scholarly journals Central odontogenic fibroma of simple type: An original observation

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110124
Author(s):  
Yassine Oueslati ◽  
Raouaa Belkacem Chebil ◽  
Lamia Oualha ◽  
Zouha Mziou ◽  
Ramzi Moatemri ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Correct Diagnosis ◽  
World Health ◽  
Simple Type ◽  
Diagnostic Dilemma ◽  
Odontogenic Tumours ◽  
Odontogenic Fibroma ◽  
Central Odontogenic Fibroma ◽  
Health Organization ◽  
Original Observation

Central odontogenic fibroma is an uncommon, benign, slow-growing intraosseous mesenchymal odontogenic tumour. It presents a diagnostic dilemma to the clinician and the pathologist because its clinical and radiological features resemble other odontogenic and/or non-odontogenic tumours, and the differential diagnosis is based on histological examination. In this report, we describe our experience with a case of a 23-year-old female patient with central odontogenic fibroma of the mandible that was diagnosed as ‘simple type’. Highlighting a subtype that was dropped from the last World Health Organization classification of head and neck tumours is important to accumulate more information about this lesion and to show its different features. Despite its rarity, central odontogenic fibroma should be included in the differential diagnosis of intrabony tumours of the jaws. These findings can better educate oral and maxillofacial surgeons about the unusual nature of this lesion, help establish a correct diagnosis and give the appropriate therapeutic management.

scholarly journals Mosaic Pattern of H3 K27M-Mutant Protein Expression in a Diffuse Midline Glioma—A Diagnostic Dilemma for the Pathologist

2021 ◽  
Author(s):  
Deepti Narasimhaiah ◽  
Bejoy Thomas ◽  
Mathew Abraham ◽  
Rajalakshmi Poyuran
Keyword(s):  
Tumor Tissue ◽  
World Health ◽  
Mutant Protein ◽  
Histone Genes ◽  
Mosaic Pattern ◽  
Diagnostic Dilemma ◽  
Who Grade ◽  
Therapeutic Implications ◽  
Health Organization ◽  
Diffuse Midline Glioma

AbstractDiffuse midline glioma, H3 K27M-mutant, is a World Health Organization (WHO) grade IV glioma arising in pons, thalamus, and spinal cord. They show mutations resulting in replacement of lysine at position 27 by methionine (K27M) of histone genes, H3F3A, HIST1H3B, and HIST1H3C. The H3 K27M mutant protein is identified in tumor tissue by immunohistochemistry. As these mutations are clonal and homogeneous, the mutant protein is normally identified in all tumor cells. Here we report a case of diffuse midline glioma with mosaic pattern of expression of H3 K27M mutant protein and discuss the diagnostic and therapeutic implications of this unusual pattern.

Pulmonary Preneoplasia

2008 ◽  
Vol 132 (7) ◽  
pp. 1073-1078 ◽  
Author(s):  
Sanja Dacic
Keyword(s):  
Diagnostic Procedures ◽  
World Health ◽  
Preneoplastic Lesions ◽  
Cell Hyperplasia ◽  
Diagnostic Dilemma ◽  
Gene Markers ◽  
Lung Carcinomas ◽  
Molecular Abnormalities ◽  
Prognostic Importance ◽  
Health Organization

Abstract Context.—Improved screening techniques for lung cancer have resulted in detection of lesions that are considered to represent precursors of invasive lung carcinomas. These lesions may cause a diagnostic dilemma particularly on small biopsy or cytology specimens. Ancillary studies are usually not helpful, and diagnosis is based on morphology alone. Recognition of these lesions is very important to prevent potential diagnostic mistakes that may result in inadequate patient management. Future molecular studies may provide clinically useful diagnostic and prognostic gene markers. Objective.—To review currently proposed morphologic criteria for precursor lesions of non–small cell lung carcinomas including squamous dysplasias, atypical adenomatous hyperplasia, and diffuse idiopathic neuroendocrine cell hyperplasia. Major molecular abnormalities are briefly discussed. Data Sources.—Published literature and recent World Health Organization classification of lung tumors. Conclusions.—Practicing surgical pathologists must be familiar with morphology of recognized pulmonary preneoplastic lesions that are more frequently detected radiographically and subjected to diagnostic procedures. Future understanding of underlying molecular abnormalities associated with progression of these lesions into invasive lung carcinoma may result in a development of molecular assays with potential diagnostic and prognostic importance.

scholarly journals COVID-19- or Tramadol-induced Seizure: A Differential Diagnosis in Young People

