scholarly journals Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects

2016 ◽  
Vol 11 (2) ◽  
pp. 426-434 ◽  
Author(s):  
Somaye Yosaee ◽  
Mahmoud Khodadost ◽  
Alireza Esteghamati ◽  
John R. Speakman ◽  
Farzad Shidfar ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Normal Weight ◽  
Analysis Of Covariance ◽  
Public Health Issue ◽  
Protective Agent ◽  
Control Groups ◽  
Obese Subjects ◽  
Healthy Obese

Metabolic syndrome (MetS), a cluster of cardiometabolic risk factors, is a challenging public health issue. The aim of current study was to test the hypothesis that concentrations of plasma adropin and leptin differ between patients with MetS and comparable age- and sex-matched control groups. This case-control study involved 153 subjects (51 per group). The study group included obese subjects with MetS and the two control groups included weight-matched subjects without MetS (“healthy”: obese) and normal weight subjects without MetS. Body composition parameters were measured using bioelectrical impedance analysis. Plasma levels of adropin, leptin, and their ratio were measured. Leptin was significantly different between obese patients with/without MetS groups and normal weight subjects. Patients with MetS had higher levels of leptin (14 ± 12.4) compared with those without MetS (11.2 ± 9.3 vs. 7 ± 7.1 obese and normal weight without MetS, respectively; p = .002). Compared with healthy obese and normal weight subjects, MetS subjects had lower levels of plasma adropin ( p < .001) and a lower plasma adropin to leptin ratio ( p < .001), which remained significant when adjusted for body fat mass by analysis of covariance ( p < .001). This study demonstrates low levels of adropin are correlated with MetS and hence identify it as a potentially protective agent against MetS development. Variation in adropin levels may partly explain the “healthy obese” phenomenon.

scholarly journals Adropin and Apelin -12, two better predictors of metabolic syndrome in obese children

2020 ◽  
Author(s):  
Chunyan Yin ◽  
hong ai zhang ◽  
Meizheng Zhang ◽  
yanfeng y xiao
Keyword(s):  
Metabolic Syndrome ◽  
Serum Levels ◽  
Normal Weight ◽  
Public Health Issue ◽  
Obese Children ◽  
Anthropometric Parameters ◽  
Specificity And Sensitivity ◽  
Novel Approach ◽  
Obese Subjects ◽  
Prospective Association

Abstract Objective Metabolic syndrome (MetS) is the most extensively described condition associated with childhood and adolescent obesity and is a challenging public health issue. Studies regarding the specificity and sensitivity of serum levels of adropin and apelin -12 as predictors of MetS are limited. The aim was to evaluate the prospective association between adropin and apelin -12 concentrations and MetS and sensitivity as predictors of MetS in the obese children. Methods This study involved 138 children. The study group included obese subjects with MetS and the two control groups included obese without MetS and normal weight subjects. Anthropometric parameters and clinical data were collected. Plasma levels of apelin -12, adropin, leptin, adiponectin and TNF-α were measured. Results Obese children with MetS had significantly higher levels of apelin -12 and significantly lower levels of adropin compared to those without MetS. In logistic regressions, we identified that apelin -12 was risk factor for metabolic syndrome and adropin was the protecting factors of having MetS after adjustment for age, sex and puberty. Furthermore, adropin and apelin -12 are two more sensitive predictors of metabolic syndrome than leptin and adiponect using ROC method. Conclusion Serum adropin and apelin -12 levels can be useful biomarkers for evaluation of the risk of MetS in obese children. This may provide a novel approach for treatment or prevention of MetS development.

Adropin and Apelin -12, two better predictors of metabolic syndrome in obese children

2020 ◽  
Author(s):  
yanfeng xiao ◽  
hong ai zhang ◽  
mei zhen zhang ◽  
chunyan yin
Keyword(s):  
Metabolic Syndrome ◽  
Serum Levels ◽  
Normal Weight ◽  
Public Health Issue ◽  
Obese Children ◽  
Anthropometric Parameters ◽  
Specificity And Sensitivity ◽  
Novel Approach ◽  
Obese Subjects ◽  
Prospective Association

Abstract Background: Metabolic syndrome (MetS) is the most extensively described condition associated with childhood and adolescent obesity and is a challenging public health issue. Studies regarding the specificity and sensitivity of serum levels of adropin and apelin -12 as predictors of MetS are limited. The aim was to evaluate the prospective association between adropin and apelin -12 concentrations and MetS and sensitivity as predictors of MetS in the obese children.Methods:: This study involved 138 children. The study group included obese subjects with MetS and the two control groups included obese without MetS and normal weight subjects. Anthropometric parameters and clinical data were collected. Plasma levels of apelin -12, adropin, leptin, adiponectin and TNF-α were measured. Results: Obese children with MetS had significantly higher levels of apelin -12 and significantly lower levels of adropin compared to those without MetS. In logistic regressions, we identified that apelin -12 was risk factor for metabolic syndrome and adropin was the protecting factors of having MetS after adjustment for age, sex and puberty. Furthermore, adropin and apelin -12 are two more sensitive predictors of metabolic syndrome than leptin and adiponect using ROC method. Conclusion: Serum adropin and apelin -12 levels can be useful biomarkers for evaluation of the risk of MetS in obese children. This may provide a novel approach for treatment or prevention of MetS development.

