Inverse Associations of Schistosoma mansoni Infection and Metabolic Syndromes in Humans: A Cross-Sectional Study in Northeast Ethiopia

Background: Recent animal and retrospective human studies have demonstrated that Schistosoma mansoni infection may have potential to protect against development of metabolic syndromes. Thus, the aim of this study was to assess metabolic panel among S. mansoni egg positives and egg negatives in stool examinations. This study was a cross-sectional study, conducted involving 120 participants from S. mansoni endemic town (Kemise) and 61 from non-endemic town (Kombolcha), Northeast Ethiopia. Stool samples were collected and examined for S. mansoni and other helminths using Kato-Katz method. Furthermore, blood samples were collected and used for determination of blood sugar, lipid profile tests, insulin, and C-reactive protein. Data were analyzed using SPSS software version 20. Chi-square test, independent mean t-test, and logistic regression models were employed on data. P values less than .05 were considered as statistically significant. Results: S. mansoni infected participants (n = 41; all from Kemise) had significantly lower levels of fasting blood sugar, low prevalence of dyslipidemia (at least one or more abnormal lipid profile tests; total cholesterol, low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglycerides) as compared with controls (n = 79 in Kemise and 61 in Kombolcha). Moreover, logistic regression model indicated that with the adjusted odds ratios, there was significant inverse association between S. mansoni infection and impaired fasting glucose (adjusted odds ratio −0.181, 95% confidence interval: 0.042-0.774). Conclusions: Low fasting blood sugar and reduced prevalence of dyslipidemia in S. mansoni egg positive participants might suggest inverse association of S. mansoni infection and development of metabolic syndromes. Furthermore, large-scale studies are recommended to assess the role of S. mansoni egg and/or worm antigens in modulating the host metabolic profile and reducing the risk of metabolic syndromes, including diabetes mellitus and cardiovascular diseases.

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Association of plant-based diets with lipid profile and anthropometric indices: a cross-sectional study

Nutrition & Food Science ◽

10.1108/nfs-06-2021-0181 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Mohadese Borazjani ◽

Mehran Nouri ◽

Kamesh Venkatakrishnane ◽

Maryam Najafi ◽

Shiva Faghih

Keyword(s):

High Density Lipoprotein ◽

Lipid Profile ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Lipoprotein Cholesterol ◽

Healthy Plant ◽

Sectional Study ◽

Anthropometric Indices ◽

Cross Sectional ◽

Content Type

Purpose Plant-based diets have been related to decreasing morbidity and mortality of many non-communicable diseases. The purpose of this study was to investigate the relationship between plant-based diets and lipid profiles and anthropometric indices. Design/methodology/approach This cross-sectional study was performed on 236 men and women selected from Shiraz health-care centers. This study used a 168-item food frequency questionnaire to calculate plant-based diet index (PDI), healthy plant-based diet index (hPDI) and unhealthy plant-based diet index (uPDI). Total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol and triglycerides were measured. Furthermore, body mass index, a body shape index and conicity index (CI) were calculated after measuring weight, height and waist circumference. Findings Higher score of PDI was significantly related to higher triglycerides level (OR = 2.16; 95% CI: 1.04, 4.48; P = 0.03). In the fully adjusted model, there was a significant association between ABSI and hPDI (OR = 4.88; 95% CI: 1.17, 20.24; P = 0.03). A significant inverse association was observed between uPDI and high-density lipoprotein (HDL) (OR = 0.45; 95% CI = 0.21, 0.98; P = 0.03). Also, this study found a decreasing, but insignificant trend in relation of ABSI (OR = 0.72; 95% CI = 0.22, 2.34) and CI (OR = 0.41; 95% CI = 0.06, 0.56) with PDI. Research limitations/implications Further studies are needed to explore the association of PDI with anthropometric indices and lipid profile and also to assess the potential causality of the observed associations. Plant-based diets according to their contents could affect triglycerides, HDL and anthropometric properties. Practical implications Hence, dietitians should consider the findings of this study such as the inverse effect of unhealthy plant-based diets on HDL and the relation between healthy plant-based diets and WC and abdominal obesity. Originality/value This study showed that adherence to a plant-based diet was related to higher triglycerides levels. Also, uPDI was inversely associated with HDL level. Furthermore, participants who adhered more to a healthy plant-based diet had higher abdominal adiposity.

