National estimate of multiple sclerosis incidence in France (2001–2007)

2012 ◽  
Vol 18 (8) ◽  
pp. 1108-1115 ◽  
Author(s):  
A Fromont ◽  
C Binquet ◽  
EA Sauleau ◽  
I Fournel ◽  
R Despalins ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Atlantic Coast ◽  
European Population ◽  
Geographic Variations ◽  
Notification Rate ◽  
North Eastern ◽  
National Estimates ◽  
The Alps ◽  
First Time ◽  
Care Costs

Background: In France, the incidence of multiple sclerosis (MS) is not well known, and MS is one of the 30 long-term illnesses for which patients are covered for 100% of their health care costs. Objective: To estimate the incidence of MS in France and its geographic variations. Methods: We estimated the national rate for notification of MS to the main French health insurance system, and its confidence interval (CI), between November 2000 and October 2007, which covers 87% of the population. We analysed geographic variations using a Bayesian approach. Results: Between November 2000 and October 2007, among a covered population of 52,449,871, some 28,682 individuals were registered as having MS. After age standardization according to the European population, the notification rate for MS was 6.8 per 100,000 (6.7–6.9), 9.8 (9.7–10.0) in women and 3.7 (3.6–3.8) in men. When the under-notification rate (11.5% and 29%) was taken into account, the notification rate per 100,000 inhabitants was estimated between 7.6 and 8.8. The notification rate was higher in north-eastern France, and lower on the Atlantic coast and in the Alps as well as on both sides of the Rhône River. Conclusions: This study, conducted on a representative French population, provides for the first time national estimates of MS incidence between November 2000 and October 2007.

Latitude continues to be significantly associated with the prevalence of multiple sclerosis: an updated meta-analysis

2019 ◽  
Vol 90 (11) ◽  
pp. 1193-1200 ◽  
Author(s):  
Steve Simpson ◽  
Wendy Wang ◽  
Peter Otahal ◽  
Leigh Blizzard ◽  
Ingrid A F van der Mei ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Latitudinal Gradient ◽  
Previous Analysis ◽  
Meta Analysis ◽  
Atlantic Coast ◽  
Sun Exposure ◽  
European Population ◽  
Search Terms ◽  
Prevalence Estimates ◽  
Measured Time

ObjectivesPrevious studies have demonstrated a strong latitudinal gradient in multiple sclerosis (MS) prevalence. Herein, we present a meta-analysis of the latitudinal gradient of MS prevalence including studies published since our 2011 review, seeking to assess the latitudinal gradient and whether it has changed since our previous analysis.MethodsStudies published up to December 2018 were located via Embase, Web of Knowledge and PubMed, using standardised search terms; data were extracted from peer-reviewed studies and these studies added to those from our previous analysis. Where age-specific data were available, prevalence estimates were age-/sex-standardised to the 2009 European population. Prevalence estimates were adjusted for study prevalence year and ascertainment methods. The latitudinal association with MS prevalence was assessed by meta-regression.ResultsA total of 94 studies met inclusion criteria, yielding 230 new prevalence points and 880 altogether with those from the prior study. There was a significant positive gradient in time-corrected MS prevalence with increasing latitude (5.27/100 000 per degree latitude), attenuating slightly to 4.34/100 000 on age-standardisation, these associations persisting on adjustment for ascertainment method. Of note, the age-standardised gradient was consistently significantly enhanced from our previous study, regardless of whether it was as-measured, time-corrected or adjusted for ascertainment methods. Certain areas, such as the Scandinavian and Atlantic Coast/Central Europe regions, showed changes in MS prevalence gradient over time, but other regional gradients were similar.ConclusionsThis new meta-analysis confirms that MS prevalence is still strongly positively associated with increasing latitude and that the gradient is increasing, suggesting that potentially modifiable environmental factors, such as sun exposure, are still strongly associated with MS risk.

scholarly journals Volcanism and Volcanogenic Submarine Sedimentation in the Paleogene Foreland Basins of the Alps: Reassessing the Source-to-Sink Systems with an Actualist View

Geosciences ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 23
Author(s):  
Andrea Di Capua ◽  
Federica Barilaro ◽  
Gianluca Groppelli
Keyword(s):  
Foreland Basin ◽  
Fault System ◽  
Foreland Basins ◽  
The North ◽  
Source To Sink ◽  
The Alps ◽  
Alpine Foreland ◽  
Alpine Foreland Basin ◽  
Tectonic Lineament ◽  
First Time

