Lipid and protein oxidation products, antioxidant status and vascular complications in poorly controlled type 2 diabetes

2012 ◽  
Vol 12 (1) ◽  
pp. 33-39 ◽  
Author(s):  
E Bigagli ◽  
L Raimondi ◽  
E Mannucci ◽  
C Colombi ◽  
G Bardini ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Protein Oxidation ◽  
Antioxidant Status ◽  
Vascular Complications ◽  
Oxidation Products ◽  
Lipid And Protein Oxidation

scholarly journals Molecular mechanisms and the vital roles of resistin, TLR 4, and NF-κB in treating type 2 diabetic complications

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Venkataiah Gudise ◽  
Bimalendu Chowdhury
Keyword(s):  
Type 2 Diabetes ◽  
Effective Treatment ◽  
Diabetic Complications ◽  
Molecular Mechanisms ◽  
Cellular Proliferation ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Rapid Progression ◽  
Main Body

Abstract Background Type 2 diabetes in obese (≥ 25 and ≥ 30 kg/m2) patients is the foremost cause of cardiovascular complications like stroke, osteoarthritis, cancers (endometrial, breast, ovarian, liver, kidney, colon, and prostate), and vascular complications like diabetic neuropathy, diabetic and retinopathy, and diabetic nephropathy. It is recognized as a global burden disorder with high prevalence in middle-income nations which might lead to a double burden on health care professionals. Hence, this review emphasizes on understanding the complexity and vital signaling tracts involved in diabetic complications for effective treatment. Main body Type 2 diabetes in overweight patients induces the creation of specific ROS that further leads to changes in cellular proliferation, hypothalamus, and fringe. The resistin, TLR4, and NF-κB signalings are mainly involved in the progression of central and fringe changes such as insulin resistance and inflammation in diabetic patients. The overexpression of these signals might lead to the rapid progression of diabetic vascular complications induced by the release of proinflammatory cytokines, chemokines, interleukins, and cyclooxygenase-mediated chemicals. Until now, there has been no curative treatment for diabetes. Therefore, to effectively treat complications of type 2 diabetes, the researchers need to concentrate on the molecular mechanisms and important signaling tracts involved. Conclusion In this review, we suggested the molecular mechanism of STZ-HFD induced type 2 diabetes and the vital roles of resistin, TLR4, and NF-κB signalings in central, fringe changes, and development diabetic complications for its effective treatment. Graphical abstract

Antioxidant status in experimental type 2 diabetes mellitus: effects of glibenclamide and glipizide on various rat tissues

1999 ◽  
Vol 51 (4-5) ◽  
pp. 436-441 ◽  
Author(s):  
Sevgi Tüzün ◽  
Ferhan K. Girgin ◽  
Eser Y. Sözmen ◽  
Gülriz Menteş ◽  
Biltan Ersöz
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Antioxidant Status ◽  
Rat Tissues ◽  
Experimental Type

Association of RAGE gene polymorphism with vascular complications in Indian type 2 diabetes mellitus patients

2014 ◽  
Vol 103 (3) ◽  
pp. 474-481 ◽  
Author(s):  
Ashok Kumar Tripathi ◽  
Diwesh Chawla ◽  
Savita Bansal ◽  
Basu Dev Banerjee ◽  
Sri Venkata Madhu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Vascular Complications

Mean Platelet Volume and Platelet Distribution Width Correlate with Microvascular Complications in Egyptian People with Type 2 Diabetes Mellitus

2021 ◽  
Vol 17 ◽  
Author(s):  
Mohammed I. Abd El-Ghany ◽  
Nahed Abdallah ◽  
Waleed Eldars
Keyword(s):  
Type 2 Diabetes ◽  
Mean Platelet Volume ◽  
Microvascular Complications ◽  
Fasting Blood Glucose ◽  
Vascular Complications ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Diabetic Microvascular Complications

Background: Type 2 diabetes is a part of metabolic syndrome associated with a higher risk of vascular complications. Diabetes is characterized by changes in platelet morphology, function, and platelet hyperactivity so, it's considered a prothrombotic condition. Morbidity and mortality in people with type 2 diabetes-related to micro and macrovascular complications. Novel biomarkers are needed to identify and treat people at higher risk. Objective: The main objective of this controlled cross-sectional study was to evaluate Platelet volume indices (PVI) in subjects with type 2 diabetes with and without complications in comparison to subjects without diabetes. Methods: Hundred and thirty-five subjects aged from 35 to 60 years were subdivided into 3 groups. Group A includes 55 subjects with type 2 diabetes with complications. Group B includes 45 subjects with type 2 diabetes without complications. Group C includes 35 normal healthy subjects. Detailed clinical history was taken. Also, PVI, fasting blood glucose (FBG), hemoglobin A1c, and creatinine were obtained. Results: Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT), and Platelet large cell ratio (P-LCR) were significantly higher among subjects with retinopathy, nephropathy, and neuropathy than other subjects with diabetes who didn't develop complications (P<0.001). At cutoff value > 11.9 fL, MPV have diagnostic sensitivity 80% and specificity 97.8%. Whereas PDW >16.9fL has a sensitivity of 74.5% and specificity of 100% for diabetic microvascular complications (retinopathy, nephropathy, and neuropathy). Conclusion: MPV and PDW may be considered as possible biomarkers for the early detection of diabetic microvascular complications.