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Correlation of lipid profile in patients with severity of liver disease: a cross sectional study in a tertiary care hospital

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20164572 ◽

2016 ◽

Vol 5 (1) ◽

pp. 326

Author(s):

Hashik P. Muhammed ◽

Kezhakkut Jayaraj

Keyword(s):

Liver Disease ◽

Lipid Profile ◽

Chronic Liver Disease ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Chronic Liver ◽

Care Hospital ◽

Sectional Study ◽

Cross Sectional ◽

Lipid Parameters

Background: Many previous studies concluded variation in the lipid parameters such as total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) with severity of liver disease. Hence, this study was conducted to find out the correlation of lipid profile in patients with severe liver disease.Methods: A cross sectional study which included 170 patients admitted with chronic liver disease. Severity of liver disease according to Child Pugh Turcotte Score. The patients were subjected to routine investigation and fasting lipid profile test. Correlation was studied using the Pearson correlation coefficient and the comparison of lipid parameters was also done.Results: Total of 170 consecutive chronic liver disease patients were analysed over a period of one year. Majority of the patients were of the age 51 to 60 years (39.8%). Among the total, 24 patients were in Child Pugh Turcotte Score class A, 47 patients were in class B and 52 were patients in class C. We could observe a significant (p<0.001) negative correlation of all the lipid profile parameters with the severity of liver disease.Conclusions: Serum TC, LDL TG and HDL were decreased in patients with cirrhosis and they are inversely correlated to severity of disease.

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LDL-C:HDL-C ratio and common carotid plaque in Xinjiang Uygur obese adults: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2018-022757 ◽

2018 ◽

Vol 8 (10) ◽

pp. e022757 ◽

Cited By ~ 4

Author(s):

Qiang Zhao ◽

Fen Liu ◽

Ying-Hong Wang ◽

Hong-Mei Lai ◽

Qian Zhao ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Independent Predictor ◽

Multivariate Logistic Regression Analysis ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Sectional Study ◽

Multivariate Logistic Regression ◽

Obese Adults ◽

Cross Sectional

ObjectiveThe aim of this study was to explore the relationship between low-density lipoprotein cholesterol:high-density lipoprotein cholesterol (LDL-C:HDL-C) ratio and common carotid atherosclerotic plaque (CCAP) among obese adults of Uygur community in Xinjiang, China.DesignA hospital-based cross-sectional study.SettingFirst Affiliated Hospital of Xinjiang Medical University.ParticipantsA total of 1449 obese adults of Uygur population who were free of coronary artery disease were included in our study from 1 January 2014 to 31 December 2016.MethodologyLipid profiles, other routine laboratory parameters and intima-media thickness of the common carotid artery were measured in all participants. Multivariate logistic regression analysis was used to examine the association between LDL-C:HDL-C ratio and CCAP.ResultsFour hundred and fifteen (28.64%) participants had CCAP. Participants with CCAP had significantly higher LDL-C:HDL-C ratio compared with those without CCAP (3.21 [2.50, 3.88] vs 2.33 [1.95, 2.97], p<0.001). Multivariate logistic regression analysis showed high LDL-C:HDL-C ratio as independent predictor of CCAP after adjusting for conventional cardiovascular risk factors. The top LDL-C:HDL-C ratio quartile (≥3.25) had an OR of 9.355 (95% CI 6.181 to 14.157) compared with the bottom quartile (<2.07) of LDL-C:HDL-C ratio (p<0.001) after adjustment for age, body mass index, smoking, diabetes mellitus and serum level of total cholesterol.ConclusionCCAP is highly prevalent in Uygur obese adults. A high LDL-C:HDL-C ratio is an independent predictor of CCAP. It may help identify obese individuals who are at high risk of CCAP and who may benefit from intensive LDL-lowering therapy.

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Pattern of dyslipidemia in hypothyroid patients: A cross sectional study

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v6i2.29133 ◽

2016 ◽

Vol 6 (2) ◽

pp. 156

Author(s):

K. G. Kibria ◽

M. R. Alam ◽

H. K. Paul ◽

M. Fariduddin ◽

M. A. Hasanat

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Thyroid Function ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Thyroid Function Tests ◽

