The cytological mechanism and effects of hypertensive cerebral hemorrhage treatment by citicoline on serum GFAP and copeptin level

In this study, 102 patients with hypertensive intracerebral hemorrhage (52 patients in the citicoline treatment group and 50 patients in the routine treatment group) were analyzed and compared. It was found that citicoline-assisted treatment of hypertensive intracerebral hemorrhage could inhibit the release of serum glial fibrillary acidic protein (GFAP) and peptides ( P < 0.05) and improve the prognosis and neurological and daily living ability of patients ( P < 0.05). In addition, CDP-choline reduced the mortality of neurons, inhibited inflammatory factors, and improved the prognosis of patients ( P < 0.05). A high dose of CDP-choline was also significantly effective in protecting neurons.

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Effect of antihypertensive agents ACEI/ARB and CCB on hypertensive intracerebral hemorrhage and inflammatory cytokines, serum ferritin, and serum P

European Journal of Inflammation ◽

10.1177/2058739218818954 ◽

2018 ◽

Vol 16 ◽

pp. 205873921881895

Author(s):

Peiyu Li ◽

Hui Yang ◽

Sheng Bi ◽

Chengji Wu

Keyword(s):

Intracerebral Hemorrhage ◽

Cerebral Hemorrhage ◽

Antihypertensive Drugs ◽

Inflammatory Factors ◽

The Third ◽

Tnf Α ◽

Significant Difference ◽

Group A ◽

Group B ◽

Hypertensive Intracerebral Hemorrhage

The aim of this study was to investigate the effect of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB) antihypertensive drugs on the treatment of hypertensive intracerebral hemorrhage (ICH) and on the expression level of inflammatory factors, serum ferritin (SF), and serum substance P (SP). A total of 160 patients with hypertensive ICH were divided into three groups according to the type of antihypertensive drugs taken before cerebral hemorrhage: group A (40 cases, taking ACEI/ARB antihypertensive drugs before cerebral hemorrhage), group B (40 cases, CCB antihypertensive drugs were regularly taken before the onset of cerebral hemorrhage), and C group (80 cases, nor any antihypertensive drugs were regularly taken before the onset of cerebral hemorrhage). Patients in group C were further divided into two groups: group D (40 cases, ARB antihypertensive drugs were regularly taken after cerebral hemorrhage) and group E (40 cases, CCB antihypertensive drugs were regularly taken after cerebral hemorrhage). On the third day, after the onset of disease, the level of serum interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, SF, and SP in all the patients was detected. At the same time, the brain computed tomography (CT) was used to evaluate the cerebral edema. On the first day and the thirty day after the onset of disease, the patient’s neurological deficit status was assessed according to the National Institutes of Health Stroke Scale (NIHSS) score. On the third day after onset, the levels of IL-1β, IL-6, TNF-α, SF, and the volume of cerebral edema in group A and group B were significantly lower than those in group C ( P < 0.05). The level of serum SP in group A and group B was significantly higher than that in group C ( P < 0.05). However, there was no significant difference between group A and group B ( P > 0.05). On the third day after onset, the mortality of each group is of no significant difference ( P > 0.05). However, NIHSS scores in group A and group B were significantly lower than those in group C ( P < 0.05). There was no statistical difference in NIHSS scores between group A and group B ( P > 0.05). In conclusion, in the early stage of hypertensive ICH, early normative use of ACEI/ARB or CCB antihypertensive drugs can improve the prognosis of patients, whose mechanism may be related to the improvement of level of serum inflammatory factors and SP and SF.

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TIMP-2 Polymorphisms Define Subtypes of Hypertensive Intracerebral Hemorrhage with Distinct Perihematomal Edema Development Patterns

Current Neurovascular Research ◽

10.2174/1567202617666191223145632 ◽

2020 ◽

Vol 17 (1) ◽

pp. 44-49

Author(s):