2020 ◽  
Vol 10 (4) ◽  
pp. 32009.1-32009.2
Author(s):  
Solmaz Nekoueifard ◽  
◽  
Mohammad Majidi ◽  
Keyword(s):  
Myocardial Infarction ◽  
Acute Kidney Injury ◽  
Differential Diagnosis ◽  
Acute Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Kidney Injury ◽  
World Health ◽  
The World ◽  
Life Threatening ◽  
Health Organization

Coronavirus disease 2019 (COVID-19) was first declared in December 2019 from Wuhan, China [1, 2]. It then has been reported a pandemic in March 2020 by the World Health Organization [3]. Clinical features of COVID-19 are different from asymptomatic to mild to moderate symptoms, such as fever, headache, myalgia, sore throat, anosmia, cough, fatigue headache, hemoptysis, and dyspnea to the life-threatening complications, including shock, pneumonia, acute respiratory distress syndrome, myocarditis, myocardial infarction, acute kidney injury, multi-organ failure, and even death [1, 2].

scholarly journals World Health Organization Classification of Odontogenic Tumors and Imaging Approach of Jaw Lesions

2020 ◽  
Vol 24 (05) ◽  
pp. 535-548
Author(s):  
Vasiliki Siozopoulou ◽  
Filip M. Vanhoenacker
Keyword(s):  
World Health Organization ◽  
Correct Diagnosis ◽  
Subsequent Treatment ◽  
World Health ◽  
Odontogenic Tumors ◽  
Main Role ◽  
World Health Organization Classification ◽  
Soft Tissue Changes ◽  
Health Organization

AbstractTumors of the jaws represent a heterogeneous group of lesions that are classified histologically in the World Health Organization Classification of Odontogenic Tumors (2017). This article provides an update of the current nomenclature. The main role of imaging is to describe the precise location and extent of these lesions. Although characterization of imaging is often difficult due to overlapping characteristics, imaging is helpful to define which lesions should be referred for histologic examination and subsequent treatment planning. Location and density are the cardinal criteria for potential characterization on imaging. Radiologically, lesions may be radiolucent, radiopaque, or of mixed density. Additional criteria include lesion demarcation, morphology, cortical breakthrough, periosteal reaction, and adjacent soft tissue changes. Final lesion characterization is only definitive after interdisciplinary discussion and radiopathologic correlation. Correct diagnosis is obtained by a combination of the patient's age, lesion location, and clinical and radiologic presentation. It is important that all physicians use a uniform nomenclature.

scholarly journals Primary Cutaneous Acral CD8+ T-Cell Lymphoma

2017 ◽  
Vol 141 (11) ◽  
pp. 1469-1475 ◽  
Author(s):  
Vivian M. Hathuc ◽  
Alexandra C. Hristov ◽  
Lauren B. Smith
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Correct Diagnosis ◽  
Cd8 T Cell ◽  
T Cell Lymphoma ◽  
World Health ◽  
T Cell Lymphomas ◽  
Pathologic Features ◽  
Health Organization

Primary cutaneous acral CD8+ T-cell lymphoma is a new provisional entity in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. This is a challenging diagnosis because of its rarity, as well as its morphologic and immunophenotypic overlap with other CD8+ cytotoxic lymphoid proliferations. Appropriate classification of this entity is crucial because of its indolent clinical behavior compared with other CD8+ T-cell lymphomas. Knowledge of the clinical setting, sites of involvement, and morphologic features can aid in correct diagnosis. Here, we review the clinical and pathologic features of primary cutaneous acral CD8+ T-cell lymphoma with an emphasis on the differential diagnosis among other C8+ T-cell lymphomas.

scholarly journals Adenomatoid Odontogenic Tumour - The Master of Disguise

2021 ◽  
Vol 10 (11) ◽  
pp. 835-838
Author(s):  
Shreyas N. Shah ◽  
Falguni Patel ◽  
Vandana Shah
Keyword(s):  
World Health ◽  
Odontogenic Tumour ◽  
Odontogenic Tumours ◽  
Facial Defect ◽  
Odontogenic Epithelium ◽  
Histological Variants ◽  
Epithelial Tumour ◽  
Adenomatoid Odontogenic Tumour ◽  
Health Organization ◽  
Slow Growing

