Can Memories of Traumatic Experiences or Addiction Be Erased or Modified? A Critical Review of Research on the Disruption of Memory Reconsolidation and Its Applications

2017 ◽  
Vol 12 (2) ◽  
pp. 290-305 ◽  
Author(s):  
Michael Treanor ◽  
Lily A. Brown ◽  
Jesse Rissman ◽  
Michelle G. Craske
Keyword(s):  
Boundary Conditions ◽  
Time Window ◽  
Clinical Intervention ◽  
Potential Effect ◽  
Neural Representation ◽  
Traumatic Experiences ◽  
Memory Reconsolidation ◽  
Future Research ◽  
Pharmacological Agents ◽  
Long Term Storage

Recent research suggests that the mere act of retrieving a memory can temporarily make that memory vulnerable to disruption. This process of “reconsolidation” will typically restabilize the neural representation of the memory and foster its long-term storage. However, the process of reconsolidating the memory takes time to complete, and during this limited time window, the original memory may be modified either by the presentation of new information or with pharmacological agents. Such findings have prompted rising interest in using disruption during reconsolidation as a clinical intervention for anxiety, posttraumatic stress, and substance use disorders. However, “boundary conditions” on memory reconsolidation may pose significant obstacles to clinical translation. The aim of this article is to critically examine the nature of these boundary conditions, their neurobiological substrates, and the potential effect they may have on disruption of reconsolidation as a clinical intervention. These boundary conditions also highlight potential constraints on the reconsolidation phenomenon and suggest a limited role for memory updating consistent with evolutionary accounts of associative learning for threat and reward. We conclude with suggestions for future research needed to elucidate the precise conditions under which reconsolidation disruption may be clinically useful.

scholarly journals Hypnotherapy for Procedural Pain and Distress in Children: A scoping Review Protocol

Pain Medicine ◽  
2021 ◽  
Author(s):  
Daly Geagea ◽  
Zephanie Tyack ◽  
Roy Kimble ◽  
Lars Eriksson ◽  
Vince Polito ◽  
...  
Keyword(s):  
Scoping Review ◽  
Grey Literature ◽  
Cochrane Library ◽  
Procedural Pain ◽  
Future Research ◽  
Theoretical Frameworks ◽  
Eligibility Criteria ◽  
Pharmacological Agents ◽  
Review Protocol ◽  
Meta Analyses

Abstract Objective Inadequately treated pain and distress elicited by medical procedures can put children at higher risks of acute and chronic biopsychosocial sequelae. Children can benefit from hypnotherapy, a psychological tailored intervention, as an adjunct to pharmacological agents to address the multiple components of pain and distress. Despite providing evidence on the effectiveness and potential superiority of hypnotherapy to other psychological interventions, research on hypnotherapy for paediatric procedural pain and distress has been predominantly limited to oncology and needle procedures. Plus, there is a lack of reporting of intervention manuals, factors influencing hypnotic responding, pain unpleasantness outcomes, theoretical frameworks, adverse events, as well as barriers and facilitators to the feasibility of delivering the intervention and study procedures. The proposed review aims to map the range and nature of the evidence on hypnotherapy for procedural pain and distress in children to identify gaps in literature and areas requiring further investigation. Methods This review will follow the Arksey and O'Malley (2005) methodology and incorporate additional scoping review recommendations by The Joanna Briggs Institute and Preferred Reporting Items for Systematic reviews and Meta-Analyses. Relevant studies will be identified through searching published literature databases (PubMed, Cochrane Library, PsycINFO, Embase, CINAHL, Scopus and Web of Science) and grey literature in addition to hand-searching of reference lists and key journals. Two authors will independently screen titles and abstracts of search results followed by full-texts review against eligibility criteria. Conclusion Findings are anticipated to guide future research and inform the development of tailored hypnotic interventions in children.

