. No loss of anastomosis was recorded and no patient died postoperatively. The symptomatic anastomotic leak was recorded in 2 (3.8%) patients and asymptomatic blind fistula was recorded in one patient 1/52 (1.9%). Diversion ileostomy was created in 1/52 patient (1.9%). Reinforcement of double-stapled anastomosis using a circular mucosa plication with combination of vacuum povidone-iodine-soaked sponge drainage led to a low acute leak and diversion rate. This pilot study requires further investigation.Registered at ClinicalTrials.gov.: Trial registration number is NCT04735107, date of registration February 2, 2021, registered retrospectively.

scholarly journals The Influence of Genetics in Myopia Control: A Pilot Study

2021 ◽  
Vol 10 (4) ◽  
pp. 808
Author(s):  
Cristina Alvarez-Peregrina ◽  
Miguel Ángel Sánchez-Tena ◽  
Clara Martinez-Perez ◽  
Catalina Santiago-Dorrego ◽  
Thomas Yvert ◽  
...  
Keyword(s):  
Pilot Study ◽  
Treatment Response ◽  
Axial Length ◽  
Contact Lenses ◽  
Control Method ◽  
Saliva Sample ◽  
Experimental Studies ◽  
Strong Linkage Disequilibrium ◽  
Student’S T ◽  
Myopia Control

Background: Many epidemiological and experimental studies have established that myopia is caused by a complex interaction between common genetic and environmental factors. The objective of this study was to describe and compare the allelic and genotypic frequencies of the rs524952 (GJD2), rs8000973 (ZIC2), rs1881492 (CHRNG), rs1656404 (PRSS56), rs235770 (BMP2), and rs7744813 (KCNQ5) SNPs (single-nucleotide polymorphism) between responder and nonresponder patients who had undergone a two-year treatment with lenses for myopia control. Method: Twenty-eight participants from the MiSight Assessment Study Spain (MASS), who had received treatment for myopia control for two years with MiSight contact lenses, were examined. The criteria for better/worse treatment response was the change in the axial length (< / ≥ 0.22 mm two years after the treatment). The clinical procedure consisted of the extraction of a saliva sample, and the participants also underwent an optometric examination. Genetic data were analyzed using SNPStats software (Catalan Institute of Oncology, Barcelona, Spain), and statistical analysis was performed using SPSS v.25 (SPSS Inc., Chicago, IL, USA). Demographic variables were analyzed using the Student’s t-test. Results: The T allele, the one with the lowest frequency, of the “rs235770” SNP was associated with a better treatment response [AL/CR (axial length/corneal radius): OR = 3.37; CI = 1.079–10.886; SE (spherical equivalent): OR = 1.26; CI: = 0.519–57.169; p = 0.019). By performing haplotype analysis, significant differences were found between the rs235770…rs1881492 and rs235770–rs1656404 polymorphisms. The latter presented a strong linkage disequilibrium with each other (r2 ≥ 0.54). Conclusion: The result of lens therapies for myopia control could vary depending on genetic variants. Studies with a larger sample are needed to confirm the results presented in this pilot study.

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