scholarly journals Dapagliflozin improves cardiovascular risk factors in Emirati patients with T2DM

2021 ◽  
Vol 12 ◽  
pp. 204201882199536
Author(s):  
Aml Mohamed Nada ◽  
Mariam Adel Younan
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Heart Rate ◽  
Cardiovascular Risk ◽  
Body Mass ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Glycosylated Hemoglobin ◽  
Rate Pressure Product ◽  
Fasting Plasma

Background: Dapagliflozin is a sodium–glucose co transporter-2 inhibitor that proved efficacy in reduction of blood glucose level through extrusion of glucose in urine. It is used in treatment of type 2 diabetes mellitus (T2DM). It also has reported cardiovascular and renal benefits in patients with T2DM. Data are very limited about its effects in Emirati patients with diabetes. Our aim was to evaluate dapagliflozin treatment in Emirati patients with T2DM. Patients and methods: This is a retrospective study involving 89 diabetes patients who were using dapagliflozin 10 mg once daily as add-on therapy for 12 months. All patients had T2DM, aged over 18 years and had an estimated glomerular filtration rate (eGFR) over 60 ml/min/1.73 m². Body weight, height, body mass index, sitting blood pressure and heart rate were collected. Fasting plasma glucose, glycosylated hemoglobin (HbA1c), lipid profile and other available biochemical parameters, for example, creatinine, blood urea nitrogen, and urine albumin/creatinine ratio were traced from medical records and eGFR was calculated. Results: Patients were aged 62.3 ± 9.4 years with a median duration of diabetes of 15 (10–20) years. Data were analyzed before, at 6 months and 12 months of treatment. Fasting plasma glucose, HbA1c, body mass index, systolic and diastolic blood pressure significantly decreased ( p = 0.002, p < 0.0005, p < 0.002, p < 0.0005, p < 0.0005, respectively). The median reduction of HbA1c was 0.7% (0.2–1.2) and 0.9% (0.5–1.8) at 6 and 12 months, respectively. Systolic blood pressure decreased by a median of 7 mmHg (4–20 mmHg) and 9 mmHg (1–10 mmHg) on the 6th and 12th month of treatment, respectively, while the diastolic decreased by a median of 3 mmHg (4 to 10 mmHg) and 6 mmHg (1–10 mmHg); without increase in heart rate ( p = 0.188). A significant reduction of body mass index, C-reactive protein and rate pressure product was noticed ( p = 0.002, p = 0.001, p < 0.0005, respectively). No decline in eGFR or microalbuminuria was noticed. Stage I chronic kidney disease with eGFR < 90 ml/min/1.73 m² showed continuous progressive reduction of HbA1c without a significant change in other variables. Conclusion: Our data indicate improved cardiovascular risk profile in dapagliflozin-treated Emirati patients with T2DM.

Abstract #713: Age Dependent Relationship Between Body Mass Index and Fasting Plasma Glucose in South-Western Nigeria

2016 ◽  
Vol 22 ◽  
pp. 152-153
Author(s):  
Taiwo Raimi ◽  
Olatunde Odusan ◽  
Olufemi Fasanmade ◽  
Adesina Odewabi ◽  
Augustine Ohwovoriole
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Dependent Relationship ◽  
Fasting Plasma ◽  
Age Dependent

scholarly journals Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0189115 ◽  
Author(s):  
Jiunn-Diann Lin ◽  
Chun-Hsien Hsu ◽  
Chung-Ze Wu ◽  
An-Tsz Hsieh ◽  
Chang-Hsun Hsieh ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Glucose Level ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Plasma Glucose Level ◽  
Fasting Plasma Glucose Level ◽  
Fasting Plasma

Associations between being overweight, variability in heart rate, and well-being in the young men

2010 ◽  
Vol 20 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Klaus Schmid ◽  
Jana Schönlebe ◽  
Hans Drexler ◽  
Michael Mueck-Weymann
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Heart Rate ◽  
Cardiovascular Risk ◽  
Diastolic Blood Pressure ◽  
Sleep Duration ◽  
Body Mass ◽  
Young Men ◽  
Well Being ◽  
Sporting Activities

