A Very Rare Case of Necrotizing Fasciitis Caused by Metallosis

2021 ◽  
pp. 153473462110094
Author(s):  
Dun-Wei Huang ◽  
Nien-Tzu Liu ◽  
Hung-Hui Liu ◽  
Niann-Tzyy Dai ◽  
Shyi-Gen Chen ◽  
...  
Keyword(s):  
Necrotizing Fasciitis ◽  
Rare Case ◽  
Soft Tissues ◽  
Group A Streptococcus ◽  
Anaerobic Bacteria ◽  
Metal Debris ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Group A ◽  
The Right

Necrotizing fasciitis is a surgically diagnosed infection of the deep soft tissues that results in high mortality. It is usually caused by aerobic and anaerobic bacteria and group A Streptococcus. Metallosis is characterized by the deposition of metal debris in the blood that causes metal poisoning and tissue damage. The abrasion of metal components that occurs after joint replacements causes metallosis, which may lead to severe complications. We report a rare case of metallosis-induced necrotizing fasciitis of the right thigh. Metallosis should be considered as a cause of necrotizing fasciitis if the patient has had a joint replacement surgery.

scholarly journals Necrotizing Fasciitis by Two Anaerobic Bacteria in an Immunocompetent Patient after Minor Trauma: A Case Report

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Marco Sciarra ◽  
Andrea Schimmenti ◽  
Tommaso Manciulli ◽  
Cristina Sarda ◽  
Marco Mussa ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Rare Case ◽  
Subcutaneous Tissue ◽  
Anaerobic Bacteria ◽  
Immunocompetent Patient ◽  
Minor Trauma ◽  
Group A Streptococci ◽  
Group A

Necrotizing fasciitis (NF) is a soft tissue infection affecting subcutaneous tissue and the muscular fascia without involvement of the muscle and can be either monomicrobial or polymicrobial. Monomicrobial infections are usually caused by group A streptococci, while infections caused by anaerobic germs usually affect immunodepressed patients. We report a rare case of NF caused by two anaerobic bacteria in an immunocompetent patient.

scholarly journals MRSA Causing Necrotizing Fasciitis in 18-Month-Old Boy

2021 ◽  
pp. 014556132098604
Author(s):  
Avani Jain ◽  
Ravi Meher ◽  
Raman Sharma
Keyword(s):  
Staphylococcus Aureus ◽  
Necrotizing Fasciitis ◽  
Group A Streptococcus ◽  
Anaerobic Bacteria ◽  
Cellular Tissue ◽  
Rapid Progression ◽  
Superficial Fascia ◽  
Group A ◽  
Severity Of The Disease ◽  
Aerobic And Anaerobic

Necrotizing fasciitis is a rare and fulminant infection of the superficial fascia and subcutaneous cellular tissue. It is commonly polymicrobial, with the combination of aerobic and anaerobic bacteria, which contributes to the rapid progression and severity of the disease. The microbes commonly involved include group A streptococcus, Enterobacteriaceae, anaerobes, and Staphylococcus aureus. Over the past few years, skin and soft tissue infections, including necrotizing fasciitis, due to methicillin-resistant Staphylococcus aureus are increasing.

Diverse disease processes of group A Streptococcus infection including severe invasive infections among members of a family

2021 ◽  
Vol 14 (4) ◽  
pp. e241339
Author(s):  
Kaori Amari ◽  
Masaki Tago ◽  
Naoko E Katsuki ◽  
Shu-ichi Yamashita
Keyword(s):  
Septic Shock ◽  
Distress Syndrome ◽  
Clinical Course ◽  
Group A Streptococcus ◽  
Bloody Stool ◽  
Laryngeal Oedema ◽  
Invasive Infections ◽  
Group A ◽  
The Right ◽  
Close Contacts

We herein report three cases of group A Streptococcus (GAS) infection in a family. Patient 1, a 50-year-old woman, was transferred to our hospital in shock with acute respiratory distress syndrome, swelling in the right neck and erythemata on both lower extremities. She required intubation because of laryngeal oedema. At the same time, patient 2, a 48-year-old man, was admitted because of septic shock, pneumonia and a pulmonary abscess. Five days later, patient 3, a 91-year-old woman, visited our clinic with bloody stool. All three patients were cured by antibiotics, and GAS was detected by specimen cultures. During these patients’ clinical course, an 84-year-old woman was found dead at home after having been diagnosed with type A influenza. All four patients lived in the same apartment. The GAS genotypes detected in the first three patients were identical. When treating patients with GAS, appropriate management of close contacts is mandatory.

scholarly journals Necrotizing fasciitis with group A Streptococci and Eggerthella lenta as a complication of Varicella in a child – case presentation –

2014 ◽  
Vol 20 (1) ◽  
pp. 35-39
Author(s):  
Cambrea Simona Claudia ◽  
Ilie Maria Margareta ◽  
Carp Dalia Sorina ◽  
Ionescu C.
Keyword(s):  
Necrotizing Fasciitis ◽  
Severe Disease ◽  
The Body ◽  
Group A Streptococci ◽  
Threatening Condition ◽  
Life Threatening ◽  
Group A ◽  
The Right ◽  
Surgery Department ◽  
Short Time

