Constituents of Talisia nervosa with Potential Utility against Metabolic Syndrome

This study is focused on the isolation and characterization of bioactive secondary metabolites from the ethanolic extract of stems of the Panamanian plant Talisia nervosa Radlk, through a series of target-based cellular assays related to the metabolic syndrome (MetS): a combination of type 2 Diabetes Mellitus (T2DM), hypercholesterolemia, inflammation, and obesity. Bioassay guided fractionation allowed the isolation of four known compounds: (-)-catechin (1), methyl gallate (2), ethyl gallate (3), and ß-D-glucopyranose,1,4,6-tris(3,4,5-trihydroxybenzoate) (4). This is the first report of (-)-catechin (1) and ß-D-glucopyranose,1,4,6-tris (3,4,5-trihydroxybenzoate) (4) from T. nervosa. Among the isolates, 1 activated PPARγ, but had no effect on PPARα. Compounds 2 -4 activated PPARα, PPARγ and LXR. Interestingly, 2 was stronger than 3 towards all three targets. Methyl gallate (2) showed the most potent effect toward both PPARα and PPARγ with an increase of 3.0 and 13-fold, respectively, while 4 was most potent in activating LXR with a fold induction of 5.3 at concentrations of 100 μg/mL. The nitric oxide (NO) production was reduced by compounds 2 and 3 with IC50 values of 7.0 and 7.5 μg/mL, respectively. ß-D-glucopyranose,1,4,6-tris (3,4,5-trihydroxybenzoate) 4) did not cause a significant increase in adipogenesis despite its strong PPARγ agonistic action (8 6-fold increase) and may represent a good candidate for the treatment of MetS without the undesirable side effect of weight gain.

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The effect of high multivitamin diet during pregnancy on food intake and glucose metabolism in Wistar rat offspring fed low-vitamin diets post weaning

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174411000523 ◽

2011 ◽

Vol 2 (5) ◽

pp. 302-310 ◽

Cited By ~ 2

Author(s):

I. M. Y. Szeto ◽

P. S. P. Huot ◽

S. A. Reza-López ◽

A. Jahan-mihan ◽

G. H. Anderson

Keyword(s):

Metabolic Syndrome ◽

Food Intake ◽

Insulin Response ◽

Fold Increase ◽

Wistar Rat ◽

Oral Glucose ◽

Glucose Response ◽

Rat Offspring ◽

Vitamin Content ◽

The Metabolic Syndrome

Rat offspring born to dams fed a high multivitamin diet (HV) are shown to have increased risks of obesity and metabolic syndrome. We hypothesized that a low-vitamin postweaning diet would enhance these characteristics in offspring born to HV dams. During pregnancy, Wistar rats were fed the AIN-93G diet with or without a 10-fold increase in vitamin content. In Experiment 1, at weaning, males were fed the recommended diet (RV) or a diet with 1/3 the vitamin content (1/3 RV) for 12 weeks. In Experiment 2, males and females were fed the RV diet or 1/6 RV diet for 35 weeks. Body weight was measured on a weekly basis, food intake on a daily basis, and for 1 h after an overnight fast following glucose gavage at 6, 12 and 24 weeks. Blood glucose and insulin responses to an oral glucose load were measured at 30 weeks. Males from HV dams, compared with those from RV dams, gained more weight in Experiment 1 (+7%,P< 0.05) and Experiment 2 (+11%,P< 0.0001), along with higher glucose response (+33%,P< 0.05). The 1/6 RV pup diet led to lower weight gain in males (−16%,P< 0.0001) and females (−13%,P< 0.0005), and lower food intake in males (−9%,P< 0.01) independent of the gestational diet. Females on the 1/6 RV diet and from HV dams had higher 1 h food intake (+36%,P< 0.05) and lower insulin response (−25%,P< 0.05) compared with those from RV dams. Exposure of the offspring to low-vitamin diets did not amplify the expression of the metabolic syndrome observed in those born to dams fed an HV diet.

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THE SIGNS OF CARBOHYDRATE-LIPID METABOLISM DISTURBANCE IN PATIENTS WITH CHRONIC HEPATITIS C

Hepatology and Gastroenterology ◽

10.25298/2616-5546-2021-5-1-56-60 ◽

2021 ◽

Vol 5 (1) ◽

pp. 56-60

Author(s):

G. M. Jeenalieva ◽

Keyword(s):

Metabolic Syndrome ◽

Chronic Hepatitis ◽

Lipid Metabolism ◽

Hepatitis C ◽

Viral Hepatitis ◽

Chronic Hepatitis C ◽

Fold Increase ◽

Russian Society ◽

The Metabolic Syndrome ◽

Viral Hepatitis C

Background. Viral hepatitis C (CHC) is an urgent problem due to its prevalence, high risk of developing liver cirrhosis and hepatocellular carcinoma. Viral hepatitis C can cause disruption of many biochemical processes in the liver cells, primarily that of carbohydrate - lipid metabolism. Objective. To study carbohydrate-lipid metabolism disturbances in patients with CHC. Material and methods. The study included 124 patients with paucisymptomatic chronic hepatitis C. The metabolic syndrome was diagnosed according to the indicators recommended by the Committee of Experts of the Russian Society of Cardiology (2007). Results. The parameters of lipid metabolism were studied in 52 of 124 patients with CHC. 29 of 52 patients with CHC (55.7%) showed a decrease in HDL cholesterol and an increase in LDL cholesterol, including a 2- fold increase in VLDL. The metabolic syndrome was detected in 22.5% of patients with CHC, 62.9% of patients had the manifestations of dyslipidemia (steatosis or steatohepatitis of the liver, obesity, arterial hypertension, insulin resistance, type 2 diabetes mellitus). Conclusions. In patients with CHC, carbohydrate-lipid metabolism disturbance was revealed as an integral indicator of metabolic syndrome, its incidence rising with the increase in activity and duration of the infectious process.

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