The 4Cs of mass customization in service industries: a customer lens

2020 ◽  
Vol 34 (4) ◽  
pp. 499-511 ◽  
Author(s):  
Jessica L. Pallant ◽  
Sean Sands ◽  
Ingo Oswald Karpen
Keyword(s):  
Boundary Conditions ◽  
Mass Customization ◽  
Design Methodology ◽  
Service Industries ◽  
Future Research ◽  
Practical Application ◽  
Theoretical Understanding ◽  
Content Type ◽  
Priority Areas ◽  
Research Priority

Purpose Increasingly, customers are demanding products that fit their individual needs. Many firms respond by cultivating product individualization via mass customization, often integrating this capability via interactive platforms that connect them with customers. Despite such customization, research to date has lacked cohesion, often taking the organizational, rather than customer, view. The purpose of this paper is to provide inconclusive theorizing in regard to customization from the consumers’ perspective. Design/methodology/approach The review and synthesis of the literature revealed that co-configuration is an underexplored domain of mass customization. Consequently, an initial conceptualization of co-configuration is developed and compared with current customization strategies. Specifically, the definition and boundary conditions of co-configuration are compared with three domains of mass customization, namely, co-production, co-construction and co-design. This led to the development of research priority areas to establish an agenda for future research on mass customization and its role in customer’ firm relationships. Findings This paper provides the delineation of four distinct consumer customization strategies, conceptualized in a matrix, and proposes separate customer journey visualizations. In advancing the theoretical understanding by means of a unifying typology, this paper identifies three existing Cs of mass customization (co-production, co-construction and co-design) and focuses specifically on a fourth (co-configuration), identified as an understudied mass customization strategy. Originality/value This paper extends the previous conceptualizations of mass customization comprising co-production, co-design and co-construction. The proposed typology establishes a foundation for four research priority areas that can improve both academic rigor and practical application.

scholarly journals Three-Dimensional Vibration Analysis of Rectangular Thick Plates on Pasternak Foundation with Arbitrary Boundary Conditions

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Huimin Liu ◽  
Fanming Liu ◽  
Xin Jing ◽  
Zhenpeng Wang ◽  
Linlin Xia
Keyword(s):  
Boundary Conditions ◽  
Admissible Function ◽  
Three Dimensional ◽  
Future Research ◽  
Pasternak Foundation ◽  
Arbitrary Boundary ◽  
Thick Plates ◽  
Arbitrary Boundary Conditions ◽  
Ritz Procedure ◽  
Three Dimensional Elasticity

This paper presents the first known vibration characteristic of rectangular thick plates on Pasternak foundation with arbitrary boundary conditions on the basis of the three-dimensional elasticity theory. The arbitrary boundary conditions are obtained by laying out three types of linear springs on all edges. The modified Fourier series are chosen as the basis functions of the admissible function of the thick plates to eliminate all the relevant discontinuities of the displacements and their derivatives at the edges. The exact solution is obtained based on the Rayleigh–Ritz procedure by the energy functions of the thick plate. The excellent accuracy and reliability of current solutions are demonstrated by numerical examples and comparisons with the results available in the literature. In addition, the influence of the foundation coefficients as well as the boundary restraint parameters is also analyzed, which can serve as the benchmark data for the future research technique.

The contribution of prosody to intelligibility, comprehensibility and accentedness in foreign language acquisition

2021 ◽  
Vol 26 (2) ◽  
pp. 273-298
Author(s):  
Pauline Degrave
Keyword(s):  
Language Acquisition ◽  
Foreign Language ◽  
Language Learners ◽  
Musical Training ◽  
Potential Effect ◽  
Future Research ◽  
General Description ◽  
Content Type ◽  
Foreign Language Learners ◽  
Foreign Language Acquisition

