A Case of Ewing Sarcoma Presenting With Cardiac Metastasis

2019 ◽  
Vol 10 (5) ◽  
pp. 632-634
Author(s):  
Ruba Murad ◽  
Rimaa Bakkar ◽  
Rehab Sukkar ◽  
Fadi Mahmoud ◽  
Alwaleed Al-Dairy
Keyword(s):  
Ewing Sarcoma ◽  
Cardiac Involvement ◽  
Definitive Diagnosis ◽  
Cardiac Metastasis ◽  
Malignant Bone Tumor ◽  
Resonance Imaging ◽  
Primary Malignant Bone Tumor ◽  
Tumor Metastases ◽  
One Year ◽  
Oncology Center

Ewing sarcoma is the second most prevalent primary malignant bone tumor. Metastases from Ewing sarcoma to the heart are very rare. Herein, we present a case of undiagnosed Ewing sarcoma in a 12-year-old boy who presented with metastasis to the left atrium. The mass was prolapsing across the mitral valve. In view of the potential risk of embolization, urgent cardiac surgery was performed before the establishment of a definitive diagnosis. Histopathology was consistent with Ewing sarcoma. Subsequent magnetic resonance imaging revealed a mass in his left fibula. The patient was referred to the oncology center and received chemotherapy. One year later, he is alive with no evidence of recurrent cardiac involvement.

A phase II study of anlotinib in treating patients with relapsed or metastatic primary malignant bone tumor.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 11525-11525
Author(s):  
Lina Tang ◽  
Xiaohui Niu ◽  
Zhen Wang ◽  
Qiqing Cai ◽  
Chongqi Tu ◽  
...  
Keyword(s):  
Phase Ii ◽  
Malignant Fibrous Histiocytoma ◽  
Bone Tumor ◽  
Ewing Sarcoma ◽  
Phase Ii Study ◽  
Fibrous Histiocytoma ◽  
Malignant Bone Tumor ◽  
Eligibility Criteria ◽  
Primary Malignant Bone Tumor ◽  
Study Results

11525 Background: Primary malignant bone tumors are rare forms of cancer and include mainly bone sarcomas, which are categorized into 3 common types based on tissue origin: osteosarcoma, chondrosarcoma and Ewing sarcoma. A phase II trial was designed to explore the anlotinib activity in patients with relapsed or metastatic primary malignant bone tumor. Methods: Eligible pts were received 12mg of anlotinib once daily, 2 weeks on and 1 week off until progression or unacceptable toxicity. Key-eligibility criteria were aged 14-70 years, histologically confirmed diagnosis of osteosarcoma, chondrosarcoma, bone derived malignant fibrous histiocytoma, giant cell tumor, Ewing sarcoma and PNET, confirmed previous chemotherapy failure, ECOG 0-1(0-2 for amputation pts), required at least one measurable lesion. We observed PFS, OS, ORR, DCR and AE in this study. Results: From August 2018 to April 2019, 42 pts were included. Of 42 efficacy-evaluable pts, 25 were man, median age was 28 (14-68) years. There were 29 pts of osteosarcoma, 9 pts of chondrosarcoma, 3pts of Ewing sarcoma and 1 pt of bone derived malignant fibrous histiocytoma. The progression-free rate at 12 weeks (PFR12weeks), ORR and DCR were 71.3%, 9.52% and 78.57%. Median PFS was 5.26 months (95%CI = 3.48-8.44). Median OS was 11.40 months (95%CI = 10.09, [ ). Median PFS of osteosarcoma and chondrosarcoma was 4.83 months (95%CI = 3.48, 7.13 ) and 2.76 months (95%CI = 1.31, [ ) respectively. The most common Gr 3-5 anlotinib-related AEs were hypertension (19.05%), hypertriglyceridemia (9.52%), hand-foot syndrome (7.14%), and proteinuria (4.76%). Conclusions: The phase II study shows a promising activity of anlotinib in patients with relapsed or metastatic primary malignant bone tumor and an acceptable toxicity. Clinical trial information: NCT03527888 .

scholarly journals Idiopathic Free-Floating Thrombus of the Common Carotid Artery

