scholarly journals Study on the Chemical Constituents of Premna Integrifolia L

2008 ◽  
Vol 3 (9) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Nguyen Thi Bich Hang ◽  
Pham Thanh Ky ◽  
Chau Van Minh ◽  
Nguyen Xuan Cuong ◽  
Nguyen Phuong Thao ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Stem Bark ◽  
Iridoid Glycoside ◽  
Phytochemical Study ◽  
Spectroscopic Evidence ◽  
Structure Determinations

Phytochemical study on the plant Premna integrifolia L. led to the isolation of twelve compounds. In which, a new acylated iridoid glycoside, 6- O-(3″- O-acetyl-2″- O-trans-p-coumaroyl)-α-L-rhamnopyranosylcatalpol (premnacorymboside A) (1), was isolated from the flowers along with 10- O-trans-p-methoxycinnamoylcatalpol (3) and verbascoside. From the leaves, a new iridoid glycoside, 6- O-(3″- O-trans-p-coumaroyl)-α-L-rhamnopyranosylcatalpol (premnacorymboside B) (2), together with 10- O-trans-p-methoxycinnamoylcatalpol (3), scutellarioside II (4), premnaodoroside A (5), 1- O-trans-p-coumaroyl-α-L-rhamnopyranoside, hexyl glucoside, 4-hydroxy-2-methoxybenzaldehyde, and 4-hydroxybenzaldehyde were obtained. The new compound premnacorymboside A (1) and scutellarioside II (4), were also isolated from the stem bark along with quercetin 3-rutinoside and leonuriside A. The structure determinations were based on physical and spectroscopic evidence.

scholarly journals Phytochemical characterization, antioxidant potential and antimicrobial activity of Averrhoa carambola L. (Oxalidaceae) against multiresistant pathogens

2020 ◽  
Author(s):  
K. B. Silva ◽  
C. T. S. Pinheiro ◽  
C. R. M. Soares ◽  
M. A. Souza ◽  
T. J. Matos-Rocha ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Iron Reduction ◽  
Chemical Constituents ◽  
Stem Bark ◽  
Total Phenol Content ◽  
Phenol Content ◽  
Multiresistant Pathogens ◽  
Phytochemical Study ◽  
Green Fruit ◽  
Dpph Method

Abstract The objective of this work was to perform the phytochemical characterization, to determine total phenols, antioxidant (AAO%) and antimicrobial potential of the ethanolic extracts of carambola. The phytochemical study was carried out through a qualitative analysis of the chemical constituents and quantitative determination of the phenol content By the Folin-Ciocalteu test. Qualitative and quantitative antioxidant tests were performed using the DPPH method (2,2 diphenyl-1-picryl-hydrazila) and iron reduction (FRAP). The minimum inhibitory concentration (MIC) was determined by microdilution in 96-well plates. The presence of pyrogallic tannins, steroids and saponins has been identified. The highest total phenol content, quantified in the samples, was found in the stem bark (0.0866 mgEAG/g) and in the fruit (0.0734 mgEAG/g). In the antioxidant evaluation, the extracts of the green fruit bagasse (AAO% 71.9%,) and stem bark at 50 μg/mL (AAO% 94%) with CE50 23.7 μg/mL. Leaf extracts, stem bark, ripe fruit bagasse and green fruit bagasse presented MICs of 100 μg/mL against multiresistant pathogenic bacteria and fungi.

scholarly journals A New Flavonoid from Malaysian Dipterocarpus cornutus

2021 ◽  
Vol 21 (5) ◽  
pp. 1132
Author(s):  
Wan Zuraida Wan Mohd Zain ◽  
Liliwirianis Nawi ◽  
Norizan Ahmat ◽  
Che Puteh Osman ◽  
Yaya Rukayadi
Keyword(s):  
East Asia ◽  
Chemical Constituents ◽  
Stem Bark ◽  
Iucn Red List ◽  
Red List ◽  
South East Asia ◽  
Phytochemical Study ◽  
The Family ◽  
Coumarin 6 ◽  
Comprehensive Study

