scholarly journals Incidence, Aetiology, and Associated Fracture Patterns of Infraorbital Nerve Injuries Following Zygomaticomaxillary Complex Fractures: A Retrospective Analysis of 272 Patients

2021 ◽  
pp. 194338752110225
Author(s):  
Kathia Dubron ◽  
Maarten Verbist ◽  
Eman Shaheen ◽  
Titiaan Jacob Dormaar ◽  
Reinhilde Jacobs ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Interpersonal Violence ◽  
Fracture Line ◽  
Infraorbital Nerve ◽  
Type B ◽  
Treatment Methods ◽  
Infraorbital Canal ◽  
Pain Symptoms ◽  
Fracture Types ◽  
Zygomaticomaxillary Complex

Study Design: Retrospective study. Objective: Zygomaticomaxillary complex (ZMC) fractures are common facial injuries with heterogeneity regarding aetiologies, fracture types, infraorbital nerve (ION) involvement, and treatment methods. The aim of this study was to identify associations between aetiologies, fracture types, and neurological complications. Additionally, treatment methods and recovery time were investigated. Methods: Medical files of 272 patients with unilateral and bilateral ZMC fractures were reviewed, whose cases were managed from January 2014 to January 2019 at the Department of Oral and Maxillofacial Surgery, University hospitals Leuven, Belgium. History of ION sensory dysfunction and facial nerve motoric dysfunction were noted during follow-up. Results: ION hypoaesthesia incidence was 37.3%, with the main causes being fall accidents, road traffic accidents, and interpersonal violence. Significant predictors of ION hypoaesthesia were Zingg type B fractures ( P = 0.003), fracture line course through the infraorbital canal ( P < .001), orbital floor fracture ( P < 0.001), and ZMC dislocation or mobility ( P = 0.001). Conclusion: Of all ZMC fractures, 37.3% exhibited ION hypoaesthesia. Only ZMC Zingg type B fractures (74.0%) were significantly more associated with ION hypoaesthesia. ION hypoesthesia was more likely (OR = 2.707) when the fracture line course ran through the infraorbital canal, and was less dependent on the degree of displacement. Neuropathic pain symptoms developed after ZMC fractures in 2.2% patients, posing a treatment challenge. Neuropathic pain symptoms were slightly more common among women, and were associated only with type B or C fractures. No other parameters were found to predict the outcome of this post-traumatic neuropathic pain condition.

Neuropathic pain symptoms in inflammatory hand osteoarthritis (OA) lower quality of life and may require another approach than anti-inflammatory treatment

2021 ◽  
Vol 29 ◽  
pp. S237-S238
Author(s):  
C. van der Meulen ◽  
L.A. van de Stadt ◽  
F.P. Kroon ◽  
M.C. Kortekaas ◽  
A. Boonen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Hand Osteoarthritis ◽  
Anti Inflammatory ◽  
Pain Symptoms

NMDA Antagonist Peptide Supplementation Enhances Pain Alleviation by Adrenal Medullary Transplants

2005 ◽  
Vol 14 (4) ◽  
pp. 203-211 ◽  
Author(s):  
Farinaz Nasirinezhad ◽  
Jacqueline Sagen
Keyword(s):  
Neuropathic Pain ◽  
Animal Models ◽  
Striated Muscle ◽  
Thermal Hyperalgesia ◽  
Nmda Antagonist ◽  
Nmda Receptor Antagonist ◽  
Intraplantar Injection ◽  
Amino Acid Peptide ◽  
Spinal Subarachnoid Space ◽  
Pain Symptoms

Spinal transplantation of adrenal medullary chromaffin cells has been shown to decrease pain responses in several animal models. Improved potency may be possible by engineering cells to produce greater levels of naturally derived analgesics. As an initial screen for potential candidates, adrenal medullary transplants were evaluated in combination with exogenously administered neuropeptides in rodent pain models. Histogranin is a 15-amino acid peptide that exhibits NMDA receptor antagonist activity. The stable derivative [Ser1]histogranin (SHG) can attenuate pain symptoms in some animal models. The formalin model for neurogenic inflammatory pain and the chronic constriction injury (CCI) model for neuropathic pain were used to evaluate the combined effects of chromaffin cell transplantation and intrathecal (IT) SHG injections. Animals were implanted with either adrenal medullary or control striated muscle tissue in the spinal subarachnoid space. For evaluation of formalin responses, animals were pretreated with SHG (0.5, 1.0, 3.0 μg) followed by an intraplantar injection of formalin, and flinching responses were quantified. Pretreatment with SHG had no significant effect on flinching behavior in control animals at lower doses, with incomplete attenuation only at the highest dose. In contrast, 0.5 μg SHG significantly reduced flinching responses in animals with adrenal medullary transplants, and 1.0 μg nearly completely eliminated flinching in these animals in the tonic phase. For evaluation of effects on neuropathic pain, animals received transplants 1 week following CCI, and were tested for thermal and mechanical hyperalgesia and cold allodynia before and following SHG treatment. The addition of low doses of SHG nearly completely eliminated neuropathic pain symptoms in adrenal medullary transplanted animals, while in control transplanted animals only thermal hyperalgesia was attenuated, at the highest dose of SHG. These results suggest that SHG can augment adrenal medullary transplants, and the combination may result in improved effectiveness and range in the treatment of chronic pain syndromes.