Validity of Visceral Fat Area Measurement by Bioelectrical Impedance Analysis in Japanese Obese Individuals

2020 ◽  
Vol 16 (5) ◽  
pp. 515-519 ◽  
Author(s):  
Hidetaka Hamasaki ◽  
Masashi Furuta ◽  
Hidekatsu Yanai
Keyword(s):  
Visceral Fat ◽  
Bioelectrical Impedance Analysis ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Normal Weight ◽  
Area Measurement ◽  
Obesity Management ◽  
Visceral Fat Area ◽  
Obese Subjects ◽  
The Difference

Introduction: Obesity management is a critical global issue. It is essential to evaluate visceral adiposity which is associated with metabolic syndrome and cardiovascular disease. Aim: This study aims at precisely evaluating the necessity of visceral adipose tissue in obesity management. Methods: We assessed the validity of visceral fat area (VFA) measurement using bioelectrical impedance analysis (BIA) with computed tomography (CT) as a reference in obese subjects. Although VFABIA exhibited significant correlation with VFACT, the difference between VFACT and VFABIA increased with an advancing degree of obesity. Result and Conclusion: The BIA device seemingly underestimated VFA in obese subjects compared with the normal-weight subjects.

scholarly journals Subcutaneous Injection Depth Does Not Affect the Pharmacokinetics or Glucodynamics of Insulin Lispro in Normal Weight or Healthy Obese Subjects

2015 ◽  
Vol 9 (4) ◽  
pp. 824-830 ◽  
Author(s):  
Amparo de la Peña ◽  
Kwee P. Yeo ◽  
Helle Linnebjerg ◽  
Edward Catton ◽  
Shobha Reddy ◽  
...  
Keyword(s):  
Insulin Lispro ◽  
Subcutaneous Injection ◽  
Normal Weight ◽  
Obese Subjects ◽  
Injection Depth ◽  
Healthy Obese

scholarly journals Biochemical and clinical characterization of metabolic phenotypes: a cross-sectional study from Maracaibo city, Venezuela

F1000Research ◽  
2019 ◽  
Vol 7 ◽  
pp. 230
Author(s):  
Valmore Bermudez ◽  
Joselyn Rojas ◽  
Juan Salazar ◽  
Maria Sofia Martinez ◽  
Luis Carlos Olivar ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Coronary Event ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Related Factors ◽  
Cross Sectional ◽  
Metabolic Phenotypes ◽  
Event Risk ◽  
Obese Subjects ◽  
Healthy Obese

Background: In 1980, Reuben Andresen observed that in certain individuals, obesity did not increase mortality, introducing an atypical phenotype called “healthy obese”. Other studies reported that 10-15 % of lean individuals presented insulin resistance, hyperglycemia and dyslipidemia. The objective of this study was to evaluate biochemical and clinical characteristics of metabolic phenotypes in Maracaibo city. Methods: A descriptive, cross-sectional sub-analysis of The Maracaibo City Metabolic Syndrome Prevalence Study, with a randomized multistage sampling was performed including 1226 non diabetic individuals from both sexes. For phenotype definition, the subjects were first classified according to their BMI into Normal-Weight, Overweight and Obese; then divided in metabolically healthy and unhealthy using a two-step analysis cluster being predictive variables: HOMA2-IR, HOMA2-βcell, triglycerides. To evaluate the relationship with coronary risk, a multiple logistic regression model was performed. Results: In the studied population, 43.9% (n=538) were healthy normal weight, 5.2% (n=64) unhealthy normal weight, 17.4% (n=217) healthy obese and 33.5% (n=411) unhealthy obese subjects. Atypical phenotypes, Metabolically Unhealthy Normal-Weight (MUNW) was more frequent in males (56.3%), whereas Metabolically Unhealthy Obese (MUO) was more frequent in females (51.3%). This phenotypes had a higher coronary event risk, especially for obese individuals (MHO: OR=1.85 CI95%: 1.11-3.09; p=0.02 and MUO: OR=2.09 CI95%: 1.34-3.28; p<0.01). Conclusion: Individuals with atypical metabolic phenotypes are common in Maracaibo city. Related factors may include insulin resistance, basal glucose, and triglycerides levels. Lastly, obese subjects show a higher coronary event risk even those with normal metabolic status.

