scholarly journals Treatment of Patellofemoral Chondral Lesions Using Microfractures Associated with a Chitosan Scaffold: Mid-Term Clinical and Radiological Results

Cartilage ◽  
2021 ◽  
pp. 194760352110115
Author(s):  
Rafael Calvo ◽  
David Figueroa ◽  
Francisco Figueroa ◽  
Jose Bravo ◽  
Martin Contreras ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Symptomatic Improvement ◽  
Rank Test ◽  
Osteochondral Lesions ◽  
Full Thickness ◽  
Chitosan Scaffold ◽  
Radiological Results ◽  
Signed Rank Test ◽  
Magnetic Resonance Imaging Mri ◽  
Clinical And Radiological Results

Objective To assess the clinical and radiological results of patellofemoral osteochondral lesions treated with microfractures associated with a chitosan scaffold. Design A retrospective observational analytical study was performed. Fifteen patients with full-thickness patellofemoral osteochondral lesions were included. Quantity and quality of the reparation cartilage was assessed with the MOCART 2.0 score on a postoperative magnetic resonance imaging (MRI), and clinical outcomes were evaluated with pre- and postoperative Kujala score tests. Shapiro-Wilk test for normality was applied as well as Wilcoxon’s signed rank test and Kruskal-Wallis H test for clinical scores within subjects and patella versus trochlea subgroups comparisons. Analysis of variance test was used for imaging subgroups comparison, with P < 0.05 defined as statistical significance. Results Mean follow-up was 33.36 months (range 24-60 months). Postoperative Kujala scores improved an average of 19 points compared with the preoperative state (SE = 17.6; P < 0.001). No statistical difference was found through the clinical location assessment ( P = 0.756), as well as the cartilage imaging assessment ( P = 0.756). The mean MOCART 2.0 scale was 67.67 (range 50-85). Conclusions Treating full-thickness patellofemoral osteochondral lesions with microfractures associated with a chitosan scaffold proved to be effective regarding defect filling and symptomatic improvement.

scholarly journals The Dancing Cord: Inherent Spinal Cord Motion and Its Effect on Cord Dose in Spine Stereotactic Body Radiation Therapy

Neurosurgery ◽  
2020 ◽  
Author(s):  
Murat Alp Oztek ◽  
Nina A Mayr ◽  
Mahmud Mossa-Basha ◽  
Matthew Nyflot ◽  
Patricia A Sponseller ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Jaccard Index ◽  
Rank Test ◽  
Spine Metastasis ◽  
Dice Coefficient ◽  
Signed Rank ◽  
Dose Planning ◽  
Dose Limits ◽  
Signed Rank Test ◽  
Magnetic Resonance Imaging Mri

Abstract BACKGROUND Spinal cord dose limits are critically important for the safe practice of spine stereotactic body radiotherapy (SBRT). However, the effect of inherent spinal cord motion on cord dose in SBRT is unknown. OBJECTIVE To assess the effects of cord motion on spinal cord dose in SBRT. METHODS Dynamic balanced fast field echo (BFFE) magnetic resonance imaging (MRI) was obtained in 21 spine metastasis patients treated with SBRT. Planning computed tomography (CT), conventional static T2-weighted MRI, BFFE MRI, and dose planning data were coregistered. Spinal cord from the dynamic BFFE images (corddyn) was compared with the T2-weighted MRI (cordstat) to analyze motion of corddyn beyond the cordstat (Dice coefficient, Jaccard index), and beyond cordstat with added planning organ at risk volume (PRV) margins. Cord dose was compared between cordstat, and corddyn (Wilcoxon signed-rank test). RESULTS Dice coefficient (0.70-0.95, median 0.87) and Jaccard index (0.54-0.90, median 0.77) demonstrated motion of corddyn beyond cordstat. In 62% of the patients (13/21), the dose to corddyn exceeded that of cordstat by 0.6% to 13.8% (median 4.3%). The corddyn spatially excursed outside the 1-mm PRV margin of cordstat in 9 patients (43%); among these dose to corddyn exceeded dose to cordstat &gt;+ 1-mm PRV margin in 78% of the patients (7/9). Corddyn did not excurse outside the 1.5-mm or 2-mm PRV cord cordstat margin. CONCLUSION Spinal cord motion may contribute to increases in radiation dose to the cord from SBRT for spine metastasis. A PRV margin of at least 1.5 to 2 mm surrounding the cord should be strongly considered to account for inherent spinal cord motion.

scholarly journals Comparative Study on the Efficacy of Anorganic Bovine Bone (Bio-Oss) and Nanocrystalline Hydroxyapatite (Ostim) in Maxillary Sinus Floor Augmentation