Dipterocarpus cornutus Dyer is commonly known as ‘keruing’. It belongs to the family of Dipterocarpaceae, an important timber family in South East Asia. D. cornutus is listed as critically endangered on IUCN Red List. Since no comprehensive study has been documented on the chemical constituents of D. cornutus, there is an urgent need to study this plant comprehensively. Phytochemical study of the stem bark of D. cornutus afforded a new flavonoid (1) and nine known compounds, which consist of flavonoids (2, 3), oligostilbenoids (4, 5, 7, 8, 9, 10), and coumarin (6). The finding of the study contributes to the chemotaxonomic differentiation in the plants of the tribe Dipterocarpae.

scholarly journals Antifungal Activity of Chemical Constituents from Piper pesaresanum C. DC. and Derivatives against Phytopathogen Fungi of Cocoa

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3256
Author(s):  
Luis C. Chitiva-Chitiva ◽  
Cristóbal Ladino-Vargas ◽  
Luis E. Cuca-Suárez ◽  
Juliet A. Prieto-Rodríguez ◽  
Oscar J. Patiño-Ladino
Keyword(s):  
Antifungal Activity ◽  
Benzoic Acid ◽  
Chemical Constituents ◽  
Chemical Study ◽  
Positive Control ◽  
Positive Influence ◽  
Phytopathogenic Fungi ◽  
Phytochemical Study ◽  
Benzoic Acid Derivatives ◽  
First Time

In this study, the antifungal potential of chemical constituents from Piper pesaresanum and some synthesized derivatives was determined against three phytopathogenic fungi associated with the cocoa crop. The methodology included the phytochemical study on the aerial part of P. pesaresanum, the synthesis of some derivatives and the evaluation of the antifungal activity against the fungi Moniliophthora roreri, Fusarium solani and Phytophthora sp. The chemical study allowed the isolation of three benzoic acid derivatives (1–3), one dihydrochalcone (4) and a mixture of sterols (5–7). Seven derivatives (8–14) were synthesized from the main constituents, of which compounds 9, 10, 12 and 14 are reported for the first time. Benzoic acid derivatives showed strong antifungal activity against M. roreri, of which 11 (3.0 ± 0.8 µM) was the most active compound with an IC50 lower compared with positive control Mancozeb® (4.9 ± 0.4 µM). Dihydrochalcones and acid derivatives were active against F. solani and Phytophthora sp., of which 3 (32.5 ± 3.3 µM) and 4 (26.7 ± 5.3 µM) were the most active compounds, respectively. The preliminary structure–activity relationship allowed us to establish that prenylated chains and the carboxyl group are important in the antifungal activity of benzoic acid derivatives. Likewise, a positive influence of the carbonyl group on the antifungal activity for dihydrochalcones was deduced.

scholarly journals Antioxidant and Antiproliferative Potentials of Ficus glumosa and Its Bioactive Polyphenol Metabolites

2021 ◽  
Vol 14 (3) ◽  
pp. 266
Author(s):  
Moses Mutuse Mutungi ◽  
Felix Wambua Muema ◽  
Festus Kimutai ◽  
Yong-Bing Xu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Stem Bark ◽  
Background Information ◽  
Antioxidant Power ◽  
Chemical Profiling ◽  
Anti Cancer ◽  
Ic50 Values ◽  
Ferric Reducing Antioxidant Power ◽  
High Cytotoxicity ◽  
Ethanol Extracts

