A New Cytotoxic Sesquiterpene and Three Anti-inflammatory Flavonoids from Egyptian Tanacetum Santolinoides
2007 ◽
Vol 2
(11)
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pp. 1934578X0700201
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Keyword(s):
Rat Paw
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A re-investigation of the methanolic extract of the aerial parts of Tanacetum santolinoides has resulted in the isolation of a new sesquiterpene, tanacetonic acid (1), along with three known methoxylated flavonoids. The structure of the isolated compounds was secured based on their IR, UV, 1D and 2D (1H-1H COSY, HSQC and HMBC) NMR spectroscopic and FAB mass spectral characteristics. The new sesquiterpene showed a significant cytotoxic activity when tested using the brine shrimp bioassay, while the three flavonoids demonstrated anti-inflammatory effects in the rat paw oedema test.
2007 ◽
Vol 2
(8)
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pp. 1934578X0700200
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Keyword(s):
Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation
2003 ◽
Vol 54
(4)
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pp. 313-318
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