AbstractAbnormalities of the autonomic nervous system have been repeatedly shown in hypertension. We studied the associations between being overweight, blood pressure, cardiac vagal tone as measured by variability in heart rate, and well-being in a large cohort of young men. We hypothesised an inverse correlation between body mass index and the variability in heart rate. Further, we assessed systolic and diastolic blood pressure as traditional indicators of cardiovascular risk. Exclusion criteria were the use of drugs or pharmaceuticals. The following data from 786 men with a mean age of 19.4 years (standard deviation = 1.4, with a range from 16 to 24 years) were analysed in a cross-sectional study: body mass index, sleep duration, sporting activities, psychological well-being, blood pressure, heart rate, and variability in heart rate. Despite the young age of the men in this study, increased values for the body mass index were already associated with a shift in sympathovagal balance trending towards sympathetic dominance. There was also a significant positive correlation between body mass index and systolic and diastolic blood pressure. A multiple stepwise regression analysis showed that significant factors, which were associated with variability in heart rate, were body mass index and sporting activities. In addition, sporting activity and sleep duration had a significant positive impact on psychological well-being. Even in young men, being overweight is associated with increased cardiovascular risk, especially an increased sympathetic and/or lowered cardiovascular tone and increased blood pressure. Our study gives additional motivation for the early prevention and treatment of obesity in childhood and adolescence.

scholarly journals Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome—A Systematic Review

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2291 ◽  
Author(s):  
Zhang ◽  
Mocanu ◽  
Cai ◽  
Dang ◽  
Slater ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Insulin Sensitivity ◽  
Body Mass ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Metabolic Parameters ◽  
Fasting Plasma

Fecal microbiota transplantation (FMT) is a gut microbial-modulation strategy that has been investigated for the treatment of a variety of human diseases, including obesity-associated metabolic disorders. This study appraises current literature and provides an overview of the effectiveness and limitations of FMT as a potential therapeutic strategy for obesity and metabolic syndrome (MS). Five electronic databases and two gray literature sources were searched up to 10 December 2018. All interventional and observational studies that contained information on the relevant population (adult patients with obesity and MS), intervention (receiving allogeneic FMT) and outcomes (metabolic parameters) were eligible. From 1096 unique citations, three randomized placebo-controlled studies (76 patients with obesity and MS, body mass index = 34.8 ± 4.1 kg/m2, fasting plasma glucose = 5.8 ± 0.7 mmol/L) were included for review. Studies reported mixed results with regards to improvement in metabolic parameters. Two studies reported improved peripheral insulin sensitivity (rate of glucose disappearance, RD) at 6 weeks in patients receiving donor FMT versus patients receiving the placebo control. In addition, one study observed lower HbA1c levels in FMT patients at 6 weeks. No differences in fasting plasma glucose, hepatic insulin sensitivity, body mass index (BMI), or cholesterol markers were observed between two groups across all included studies. While promising, the influence of FMT on long-term clinical endpoints needs to be further explored. Future studies are also required to better understand the mechanisms through which changes in gut microbial ecology and engraftment of microbiota affect metabolic outcomes for patients with obesity and MS. In addition, further research is needed to better define the optimal fecal microbial preparation, dosing, and method of delivery.

Serum total sialic acid, a reputed cardiovascular risk factor, and its relationship to lipids, plasma fasting insulin, blood pressure and body mass index in normal individuals

1998 ◽  
Vol 95 (1) ◽  
pp. 53-57 ◽  
Author(s):  
M. CROOK ◽  
P. LUMB ◽  
V. ANDREWS ◽  
R. SWAMINATHAN
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Sialic Acid ◽  
Serum Cholesterol ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Fasting Insulin ◽  
Fasting Serum ◽  
Total Sialic Acid ◽  
Fasting Plasma

1.Serum sialic acid is a reputed cardiovascular risk factor, but the reason why this is so is not clear. We therefore studied its relationship with other known cardiovascular risk factors (particularly those associated with insulin resistance) in 100 healthy young subjects (54 females and 46 males, age 20.7±0.89 years). 2.There was a significant univariate correlation between serum total sialic acid and fasting plasma insulin. Serum total sialic acid also correlated with fasting plasma glucose concentration and serum cholesterol and triacylglycerol. 3.In females there was a strong univariate correlation between serum total sialic acid and plasma fasting insulin and glucose concentrations, although in males there was a weaker univariate correlation between serum total sialic acid and fasting plasma glucose and the insulin resistance index. In addition, serum total sialic acid significantly correlated with systolic blood pressure, fasting serum cholesterol and triacylglycerol concentrations and body mass index in the females. In males serum total sialic acid significantly positively correlated with fasting serum cholesterol and triacylglycerol concentrations, and correlated inversely with the hip/waist ratio. 4.In multiple regression analysis of the 100 subjects serum total sialic acid correlated independently with fasting serum cholesterol, glucose and also plasma insulin concentrations. In females serum total sialic acid independently correlated with systolic and diastolic blood pressure, and serum cholesterol and fasting plasma glucose concentrations, although there was no significant independent correlation between serum total sialic acid and any of the other variables in the males.

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