scholarly journals New Cytotoxic Steroid Produced by the Soil-Derived Fungus Aspergillus flavus JDW-1

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1985037 ◽  
Author(s):  
Wenqiang Guo ◽  
Wenjie Liu ◽  
Feng Xiao ◽  
Miaomiao Zhang ◽  
Longqiang Li ◽  
...  
Keyword(s):  
Aspergillus Flavus ◽  
Spectroscopic Data ◽  
Inhibitory Concentration ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Crystallographic Analysis ◽  
Scavenging Activity ◽  
X Ray ◽  
Hct 116 ◽  
Absolute Stereochemistry

One new steroid 1, together with seven known compounds 2 to 8, were discovered in the extract of a soil-derived fungus Aspergillus flavus JDW-1. The structure, including the absolute stereochemistry of new compound 1, was established by interpretation of extensive nuclear magnetic resonance spectroscopic data and further confirmed by X-ray crystallographic analysis. The cytotoxicity of 1 against the A-549, Hela, HCT-116, MGC-803, and HO-8910 cell lines was evaluated, which showed cytotoxicity with the half-maximal inhibitory concentration (IC50) values as 5.00 to 22.38 μM. Compounds 2 to 8 exhibited moderate radical scavenging activity against DPPH with IC50 values ranging from 4.7 to 28.5 μM.

scholarly journals New furoisocoumarins and isocoumarins from the mangrove endophytic fungus Aspergillus sp. 085242

2016 ◽  
Vol 12 ◽  
pp. 2077-2085 ◽  
Author(s):  
Ze’en Xiao ◽  
Senhua Chen ◽  
Runlin Cai ◽  
Shao’e Lin ◽  
Kui Hong ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Spectroscopic Data ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
X Ray ◽  
Mangrove Endophytic Fungus ◽  
The Absolute ◽  
Aspergillus Sp ◽  
First Time

The chemical investigation of the mangrove endophytic fungus Aspergillus sp. 085242 afforded eight isocoumarin derivatives 1–8 and one isoquinoline 9. Asperisocoumarins A and B (1 and 2) were new furoisocoumarins, and asperisocoumarins E and F (5 and 6) were new isocoumarins. Their structures were established by analysis of their spectroscopic data and the absolute configuration of compound 2 was unambiguously determined by X-ray structure analysis and ECD calculation. Moreover, the absolute configurations of compounds 3–5 were assigned by comparison of their ECD spectra with isocoumarins described in the literature. Asperisocoumarins C and D (3 and 4) were fully characterized spectroscopically and isolated from a natural source for the first time. Asperisocoumarins A–D (1–4) related to the class of furo[3,2-h]isocoumarins are rarely occurring in natural sources. Compounds 2, 5, and 6 showed moderate α-glucosidase inhibitory activity with IC50 of 87.8, 52.3, and 95.6 μM, respectively. In addition, compounds 1 and 3 exhibited weak radical scavenging activity with EC50 values of 125 and 138 μM, respectively.

scholarly journals Anion-Dependent Synthesis of Cu(II) Complexes with 2-(1H-Tetrazol-5-yl)-1H-indole: Synthesis, X-Ray Structures, and Radical Scavenging Activity

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Petr Halaš ◽  
Juraj Kuchár ◽  
Radovan Herchel
Keyword(s):  
Theoretical Calculations ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
X Ray ◽  
X Ray Crystallography ◽  
Anionic Ligand ◽  
Vis Spectroscopy ◽  
Indole Synthesis

Two mononuclear Cu(II) complexes, [Cu(phen)2(HL)]ClO4·H2O·2DMF (1) and [Cu(phen)2(HL)2]·EtOH (2), comprising 1,10-phentantroline (phen) and 2-(1H-tetrazol-5-yl)-1H-indole ligand (H2L) ligands are reported. Analysis and characterization of the samples were performed using standard physicochemical techniques, elemental analysis, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and UV-vis spectroscopy. Single-crystal X-ray crystallography revealed the formation of a pentacoordinate complex in 1 and a hexacoordinate complex in 2, in which the anionic ligand HL− has undergone monodentate coordination through the tetrazole unit. Furthermore, the crystal structure of H2L·MeOH is also discussed. The potential application of compounds 1 and 2 in bioinorganic chemistry was addressed by investigating their radical scavenging activity with the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and the results were supported also by theoretical calculations.