Ficus glumosa Delile (Moraceae), a reputed plant that is used in herbal medicine, is of high medicinal and nutritional value in local communities primarily ascribed to its phytochemical profile. Currently, there are hardly any fine details on the chemical profiling and pharmacological evaluation of this species. In this study, the flavonoids and phenolics contents of the ethanol extracts and four extracted fractions (petroleum ether (PE), ethyl acetate (EA), n-butanol, and water) of the stem bark of Ficus glumosa were firstly quantified. Further, their antioxidant and antiproliferative potentials were also evaluated. The quantitative determination indicated that the EA and n-butanol fractions possessed the highest total flavonoids/phenolics levels of 274.05 ± 0.68 mg RE/g and 78.87 ± 0.97 mg GAE/g, respectively. Similarly, for the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and ferric-reducing antioxidant power (FRAP) assays, the EA fraction exhibited high potency in both DPPH and ABTS+ scavenging activities with IC50 values of 0.23 ± 0.03 mg/mL, 0.22 ± 0.03 mg/mL, and FRAP potential of 2.81 ± 0.01 mg Fe2+/g, respectively. Furthermore, the EA fraction displayed high cytotoxicity against human lung (A549) and colon (HT-29) cancer cells. Additionally, the liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) was employed in order to characterize the chemical constituents of the EA fraction of Ficus glumosa stem bark. Our findings revealed 16 compounds from the EA fraction that were possibly responsible for the strong antioxidant and anti-proliferative properties. This study provides edge-cutting background information on the exploitation of Ficus glumosa as a potential natural antioxidant and anti-cancer remedy.

scholarly journals Chemical constituents of the underground stem bark of Duguetia furfuracea (Annonaceae)

2007 ◽  
Vol 18 (8) ◽  
pp. 1560-1565 ◽  
Author(s):  
Denise B. da Silva ◽  
Elaine C. O. Tulli ◽  
Walmir S. Garcez ◽  
Evandro A. Nascimento ◽  
João M. de Siqueira
Keyword(s):  
Chemical Constituents ◽  
Stem Bark ◽  
Underground Stem

Chemical Constituents and Cytotoxicity from the Stem Bark of Citrus medica

Heterocycles ◽  
2009 ◽  
Vol 78 (5) ◽  
pp. 1309 ◽  
Author(s):  
Tian-Shung Wu ◽  
Yu-Yi Chan ◽  
Yao-Haur Kuo
Keyword(s):  
Chemical Constituents ◽  
Stem Bark ◽  
Citrus Medica

scholarly journals Seasonal effects and antifungal activity from bark chemical constituents of Sterculia apetala (Malvaceae) at Pantanal of Miranda, Mato Grosso do Sul, Brazil

2015 ◽  
Vol 45 (3) ◽  
pp. 283-292 ◽  
Author(s):  
Fernanda Mussi FONTOURA ◽  
Rosemary MATIAS ◽  
Juliane LUDWIG ◽  
Ademir Kleber Morbeck de OLIVEIRA ◽  
José Antonio Maior BONO ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Chemical Constituents ◽  
Chemical Study ◽  
Stem Bark ◽  
Seasonal Effects ◽  
Chemical Components ◽  
Phytochemical Analysis ◽  
Wet Season ◽  
Mycelium Growth ◽  
Mato Grosso

In the Southern Pantanal, the hyacinth macaw (Anodorhynchus hyacinthinus), an endangered species, often chooses the manduvi tree (Sterculia apetala) as a nesting site, because of its physical properties. In addition, the chemical composition of the wood may also contribute to a nesting selection by the hyacinth macaws. The objective of this study was to determine the main chemical components of S. apetala bark for two seasons, and evaluate its fungicidal potential. Bark samples from S. apetala trees with and without nests of A. hyacinthinus were collected in January (wet season) and August (dry season) of 2012. The inhibition of mycelium growth (MGI) from tree samples with and without nests were assessed using a phytochemical analysis to evaluate their antifungal activity against Trichoderma sp. Phytochemical analysis confirmed the presence of phenolic compounds and flavonoids. In both seasons, samples obtained from nested trees had higher content of total phenols than those collected from non-nested trees. The average content of total flavonoids was higher in January for samples with nest and in August for samples without nest. All selected samples showed antifungal activity, and those with nest collected in August (peak of hyacinth macaw breeding) resulted in an MGI of 51.3%. Therefore, this percentage, related to the content of flavonoids and the presence of coumarins, may influence the reproductive success of hyacinth macaws and other species of birds, in this region. This is the first chemical study report with the stem bark of S. apetala.

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