A New Flavonol From Saussurea involucrata With Anti-Inflammatory Activity
2021 ◽
Vol 16
(5)
◽
pp. 1934578X2110076
Keyword(s):
Tnf Α
◽
A new flavonol named 6-(2'',3''-epoxy-3''-methylbutyl)-resokaempferol (1), together with five known compounds (2-6) were isolated from the EtOAc-soluble extract of the aerial part of Saussurea involucrata. Their structures were elucidated on the basis of spectroscopic methods. All compounds were evaluated for their anti-inflammatory effects by measuring the production of nitric oxide (NO) and TNF-α in vitro. Among them, compound 1 showed potential inhibitory activity on the production of NO and TNF-α in LPS-induced RAW 264.7 cells with IC50 values of 48.0 ± 1.5 and 41.4 ± 1.7 µM, respectively.
Keyword(s):
2018 ◽
Vol 11
(4)
◽
pp. 149
◽
Keyword(s):
Fermentation Improves Anti-Inflammatory Effect of Sipjeondaebotang on LPS-Stimulated RAW 264.7 Cells
2012 ◽
Vol 40
(04)
◽
pp. 813-831
◽
2018 ◽
Vol 15
(2)
◽
pp. 26
Keyword(s):