Abstract The purpose of this paper is to review recent research illustrating the importance of prosody in foreign language acquisition, and to examine whether music might help in this learning process. The paper starts off by defining prosody and by examining previous research on foreign language prosody acquisition, stating the difficulties for learners and the potential effect of non-native prosody on communication, notably on comprehensibility, intelligibility and accentedness. A subsequent section focuses on prosodic characteristics of Dutch and the problems foreign language learners may encounter in acquiring them. Based on this general description of foreign language prosody acquisition, the paper then zooms in on the link between music and prosody, and on the potential effect of musical training, musical abilities or the use of music in the foreign language classroom on foreign language prosody acquisition. The paper ends with a short discussion on avenues for future research.

scholarly journals The Role of Formal Theory in Social Work Research: Formalizing Family Systems Theory

10.18060/7942 ◽  
2013 ◽  
Vol 14 (2) ◽  
pp. 501-517 ◽  
Author(s):  
Suzanne Taylor Sutphin ◽  
Shannon McDonough ◽  
Amber Schrenkel
Keyword(s):  
Social Work ◽  
Systems Theory ◽  
Family Systems ◽  
Scientific Research ◽  
Formal Theory ◽  
Potential Effect ◽  
Family Systems Theory ◽  
Assessment Tools ◽  
Future Research ◽  
Social Work Research

Formal theories are critical to accumulating knowledge through scientific research to advance the discipline and practice. The use of formal theory in social work research is currently absent. Family Systems Theory (FST) is commonly used in social work; however, it currently lacks the criteria to be considered a formal theory. We use FST to demonstrate the formalization process and its potential effect on social work research and practice. Currently, FST is being used as a perspective, to develop theories and models used in marriage and family therapy, and to develop assessment tools. We identify the components of a formal theory while presenting a formal version of FST. Directions for future research are suggested including the benefits of using formal theory to direct scientific research and guide the development of evidence-based practice.

Adverse Childhood Experiences and Traumatic Stress Disorders

2021 ◽  
Author(s):  
Damion J. Grasso
Keyword(s):  
Adverse Childhood Experiences ◽  
Research Priorities ◽  
Stress Disorders ◽  
Traumatic Experiences ◽  
School Age Children ◽  
Future Research ◽  
Risk And Resilience ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Adolescents And Adults

Adverse childhood experiences (ACEs) refer to a broad range of events that can reflect physical or psychological threats to safety, as well as deprivation of basic needs, essential resources, or caregiving necessary for children to thrive and attain healthy development. ACEs can constitute potentially traumatic experiences or nontraumatic adversities with the potential to exacerbate trauma-related impairment or compromise trauma recovery and resilience. This chapter explores ACEs in the context of trauma and trauma-related impairment across the life span. It covers research employing variable- and person-centered analytic strategies for quantifying cumulative and unique constellations of ACEs that probabilistically co-occur, contemporaneously or across development, to influence risk and resilience. Studies examining intergenerational patterns and biological correlates are introduced and progress toward delineating causal risk mechanisms discussed. In addition, several existing tools and methods for assessing ACEs in young and school-age children, adolescents, and adults are summarized. Clinical and public health implications of ACE screening in healthcare, schools, and other settings are considered, as is the clinical application of research on ACEs in trauma-specific prevention and treatment. The chapter concludes with a focus on future research priorities.

Memory Reconsolidation as a Common Change Process

2020 ◽  
pp. 328-360
Author(s):  
Rhonda Goldman ◽  
Alyssa Fredrick-Keniston
Keyword(s):  
Change Process ◽  
Memory Model ◽  
Memory Reconsolidation ◽  
Future Research ◽  
Therapeutic Approaches ◽  
Therapeutic Modalities ◽  
Change Mechanisms ◽  
Definition Of ◽  
Constituent Elements

Memory reconsolidation is considered as a common change process that exists across the major individual therapeutic modalities that are aimed at promoting and sustaining long- term, enduring change. The integrative memory model is reviewed in terms of how it may provide the field of psychotherapy integration with a description of a process that all individual therapies seek to achieve. First, the change mechanisms underlying each of the major therapeutic approaches including behavioral, cognitive-behavioral, psychodynamic and emotion-focused therapies are examined to determine the degree to which they describe a memory reconsolidation process. Next, some of the newer, modern integrative therapeutic approaches are reviewed to consider whether they too are promoting a memory reconsolidation process, although not necessarily naming it as such. The memory reconsolidation model and its constituent elements are then examined in depth to determine the degree to which the various therapy models promote and encourage relative aspects of the memory reconsolidation process. Finally, a potentially clarifying definition of terms is proposed and future research is suggested that would help the field determine the degree to which memory reconsolidation is a common change process and if so, how it can best be promoted.

