Comparative Assessment of PASI and Variations of PGA×BSA as Measures of Psoriasis Severity
Background Commonly used instruments for measuring psoriasis, such as Psoriasis Area and Severity Index (PASI), have limitations, including high complexity. Objective Determine if PGA×BSA or PGA×√BSA are practical alternatives to PASI for measuring severity and treatment response. Methods Data from a Phase 3 study in 1,101 patients treated for moderate to severe psoriasis were used. PASI was the reference standard. Correlations (Pearson coefficients), test-retest reliability (intraclass correlation coefficients), responsiveness to treatment (percentage change and effect size), and correspondence (sensitivity and specificity) were assessed. Results Correlation coefficients of change (baseline at Week 12) were 0.90 between PASI and either PGA×BSA and PGA×√BSA. ICCs were 0.90. Both instruments demonstrated similar percentage change from baseline and effect sizes. Sensitivities of PGA×BSA and PGA×√BSA were 99% and 95%, and specificities were 76% and 87%, respectively. Conclusions PGA×BSA and PGA×√BSA had similar measurement properties as PASI. PGA×BSA is a practical alternative to PASI.