Potential effects of high plasma to red blood cell ratio transfusion in pediatric trauma

Trauma ◽  
2016 ◽  
Vol 19 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Ruth S Hwu ◽  
Martin S Keller ◽  
Philip C Spinella ◽  
David Baker ◽  
Yu Tao ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Massive Transfusion ◽  
Pediatric Trauma ◽  
Retrospective Chart Review ◽  
High Plasma ◽  
High Ratio ◽  
Total Blood ◽  
Significant Difference

Objective High ratio of plasma to red blood cells during massive transfusion is associated with improved survival of traumatic injuries in adults, but this has not been demonstrated in children. Our objective was to compare the outcome of children who received high (≥1:2) versus low (<1:2) plasma: red blood cells (P:R) ratios at 24 h from injury. Methods We conducted a retrospective chart review of children <18 years of age who presented to the emergency department over a 7-year period and received massive transfusion (≥40 ml/kg red blood cells or ≥80 ml/kg total blood products in 24 h). Our primary outcome of interest was in-hospital mortality. Results We identified 38 children who received massive transfusion. There was no significant difference in in-hospital mortality (45.8% vs. 64.3%) between the high (n = 24, median ratio 1:1.1) and low P:R ratio (n = 14, median 1:3.2) groups. In subset analyses, there was reduced mortality for high P:R patients with BIG score ≥24 (69.2% vs. 100%) and those taken to the operating room within 6 h of arrival (21.4% vs. 60.0%), respectively ( p < 0.05). There was a trend for improved survival in high P:R patients without severe traumatic brain injury (TBI) (0% vs. 40.0%). Conclusions This study suggests that high P:R transfusion may improve in-hospital survival of injured children at high risk of mortality and in children without severe TBI, supporting the need for large, multi-center studies.

scholarly journals Efek Merokok Terhadap Viskositas Darah

2020 ◽  
Vol 7 (1) ◽  
pp. 1036
Author(s):  
Sartika Sartika
Keyword(s):  
Red Blood Cells ◽  
Blood Viscosity ◽  
Blood Cells ◽  
Sampling Technique ◽  
The Body ◽  
Exclusion Criteria ◽  
Total Blood ◽  
Purposive Sampling ◽  
Protein Levels ◽  
Significant Difference

Blood viscosity is strongly influenced by hematocrit and total protein levels. In general, active smokers have high hematocrit levels because cigarettes contain carbon monoxide which has a tendency to bind to hemoglobin faster than oxygen. So that oxygen levels in blood vessels can decrease. One of the body's physiological responses in meeting the needs of oxygen in the body is by increasing the production of red blood cells. Increased levels of red blood cells will affect total hematocrit levels. An increase in large molecular proteins such as fibrinogen also affects total blood viscosity.This research uses a quantitative approach to see the effect of smoking on blood viscosity. The population this study were all active smokers in Kendari. The sample this study were male active smokers who were selected using a purposive sampling technique in accordance with established inclusion and exclusion criteria. The sample this study as many as 40 people were divided into two groups, 20 active smokers and 20 non-smokers. Mann Whitney analysis results show that there is no significant difference in viscosity in smokers and non-smokers. However, Pearson analysis found that smoking has a significant correlation with blood viscosity.Keywords: Smoker, Blood Viscosity.ABSTRAKViskositas   darah   sangat   dipengaruhi   oleh  kadar hematokrit dan protein total. Pada umumnya perokok aktif memiliki kadar hematokrit yang tinggi karena rokok mengandung karbon monoksida yang memiliki kecenderungan berikatan dengan hemoglobin lebih cepat dibandingkan dengan oksigen. Sehingga kadar oksigen dalam pembuluh darah dapat menurun. Salah satu respon fisiologi tubuh dalam memenuhi kebutuhan oksigen dalam tubuh yaitu dengan cara meningkatkan produksi sel darah merah. Kadar sel darah merah  yang meningkat akan mempengaruhi kadar hematokrit total. Peningkatan protein bermolekul besar seperti fibrinogen juga mempengaruhi viskositas darah total.  Penelitian ini menggunakan pendekatan kuantitatif untuk melihat efek merokok terhadap viskositas darah. Populasi dalam penelitian ini adalah semua perokok aktif di Kendari. Sampel dalam penelitian ini adalah laki-laki perokok aktif yang dipilih dengan menggunakan teknik purposive sampling sesuai dengan kriteria inklusi dan eksklusi yang telah ditetapkan. Sampel dalam penelitian ini sebanyak 40 orang yang dibagi dalam dua kelompok yaitu kelompok laki-laki perokok aktif sebanyak 20 orang dan kelompok laki-laki bukan perokok sebanyak 20 orang. Hasil analisis Mann Whitney menunjukan bahwa tidak ada perbedaan viskositas yang signifikan pada perokok dan non-perokok. Namun Analisis Pearson diperoleh bahwa kebiasaan merokok mempunyai korelasi yang signifikan terhadap viskositas darah.Kata kunci: Perokok, Viskositas Darah.