scholarly journals Green Synthesis of Polymer-Capped Copper Nanoparticles Using Ocimum sanctum Leaf Extract: Antibacterial and Antioxidant Potential

2021 ◽  
Vol 14 (4) ◽  
pp. 1831-1838
Author(s):  
Chirag Makvana
Keyword(s):  
Copper Nanoparticles ◽  
Leaf Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Ocimum Sanctum ◽  
Scavenging Activity ◽  
X Ray Diffraction ◽  
X Ray ◽  
Uv Visible

The advancement of green nanotechnology has piqued the interest of researchers into the environmentally responsible production of nanoparticles. Conventionally used chemical methods for the synthesis of the nanoparticles have shown adverse effect on environment due to the use of highly toxic chemicals. They are also expensive as they utilize costly chemicals as a reducing and capping agent. Use of plant extract can be an environment friendly and cost-effective approach for the synthesis of nanoparticles. Copper is the metal which humans utilize from the ancient time period and it doesn’t show any adverse effect on humankind as well as on environment. Leaf extract of Ocimum sanctum was employed with CuSO4 (1:9, v/v) to synthesize stable copper nanoparticles (CuNPs) that were then functionalized with Polyvinyl Pyrrolidone (PVP) polymer. Characterization of synthesized copper nanoparticles was carried out using UV–Visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). Synthesized CuNPs were subjected against the human pathogenic bacterial strain to evaluate their antibacterial potency. Antioxidative characteristics of CuNPs were analyzed using DPPH free radical scavenging activity. The UV–visible spectra of CuNPs showed unique peaks at 322 and 247 nm indicates the stable formation of nanoparticles. X-ray diffraction pattern suggest the face cubic centered (FCC) structure of copper nanoparticles. FTIR analysis revealed the presence of biomolecules attached on the surface of CuNPs. TEM analysis proven the synthesis of spherical shaped CuNPs with the average particle size of 73.50 ± 1.78 nm. Biosynthesized CuNPs showed maximum zone of inhibition against E. coli which was tends to be 20 mm. 51.48 % of DPPH free radical scavenging activity was observed by synthesized PVP coated CuNPs. As a result, this technology can be employed for the quick and environmentally friendly biosynthesis of stable copper nanoparticles with antibacterial and antioxidant activities with the size range from 10 to 100 nm, implying their potential application in the healthcare, clinical as well as pharmaceutical fields

Antioxidant Activities of Three Dihydrochalcone Glucosides from Leaves of Lithocarpus pachyphyllus

2004 ◽  
Vol 59 (7-8) ◽  
pp. 481-484 ◽  
Author(s):  
Wei-Min Yang ◽  
Ji-Kai Liu ◽  
Xiang-Dong Qin ◽  
Wan-Lin Wu ◽  
Zhi-He Chen
Keyword(s):  
Lipid Peroxidation ◽  
Inhibitory Concentration ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Liver Homogenate ◽  
Effective Concentration ◽  
Scavenging Activity ◽  
Sod Activity

AbstractIn vitro antioxidant activities of three sweet dihydrochalcone glucosides from the leaves of Lithocarpus pachyphyllus (Kurz) Rehd. (Fagaceae), trilobatin 2″-acetate (1), phloridzin (2) and trilobatin (3), were investigated. The IC50 (50% inhibitory concentration) values for compounds 1-3 of lipid peroxidation in rat liver homogenate were 261, 28, 88 μm, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 (50% effective concentration) values of 575, 167, 128 μm, and glutathione peroxidase (GSH-Px) activity with EC50 values of 717, 347, 129 μm, respectively, and showed only weak DPPH (1,1- diphenyl-2-picrylhydrazyl) radical scavenging activity

Pigments of Fungi. LVII. Structure and X-Ray Crystallographic Analysis of Dermocanarin 10, a New Naphthalene - Dihydroanthracenone Dimer from an Australian Dermocybe Toadstool

1999 ◽  
Vol 52 (9) ◽  
pp. 881 ◽  
Author(s):  
Melvyn Gill ◽  
Petra M. Millar ◽  
Evelin Raudies ◽  
Somphone Phonh-Axa ◽  
Jonathan M. White ◽  
...  
Keyword(s):  
Single Crystal ◽  
Structure Analysis ◽  
Spectroscopic Data ◽  
Crystallographic Analysis ◽  
Fungal Metabolite ◽  
X Ray ◽  
Absolute Stereochemistry