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Adileh Shirmohammadi ◽  
Leila Roshangar ◽  
Mohammad Taghi Chitsazi ◽  
Reza Pourabbas ◽  
Masoumeh Faramarzie ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Rank Test ◽  
Bovine Bone ◽  
Sinus Augmentation ◽  
Implant Placement ◽  
Nanocrystalline Hydroxyapatite ◽  
Signed Rank Test ◽  
Sinus Floor Augmentation ◽  
Sinus Floor ◽  
The Difference

Purpose. The aim of this study was to evaluate the efficacy of anorganic bovine bone (Bio-Oss) in comparison with nanocrystalline hydroxyapatite (Ostim) in sinus floor augmentation. Methods. Ten patients aged 40–80 were selected. All the patients needed sinus floor augmentation due to insufficient bone for simultaneous implant placement. The patients underwent panoramic radiography and cone beam computed tomography (CBCT) prior to surgical procedure. After lifting the sinus membrane, Bio-Oss and Ostim are randomly grafted at one of the two sides. Biopsies were obtained from areas identified 5 months after the surgery and before implant placement and then were prepared for histological analysis. Statistical analysis was performed with nonparametric Wilcoxon signed-rank test for comparison of histological and radiological parameters between the two groups. Results. Histological findings revealed a significant increase in percentages of new bone in the Ostim group (P=0.015). Furthermore, new bone density was greater with Ostim compared to Bio-Oss (P=0.038); however, the difference in height increase after surgery did not reach statistical significance (P=0.191). Conclusion. Despite the limitations of this trial, Ostim and Bio-Oss are useful biomaterials in sinus augmentation and Ostim seems to be even more effective in new bone formation.

scholarly journals Effects of a periodized functional strength training program (FST) on Functional Movement Screen (FMS) in physical education students

2020 ◽  
Vol 24 (3) ◽  
pp. 162-167
Author(s):  
Michał Sawczyn
Keyword(s):  
Physical Education ◽  
Strength Training ◽  
Statistical Significance ◽  
Rank Test ◽  
Training Intervention ◽  
Control Group ◽  
Before And After ◽  
Signed Rank Test ◽  
The Difference ◽  
Experimental Group

Background and Study Aim: To examine the effects of periodized functional strength training (FST) on FMS scores of sport university students with higher risk of injury. Material and Methods: Thirty three  participants (age 21.6±1.3 years, height 177.8±6.9 m, mass 80.4±7.7 kg) with FMS total score ≤ 14 were selected from eighty two volunteered students of University of Physical Education and Sport in Gdańsk and randomly assigned to experimental group (n=16) and control group (n=17). The FMS test was conducted one week before and one week after the 12 week training intervention. The experimental group participated in FST program through 12 weeks. The control group did not engaged in any additional physical activity than planned in their course of study. The  collected  data  were  analysed  using Statistica 13.3 pl (StatSoft Inc). Wilcoxon signed rank test was used to establish the statistical significance of the difference between FMS total scores within each group and Mann Whitney U test between groups before and after the 12 week training intervention. Results: 45 % of volunteers in the first FMS testing showed total scores ≤14. The experimental group that participated in FST program changed significantly FMS total scores after 12 weeks (p<0.05). There were also significant differences in FMS total score between groups after the experiment (p<0.05). Conclusions: There is a need for injury prevention programs for students of University of Physical Education and Sport in Gdańsk. It is clear from this study that FST is effective in improving FMS total score in students with cut off score ≤14.

Tests for Probability of A Reaction and Difference Between Reactions Where Treatment Increases Marker-Values of Particular Subjects but Decreases Others

2020 ◽  
Author(s):  
Torao Ishida ◽  
Ken Takagi ◽  
Gui-feng Wang ◽  
Nobuyuki Tanahashi ◽  
Jun Kawanokuchi ◽  
...  
Keyword(s):  
Statistical Significance ◽  
T Test ◽  
Rank Test ◽  
Combination Antiretroviral Therapy ◽  
Cd4 Counts ◽  
Paired Samples ◽  
Signed Rank ◽  
Immunodeficiency Virus ◽  
Signed Rank Test ◽  
The Difference

Abstract PD-1 has a role in regulating the response of the immune system to the cells of the human body. Paris et al. reported that combination antiretroviral therapy did not change % CD4+ of PD-1highCTLA-4lowCD127high early/intermediated T cells of human immunodeficiency virus infected patients but increased the percent of the marker limited to initial CD4 counts <200 with Wilcoxon signed-rank test. We hypothesized that the treatment increased the marker value in patients whose initial marker value is less than a particular value and decreased the marker value in other patients and that the test misleadingly concluded that the treatment did not change the marker value. General subgroup analyses correctly estimate the statistical significance of such a reaction or difference between such reactions only when the reaction of both of subgroups or both difference between such subgroups is statistically significant. We propose Ishida’ t-test for paired samples that can correctly judge the probability without division of the group into subgroups, and Ishida’ t-test for unpaired samples that can correctly judge the statistical significance of the difference between such reactions. We also showed that many treatments cause such increase and decrease of marker values relating PD-1 of subjects.

