Machine Learning-Based Anomaly Detection Algorithms to Alert Patients Using Sensor Augmented Pump of Infusion Site Failures

2021 ◽  
pp. 193229682199785
Author(s):  
Lorenzo Meneghetti ◽  
Eyal Dassau ◽  
Francis J. Doyle ◽  
Simone Del Favero
Keyword(s):  
Machine Learning ◽  
Anomaly Detection ◽  
Machine Learning Algorithms ◽  
Infusion Site ◽  
Detection Algorithms ◽  
Quality Of Therapy ◽  
Unsupervised Anomaly Detection ◽  
Novel Method

Background: Personal insulin pumps have shown to be effective in improving the quality of therapy for people with type 1 diabetes (T1D). However, the safety of this technology is limited by the possible infusion site failures, which are linked with hyperglycemia and ketoacidosis. Thanks to the large availability of collected data provided by modern therapeutic technologies, machine learning algorithms have the potential to provide new way to identify failures early and avert adverse events. Methods: A clinical dataset ( N = 20) is used to evaluate a novel method for detecting real-time infusion site failures using unsupervised anomaly detection algorithms, previously proposed and developed on in-silico data. An adapted feature engineering procedure is introduced to make the method able to operate in the absence of a closed-loop (CL) system and meal announcements. Results: In the optimal configuration, we obtained a performance of 0.75 Sensitivity (15 out of 20 total failures detected) and 0.08 FP/day, outperforming previously proposed literature algorithms. The algorithm was able to anticipate the replacement of the malfunctioning infusion sets by ~2 h on average. Conclusions: On the considered dataset, the proposed algorithm showed the potential to improve the safety of patients treated with sensor-augmented pump systems.

MACHINE LEARNING AND ANOMALY DETECTION ALGORITHMS FOR DAMAGE CHARACTERIZATION FROM COMPLIANCE DATA IN 3-POINT BENDING FATIGUE

2021 ◽  
pp. 1-12
Author(s):  
Subodh Kalia ◽  
Jakob Zeitler ◽  
Chilukuri Mohan ◽  
Volker Weiss
Keyword(s):  
Machine Learning ◽  
Anomaly Detection ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Bending Fatigue ◽  
Three Point Bending ◽  
Short Intervals ◽  
Detection Algorithms ◽  
Vector Machines ◽  
Damage Indicators

Abstract Three-point bending fatigue compliance datasets of multi-layer fiberglass-weave/epoxy test specimens, including five and ten mil interlayers, were analyzed using Artificial Intelligence (AI) methods along with statistical analysis, revealing the existence of three different compliance-based damage modes. Anomaly detection algorithms helped discover damage indicators observable in short intervals (of 50 cycles) in the compliance data, whose patterns vary with the material and the number of load cycles to which the material is subjected. Machine learning algorithms were applied using the compliance features to assess the likelihood that material failure may occur within a certain number of future loading cycles. High accuracy, precision, and recall rates were achieved in the classification task, for which we evaluated several algorithms, including various variations of neural networks and support vector machines. Thus our work demonstrates the utility of AI algorithms for discovering a diversity of damage mechanisms and failures.

1290-P: Gut Microbiota in New-Onset Pediatric Patients with Type 1 Diabetes: Machine Learning Algorithms to Classify Microorganisms Disease-Linked

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1290-P
Author(s):  
GIUSEPPE D’ANNUNZIO ◽  
ROBERTO BIASSONI ◽  
MARGHERITA SQUILLARIO ◽  
ELISABETTA UGOLOTTI ◽  
ANNALISA BARLA ◽  
...  
Keyword(s):  
Machine Learning ◽  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Pediatric Patients ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
New Onset

scholarly journals Unsupervised Anomaly Detection with Distillated Teacher-Student Network Ensemble

Entropy ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 201
Author(s):  
Qinfeng Xiao ◽  
Jing Wang ◽  
Youfang Lin ◽  
Wenbo Gongsa ◽  
Ganghui Hu ◽  
...  
Keyword(s):  
Anomaly Detection ◽  
Multivariate Data ◽  
Failure Detection ◽  
Superior Performance ◽  
Detection Algorithms ◽  
Teacher Student ◽  
Model Complex ◽  
Unsupervised Anomaly Detection ◽  
Real World Datasets ◽  
Complex Features

We address the problem of unsupervised anomaly detection for multivariate data. Traditional machine learning based anomaly detection algorithms rely on specific assumptions of normal patterns and fail to model complex feature interactions and relations. Recently, existing deep learning based methods are promising for extracting representations from complex features. These methods train an auxiliary task, e.g., reconstruction and prediction, on normal samples. They further assume that anomalies fail to perform well on the auxiliary task since they are never trained during the model optimization. However, the assumption does not always hold in practice. Deep models may also perform the auxiliary task well on anomalous samples, leading to the failure detection of anomalies. To effectively detect anomalies for multivariate data, this paper introduces a teacher-student distillation based framework Distillated Teacher-Student Network Ensemble (DTSNE). The paradigm of the teacher-student distillation is able to deal with high-dimensional complex features. In addition, an ensemble of student networks provides a better capability to avoid generalizing the auxiliary task performance on anomalous samples. To validate the effectiveness of our model, we conduct extensive experiments on real-world datasets. Experimental results show superior performance of DTSNE over competing methods. Analysis and discussion towards the behavior of our model are also provided in the experiment section.