Ru Chen ◽

Zhi Song ◽

Mingzhu Deng ◽

Wen Zheng ◽

Jia Liu ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

Cerebral Edema ◽

Cerebral Hemorrhage ◽

Functional Outcomes ◽

Hematoma Volume ◽

Development Patterns ◽

Genotype Group ◽

Major Threat ◽

Hypertensive Intracerebral Hemorrhage ◽

Perihematomal Edema

Background: Perihematomal edema (PHE) is a major threat leading to poor functional outcomes after intracerebral hemorrhage (ICH). TIMP-2 is considered to participate in the formation of PHE after ICH by antagonizing the damaging effects of MMP-2. In the early study, the polymorphisms of TIMP-2 rs8179090 have shown to influence the expression of TIMP-2. Objective: To prove that the severity of PHE was different in ICH patients with different TIMP-2 rs8179090 genotypes. Methods: In this prospective study, 130 hypertensive ICH patients were enrolled. The poly phisms of rs8179090 in TIMP-2 were determined. The hematoma volume and PHE volume were measured by computed tomography (CT) scan immediately after the onset of ICH, and were measured again one week and two weeks after the onset. Then, the comparison of TIMP-2 rs8179090 genotypes was made. Result: TIMP-2-418 position (rs8179090) had two genotypes in the studied population, GC and GG. Patients with the GC genotype developed more severe PHE, with a higher incidence of delayed cerebral edema in cerebral hemorrhage than those with the GG genotype. Conclusion: We have found that the GC genotype group may develop more severe PHE, with an increased incidence of delayed cerebral edema in cerebral hemorrhage.

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Effect of mild hypothermia on expression of inflammatory factors in surrounding tissue after minimally invasive hematoma evacuation in the treatment of hypertensive intracerebral hemorrhage

Experimental and Therapeutic Medicine ◽

10.3892/etm.2018.6014 ◽

2018 ◽

Cited By ~ 1

Author(s):

Jianhua Zhao ◽

Qing Mao ◽

Zhongxin Qian ◽

Jun Zhu ◽

Zhun Qu ◽

...

Keyword(s):

Minimally Invasive ◽

Intracerebral Hemorrhage ◽

Mild Hypothermia ◽

Surrounding Tissue ◽

Inflammatory Factors ◽

Hematoma Evacuation ◽

Hypertensive Intracerebral Hemorrhage

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Nursing Effect of Stellate Ganglion Block on Cerebral Infarction Based on Message Authentication Code Diameter Algorithm

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2020.2880 ◽

2020 ◽

Vol 10 (2) ◽

pp. 410-415

Author(s):

Ping Li ◽

Tan Wang ◽

Sitong Yan ◽

Xiaoxu Yuan ◽

Zhiwen Liu

Keyword(s):

Treatment Group ◽

Minimally Invasive ◽

Intracerebral Hemorrhage ◽

Pulmonary Infection ◽

Stellate Ganglion ◽

Stellate Ganglion Block ◽

Control Group ◽

Invasive Treatment ◽

Ganglion Block ◽

Hypertensive Intracerebral Hemorrhage

Objective: To investigate the influence of stellate ganglion block on the prognosis of patients with hypertensive intracerebral hemorrhage according to the inclusion criteria and whether the complications such as rebleeding and pulmonary infection are related to the occurrence of complications such as recurrent hemorrhage and pulmonary infection. The use of ganglion blockade in the clinical application of cerebrovascular disease and possible risks. Methods: A total of 138 patients with hypertensive intracerebral hemorrhage who were treated with different treatments in neurosurgery from March 2013 to December 2015 were included in the study. Among them, 67 patients in the treatment group (MAC diameter algorithm stellate ganglion block + conventional treatment) and 71 patients in the control group were collected. The medical records of the two groups were collected for retrospective analysis. Result: There was a difference in the prognosis between the two groups (P = 0.042). There was a difference in the prognosis between the early planetary ganglion block and the late planetary ganglion block in the treatment group (P = 0.043). There were no statistically significant differences between the two groups in the incidence of pulmonary infection (P = 0.194) and rebleeding (P = 0.856) during treatment. Conclusion: Stellate ganglion block is helpful for the prognosis of patients with hypertensive intracerebral hemorrhage. Based on MAC diameter algorithm, stellate ganglion block as a minimally invasive, simple, safe and easy-to-use minimally invasive treatment method has certain curative effect on patients with hypertensive cerebral hemorrhage, especially in early application, which is worthy of clinical promotion.

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SERUM GLIAL FIBRILLARY ACIDIC PROTEIN IN THE DIFFERENTIAL DIAGNOSIS OF INTRACEREBRAL HEMORRHAGE AND ACUTE ISCHEMIC STROKE: A SYSTEMATIC REVIEW AND DIAGNOSTIC TEST ACCURACY META-ANALYSIS

10.26226/morressier.58e389add462b802923855f8 ◽

2017 ◽

Author(s):

Aristeidis Katsanos

Keyword(s):

Systematic Review ◽

Differential Diagnosis ◽

Ischemic Stroke ◽

Glial Fibrillary Acidic Protein ◽

Intracerebral Hemorrhage ◽

Acute Ischemic Stroke ◽

Diagnostic Test ◽

Meta Analysis ◽

Diagnostic Test Accuracy ◽

Test Accuracy

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Clinical Study of Qingpeng Ointment Treatment of Shoulder-Hand Syndrome After Cerebral Hemorrhage During the Rehabilitation Period

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666201211093227 ◽

2020 ◽

Vol 23 ◽

Author(s):

Ruihuan Pan ◽

Shanshan Ling ◽

Haodong Yang ◽

Yan Huang ◽

Lechang Zhan ◽

...