Adenomatoid odontogenic tumour, truly coined as one of the masters of disguise of orofacial pathologies, was first reported in the literature by Steen Lands.1 Philipson and Brin used the terminology adenomatoid odontogenic tumour for this pathology with its commonly accepted abbreviation AOT.2 Later on, adenomatoid odontogenic tumour (AOT) name was accepted by the World Health Organization (WHO) in 1971. In 2005, WHO revealed the histological variants of the adenomatoid odontogenic tumour and classified it as a tumour comprised of odontogenic epithelium showing various patterns in histopathologic view within a mature connective tissue stroma.3 It is seldom noticed neoplasm which comprises only 3 % of all the odontogenic tumours. It was commonly found in the maxilla with female predilection and mostly in association with impacted canines.4-6 Adenomatoid odontogenic tumour is an odontogenic epithelial tumour usually seen in females in their second decade of life. The tumour is slow growing in nature which eventually results in painless expansion of jaw. The maxilla is commonly affected than mandible. Being benign in nature, most of the AOT cases usually got treated with conservative surgical enucleation but the greater size of tumour can leave behind an oro-facial defect. To prevent such type of incident, it is important to diagnose them early and treat accordingly. Herewith, we are presenting a case report of adenomatoid odontogenic tumour of mandible in a male patient.

scholarly journals Queratocisto odontogênico em mandíbula: relato de caso

2020 ◽  
Vol 9 (6) ◽  
pp. 665-669
Author(s):  
Thauany Vasconcelos ◽  
Lucas André Barros Ferreira ◽  
Sirius Dan Inaoka ◽  
Davi Felipe Neves Costa
Keyword(s):  
Rio De Janeiro ◽  
Benign Lesion ◽  
Odontogenic Tumor ◽  
World Health ◽  
Keratocystic Odontogenic Tumor ◽  
Imaging Features ◽  
Odontogenic Tumours ◽  
Health Organization ◽  
Head Neck

Introdução: O queratocisto odontogênico é por definição um cisto de desenvolvimento que apresenta caráter agressivo afetando o complexo bucomaxilofacial. Tendo em vista que muitas vezes são assintomáticos, o seu diagnóstico normalmente é obtido através de exames radiográficos de rotina. Objetivo: apresentar um caso clínico referente ao diagnóstico e tratamento de um queratocisto odontogênico em região posterior de mandíbula. Caso clínico: Paciente do sexo feminino, normosistemica, feoderma. Observou-se aumento de volume extraoral, lado direito da face em região de ângulo mandibular. Ao exame radiografico periapical, observou-se uma imagem radiolúcida, bem delimitada, unilocular, associada ao dente 47.  Ao exame físico intraoral, observou-se abaulamento ósseo na região do referido dente. Foi então solicitada uma tomografia computadorizada, na qual foi detectada extensa lesão óssea expansiva em ramo mandibular direito. Realizou-se uma punção aspirativa local, detectando presença de conteúdo líquido. Primeiramente foi realizada uma biópsia incisional com instalação de dispositivo descompressivo. O laudo histopatológico foi de cisto odontogênico inflamatório. O dispositivo de descompressão permaneceu por 9 meses, apresentando uma diminuição significativa da lesão. Foi realizada então, a enucleação da lesão remanescente, associado a exodontia dos dentes 47 e 48 e enviado material para histopatológico, que dessa vez, confirmou diagnóstico de queratocisto odontogênico. Ao exame de imagem pós-operatório de 6 meses, observou-se formação óssea completa sem sinais de recidiva. Conclusão: O tratamento proposto se mostrou eficaz no tratamento do queratocisto odontogênico, o acompanhamento com exames de imagem é de extrema importância, tendo em vista a possibilidade de recidiva. Descritores: Recidiva; Cistos Odontogênicos; Patologia Bucal. Referências Freitas DA, Veloso DA, Santos ALD, Freitas VA. Ceratocistoodontogênico maxilar: relato de caso clínico. RGO Rev Gauch Odontol. 2015;63(4):484-88. Antunes AA, Avelar RL, Santos TS, Andrade ESS, Dourado E. Tumor odontogênico ceratocístico: análise de 69 casos/ Keratocystic odontogenic tumor: analysisof 69 cases. Rev bras cir cabeça pescoço. 2007;36(2):80-2. Moura BS, Cavalcante MA, Hespanhol W. Tumor odontogênico ceratocístico. Rev Col Bras Cir. 2016;43(6):466-71. Wright JM, Vered M. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors. Head Neck Pathol. 2017;11(1):68-77. Neville BW, Allen CM, Damm DD, Chi A. oral and maxillofacial pathology, 4. ed. Rio de Janeiro: Elsevier; 2016. Aciole GTS, Santos MAM, Aciole JMS, Ribeiro Neto N, Pinheiro, ALB. Tumor odontogênicoqueratocistorecidivante: tratamento cirúrgico conservador ou radical? Relato de caso clínico. Rev cir traumatol buco-maxilo-fac. 2010;10(1):43-8. Hupp JR. Cirurgia oral e maxilofacial contemporânea. 6. ed. Rio de Janeiro: Elsevier, 2015. Marques JAF, Neves, JL, Alencar, DA, Lemos IM, Marques LC. Ceratocisto Odontogênico: relato de caso. Sitientibus. 2006;34(1):59-69. Conceição ACA, Santos AM, Santos GP, Almeida AJ, Dias AMN, Mainenti P. Tumor odontogênico queratocístico: atualidades. RIEE. 2012;4(1): 29-35. Pereira CCS, Carvalho ACG de S, Jardim ECG, Shinohara EH, Garcia Júnior IR. Tumor Odontogênico Queratocístico e considerações diagnósticas. RBCS. 2012;10(32):73-9. Balmick S, Hespanhol W, Cavalcante MAA, Gandelmann IHA. Recidiva do Tumor Odontogênico Ceratocístico: Análise retrospectiva de 10 anos. Rev cir traumatol buco-maxilo-fac. 2011;11(1):85-91. Borghesi A, Nardi C, Giannitto C, Tironi A, Maroldi R, Di Bartolomeo F, Preda L. Odontogenic keratocyst: imaging features of a benign lesion with an aggressive behaviour. Insights Imaging. 2018;9(5):883-97.  Johnson NR, Batstone MD, Savage NW. Management and recurrence of keratocystic odontogenic tumor: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(4):e271-76. Araújo S, Oliveira LKR, Pigatti FM, Mayrink G. Queratocisto odontogênico em região anterior da maxila: relato de caso. HU rev. 2019;45(1):82-6. Oliveira Júnior HCC, Chaves Netto HDM, Rodrigues MTV, Pinto JMV, Nóia CF. Descompressão cirúrgica no tratamento de lesões císticas da cavidade oral. Rev cir traumatol buco-maxilo-fac. 2014;14(1):15-20. Pazdera J, Kolar Z, Zboril V, Tvrdy P, Pink R. Odontogenic keratocysts/keratocystic odontogenic tumours: biological characteristics, clinical manifestation and treatment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014;158(2):170-74.