This work critically reviews the Eocene–Oligocene source-to-sink systems accumulating volcanogenic sequences in the basins around the Alps. Through the years, these volcanogenic sequences have been correlated to the plutonic bodies along the Periadriatic Fault System, the main tectonic lineament running from West to East within the axis of the belt. Starting from the large amounts of data present in literature, for the first time we present an integrated 4D model on the evolution of the sediment pathways that once connected the magmatic sources to the basins. The magmatic systems started to develop during the Eocene in the Alps, supplying detritus to the Adriatic Foredeep. The progradation of volcanogenic sequences in the Northern Alpine Foreland Basin is subsequent and probably was favoured by the migration of the magmatic systems to the North and to the West. At around 30 Ma, the Northern Apennine Foredeep also was fed by large volcanogenic inputs, but the palinspastic reconstruction of the Adriatic Foredeep, together with stratigraphic and petrographic data, allows us to safely exclude the Alps as volcanogenic sources. Beyond the regional case, this review underlines the importance of a solid stratigraphic approach in the reconstruction of the source-to-sink system evolution of any basin.

scholarly journals A review of cephalopods (Phylum: Mollusca) of the Canary Current Large Marine Ecosystem (Central-East Atlantic, African coast)

2021 ◽  
pp. 1-25
Author(s):  
Amanda Luna ◽  
Francisco Rocha ◽  
Catalina Perales-Raya
Keyword(s):  
North Atlantic ◽  
Atlantic Coast ◽  
Marine Ecosystem ◽  
Western Sahara ◽  
Guinea Bissau ◽  
Distribution Ranges ◽  
Large Marine Ecosystem ◽  
Sepiola Atlantica ◽  
First Time ◽  
Subsequent Identification

Abstract An extensive review of cephalopod fauna in the Central and North Atlantic coast of Africa was performed based on material collected during 10 research cruises in these waters. In the Canary Current Large Marine Ecosystem (CCLME) area, a total of 378,377 cephalopod specimens was collected from 1247 bottom trawl stations. Of those specimens, 300 were sampled for subsequent identification in the laboratory and found to belong to 65 different species and 23 families. After an exhaustive review of the existing literature on the cephalopods and new data obtained from the surveys, an updated checklist of 138 species was generated for the CCLME area. Our knowledge of the known geographic distribution ranges of several species has been expanded: Muusoctopus januarii has been sighted from Guinea–Bissau waters, passing through Western Sahara, to Morocco waters for the first time; Lepidoteuthis grimaldii and Octopus salutii have been sighted off Morocco waters for the first time; Austrorossia mastigophora, Abralia (Heterabralia) siedleckyi, Abralia (Pygmabralia) redfieldi and Sepiola atlantica have been cited off Western Sahara waters for the first time; Magnoteuthis magna, Abralia (Asteroteuthis) veranyi and Octopoteuthis megaptera have been sighted off Moroccan and Western Sahara waters for the first time; Ancistroteuthis lichtensteinii, Opisthoteuthis grimaldii, Onykia robsoni, Muusoctopus levis and Bathypolypus valdiviae have been cited in the Guinea–Bissau coast for the first time; the northern geographic limit of Bathypolypus ergasticus has been expanded to Morocco, Western Sahara and Mauritania and southward to Guinea–Bissau waters. The presence of Muusoctopus johnsonianus in Senegalese waters has been reported for the first time. A Chtenopteryx sicula specimen was reported in Western Sahara waters. A specimen belonging to the poorly known Cirrothauma murrayi species was found in South Moroccan waters. Amphitretus pelagicus, a probably cosmopolitan species, has been reported in the Western Sahara and Guinea–Bissau waters. Some species that were previously recorded in the area, Sepia angulata, Sepia hieronis, Heteroteuthis dagamensis, Helicocranchia joubini and Tremoctopus gelatus, were removed from the final checklist and considered to be not present in the CCLME area. Cycloteuthis akimushkini was substituted with Cycloteuthis sirventi, its senior synonym, in the final checklist. Similarly, Mastigoteuthis flammea and Mastigoteuthis grimaldii were substituted with Mastigoteuthis agassizii.