scholarly journals Multiple Jobholding: An Integrative Systematic Review and Future Research Agenda

2019 ◽  
Vol 46 (1) ◽  
pp. 165-191
Author(s):  
Emily D. Campion ◽  
Brianna B. Caza ◽  
Sherry E. Moss
Keyword(s):  
Systematic Review ◽  
Boundary Conditions ◽  
Research Agenda ◽  
Practical Knowledge ◽  
Additional Research ◽  
Future Research ◽  
Work Roles ◽  
Future Research Agenda ◽  
Demographic Predictors

Despite sizable but varying estimates of multiple jobholding (MJH) and decades of research across disciplines (e.g., management, economics, sociology, health and medicine), our understanding of MJH is rather limited. The purpose of this review is to provide a coherent synthesis of the literature on MJH, or working more than one job. Beginning with a discussion of the motivations and demographic predictors that forecast MJH, we note a distinct divide between the research that predicts MJH and the research that examines outcomes, with few studies exploring how motivations might relate to MJH experiences and outcomes. Another significant observation in this review is the inconsistency of findings across and within disciplines regarding whether MJH is depleting or enriching. Using this framework to organize our review, we attempt to reconcile the generally mixed results by presenting research on mechanisms and boundary conditions of MJH to explain how and when multiple jobholders (MJHers) are depleted or enriched. By integrating findings from the literature, we are able to articulate more clearly the paths of depletion and enrichment and discuss how push versus pull-based motivations to hold multiple jobs likely predict these pathways. Finally, we provide a strategic agenda highlighting areas where additional research is urgently needed to equip scholars with practical knowledge on how to help MJHers manage their multiple work roles and how to help organizations manage MJHers.

Stroke Management

1993 ◽  
Vol 6 (6) ◽  
pp. 297-303
Author(s):  
Susan C. Fagan
Keyword(s):  
Cerebral Ischemia ◽  
Antiplatelet Agent ◽  
The United States ◽  
Minor Stroke ◽  
Future Research ◽  
Stroke Management ◽  
Pharmacological Agents ◽  
Glutamate Antagonists ◽  
First Line Therapy ◽  
Patients At Risk

With as many as 500,000 new strokes per year in the United States, the need for safe and effective therapy of these patients is evident. The area in which the greatest impact has been made is in the development of prophylactic treatments for patients at risk of stroke. Aspirin, long the mainstay of stroke management, has repeatedly been shown to reduce the risk of cerebral ischemia in patients who have had a transient ischemic attack (TIA) or minor stroke and is first-line therapy for these patients. Either 325 mg or 975 mg of aspirin may be used. Ticlopidine (250 mg twice daily) is a new antiplatelet agent that is recommended for the prophylaxis of stroke in patients who cannot tolerate or who are resistant to aspirin therapy. The surgical procedure, carotid endarterectomy, has been shown to reduce the stroke rate in symptomatic patients, with between 70% to 99% stenosis of a carotid artery. The use of warfarin has been shown to be extremely useful in patients with atrial fibrillation for prevention of recurrent embolic events. The use of pharmacological agents in the acute treatment of the ischemic stroke patient has not yet been proven successful. It is hoped that with the trend towards hyperacute (less than 6 hours) intervention, investigators may be successful in finding an agent to decrease the ultimate neurological deficit due to stroke. Some of the more promising agents are thrombolytics, glutamate antagonists, and aminosteroids. Future research in cerebral ischemia will undoubtedly improve the prognosis of stroke patients.

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