scholarly journals Increased Expression of Tissue Factor and Receptor for Advanced Glycation End Products in Peripheral Blood Mononuclear Cells of Patients With Type 2 Diabetes Mellitus with Vascular Complications

2004 ◽  
Vol 5 (2) ◽  
pp. 163-169 ◽  
Author(s):  
A. E. Buchs ◽  
A. Kornberg ◽  
M. Zahavi ◽  
D. Aharoni ◽  
C. Zarfati ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Advanced Glycation End Products ◽  
Mononuclear Cells ◽  
Vascular Complications ◽  
Advanced Glycation ◽  
Peripheral Blood Mononuclear ◽  
Glycation End Products ◽  
End Products ◽  
Blood Mononuclear Cells

The aim of the study was to determine the correlation between the expression of tissue factor (TF) and the receptor for advanced glycation end products (RAGEs) and vascular complications in patients with longstanding uncontrolled type 2 diabetes (T2D). TF and RAGE mRNAs as well as TF antigen and activity were investigated in 21 T2D patients with and without vascular complications. mRNA expression was assessed by reverse transcriptase–polymerase chain reaction (RT-PCR) in nonstimulated and advanced glycation end product (AGE) albumin–stimulated peripheral blood mononuclear cells (PBMCs). TF antigen expression was determined by enzyme-linked immunosorbent assay (ELISA) and TF activity by a modified prothrombin time assay. Basal RAGE mRNA expression was 0.2 ± 0.06 in patients with complications and 0.05 ± 0.06 patients without complications (P= .004). Stimulation did not cause any further increase in either group. TF mRNA was 0.58 ± 0.29 in patients with complications and 0.21 ± 0.18 in patients without complications (P= .003). Stimulation resulted in a nonsignificant increase in both groups. Basal TF activity (U/106PBMCs) was 18.4 ± 13.2 in patients with complications and 6.96 ± 5.2 in patients without complications (P= .003). It increased 3-fold in both groups after stimulation (P= .001). TF antigen (pg/106PBMCs) was 33.7 ± 28.6 in patients with complications, 10.4 ± 7.8 in patients without complications (P= .02). Stimulation tripled TF antigen in both groups of patients (P= .001). The RAGE/TF axis is up-regulated inT2Dpatients with vascular complications as compared to patients without complications. This suggests a role for this axis in the pathogenesis of vascular complications in T2D.

scholarly journals Effect of Vitamin C on Blood Glucose & Serum Lipids in Type 2 Diabetes Patients

KYAMC Journal ◽  
2017 ◽  
Vol 4 (1) ◽  
pp. 337-340 ◽  
Author(s):  
Ronjon Kumer Nath ◽  
Marufa Akhter ◽  
Kali Rani Sarker ◽  
Md Rezwanur Rahman ◽  
Shahela Sultana Chowdhury ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Vitamin C ◽  
Serum Lipids ◽  
Vascular Complications ◽  
Density Lipoprotein ◽  
Glycated Haemoglobin ◽  
Antioxidant Vitamin ◽  
Daily Consumption

Background & objectives: The prevalence of diabetes is rising at an alarming sign through out the world & is one of the major metabolic disorders that cause micro & macro-vascular complications. Dyslipidaemia is considered as risk factor for cardiovascular disease & it is higher risk in diabetes subjects than normal. The control of glycemic & lipid profile status can reduced the risk of micro & macro-vascular complications. As vitamin C is anti oxidant vitamins so we aimed to evaluate the beneficial effects of its on blood glucose & serum lipids in T2DM patients.Materials & methods: A total of 46 patients with T2DM were included in this study. They received 1000 mg of vitamin C for eight weeks. Fasting blood sugar (FBS), triglyceride (TG), total cholesterol (TC), low & high density lipoprotein (LDL & HDL) and glycated haemoglobin (HbA1c) were measured before & after vitamin consumption and the results were analyzed.Results: A significant decrease in TG, TC, LDL, and HbA1c was seen in the group supplemented with 1000 mg vitamin C. In case of FBG & HDL there was no significant difference.Interpretation & conclusions: Our results indicate that daily consumption of 1000 mg supplementary antioxidant vitamin-C may be beneficial in decreasing glycemic status and lipids in patients with type 2 diabetes and thus reducing the risk of complications.KYAMC Journal Vol. 4, No.-1, July 2013, Page 337-340

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