Extended dosing of monoclonal antibodies in multiple sclerosis

2021 ◽  
pp. 135245852110657
Author(s):  
Zoé LE van Kempen ◽  
Alyssa A Toorop ◽  
Finn Sellebjerg ◽  
Gavin Giovannoni ◽  
Joep Killestein
Keyword(s):  
Multiple Sclerosis ◽  
Monoclonal Antibodies ◽  
Treatment Options ◽  
Future Research ◽  
Therapeutic Drug ◽  
Therapeutic Landscape ◽  
Anti Cd20 ◽  
Dosing Intervals ◽  
Care Costs ◽  
Review Current

Over the past two decades, treatment options for patients with multiple sclerosis (MS) have increased exponentially. In the current therapeutic landscape, “no evidence of MS disease activity” is within reach in many of our patients. Minimizing risks of complications, improving treatment convenience, and decreasing health care costs are goals that are yet to be reached. One way to optimize MS therapy is to implement personalized or extended interval dosing. Monoclonal antibodies are suitable candidates for personalized dosing (by therapeutic drug monitoring) or extended interval dosing. An increasing number of studies are performed and underway reporting on altered dosing intervals of anti-α4β1-integrin treatment (natalizumab) and anti-CD20 treatment (ocrelizumab, rituximab, and ofatumumab) in MS. In this review, current available evidence regarding personalized and extended interval dosing of monoclonal antibodies in MS is discussed with recommendations for future research and clinical practice.

Phimodera flori Fieber, found in Greece on Mount Olympus, new to the Balkan Peninsula (Hemiptera: Heteroptera: Scutelleridae)

Zootaxa ◽  
2021 ◽  
Vol 4958 (1) ◽  
pp. 649-653
Author(s):  
PARIDE DIOLI
Keyword(s):  
Balkan Peninsula ◽  
Southern Europe ◽  
High Altitudes ◽  
First Report ◽  
Asian Species ◽  
Central Asian ◽  
The Alps ◽  
First Time

The first report of Phimodera flori Fieber, 1863 (Hemiptera: Heteroptera: Scutelleridae) in the Balkan Peninsula (Mt. Olympus, Greece) is presented. This continental European and Central Asian species is rare in southern Europe where it has been found only at high altitudes of the Alps and the Pyrenees so far. It has been regarded as extinct from the 1970’s in many countries. The species is recorded for the first time for Greece, being Mt. Olympus the southernmost known locality. 

scholarly journals Sea-level fluctuations and coastal evolution in the state of Rio de Janeiro, southeastern Brazil

2014 ◽  
Vol 86 (2) ◽  
pp. 671-683 ◽  
Author(s):  
JOÃO WAGNER A. CASTRO ◽  
KENITIRO SUGUIO ◽  
JOSÉ C.S. SEOANE ◽  
ALINE M. DA CUNHA ◽  
FABIO F. DIAS
Keyword(s):  
Sea Level ◽  
Rio De Janeiro ◽  
Atlantic Coast ◽  
Southeastern Brazil ◽  
Brazilian Coast ◽  
14C Dating ◽  
Relative Sea Level ◽  
Coastal Evolution ◽  
The Holocene ◽  
First Time

The present paper aims to investigate the relative sea-level and the coastal evolution during the Holocene in the Rio de Janeiro coastline, based on geological and biological indicators. Using topographic survey, excavation and coring, and 14C dating of these coastal deposits and beachrocks outcrops, we have reconstructed a sea-level curve for the Holocene. For the first time on the Brazilian coast it was identified a negative record of relative sea-level during Late Pleistocene and Early Holocene transition. After the transition, a relatively rapid increase of sea-level began. At approximately at 8500 cal yr BP, the sea-level was 0.5 m below the current level, was overtaken for the first time in the Holocene, at approximately 7500 cal yr BP. The maximum level of +2.5 m was reached between 4770 and 4490 cal yr BP. At the point of maximum transgression, the sea-level began a general behavior of lowering until the present. These results confirm other data already obtained elsewhere along the Atlantic coast of South America. The results of this study are consistent with previous researches and they help to refine the Holocene sea-level record along the Brazilian coast.

Descriptive and illustrated diagnosis of Ophiuroidea fauna (Echinodermata) in the shallow waters of North-eastern Brazil

2015 ◽  
Vol 8 ◽  
Author(s):  
Fabilene Gomes Paim ◽  
Maria Cecília Guerrazzi ◽  
Michela Borges
Keyword(s):  
Brittle Star ◽  
Shallow Waters ◽  
Bottom Substrate ◽  
Eastern Brazil ◽  
North Eastern ◽  
Amphipholis Squamata ◽  
Biological Substrates ◽  
Almost All ◽  
First Time ◽  
Ophiocoma Echinata