The Influence of Breast Cancer on the Distribution of Cherry Angiomas on the Anterior Thoracic Wall: A Case Series Study

Dermatology ◽  
2018 ◽  
Vol 235 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Antonio Guastafierro ◽  
Vincenzo Verdura ◽  
Bruno Di Pace ◽  
Mario Faenza ◽  
Corrado Rubino
Keyword(s):  
Breast Cancer ◽  
Statistical Significance ◽  
Case Series ◽  
Thoracic Wall ◽  
Rank Test ◽  
P Value ◽  
Unilateral Breast Cancer ◽  
Case Series Study ◽  
Signed Rank Test ◽  
The Difference

Background/Aims: Cherry angiomas (CAs) are one of the most common vascular manifestations of the skin. By and large, these benign lesions often only represent an aesthetic problem. In the literature, few authors have focused on the pathogenesis of these lesions, and some risk factors have been identified, such as the presence of cutaneous and non-skin neoplasias. In this study, the correlation between the distribution of CAs and breast cancer was investigated. Methods: We carried out a study whereby 50 women with unilateral breast cancer and the presence of CAs on the anterior thoracic wall were evaluated, with a particular focus on the difference in the number of CAs between the two haemithoraces. The data was elaborated using the Wilcoxon signed-rank test in order to evaluate whether there was a statistical significance in the distribution of CAs. Results: In 31 patients we found that the number of CAs was greater on the cancerous breast than on the contralateral one (p value <0.0001). This was confirmed both in the group of patients suffering from ductal breast cancer and in the group with early invasive breast tumours. Conclusion: It is not clear whether CAs develop prior to or following breast cancer, indicating the possibility that this cutaneous manifestation could take on a predictive, prognostic development or represent only an epiphenomenon. Further in-depth studies into the pathogenesis of CAs and the relationship with breast cancer could lead to noteworthy diagnostic-therapeutic advances.

scholarly journals A Visual Scan Analysis Protocol for Postural Assessment at School in Young Students

2020 ◽  
Vol 17 (8) ◽  
pp. 2915 ◽  
Author(s):  
Maria E. Alves ◽  
Daniel A. Marinho ◽  
Duarte N. Carneiro ◽  
Jorge Alves ◽  
Pedro Forte ◽  
...  
Keyword(s):  
Middle School ◽  
Middle School Students ◽  
Statistical Significance ◽  
School Context ◽  
Rank Test ◽  
School Students ◽  
Perfect Agreement ◽  
X Ray ◽  
Signed Rank ◽  
Signed Rank Test

The aim of this study was to compare the X-ray diagnosis with a non-invasive method for spine alignment assessment adopting a visual scan analysis with a plumb line and simetograph in middle-school students. The sample of this study was composed of 31 males and 50 females with an average age of 14.23 (± 3.11) years. The visual scan analysis was assessed at a school; whereas, the X-ray was performed in a hospital. The Wilcoxon signed-rank test was used to assess the differences between methods and scoliosis classifications (non-accentuated <10º and scoliosis >10º), and the Kappa was used to assess the agreement between methods. The comparisons between the methods revealed non-significant differences (z = −0.577; p = 0.564), with almost perfect agreement between tests (K = 0.821; p < 0.001). Moreover, no statistical significance was observed between methods by the scoliosis classification (z = −1.000; p = 0.317), with almost perfect agreement between tests (K = 0.888; p < 0.001). This research supports the conclusion that there are no significant differences between the two methods. Therefore, it should be highlighted that this field test should be used by physical education teachers in their classes, or in a school context, in order to determine misalignments or scoliosis prevalence among middle-school students.

scholarly journals Comparing Forecast Skill

2014 ◽  
Vol 142 (12) ◽  
pp. 4658-4678 ◽  
Author(s):  
Timothy DelSole ◽  
Michael K. Tippett
Keyword(s):  
Climate Model ◽  
Permutation Test ◽  
Statistical Significance ◽  
Forecast Skill ◽  
Sign Test ◽  
Rank Test ◽  
Basic Question ◽  
Seasonal Forecasts ◽  
The North ◽  
Signed Rank Test