2002 ◽  
Vol 29 (1) ◽  
pp. 97-99 ◽  
Author(s):  
Brian Silver ◽  
Irene Gulka ◽  
Michael Nicolle ◽  
Ramesh Sahjpaul ◽  
Vladimir Hachinski
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Multimodal Imaging ◽  
Doppler Ultrasonography ◽  
Resonance Imaging ◽  
Wall Defect ◽  
Floating Thrombus ◽  
Weighted Magnetic Resonance Imaging ◽  
The Common ◽  
One Year

Background:The observation of an intraluminal common carotid artery thrombus overlying a wall defect at ultrasonography or angiography is unusual. To our knowledge, there are no previous reports of a free-floating thrombus in the common carotid artery.Case Report:A 45-year-old woman who was previously healthy and on no medications presented with acute hemiparesis and aphasia. Following testing that included carotid duplex and trancranial Doppler ultrasonography, diffusion-weighted magnetic resonance imaging, and digital subtraction angiography, the patient underwent emergency open embolectomy. No underlying wall defect was seen at the time of imaging or surgery. No obvious hypercoagulable state could be identified. Her NIH Stroke Scale score improved from 26 at admission to 2 at three months and 1 at one year.Conclusions:Multimodal imaging may have improved diagnosis and management in this patient with a unique finding. The source of the thrombus remains obscure.

scholarly journals Intraorbital wooden foreign body detected by computed tomography and magnetic resonance imaging

2016 ◽  
Vol 30 (1) ◽  
pp. 88-91 ◽  
Author(s):  
Alfredo Di Gaeta ◽  
Francesco Giurazza ◽  
Eugenio Capobianco ◽  
Alvaro Diano ◽  
Mario Muto
Keyword(s):  
Computed Tomography ◽  
Foreign Body ◽  
Magnetic Resonance ◽  
Delayed Diagnosis ◽  
Clinical History ◽  
Definitive Diagnosis ◽  
Double Vision ◽  
Resonance Imaging ◽  
Wooden Foreign Body ◽  
The Right

To identify and localize an intraorbital wooden foreign body is often a challenging radiological issue; delayed diagnosis can lead to serious adverse complications. Preliminary radiographic interpretations are often integrated with computed tomography and magnetic resonance, which play a crucial role in reaching the correct definitive diagnosis. We report on a 40 years old male complaining of pain in the right orbit referred to our hospital for evaluation of eyeball pain and double vision with an unclear clinical history. Computed tomography and magnetic resonance scans supposed the presence of an abscess caused by a foreign intraorbital body, confirmed by surgical findings.

Left ventricular hydatid cyst: an uncommon cause of chest pain in young adults

2012 ◽  
Vol 23 (3) ◽  
pp. 460-462 ◽  
Author(s):  
Ravindranath K. Shankarappa ◽  
Nagaraja Moorthy ◽  
Prabhavathi Bhat ◽  
Manjunath C. Nanjappa
Keyword(s):  
Chest Pain ◽  
Hydatid Cyst ◽  
Hydatid Disease ◽  
Cardiac Involvement ◽  
Ventricular Myocardium ◽  
Acute Onset ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Resonance Imaging ◽  
Conventional Risk Factors

AbstractIsolated cardiac involvement in hydatid disease is very rare. We report the case of a young adult male who presented to the emergency department with acute onset of chest pain and was surprisingly detected to have a hydatid cyst in the left ventricular myocardium. The transthoracic echocardiography and cardiac magnetic resonance imaging confirmed the diagnosis. Cardiac hydatid disease should be considered in the differential diagnosis of chest pain in young individuals in the absence of conventional risk factors of atherosclerosis.

Definitive Diagnosis and Location of Peanuts in the Airways Using Magnetic Resonance Imaging Techniques

1994 ◽  
Vol 23 (6) ◽  
pp. 1379-1382 ◽  
Author(s):  
Hitoshi Imaizumi ◽  
Masamitsu Kaneko ◽  
Satoshi Nara ◽  
Hiroko Saito ◽  
Koji Asakura ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Definitive Diagnosis ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Techniques
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