In this study, we present descriptions, illustrations, comments, and bathymetric and geographic distributions of the brittle star species related to the estuary region of Camamu Bay, located in the State of Bahia, Brazil. The brittle star fauna lives on biological substrates, sand bottoms, mud and rubble in the Camamu Bay and comprises 12 species divided into five families. Almost all of them are common in the tropical and subtropical fauna of the regions of shallow water.Ophiophragmus filograneusis reported for the first time in Bahia, and nine other species are recorded for the first time in Camamu Bay:Amphipholis januarii, Amphipholis squamata, Ophiophragmus filograneus, Ophiostigma isocanthum,Ophioderma cinerea, Ophioderma januarii, Ophiactis lymani, Ophiactis savignyi andOphiocoma echinata.The results suggest that the ophiuroid assemblages are strongly affected by marine currents as well as by different kinds of bottom substrate.

scholarly journals Effects of aerosols on precipitation in north-eastern North America

2014 ◽  
Vol 14 (10) ◽  
pp. 5111-5125 ◽  
Author(s):  
R. Mashayekhi ◽  
J. J. Sloan
Keyword(s):  
North America ◽  
Atlantic Coast ◽  
Inverse Correlation ◽  
Cloud Droplet ◽  
Cloud Microphysics ◽  
Convective Precipitation ◽  
Eastern North America ◽  
Anthropogenic Aerosols ◽  
Convective Rain ◽  
North Eastern

Abstract. The changes in precipitation in north-eastern North America caused by chemistry – and particularly anthropogenic aerosols – are investigated using the Weather Research Forecasting with Chemistry (WRF/Chem v3.2) model. The simulations were carried out for a five-month period from April to August 2009. The model results show that non-negligible changes in both convective and cloud-resolved (non-convective) precipitation are caused by chemistry and/or aerosols over most parts of the domain. The changes can be attributed to both radiative and microphysical interactions with the meteorology. A chemistry-induced change of approximately −15% is found in the five-month mean daily convective precipitation over areas with high convective rain; most of this can be traced to radiative effects. Total convective rain is greater than total non-convective rain in the domain, but a chemistry-induced increase of about 30% is evident in the five-month mean daily non-convective precipitation over the heavily urbanized parts of the Atlantic coast. The effects of aerosols on cloud microphysics and precipitation were examined for two particle size ranges, 0.039–0.1 μm and 1–2.5 μm, representing the nucleation and accumulation modes respectively. Strongly positive spatial correlation between cloud droplet number and non-convective rain are found for activated (cloud-borne) aerosols in both size ranges. Non-activated (interstitial) aerosols have a positive correlation with cloud droplet number and non-convective rain when they are small and an inverse correlation for larger sizes.

scholarly journals New records of benthic marine algae from Morocco (eastern Atlantic Ocean): morphology, taxonomy and distribution

2018 ◽  
Vol 43 ◽  
pp. 111-116
Author(s):  
Mustapha Hassoun ◽  
Hanaa Moussa ◽  
Ghizlane Salhi ◽  
Hanaa Zbakh ◽  
Hassane Riadi ◽  
...  
Keyword(s):  
Atlantic Ocean ◽  
New Record ◽  
Pacific Islands ◽  
New Records ◽  
Atlantic Coast ◽  
Marine Macroalgae ◽  
Eastern Coast ◽  
Western Coast ◽  
Eastern Atlantic Ocean ◽  
First Time

AbstractWe report new records and corological data for three Moroccan marine macroalgae that complete their distribution information. Radicilingua thysanorhizans is new record for Morocco; Champia compressa is recorded for the first time from the eastern coast of the Atlantic Ocean. Diplothamnion jolyi is widely distributed in the western coast of the Atlantic coast and Pacific Islands, and recently reported from the Mediterranean Sea; this new record from Moroccan Atlantic coast extends their distribution range.Key words: Algae, Atlantic Ocean, Champia compressa, Diplothamnion jolyi, Radicilingua thysanorhizans.ResumenSe aportan nuevos registros y datos corológicos para tres macroalgas marinas de Marruecos, que completan la información sobre su distribución. Radicilingua thysanorhizans es cita nueva para Marruecos. Champia compressa se registra por la primera vez en la costa oriental del Océano Atlántico. Diplothamnion jolyi se distribuye ampliamente en la costa occidental de la costa atlántica y las islas del Pacífico y ha sido recientemente citada en el mar Mediterráneo; esta nueva cita para costa Atlántica Marroquí amplia su rango de distribución.Palabras clave: Algae, Océano Atlántico, Champia compressa, Diplothamnion jolyi, Radicilingua thysanorhizans.

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