Abstract A basic question in forecasting is whether one prediction system is more skillful than another. Some commonly used statistical significance tests cannot answer this question correctly if the skills are computed on a common period or using a common set of observations, because these tests do not account for correlations between sample skill estimates. Furthermore, the results of these tests are biased toward indicating no difference in skill, a fact that has important consequences for forecast improvement. This paper shows that the magnitude of bias is characterized by a few parameters such as sample size and correlation between forecasts and their errors, which, surprisingly, can be estimated from data. The bias is substantial for typical seasonal forecasts, implying that familiar tests may wrongly judge that differences in seasonal forecast skill are insignificant. Four tests that are appropriate for assessing differences in skill over a common period are reviewed. These tests are based on the sign test, the Wilcoxon signed-rank test, the Morgan–Granger–Newbold test, and a permutation test. These techniques are applied to ENSO hindcasts from the North American Multimodel Ensemble and reveal that the Climate Forecast System, version 2, and the Canadian Climate Model, version 3 (CanCM3), outperform other models in the sense that their squared error is less than that of other single models more frequently. It should be recognized that while certain models may be superior in a certain sense for a particular period and variable, combinations of forecasts are often significantly more skillful than a single model alone. In fact, the multimodel mean significantly outperforms all single models.

scholarly journals Vitrectomy for laser-induced full-thickness macular hole

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xin Wang ◽  
Ting Zhang ◽  
Rui Jiang ◽  
Gezhi Xu
Keyword(s):  
Visual Acuity ◽  
Yttrium Aluminum Garnet ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Internal Limiting Membrane ◽  
Rank Test ◽  
Retinal Layer ◽  
Full Thickness ◽  
Before And After ◽  
Signed Rank Test

Abstract Background To report the structure and visual outcomes of pars plana vitrectomy (PPV) for laser-induced full-thickness macular holes (MHs). Methods This retrospective study enrolled 10 patients who underwent vitrectomy for MHs caused by laser injury. Best corrected visual acuity (BCVA), macular spectral-domain optical coherence tomography (OCT) and OCT angiography (OCTA) were used for assessment. Results Four patients were injured by unexpected expose of an yttrium aluminum garnet (YAG) laser, and six patients were accidentally injured by a handheld laser. The MH minimum diameters (MDs) ranged from 55 to 966 μm (mean = 548.00 ± 286.10 μm), and BCVA ranged from 20/400 to 20/50 (mean = logMAR 0.87 ± 0.29) preoperatively. All 10 eyes underwent PPV, internal limiting membrane (ILM) peeling, and gas tamponade. All eyes demonstrated closure of the MH with different degrees of discontinuity of the outer layer of the retina, and four eyes exhibited serious retinal pigment epithelium (RPE) destruction. Postoperative BCVA values were significantly improved (mean = logMAR 0.55 ± 0.33; P = 0.032, t = 2.234). The mean BCVA of the destroyed RPE group was significantly worse than that of the non-destroyed RPE group both before and after surgery (P = 0.019; Wilcoxon signed rank test). Further, OCTA indicated choroidal ischemia in the laser-induced MHs. Conclusion Vitrectomy can be successful in closing laser-induced full-thickness MHs and improving visual acuity. However, If RPE/choroid is involved in laser damage in addition to the outer retinal layer, this may indicate poor visual prognosis.

scholarly journals Determinants of Salary Expectations – A Survey of Accounting and Controlling Students

2020 ◽  
Vol 11 (37) ◽  
pp. 15-28
Author(s):  
Bartosz Kurek ◽  
Ireneusz Górowski
Keyword(s):  
Foreign Language ◽  
Linear Models ◽  
Statistical Significance ◽  
Research Problem ◽  
Policy Implications ◽  
Male Students ◽  
Rank Test ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Salary Expectations

RESEARCH OBJECTIVE: The aim of the paper is to identify and quantify selected salary expectations determinants (including gender) of Accounting and Controlling students at Cracow University of Economics. THE RESEARCH PROBLEM AND METHODS: We conduct a survey of expected salaries among students . We use Shapiro-Wilk W test and Wilcoxon signed-rank test for initial analysis. We then build econometric linear models in which salary expectations are dependent variables, whereas GPA, holding a foreign language certificate, gender and age are independent variables. We estimate these models by OLS. We use Huber/White robust standard errors to assess statistical significance of each parameter. THE PROCESS OF ARGUMENTATION: Graduates of accounting pro­grammes are sought at the labour market. For cognitive purposes and edu­cational policy implications it is of utmost importance to understand which observable factors differentiate students in their salaries’ expectations. RESEARCH RESULTS: We find a number of variables that are statistically significant and associated with the expected salary. Higher salaries for graduates of Accounting and Controlling major are expected by: students with lower GPA, holders of a foreign language certificate, male students, younger students. On the contrary, lower salaries are expected by students with higher GPA, students who do not hold a foreign language certificate, female students, older students. CONCLUSIONS, INNOVATIONS, AND RECOMMENDATIONS: Students differ among themselves – thus we observe various salary expectations. Nonetheless, some of the obtained results are puzzling. We find that female stu­dents demand lower salaries. Similarly it is surprising that students with lower GPA expect higher salaries. As a result, we recommend to further investigate determinants of salary expectations.

Sign in / Sign up

Export Citation Format

Share Document