Sectional Study ◽

Cross Sectional ◽

Hypothyroid Patients

Background: An association between thyroid dysfunction and dyslipidemia prevails. Levels of total cholesterol, low density lipoprotein cholesterol, triglycerides tend to increase as thyroid function declines.Objective: To find out the pattern of dyslipidemia in hypothyroid patients. Methods: Sixty cases were selected as a sample of convenience in this cross sectional study from in-patienl depa1tment of Medicine and Endocrinology, BSMMU. Meticulous history taking and thorough clinical examinations were done. Report of lipid profile and thyroid function tests were recorded from patients file. All the information's were recorded in a pre-designed sttuctured questionnaire. Collected data were classified, edited, coded and entered into the computer for statistical analysis by using SPSS. Results: Among the 60 cases, 43 (72%) were female; 17(28%) were male. Age range was 24-59 years with a mean age of 38.80 (± I 0.35) years. Majority 38(65%) were housewife, followed by service holder 11(18.33%), 08(13.3%) were business men and 02(3.3%) had other occupations. Majority 42(70%) patients were taking thyroxin. Mean Total cholesterol (TC), LDL cholesterol, Triglyceride (TG) and HDL were 222.20(±42.25); 138.63(±31.51); 243.36(±83.13) and 37.30(±5.12) respectably. Conclusion: All hypothyroid subjects had dyslipidemia. The present study indicated that hypothyroidism was associated with an abnormal lipid profile, especially with respect to the levels of total cholesterol and triglyceride.

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Lipid Profile Abnormalities in Bangladeshi Type 2 Diabetic Patients Attending a Tertiary Care Hospital: A Cross-Sectional Study

Bangladesh Critical Care Journal ◽

10.3329/bccj.v7i1.40767 ◽

2019 ◽

Vol 7 (1) ◽

pp. 44-47

Author(s):

Afsana Begum ◽

SM Rezaul Irfan

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Lipid Profile ◽

Density Lipoprotein ◽

Serum Levels ◽

Cross Sectional Study ◽

Care Hospital ◽

Sectional Study ◽

Cross Sectional

Diabetes Mellitus is one of the leading non-communicable diseases all over the world including Bangladesh. Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Impaired lipid profile is commonly present in type 2 diabetes. We aimed to research serum lipid profile abnormalities hypothesizing that early detection and treatment of lipid abnormalitiescan minimize the risk for atherogenic cardiovascular disorder and cerebrovascular accident in patients with type 2 diabetes mellitus. This observational cross sectional study was carried out in the department of Biochemistry, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM).A total 105patients with T2DM of age within the range of 30-45 years were selected& their Fasting blood glucose (FBG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and glycatedhaemoglobin (HbA1c) levels were evaluated. Significantly higher mean serum levels of TC, TG and LDL and significantly lower mean serum levels of HDL were noted in patients with diabetes . Significant correlations were observed between HbA1c value and serum levels of TC, TG and HDL (p<0.05) but no correlation of HbA1c value withlow density lipoprotein in diabetes patient.The study showed widespread lipid abnormalities in the course of diabetes triggered dyslipidemia as hypercholesterolemia, hypertriglyceridemia, elevated LDL and decreased HDL. Bangladesh Crit Care J March 2019; 7(1): 44-47

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Prevalence and Determinants of Dyslipidemia: Data from a Saudi University Clinic

The Open Public Health Journal ◽

10.2174/1874944501811010416 ◽

2018 ◽

Vol 11 (1) ◽

pp. 416-424 ◽

Cited By ~ 3

Author(s):

Yasser Taher Al-Hassan ◽

Eduardo L. Fabella ◽

Edric Estrella ◽

Mohammad Aatif

Keyword(s):

Logistic Regression ◽

Lipid Profile ◽

Odds Ratio ◽

Profile Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Multivariable Logistic Regression Model ◽

Cross Sectional ◽

The Relationship ◽

Prevalent Form

Background: Dyslipidemia is a risk factor for cardiovascular diseases. The relationship between demographic factors and dyslipidemia in Saudi Arabia is not completely explored. Objectives: This analytic cross-sectional study was conducted to describe the lipid profile, determine the proportion and identify significant demographic determinants of dyslipidemia among patients who have undergone lipid profile analysis in a university multispecialty clinic. Methods: The results of lipid profile examination of 1,541 King Faisal University clinic patients from 1 April, 2014 to 7 March, 2016 were compiled and subjected to descriptive and analytical statistics using STATA MP version 14. Multivariable logistic regression model using Adjusted Odds Ratio (AOR) and 95% Confidence Interval (CI) was fitted to analyze the independent predictors of dyslipidemia. Results: The prevalence of hypercholesterolemia, hypertriglyceridemia, hypo-HDL-cholesterolemia, and hyper-LDL-cholesterolemia were 13.8%, 17.0%, 40.0% 12.85%, respectively. Logistic regression revealed that in comparison with those who were 20 years old and below, those who were between the age of 40-49 years were 4.5 times more likely to have hypercholesterolemia and 3.5 times more likely to have hyper-LDL-cholesterolemia. Similarly, those who were 30-39 years old were 4.3 times and 3 times more likely to have hypertriglyceridemia and hypercholesterolemia, respectively. The same stage group was 3 times more likely to develop hyper-LDL-cholesterolemia. Females were 1.4 times more like to have hypercholesterolemia; non-Saudis were nearly twice as likely to develop hypertriglyceridemia than Saudis. Conclusion: Hypo-HDL-cholesterolemia was the most prevalent form of dyslipidemia. Age, gender and nationality were significant determinants of specific types of dyslipidemia.

