Shorter GGN Repeats in Androgen Receptor Gene Would Not Increase the Risk of Prostate Cancer

The association between the polymorphic GGN repeat in androgen receptor gene and prostate cancer susceptibility has been studied extensively. But the results of these polymorphisms with prostate cancer risk remain inconclusive. Previous meta-analysis showed short GGN repeats (≤16 repeats) had high risks for prostate cancer compared with longer GGN repeats (>16 repeats). Many studies have been published since the release of the previous meta-analysis. Here, we conducted an updated meta-analysis to demonstrate whether short repeats have higher risks for prostate cancer compared to long repeats. Five databases (PubMed, EMBASE, Cochrane Library, The China National Knowledge Infrastructure, and Web of Science) were last searched until January 1, 2016. Random- or fixed-effects model was performed based on the heterogeneity among studies. The potential publication bias was assessed via Begg funnel plot and Egger regression test. Twelve out of 157 studies were extracted. The result indicated that there was no significant difference between short repeat group and long repeat group in the overall analysis ( I2 = 80.6%, P = .000, odds ratio = 1.31, 95% confidence interval: 0.93-1.83). There was no association between the length of GGN repeats and the occurrence of prostate cancer in both Caucasian and African American ( I2 = 6.7%, P = .359, odds ratio = 1.11, 95% confidence interval: 0.94-1.32; and I2 = 74.1%, P = .050, odds ratio = 0.963, 95% confidence interval: 0.36-2.58). Our result demonstrated that a shorter GGN repeat polymorphism cannot increase the risk of prostate cancer compared to the longer GGN repeats. That’s different with previous meta-analysis.

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Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis

Scientific Reports ◽

10.1038/srep40554 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 8

Author(s):

Hong Weng ◽

Sheng Li ◽

Jing-Yu Huang ◽

Zi-Qi He ◽

Xiang-Yu Meng ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Receptor Gene ◽

Androgen Receptor Gene ◽

Receptor Gene Polymorphisms

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Efficacy of Transparent vs. Pressure Dressing in Prevention of Post-Cardiac Catheterization Pain, Discomfort and Hematoma: A Systematic Review and Meta-analysis of RCTs

Journal of Caring Sciences ◽

10.34172/jcs.2021.019 ◽

2021 ◽

Vol 10 (2) ◽

pp. 103-110

Author(s):

Suresh K Sharma ◽

Kalpana Thakur ◽

Shiv K Mudgal ◽

Barun Kumar

Keyword(s):

Systematic Review ◽

Confidence Interval ◽

Cardiac Catheterization ◽

Odds Ratio ◽

English Language ◽

Data Extraction ◽

Meta Analysis ◽

Cochrane Library ◽

Significant Difference ◽

Pressure Dressing

ABSTRACT Introduction: There is lack consensus on superiority of transparent vs. pressure dressing for prevention of post-cardiac catheterization pain, discomfort and hematoma. Therefore, we conducted this systematic review and meta-analysis of available RCTs on this subject. Methods: We performed a systematic search of RCTs published between in 2000-2019 in English language using databases including PubMed Medline, EMBASE, CINAHL, Cochrane Library, ERMED Journals, Clinical trials database, DELNET, Google Scholar and Discovery Search. Studies conducted on adult patients with femoral dressing after cardiac catheterization measuring pain, discomfort, hematoma as intended outcomes have been included. Data extraction, critical appraisal, assessment of risk bias was done and decisions on quality were made on mutual consensus. Mantel-Haenszel (MH) and odds ratio for dichotomous variables was calculated by Review Manager 5.3 software. Results: Out of all identified studies, only 5 studies comprising 664 patients fulfilled the inclusion criteria and met the quality assessment. Incidence of discomfort (25, 333) were significantly less in transparent dressing group as compared to pressure dressing group (149, 331); odds ratio 0.10, 95% confidence interval [CI] 0.06-0.15; I2 = 0%, P= 0.00. Four studies reported significantly lower number of pain cases in transparent dressing (17, 203) as compared to pressure dressing (57, 201); odds ratio 0.13, 95% confidence interval [CI] 0.03-0.59; I2 = 47%, P= 0.01). However, incidence of hematoma did not reveal any significant difference between two groups. Conclusion: Transparent dressing is a better option in patients with femoral/groin dressing after cardiac catheterization as it is more effective in prevention of pain and discomfort.