ABSTRACT Necrotizing fasciitis is a life threatening condition that can be quickly spread through the flesh surrounding the muscle. The disease can be polymicrobial, or caused by group A beta hemolytic Streptococci, or by Clostridium spp. We present a case of a 7 years old girl, which was hospitalized in Children Infectious Diseases Department in a 7th day of chickenpox (hematic crusts all over the body), high fever, asthenia, vomiting, oligoanuria, and tumefaction, pain and functio lessa in the right thigh. In a very short time in the right thigh swelling, edema and congestion have increased gradually, and in the third highest middle thigh the ecchymotic areas appeared evolving towards bubbles and blisters which included the right thigh and calf. After excluding the diagnosis of thrombophlebitis was raised suspicion of necrotizing fasciitis. CT pelvic scan evidenced pelvic asymmetry by maximus and medium right gluteal muscles swelling with important inflammatory infiltrate extended laterally in the subcutaneous adipose tissue. In blood culture was isolated Eggerthella lenta, and from throat swab was isolated group A Streptococci. Treatment consists of a combination of antibiotics associated with intravenous immunoglobulin administration. Despite medical treatment evolution worsened and required transfer in a pediatric surgery department where emergent surgical debridement associated with intensive antibiotic therapy was done. After this intervention evolution was slowly favorable without major limb dysfunction. Polymicrobial necrotizing fasciitis is a severe disease, which if recognized early can have a favorable outcome.

scholarly journals The Majority of 9,729 Group A Streptococcus Strains Causing Disease Secrete SpeB Cysteine Protease: Pathogenesis Implications

2015 ◽  
Vol 83 (12) ◽  
pp. 4750-4758 ◽  
Author(s):  
Randall J. Olsen ◽  
Anjali Raghuram ◽  
Concepcion Cantu ◽  
Meredith H. Hartman ◽  
Francisco E. Jimenez ◽  
...  
Keyword(s):  
Necrotizing Fasciitis ◽  
Cysteine Protease ◽  
Protease Activity ◽  
Sequence Data ◽  
Group A Streptococcus ◽  
Whole Genome Sequence ◽  
Wild Type ◽  
Tissue Destruction ◽  
Lethal Challenge ◽  
Group A

Group A streptococcus (GAS), the causative agent of pharyngitis and necrotizing fasciitis, secretes the potent cysteine protease SpeB. Several lines of evidence suggest that SpeB is an important virulence factor. SpeB is expressed in human infections, protects mice from lethal challenge when used as a vaccine, and contributes significantly to tissue destruction and dissemination in animal models. However, recent descriptions of mutations in genes implicated in SpeB production have led to the idea that GAS may be under selective pressure to decrease secreted SpeB protease activity during infection. Thus, two divergent hypotheses have been proposed. One postulates that SpeB is a key contributor to pathogenesis; the other, that GAS is under selection to decrease SpeB during infection. In order to distinguish between these alternative hypotheses, we performed casein hydrolysis assays to measure the SpeB protease activity secreted by 6,775 GAS strains recovered from infected humans. The results demonstrated that 84.3% of the strains have a wild-type SpeB protease phenotype. The availability of whole-genome sequence data allowed us to determine the relative frequencies of mutations in genes implicated in SpeB production. The most abundantly mutated genes were direct transcription regulators. We also sequenced the genomes of 2,954 GAS isolates recovered from nonhuman primates with experimental necrotizing fasciitis. No mutations that would result in a SpeB-deficient phenotype were identified. Taken together, these data unambiguously demonstrate that the great majority of GAS strains recovered from infected humans secrete wild-type levels of SpeB protease activity. Our data confirm the important role of SpeB in GAS pathogenesis and help end a long-standing controversy.

scholarly journals Complete Ossification of the Stylohyoid Chain as Cause of Eagle's Syndrome: A Very Rare Case Report

2014 ◽  
Vol 15 (4) ◽  
pp. 500-505 ◽  
Author(s):  
Antônio Sérgio Guimarães ◽  
Daniel Humberto Pozza ◽  
Idercy Cabral de Castro ◽  
Iván Claudio Suazo Galdames ◽  
Sandro Palla
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Soft Tissues ◽  
Surgical Excision ◽  
Styloid Process ◽  
Eagle’S Syndrome ◽  
Elongated Styloid Process ◽  
Rare Case Report ◽  
The Right ◽  
Stylohyoid Chain

ABSTRACT Aim To report on a patient with Eagle's syndrome with a complete and very large ossification of the stylohyoid complex on the right side that to our best knowledge has never been published previously. Background Eagle's syndrome is characterized by a set of symptoms that are caused by the irritation of the neurovascular and soft-tissues caused by an elongated styloid process or ossification of stylohyoid ligament. Case description Because of the high discomfort and pain degree as well as limitations of mandibular and head mobility and also the thickness of the ossified stylohyoid chain, the patient was treated surgically by removing the hypertrophic segment. Conclusion These symptoms subsided completely after the surgical excision of the anomaly. The elongated styloid process on the left side was symptom free. Clinical significance Eagle's syndrome symptoms are not specific and can mimic those of other disorders, the syndrome must be included in the differential diagnosis of patients with pain in the orofacial, pharyngeal and cervical area. How to cite this article Guimarães AS, Pozza DH, de Castro IC, Galdames ICS, Palla S. Complete Ossification of the Stylohyoid Chain as Cause of Eagle's Syndrome: A Very Rare Case Report. J Contemp Dent Pract 2014;15(4):500-505.

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