The utility of visceral fat level measured by bioelectrical impedance analysis in predicting metabolic syndrome

2020 ◽  
Vol 14 (6) ◽  
pp. 519-523
Author(s):  
Yi-Chen Lee ◽  
Yi-Hsuan Lee ◽  
Pei-Ni Chuang ◽  
Chia-Sheng Kuo ◽  
Chia-Wen Lu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Visceral Fat ◽  
Bioelectrical Impedance Analysis ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Fat Level

Whole-body Electromyostimulation plus Caloric Restriction in Metabolic Syndrome

2020 ◽  
Author(s):  
Alfonso Bellia ◽  
Bruno Ruscello ◽  
Rolando Bolognino ◽  
Gianluca Briotti ◽  
Paolo Roberto Gabrielli ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Caloric Restriction ◽  
Fat Mass ◽  
Systolic Pressure ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Whole Body ◽  
Middle Aged ◽  
The Metabolic Syndrome ◽  
Early Effects

AbstractWe investigated early effects of Whole-Body Electromyostimulation added to hypocaloric diet on metabolic syndrome features in sedentary middle-aged individuals. We randomly assigned 25 patients to Whole-Body Electromyostimulation plus caloric restriction or caloric restriction alone for 26 weeks. Anthropometrics, blood pressure, fasting glucose and insulin, HOMA-IR, glycated hemoglobin, lipids, uric acid, creatinphosphokynase, C-reactive protein were assessed. Body composition was evaluated with direct-segmental, multi-frequency Bioelectrical Impedance Analysis. Both groups lost approximately 10% of weight, with similar effects on waist circumference and fat mass. Change in free-fat mass was significantly different between groups (caloric restriction −1.5±0.2 vs. Whole-Body Electromyostimulation plus caloric restriction +1.1±0.4 kg, p=0.03). Whole-Body Electromyostimulation plus caloric restriction group experienced greater percent reductions in insulin (−45.5±4.4 vs. −28.2±3.6%, p=0.002), HOMA-IR (–51.3±3.2 vs. –25.1±1.8%, p=0.001), triglycerides (−22.5±2.9 vs. −4.1±1.6%, p=0.004) and triglycerides/HDL (p=0.028). Subjects trained with Whole-Body Electromyostimulation had also significant improvement in systolic pressure (138±4 vs. 126±7 mmHg, p=0.038). No discontinuations for adverse events occurred. In middle-aged sedentary subjects with the metabolic syndrome, Whole-Body Electromyostimulation with caloric restriction for 26 weeks can improve insulin-resistance and lipid profile compared to diet alone. Further studies are needed to ascertain long-term efficacy and feasibility of this approach in individuals with the metabolic syndrome.

scholarly journals Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin Study

2008 ◽  
Vol 158 (3) ◽  
pp. 333-341 ◽  
Author(s):  
T Lappalainen ◽  
M Kolehmainen ◽  
U Schwab ◽  
L Pulkkinen ◽  
D E Laaksonen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Weight Reduction ◽  
Serum Amyloid A ◽  
Normal Weight ◽  
Serum Amyloid ◽  
Serum Concentrations ◽  
Amyloid A ◽  
Obese Subjects

ObjectiveSerum amyloid A (SAA) is a novel link between increased adipose tissue mass and low-grade inflammation in obesity. Little is known about the factors regulating its serum concentration and mRNA levels. We investigated the association between SAA and leptin in obese and normal weight subjects and analyzed the effect of weight reduction on serum SAA concentration and gene expression in adipose tissue of the obese subjects.MethodsSeventy-five obese subjects (60±7 years, body mass index (BMI) 32.9±2.8 kg/m2, mean±s.d.) with impaired fasting plasma glucose or impaired glucose tolerance and other features of metabolic syndrome, and 11 normal weight control subjects (48±9 years, BMI 23.7±1.9 kg/m2) were studied at the baseline. Twenty-eight obese subjects underwent a 12-week intensive weight reduction program followed by 5 months of weight maintenance. Blood samples and abdominal s.c. adipose tissue biopsies were taken at the baseline and after the follow-up. Gene expression was studied using real-time quantitative PCR.ResultsThe gene expressions in women and serum concentrations of leptin and SAA were interrelated independently of body fat mass in the obese subjects (r=0.54, P=0.001; r=0.24, P=0.039 respectively). In multiple linear regression analyses, leptin mRNA explained 38% of the variance in SAA mRNA (P=0.002) in the obese women. Weight loss of at least 5% increased SAA mRNA expression by 48 and 36% in men and women, but serum SAA concentrations did not change.ConclusionsThe association between SAA and leptin suggests an interaction between these two adipokines, which may have implications in inflammatory processes related to obesity and the metabolic syndrome.

scholarly journals Predictors of the incident metabolic syndrome in healthy obese subjects: a decade of follow-up from the Tehran Lipid and Glucose Study

2013 ◽  
Vol 68 (3) ◽  
pp. 295-299 ◽  
Author(s):  
F Hosseinpanah ◽  
P Nazeri ◽  
S Ghareh ◽  
M Tohidi ◽  
F Azizi
Keyword(s):  
Metabolic Syndrome ◽  
Obese Subjects ◽  
Healthy Obese
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