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The CAG repeat polymorphism of androgen receptor gene and prostate cancer: a meta-analysis

Molecular Biology Reports ◽

10.1007/s11033-011-1014-9 ◽

2011 ◽

Vol 39 (3) ◽

pp. 2615-2624 ◽

Cited By ~ 20

Author(s):

Mingliang Gu ◽

Xiaoqun Dong ◽

Xuezhi Zhang ◽

Wenquan Niu

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Meta Analysis ◽

Receptor Gene ◽

Androgen Receptor Gene ◽

Cag Repeat ◽

Repeat Polymorphism

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The effectiveness of nonsteroidal anti-inflammatory drugs and acetaminophen in reduce the risk of amyotrophic lateral sclerosis? A meta-analysis

Scientific Reports ◽

10.1038/s41598-020-71813-1 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Min Cheol Chang ◽

Sang Gyu Kwak ◽

Jin-Sung Park ◽

Donghwi Park

Keyword(s):

Confidence Interval ◽

Odds Ratio ◽

Meta Analysis ◽

Convincing Evidence ◽

Cochrane Library ◽

Control Group ◽

Inclusion Criteria ◽

Control Groups ◽

Significant Difference ◽

And Control

Abstract To test the hypothesis that aspirin, non-aspirin nonsteroidal anti-infammatory drugs (NA-NSAIDs), or acetaminophen can reduce the risk of ALS, we conducted a systematic review and meta-analysis of related previous studies. A comprehensive search was conducted on the PubMed, Embase, Cochrane Library and SCOPUS databases. It included studies published up to 29 February 2020 that fulfilled our inclusion criteria. Aspirin, acetaminophen and NA-NSAIDs use information, between the ALS and control groups, was collected for the meta-analysis. Rates of aspirin, NA-NSAID, and acetaminophen use in ALS group, compared with control group were investigated. In the results, only three studies that relate the risk of ALS to aspirin, NA-NSAIDs and acetaminophen use satisfied the inclusion criteria for the meta-analysis. Regarding aspirin, the studies did not show any statistically significant difference in aspirin use between the ALS and control groups (Odds ratio, 1.04 [95% confidence interval, 0.90–1.21]). NA-NSAIDs and acetaminophen use, however, did show up statistically significant differences in between the ALS and control groups. (Odds ratio, 0.82 [95% confidence interval, 0.73–0.91]) and (Odds ratio, 0.80 [95% confidence interval, 0.69–0.93]). However, our study has some limitations. Firstly, we only included a small number of studies. Secondly, the included studies did not control for past medical history, which may have confounded their results, and in turn, could have caused bias in our study. Thirdly, in this meta-analysis, the ALS patients were not subdivided into sporadic or familial type. Lastly, the studies also did not consider the types of NSAIDs and dosages used of each drug. For more convincing evidence regarding the effectiveness of aspirin, NA-NSAIDs and acetaminophen to reduce the risk of ALS occurrence, more qualified prospective studies are required. In conclusion, the use of NA-NSAIDs and acetaminophen is associated with a decreased risk for the development of ALS. In contrast, aspirin did not have any effect on the reduction of the risk of ALS occurrence.

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Vitamin D Receptor Gene FokI Polymorphism Contributes to Increasing the Risk of Tuberculosis: Evidence from a Meta-Analysis

10.21203/rs.3.rs-774522/v1 ◽

2021 ◽

Author(s):

Bin Li ◽

Yunxia Li ◽

Fei Wen ◽

Zhaofen Wang

Keyword(s):