A Tale of 2 Morphologies: Diagnostic Pitfalls in TFEB-Associated Renal Cell Carcinomas, Including a Novel NEAT1-TFEB Fusion

2020 ◽  
pp. 106689692095627
Author(s):  
Aarti E. Sharma ◽  
Megan Parilla ◽  
Pankhuri Wanjari ◽  
Jeremy P. Segal ◽  
Tatjana Antic
Keyword(s):  
Renal Cell ◽  
Correct Diagnosis ◽  
Epithelioid Cell ◽  
World Health ◽  
Renal Tumors ◽  
Renal Neoplasm ◽  
Renal Cell Carcinomas ◽  
Perivascular Epithelioid Cell ◽  
Variable Morphology ◽  
Health Organization

Aims Translocation-associated renal cell carcinomas (RCCs) have been extensively subcharacterized in recent years, such that each is largely recognized by the 2016 World Health Organization as categorical neoplastic entities in the genitourinary tract. Those belonging to the t(6;11) family of tumors classically have a fusion between TFEB and MALAT1/α, and display a particular histomorphology. Specifically, they show a biphasic population of both small and large epithelioid cells, the smaller component of which surrounds basement membrane-type material. Despite this apt description, the tumors have variable morphology and mimic other RCCs including those with TFE3 translocations. Therefore, a high degree of suspicion is required to make the correct diagnosis. Methods The 2 cases described in this article were of strikingly different appearance, and initially considered consistent with other non-translocation–associated renal tumors. These included clear cell RCC (CCRCC), perivascular epithelioid cell tumor (PEComa), and other eosinophilic RCCs (mainly papillary RCC type 2). Results Using RNA sequencing techniques, they were found to harbor distinct pathogenic rearrangements involving the TFEB gene, namely, fusions with CLTC and NEAT1 (the latter partnering heretofore never reported). Conclusions These alterations manifested in 2 notably dissimilar lesions, underscoring the importance of including this family of carcinomas in the differential of any renal neoplasm that does not display immunophenotypic characteristics consistent with its morphology.

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