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Prevalence of thyroid dysfunction and its relationship with the lipid profile in patients in hospital from Encarnación

Revista de Ciencia y Tecnología ◽

10.36995/j.recyt.2021.36.009 ◽

2021 ◽

pp. 99-111

Author(s):

Edith N. Genéz Yeza ◽

Claudia N. Mir ◽

Rocío M. Ares ◽

Williams R. Pedrozo ◽

Graciela A. Bonneau

Keyword(s):

Logistic Regression ◽

Lipid Profile ◽

Medical Records ◽

Thyroid Dysfunction ◽

Population Sample ◽

Cross Sectional Study ◽

Regional Hospital ◽

Sectional Study ◽

Cross Sectional ◽

Thyroid Dysfunctions

Thyroid dysfunctions are a cause of morbidity and disability worldwide. Little information has been found on the prevalence of thyroid dysfunctions in Paraguay, so this study provides data on their presentation. The objective was to determine the prevalence of thyroid dysfunction and its relationship with the lipid profile in adult outpatients attending the laboratory of the Regional Hospital of Encarnación, during January-November 2016. A descriptive cross-sectional study was performed, based on the review of 250 medical records, 84 % of whom were women; the median age was 39 (35-47) years in men and 36 (32-43) years in women. Thirty percent were hypothyroid and 3 % hyperthyroid; the most frequent thyroid dysfunction was subclinical hypothyroidism with 19 %. Highly significant differences were found for total cholesterol, LDL, VLDL and thyrotrophin between hypothyroid vs euthyroid, with the former having more atherogenic profiles. Logistic regression was used to assess the contribution of dyslipidaemia, finding a significant association with hypothyroidism (OR=3.24(1.81-5.81), p<0.001). Thirty-three percent of this population sample, 1 in 3 individuals, had thyroid dysfunction. These could be managed appropriately and further complications could be avoided.

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The Correlation Between Lipid Profile and Xanthelasma

Berkala Ilmu Kesehatan Kulit dan Kelamin ◽

10.20473/bikk.v32.2.2020.119-125 ◽

2020 ◽

Vol 32 (2) ◽

pp. 119

Author(s):

Puridelko Kampar

Keyword(s):

Serum Level ◽

Lipid Profile ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Age Group ◽

Sectional Study ◽

Cross Sectional ◽

The Subject ◽

Yellowish Plaque

Background: Xanthelasma is an abnormal lipid deposition on palpebrae, which is observable as yellowish plaque or nodules. Its incidence is 0.56–1.5% with onset of 15–73 years old and mostly occurs in the fourth and fifth decade. Few reports of xanthelasma did not cover the correlation between lipid profile and xanthelasma in Indonesia. Purpose: To find a correlation between lipid profile with xanthelasma in Dr. M. Djamil Hospital, Padang. Methods: This was an analytic cross-sectional study with consecutive sampling. There were 36 participants (18 xanthelasma and 18 control). Result: The highest age group was >36 - ≤45 years old (38.89%). More cases were observed in female (66.67%). Body mass index examination of xanthelasma revealed that most were overweight (55.56%). Grade I xanthelasma was the most common (72.22%). The cholesterol serum level of xanthelasma patients was higher than the subject controls (224.61±29.77 mg/dl versus 169.39±35.84 mg/dl) (p<0,05). The High Density Lipoprotein (HDL) serum level of xanthelasma patients was lower than controls (46.44±14.19 mg/dl versus 51.78±15.9 mg/dl) (p>0,05). The Low Density Lipoprotein (LDL) serum level of xanthelasma patients was higher than control (139.39±29.73 mg/dl versus 106.50±35.43 mg/dl) (p<0,05). Triglyceride serum level of xanthelasma patients was higher than the controls (167.83±87.26 mg/dl versus 121.61±54.52 mg/dl) (p>0,05). Conclusion: There was a correlation between higher cholesterol and LDL serum level with xanthelasma. No correlation between lower HDL and a higher triglyceride serum level with xanthelasma.