scholarly journals Possible factors for ankle fractures

2010 ◽  
Vol 67 (3) ◽  
pp. 225-228 ◽  
Author(s):  
Dejan Tabakovic ◽  
Radovan Manojlovic ◽  
Marko Kadija ◽  
Mihailo Ille ◽  
Goran Turkovic ◽  
...  
Keyword(s):  
Body Weight ◽  
Significant Risk ◽  
Ankle Fractures ◽  
Type B ◽  
Physical Exercises ◽  
Appropriate Treatment ◽  
Fracture Body ◽  
Type C ◽  
Fracture Types

Background/Aim. Classification of ankle fractures is commonly used for selecting an appropriate treatment and prognosing an outcome of definite management. One of the most used classifications is the Danis-Weber classification. To the best of our knowledge, in the available literature, there are no parameters affecting specific types of ankle fractures according to the Danis-Weber classification. The aim of this study was to analyze the correlation of the following parameters: age, body weight, body mass index (BMI), height, osteoporosis, osteopenia and physical exercises with specific types of ankle fractures using the Danis-Weber classification. Methods. A total of 85 patients grouped by the Danis-Weber classification fracture types were analyzed and the significance of certain parameters for specific types of ankle fractures was established. Results. The proportion of females was significantly higher (p < 0.001) with a significantly higher age (59.9 years, SD ? 14.2) in relation to males (45.1 years, SD ? 12.8) (p < 0.0001). Type A fracture was most frequent in the younger patients (34.2 years, SD ? 8.6), and those with increased physical exercises (p = 0.020). In type B fracture, the risk factor was osteoporosis (p = 0.0180), while in type C fracture, body weight (p = 0.017) and osteoporosis (p = 0.004) were significant parameters. Conclusion. Statistical analysis using the Danis-Weber classification reveals that there are certain parameters suggesting significant risk factors for specific types of ankle fractures.

scholarly journals Does the Lag Time Between Injury and Treatment Affect Recovery of Infraorbital Nerve Disturbances in Zygomaticomaxillary Complex Fractures?

2020 ◽  
Vol 13 (2) ◽  
pp. 105-108
Author(s):  
Reza Tabrizi ◽  
Majid Neamati ◽  
Sara Rajabloo ◽  
Fatemeh Latifi
Keyword(s):  
Lag Time ◽  
Cross Sectional Study ◽  
Open Reduction Internal Fixation ◽  
The Self ◽  
Infraorbital Nerve ◽  
Sectional Study ◽  
Analog Scale ◽  
Cross Sectional ◽  
Zygomaticomaxillary Complex ◽  
Delay In Treatment

Study Design: A cross-sectional study. Objective: Neurosensory disturbances (NSDs) of the infraorbital nerve (ION) are common following orbito-zygomaticomaxillary complex (ZMC) fractures. This study aimed to evaluate the effect of lag time between injury and treatment on recovery of NSDs of the ION following open reduction internal fixation. Methods: Subjects who had ZMC fracture and paresthesia were studied. The lag time between injury and treatment was considered as the predictive factor. The level of NSDs according to the brush test and two-point discrimination (TPD) test and self-reported NSD were the outcomes of this study. Self-reported NSD was quantified using a visual analog scale. Results: Forty patients were studied. The lag time between injury and treatment had a significant correlation with the result of the TPD test and the self-reported level of NSD. In 73.6% of patients who had NSD following ZMC fracture, every 1-day delay in treatment increased the incidence of self-reported paresthesia by 0.44. Conclusions: It seems, a delay in treatment of ZMC fractures increased the risk of NSD.

scholarly journals (−)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury

Life Sciences ◽  
2019 ◽  
Vol 227 ◽  
pp. 122-128 ◽  
Author(s):  
L.T. Melo ◽  
V. Panchalingam ◽  
P. Cherkas ◽  
A.R. Campos ◽  
L. Avivi-Arber ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Infraorbital Nerve ◽  
Central Sensitisation

scholarly journals The Prevalence of Protrusion of Infraorbital Nerve into Maxillary Sinus Identified on CT Scan of the Paranasal Sinuses at a Tertiary Hospital in Nepal

2018 ◽  
Vol 8 (1) ◽  
pp. 7-12
Author(s):  
Rupesh Gautam ◽  
Deepak Adhikari ◽  
Matrika Dhital ◽  
Sudip Thakur ◽  
Bhawana Adhikari
Keyword(s):  
Ct Scan ◽  
Maxillary Sinus ◽  
Paranasal Sinuses ◽  
Tertiary Hospital ◽  
Sinus Surgery ◽  
Infraorbital Nerve ◽  
Median Length ◽  
Accidental Injury ◽  
Medical College ◽  
Infraorbital Canal

Introduction: The variation in the course of infraorbital canal and protrusion of the infraorbital nerve through it to the maxillary sinus may lead to its accidental injury during reconstructive or endoscopic sinus surgery. Preoperative identification of this variant will prevent unintended injuries. Methods: A retrospective study of 307 patients who underwent CT scan study of the paranasal sinuses at Chitwan Medical College, Nepal was conducted. The protrusion of infraorbital nerve to the maxillary sinus was identified and the length of the bony septum along with the infraorbital nerve was measured. It was further classified as Class I to III according to the length of the septum.Results: The prevalence of protrusion of inferior orbital nerve in our study was 11.40 % and bilateral protrusion was 5.8 %.  The median length of the protruding component along with the septum was 4.9 mm. Conclusion: Preoperative identification of the normal protrusion of infraorbital nerve to the maxillary sinus will prevent accidental injuries during sinus surgery. CT scan of the paranasal sinus would be the modality of choice for identification of this variant. 

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