Vitamin D ◽

Confidence Interval ◽

Gene Polymorphism ◽

Vitamin D Receptor ◽

Odds Ratio ◽

Meta Analysis ◽

Receptor Gene ◽

Recessive Model ◽

Cochrane Library ◽

Increased Risk

Abstract Purpose In the present study, we explored the link between vitamin D receptor (VDR) FokI gene polymorphisms with tuberculosis(TB). Methods Based on a comprehensive search of PubMed, Embase, Web of Science, Elsevier Science Direct, Cochrane Library, CNKI, Wanfang, and Chongqing VIP databases, we searched case-control study on FokI gene polymor-phism and TB susceptivity. The Newcastle-Ottawa Scale(NOS) was used to evaluate the quality of the literature and extracted data, and R 4.0.5 software was used for the meta-analysis. Results: Among the 243 selected articles, 35 in the meta analysis. The meta-analysis showed that the FokI gene polymorphism allene gene model(f vs F, Odds ratio=1.22,95% confidence interval:1.11-1.36); dominant model (ff+fF vs F, Odds ratio=1.29,95% confidence interval:1.13-1.47); recessive model(ff vs fF+FF, Odds ratio=1.31,95% confidence interval:1.09-1.56); codominant (ff vs FF, Odds ra-tio=1.48,95% confidence interval:1.19-1.83); codominant(fF vs FF, Odds ratio=1.23,95% confidence interval:1.09-1.39). The meta-analysis indicates a high level of heterogeneity between the VDR FokI gene polymorphism and TB and the race is a source of heterogeneity in the results. Conclusion The present update meta-analysis suggest that FokI gene polymorphism is significantly associated with an increased risk of TB.

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Faculty Opinions recommendation of Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13357348.14726748 ◽

2011 ◽

Author(s):

Abraham Zlotogorski ◽

Yuval Ramot

Keyword(s):

Androgen Receptor ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Receptor Gene ◽

Androgen Receptor Gene ◽

Androgenetic Alopecia ◽

Receptor Gene Polymorphisms

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Association of androgen receptor gene CAG and GGN repeat polymorphism with cryptorchidism: A meta-analysis

Andrologia ◽

10.1111/and.12909 ◽

2017 ◽

Vol 50 (3) ◽

pp. e12909 ◽

Cited By ~ 4

Author(s):

Qi Wang ◽

Xing Ge ◽

Heng-Xue Wang ◽

Qiao-Mei Shi ◽

Zhen Ding ◽

...

Keyword(s):

Androgen Receptor ◽

Meta Analysis ◽

Receptor Gene ◽

Androgen Receptor Gene ◽

Repeat Polymorphism

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Radiofrequency ablation versus hepatic resection for recurrent hepatocellular carcinoma: an updated meta-analysis

BMC Gastroenterology ◽

10.1186/s12876-020-01544-0 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Daopeng Yang ◽

Bowen Zhuang ◽

Yan Wang ◽

Xiaoyan Xie ◽

Xiaohua Xie

Keyword(s):

Hepatocellular Carcinoma ◽

Radiofrequency Ablation ◽

Hepatic Resection ◽

Fixed Effects ◽

Meta Analysis ◽

Cochrane Library ◽

Recurrent Hepatocellular Carcinoma ◽

Major Complications ◽

Alternative Treatment Option ◽

Significant Difference

Abstract Background The clinical benefits of treatment with radiofrequency ablation (RFA) and repeat hepatic resection (RHR) for recurrent hepatocellular carcinoma (RHCC) remain controversial. This meta-analysis aims to evaluate the outcomes and major complications of RFA versus RHR in patients with early-stage RHCC. Methods PubMed, Embase, Web of Science and the Cochrane Library were systematically searched for comparative studies on the evaluation of RHR versus RFA for RHCC. The primary outcome was overall survival (OS), and the secondary outcomes were progression-free survival (PFS) and major complications. Meta-analysis was performed using a random-effects model or fixed-effects model, and heterogeneity was tested by the Cochran Q statistic. Results Ten studies with 1612 patients (RHR = 654, RFA = 958) were included in the meta-analysis. The meta-analysis showed that RHR had superior OS (HR 0.77, 95% CI =0.65–0.92, P = 0.004) and PFS (HR 0.81, 95% CI =0.67–0.98, P = 0.027) compared to RFA, whereas major complications may be less frequent in the RFA group (OR 0.15, 95% CI = 0.06–0.39, P < 0.001). In the subgroup analysis of patients with single RHCC ≤3 cm, OS (HR 1.03, 95% CI =0.69–1.52, P = 0.897) and PFS (HR 0.99, 95% CI = 0.71–1.37, P = 0.929) showed no significant differences in the comparison of RHR and RFA. In single RHCC> 3 cm and ≤ 5 cm, RFA showed an increased mortality in terms of OS (HR 0.57, 95% CI = 0.37–0.89, P = 0.014). Conclusion RHR offers a longer OS and PFS than RFA for patients with RHCC, but no statistically significant difference was observed for single RHCC ≤3 cm. The advantages of fewer major complications may render RFA an alternative treatment option for selected patients.

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