The structure and absolute stereochemistry of the fungal metabolite dermocanarin 10 (2), which differs from all previous members of the dermocanarin group by virtue of the connectivity between the anthraquinone and dimethoxynaphthol rings, is deduced from spectroscopic data and confirmed by a single-crystal X-ray structure analysis.

scholarly journals PHENOLIC COMPOUND FROM THE STEM BARK OF MANGGIS HUTAN (Garcinia bancana Miq.) AND THEIR ANTIOXIDANT ACTIVITY

2010 ◽  
Vol 9 (2) ◽  
pp. 321-327 ◽  
Author(s):  
Muharni Muharni ◽  
Supriyatna Supriyatna ◽  
Husein H. Bahti ◽  
Dachriyanus Dachriyanus
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Spectroscopic Data ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Stem Bark ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Ic50 Value ◽  
Reported Data

A phenolic compoud, (-)-epicatechin, was isolated from  the stem bark of Garcinia bancana. The structure of this compound was determined base on spectroscopic  data such as including UV, IR, 1-D, 2-D NMR, and comparison with the reported data. Biological activity of this compound at free radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and inhibitory xanthine oxidase(XO) activity showed that (-)- epicathechin active at two methods with IC50 value 8.1 and 8.6 mg/mL respectively.   Keywords: phenolic, (-)-epicatechin, Garcinia  bancana, DPPH, XO

scholarly journals ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF ALKALOID EXTRACT OF CUCUMIS TRIGONUS ROXB

2019 ◽  
pp. 44-48
Author(s):  
PRATIMA H
Keyword(s):  
Antibacterial Activity ◽  
Superoxide Radical ◽  
Inhibitory Concentration ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Peroxide Radical ◽  
Scavenging Activity ◽  
Alkaloid Extracts ◽  
Dpph Radical Scavenging

Objective: To evaluate the antioxidant and antibacterial efficiency of alkaloids of root, leaf, and fruit of Cucumis trigonus. Methods: The antioxidant and antibacterial properties of alkaloid extracts were assessed by ferric thiocynate (FTC), 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, hydrogen peroxide radical scavenging assay, superoxide radical scavenging activity and ferric reducing power were analyzed separately for its inhibition percentage at different concentration (20µg, 30µg, 40µg and 50µg/ml) and antibacterial activity by agar disc diffusion and minimum inhibitory concentration (MIC) against Staphylococcus aureus (MTCC Code-9886), Pseudomonas aeruginosa (MTCC Code-6458). Results: The highest percentage of extraction yield was observed in fruit followed by leaf and root. The maximum content of alkaloid was found in fruit and root compared to leaf. The scavenging efficiencies of the extracts increased with the increasing concentrations. Appreciable levels of total antioxidant activity by FTC (2.112±0.011%), DPPH radical scavenging activity (1.912±0.001%), superoxide radical scavenging activity (0.955±0.021%) and hydrogen peroxide radical scavenging activity (0.914±0.087 %) were observed at 50µg/ml of fruit extract. However, ferric reducing power was more in the root (0.893±0.0870%) compared to fruit (0.791±0.023%) and leaf (0.520±0.00 %) at 50µg/ml. The alkaloid extracts of root and fruit exhibited more antibacterial activity against Staphylococcus aureus (16.51±0.05 and 19.68±0.03 mm) and Pseudomonas aeruginosa (12.2±0.03 and14.2±0.06) at 100µg/ml than leaf. The minimum inhibitory concentration (MIC) of the root, leaf, and fruit was in the range of 3.125µg/ml to 35µg/ml for the pathogenic bacteria. Conclusion: Data from the present results revealed that the alkaloid extracts of fruit and root of C. trigonus show good antioxidant and antibacterial potential than leaf. Hence, may be explored for the formation of new antibacterial with antioxidant drugs.

On Efficient Synthesis, X‐Ray Analysis and DPPH Radical Scavenging Activity of Pyrazolone‐Based trans ‐Chalcones

2019 ◽  
Vol 4 (37) ◽  
pp. 11098-11102 ◽  
Author(s):  
Faryal Chaudhry ◽  
Nadia Asif ◽  
Sadia Naureen ◽  
Munawar Ali Munawar ◽  
Misbahul Ain Khan
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
Efficient Synthesis ◽  
Dpph Radical ◽  
Dpph Radical Scavenging Activity ◽  
X Ray ◽  
Dpph Radical Scavenging
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