scholarly journals MACHINE LEARNING METHODS IN MONITORING OPERATING BEHAVIOUR OF MARINE TWO-STROKE DIESEL ENGINE

Transport ◽  
2020 ◽  
Vol 35 (5) ◽  
pp. 462-473
Author(s):  
Aleksandar Vorkapić ◽  
Radoslav Radonja ◽  
Karlo Babić ◽  
Sanda Martinčić-Ipšić
Keyword(s):  
Machine Learning ◽  
Anomaly Detection ◽  
Fuel Consumption ◽  
Performance Monitoring ◽  
Absolute Error ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Operating Parameters ◽  
Detection Model ◽  
Modelling Framework

The aim of this article is to enhance performance monitoring of a two-stroke electronically controlled ship propulsion engine on the operating envelope. This is achieved by setting up a machine learning model capable of monitoring influential operating parameters and predicting the fuel consumption. Model is tested with different machine learning algorithms, namely linear regression, multilayer perceptron, Support Vector Machines (SVM) and Random Forests (RF). Upon verification of modelling framework and analysing the results in order to improve the prediction accuracy, the best algorithm is selected based on standard evaluation metrics, i.e. Root Mean Square Error (RMSE) and Relative Absolute Error (RAE). Experimental results show that, by taking an adequate combination and processing of relevant sensory data, SVM exhibit the lowest RMSE 7.1032 and RAE 0.5313%. RF achieve the lowest RMSE 22.6137 and RAE 3.8545% in a setting when minimal number of input variables is considered, i.e. cylinder indicated pressures and propulsion engine revolutions. Further, article deals with the detection of anomalies of operating parameters, which enables the evaluation of the propulsion engine condition and the early identification of failures and deterioration. Such a time-dependent, self-adopting anomaly detection model can be used for comparison with the initial condition recorded during the test and sea run or after survey and docking. Finally, we propose a unified model structure, incorporating fuel consumption prediction and anomaly detection model with on-board decision-making process regarding navigation and maintenance.

scholarly journals Assessing automated CMR contouring algorithms using systematic contour quality scoring analysis

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
M Omer ◽  
A Amir-Khalili ◽  
A Sojoudi ◽  
T Thao Le ◽  
S A Cook ◽  
...  
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Random Order ◽  
Standard Operating Procedure ◽  
Left Ventricular ◽  
Quality Score ◽  
Machine Learning Algorithms ◽  
Dice Similarity Coefficient ◽  
National Budget

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): SmartHeart EPSRC programme grant (www.nihr.ac.uk), London Medical Imaging and AI Centre for Value-Based Healthcare Background Quality measures for machine learning algorithms include clinical measures such as end-diastolic (ED) and end-systolic (ES) volume, volumetric overlaps such as Dice similarity coefficient and surface distances such as Hausdorff distance. These measures capture differences between manually drawn and automated contours but fail to capture the trust of a clinician to an automatically generated contour. Purpose We propose to directly capture clinicians’ trust in a systematic way. We display manual and automated contours sequentially in random order and ask the clinicians to score the contour quality. We then perform statistical analysis for both sources of contours and stratify results based on contour type. Data The data selected for this experiment came from the National Health Center Singapore. It constitutes CMR scans from 313 patients with diverse pathologies including: healthy, dilated cardiomyopathy (DCM), hypertension (HTN), hypertrophic cardiomyopathy (HCM), ischemic heart disease (IHD), left ventricular non-compaction (LVNC), and myocarditis. Each study contains a short axis (SAX) stack, with ED and ES phases manually annotated. Automated contours are generated for each SAX image for which manual annotation is available. For this, a machine learning algorithm trained at Circle Cardiovascular Imaging Inc. is applied and the resulting predictions are saved to be displayed in the contour quality scoring (CQS) application. Methods: The CQS application displays manual and automated contours in a random order and presents the user an option to assign a contour quality score 1: Unacceptable, 2: Bad, 3: Fair, 4: Good. The UK Biobank standard operating procedure is used for assessing the quality of the contoured images. Quality scores are assigned based on how the contour affects clinical outcomes. However, as images are presented independent of spatiotemporal context, contour quality is assessed based on how well the area of the delineated structure is approximated. Consequently, small contours and small deviations are rarely assigned a quality score of less than 2, as they are not clinically relevant. Special attention is given to the RV-endo contours as often, mostly in basal images, two separate contours appear. In such cases, a score of 3 is given if the two disjoint contours sufficiently encompass the underlying anatomy; otherwise they are scored as 2 or 1. Results A total of 50991 quality scores (24208 manual and 26783 automated) are generated by five expert raters. The mean score for all manual and automated contours are 3.77 ± 0.48 and 3.77 ± 0.52, respectively. The breakdown of mean quality scores by contour type is included in Fig. 1a while the distribution of quality scores for various raters are shown in Fig. 1b. Conclusion We proposed a method of comparing the quality of manual versus automated contouring methods. Results suggest similar statistics in quality scores for both sources of contours. Abstract Figure 1

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