scholarly journals Multimodal Diagnostics of Microrheologic Alterations in Blood of Coronary Heart Disease and Diabetic Patients

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 76
Author(s):  
Anastasia Maslianitsyna ◽  
Petr Ermolinskiy ◽  
Andrei Lugovtsov ◽  
Alexandra Pigurenko ◽  
Maria Sasonko ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Optical Methods ◽  
Diabetic Patients ◽  
Aggregation Index ◽  
Significant Difference

Coronary heart disease (CHD) has serious implications for human health and needs to be diagnosed as early as possible. In this article in vivo and in vitro optical methods are used to study blood properties related to the aggregation of red blood cells in patients with CHD and comorbidities such as type 2 diabetes mellitus (T2DM). The results show not only a significant difference of the aggregation in patients compared to healthy people, but also a correspondence between in vivo and in vitro parameters. Red blood cells aggregate in CHD patients faster and more numerously; in particular the aggregation index increases by 20 ± 7%. The presence of T2DM also significantly elevates aggregation in CHD patients. This work demonstrates multimodal diagnostics and monitoring of patients with socially significant pathologies.

Hematological condition of breeding bulls after a long winter period of operation in the conditions of the Udmurt Republic

2022 ◽  
pp. 67-73
Author(s):  
A. Abilov ◽  
A. Azhmyakov ◽  
I. Novgorodova ◽  
N. Bogolyubova
Keyword(s):  
Red Blood Cells ◽  
Reference Values ◽  
Blood Cells ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Winter Period ◽  
Black And White ◽  
Significant Difference ◽  
White Breed ◽  
Udmurt Republic

Purpose: to study hematological parameters of blood in bulls-producers of dairy breeds on the day of semen collection in the Udmurt Republic after a long winter period of operation, depending on the breeds, age and place of selection.Materials and methods. The work was performed at the Federal Research Center for Animal Husbandry named after Academy Member L. K. Ernst on the basis of AO "Udmurtplem" of the Udmurt Republic in the period from 2020 to 2021 on dairy bulls (n=20) aged 15-69 months, including a purebred Holstein breed of domestic selection (n=6), a Holstein black-and-white breed of European selection (the Netherlands, n=6), a black-and-white breed with blood transfusion on Holsteins on at the level of 94-98% (n=8). The content of white blood cells, red blood cells, hemoglobin and hematocrit, depending on age and breed, was studied on the ABC VET hematological analyzer on the day of taking the seed.Results. It was found that on average, in 20 bulls aged 15-69 months, the level of white blood cells was at the level of reference values of 8.8±0.25 x 109/l, red blood cells 10.3 x 1012/l, which is 50% more than the reference values. The concentration of hemoglobin is 128.0±2.92 g/l, hematocrit is on average 54.3%, with a norm of 24-46%. Breeding bulls at a reliable level, differing in age, showed that some animals had high indicators for red blood cells of 10.3±0.26 x 102, for hematocrit of 54.3% against 24-46% of reference values. Also, according to hematological indicators, there was a tendency to increase the concentration of hemoglobin and hematocrit in European-bred bulls.Conclusion. The study of the variability in hematological parameters depending on the selection showed that there is no significant difference in leukocytes and all indicators are at the level of reference values, and in erythrocytes more than 50% than the highest indicators. The highest hemoglobin values were at the level of 141-156 g/l instead of 128 g/l according to the highest reference values. Hematocrit also showed high max values in all groups in comparison with the reference values of 59-66% versus 46% in the norm. It is necessary when analyzing hematological blood parameters in addition to the average statistical indicators (M+m) also, monitor the variability (min-max) in order to obtain more objective information.

Massive Transfusion

2018 ◽  
pp. 169-180
Author(s):  
Jay Berger
Keyword(s):  
Red Blood Cells ◽  
Blood Volume ◽  
Blood Cells ◽  
Massive Transfusion ◽  
Fresh Frozen Plasma ◽  
Metabolic Complications ◽  
Packed Red Blood Cells ◽  
Fresh Frozen ◽  
Life Threatening ◽  
Frozen Plasma

Massive transfusion is defined as transfusion of 3 units of packed red blood cells in less than 1 hour in an adult, replacement of more than 1 blood volume in 24 hours, or replacement of more than 50% of blood volume in 3 hours. Massive transfusion protocols are implemented in cases of life-threatening hemorrhage after trauma, during a surgical procedure, or during childbirth. These protocols are intended to minimize the adverse effects of hypovolemia, dilutional anemia, metabolic complications, and coagulopathy with early empiric replacement of blood products and transfusion of fresh frozen plasma, platelets, and packed red blood cells in a composition that approximates that of whole blood.

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