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Dietary inflammatory index is associated with lipid profile and interleukin-6 in postmenopausal women: A cross-sectional study

10.21203/rs.2.23968/v1 ◽

2020 ◽

Author(s):

Zahra Aslani ◽

Fereydoun Siassi ◽

Mostafa Qorbani ◽

Nitin Shivappa ◽

James R Hébert ◽

...

Keyword(s):

Lipid Profile ◽

Postmenopausal Women ◽

Interleukin 6 ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Lipoprotein Cholesterol ◽

Dietary Inflammatory Index ◽

Sectional Study ◽

Cross Sectional ◽

Inflammatory Index

Abstract Background: The prevalence of diseases associated with chronic inflammation is higher in postmenopausal women. The dietary inflammatory index (DII®) was developed to evaluate the diet-associated inflammation. The aim of this study was to evaluate the association between the DII score and levels of fasting blood sugar (FBS), lipid profile, and inflammatory biomarkers.Methods: This cross-sectional study was conducted on 175 postmenopausal women referred to the southern health centers and health clinics affiliated to the southern municipality of Tehran, Iran. The DII score was calculated using dietary intakes derived from a validated food frequency questionnaire (FFQ). Concentrations of FBS, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were determined. Using linear regression models, we evaluated the association between the DII score and blood biomarkers. Results: After adjustment for covariates, the highest DII score category was associated with higher TG value (bDIIt3vs1= 0.08, p=0.03), TG/HDL-C ratio (bDIIt3vs1= 0.10, p=0.04), and IL-6 concentration (bDIIt3vs1= 0.06, p=0.01) compared to the first category of the DII score. Conclusions: We found a positive association between pro-inflammatory diet and unfavorable biomarkers in postmenopausal women.

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A high triglyceride/ high-density lipoprotein ratio is associated with an increased risk of insulin resistance in the US population: a cross-sectional study from the US National Health and Nutrition Examination Survey, 2017–2018

10.21203/rs.3.rs-154501/v1 ◽

2021 ◽

Author(s):

Rongpeng Gong ◽

Zheng Li ◽

Ya Liu ◽

Gang Luo ◽

Lixin Yang ◽

...

Keyword(s):

Insulin Resistance ◽

Logistic Regression ◽

Density Lipoprotein ◽

Smooth Curve ◽

Cross Sectional Study ◽

American Population ◽

Sectional Study ◽

Cross Sectional ◽

The Us ◽

The Relationship

Abstract Background Some previous studies have reported that the ratio of triglycerides to high-density lipoprotein may indicate insulin resistance, but the results suggest that there are differences between different ethnic groups. In this study, the NHANES 2017-2018 database was used to explore the relationship between TG/HDL-C and IR in the American population. Methods This trial comes from a cross-sectional study of NHANES ( http://www.cdc.gov/nchs/nhanes/ ) conducted by the National Center for Health Statistics (NCHS) of the US Centers for Diseases and Control and Prevention. IR uses the homeostatic model assessment (HOMA) formula as an indicator: [fasting insulin (μU/mL)×fasting blood glucose (mmol/L)]/22.5, with ≥75th percentile of HOMA-IR as an indicator. Use logistic regression to explore the relationship between TG/HDL ratio and IR occurrence. Results In this study, a total of 450 participants (40%,450/1902) developed insulin resistance. Using logistic regression model of the association between TG/HDL-C and insulin resistance risk, after adjusting for potential confounding factors, as the TG/HDL ratio increases, the probability of insulin resistance increases significantly (OR: 1.91, 95% CI: 1.59-2.30, P<0.0001). At the same time, we performed a smooth curve fitting and found a non-linear relationship between TG/HDL and IR. Even if the adjusted covariate is deleted from the model, the association remains unchanged. The smooth curve of TG/HDL-C The inflexion point is 0.95. When TG/HDL-C<0.95, the effect value is very significant (OR: 27.34, 95%CI, 10.61-70.47, P<0.0001), when TG/HDL-C≥0.95, the effect value is relatively reduced (OR: 1.29, 95% CI, 1.03-1.61, P<0.0001). We grouped them by inflexion points. Multiple regression equations showed that after adjustment, the group's risk of insulin resistance greater than 0.95 increased by two times compared with the group less than 0.95. Conclusions In this study, we found that the increase of TG/HDL-C ratio in the American population was significantly related to IR. It is clinically acceptable and can save some extra costs for patients. However, in different situations, combining the TG/HDL-C ratio with other risk factors to predict whether IR will occur is worthwhile for the next step.

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