Keyword(s):

Treatment Group ◽

Cerebral Hemorrhage ◽

Clinical Medicine ◽

External Rotation ◽

Statistical Significance ◽

Hand Function ◽

Tibetan Medicine ◽

Controlled Study ◽

Control Group ◽

The Difference

Background: Shoulder-hand syndrome (SHS) refers to a syndrome causing sudden edema, shoulder pain and limited hand function. Qingpeng ointment, a kind of Tibetan medicine, can reduce swelling, relieve pain, tonify stagnation and clear the meridians, which is consistent with the pathological mechanism of SHS after stroke. Therefore, if clinical trials can be used to explore the effectiveness of Qingpeng ointment for treatment of poststroke SHS and promote its application in clinical medicine, this is of specific significance for the treatment of poststroke SHS. Objective: To investigate the clinical efficacy and safety of Qingpeng ointment in the treatment of poststroke SHS. To provide an objective basis for a better therapeutic treatment for poststroke SHS． Method: A prospective, randomized, controlled study was conducted. This study recruited 120 patients with poststroke SHS who met the inclusion criteria. They were randomized into the treatment group and the control group, with 60 patients allocated to each group. The treatment group received routine medical treatment and rehabilitative care after using the Qingpeng ointment, while the patients in the control group received only routine treatment without the ointment. All patients received clinical assessment with the Visual Analogue Scale (VAS), measurement of the range of motion (ROM) of the upper-limb joints, the Fugl-Meyer Assessment of Upper Extremity (FMA-U) and the Modified Barthel Index Score (MBI) before and after the whole treatment. Results: After 4 weeks of treatment, the VAS scores of both groups were decreased significantly (P＜0.05), and the difference between the two groups was statistically significant (P < 0.05). There is no statistical significance for the difference between the treatment group and control group in terms of the FMA-U and MBI scores and the forward bend, backward, outstretch, external rotation and pronation angles after treatment. The increases in the values of VAS, FMA-M and MBI in the treatment group were greater than those in the control group, and the difference was statistically significant (P < 0.05). The increases in the values of the forward bend, outreach and external rotation angles in the treatment group were greater than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion: The treatment group showed better results than the control group in terms of the relief of pain symptoms, the improvement of motor function and the improvement of the activities of daily living for patients with shoulder-hand syndrome after cerebral hemorrhage. Qingpeng ointment is effective and safe in treating poststroke SHS.

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Very Early Exercise Rehabilitation After Intracerebral Hemorrhage Promotes Inflammation in the Brain

Neurorehabilitation and Neural Repair ◽

10.1177/15459683211006337 ◽

2021 ◽

pp. 154596832110063

Author(s):

Keigo Tamakoshi ◽

Madoka Maeda ◽

Shinnosuke Nakamura ◽

Nae Murohashi

Keyword(s):

Intracerebral Hemorrhage ◽

Protein Expression ◽

Brain Regions ◽

Motor Dysfunction ◽

Inflammatory Factors ◽

Mrna Levels ◽

Exercise Rehabilitation ◽

Early Exercise ◽

Polymerase Chain ◽

To Receive

Background Very early exercise has been reported to exacerbate motor dysfunction; however, its mechanism is largely unknown. Objective This study examined the effect of very early exercise on motor recovery and associated brain damage following intracerebral hemorrhage (ICH) in rats. Methods Collagenase solution was injected into the left striatum to induce ICH. Rats were randomly assigned to receive placebo surgery without exercise (SHAM) or ICH without (ICH) or with very early exercise within 24 hours of surgery (ICH+VET). We observed sensorimotor behaviors before surgery, and after surgery preexercise and postexercise. Postexercise brain tissue was collected 27 hours after surgery to investigate the hematoma area, brain edema, and Il1b, Tgfb1, and Igf1 mRNA levels in the striatum and sensorimotor cortex using real-time reverse transcription polymerase chain reaction. NeuN, PSD95, and GFAP protein expression was analyzed by Western blotting. Results We observed significantly increased skillful sensorimotor impairment in the horizontal ladder test and significantly higher Il1b mRNA levels in the striatum of the ICH+VET group compared with the ICH group. NeuN protein expression was significantly reduced in both brain regions of the ICH+VET group compared with the SHAM group. Conclusion Our results suggest that very early exercise may be associated with an exacerbation of motor dysfunction because of increased neuronal death and region-specific changes in inflammatory factors. These results indicate that implementing exercise within 24 hours after ICH should be performed with caution.

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