scholarly journals Effectiveness of supportive care measures to reduce infections in pediatric AML: a report from the Children’s Oncology Group

Blood ◽  
2013 ◽  
Vol 121 (18) ◽  
pp. 3573-3577 ◽  
Author(s):  
Lillian Sung ◽  
Richard Aplenc ◽  
Todd A. Alonzo ◽  
Robert B. Gerbing ◽  
Thomas Lehrnbecher ◽  
...  
Keyword(s):  
Supportive Care ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Oncology Group ◽  
Infection Rates ◽  
Key Points ◽  
Pediatric Aml ◽  
Stimulating Factor ◽  
Related Mortality ◽  
Systemic Antibacterial

Key Points Systemic antibacterial and granulocyte colony-stimulating factor prophylaxis appear to reduce bacterial infection rates. Mandatory hospitalization during profound neutropenia did not reduce infection or significantly reduce nonrelapse-related mortality.

scholarly journals Lower risk for serious adverse events and no increased risk for cancer after PBSC vs BM donation

Blood ◽  
2014 ◽  
Vol 123 (23) ◽  
pp. 3655-3663 ◽  
Author(s):  
Michael A. Pulsipher ◽  
Pintip Chitphakdithai ◽  
Brent R. Logan ◽  
Willis H. Navarro ◽  
John E. Levine ◽  
...  
Keyword(s):  
Adverse Events ◽  
Lower Risk ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Serious Adverse Events ◽  
Increased Risk ◽  
Key Points ◽  
Life Threatening ◽  
Stimulating Factor

Key Points BM donors have a threefold higher risk for life-threatening, serious unexpected, or chronic adverse events vs PBSC donors (0.99% vs 0.31%). Donors receiving granulocyte colony-stimulating factor for PBSC collection had no evidence of increased risk for cancer, autoimmune illness, and stroke.

Granulocyte colony-stimulating factor – why it is worth to use filgrastim?

2020 ◽  
Vol 13 (3) ◽  
pp. 285-288
Author(s):  
Natalia Ścirka ◽  
Tomasz Kubiatowski
Keyword(s):  
Secondary Prevention ◽  
Side Effect ◽  
Common Side Effect ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Primary And Secondary Prevention ◽  
Mortality Factors ◽  
Stimulating Factor ◽  
Treatment Related Mortality ◽  
Related Mortality

Neutropenia fever is one of the most common side effect of chemotherapy and might lead to severe complications and death. The use of granulocyte colony-stimulating factors in primary and secondary prevention of neutropenia fever leads to reduction in hospitalization time and significantly affects the decrease in treatment-related mortality. Factors stimulating granulocyte colonies prevent the need to reduce the dose of the cytostatics and to extend the intervals between the treatment cycles, which increases the effectiveness of therapy.

scholarly journals Granulocyte colony-stimulating factor mobilizes dormant hematopoietic stem cells without proliferation in mice

Blood ◽  
2017 ◽  
Vol 129 (14) ◽  
pp. 1901-1912 ◽  
Author(s):  
Jeffrey M. Bernitz ◽  
Michael G. Daniel ◽  
Yesai S. Fstkchyan ◽  
Kateri Moore
Keyword(s):  
Stem Cells ◽  
Progenitor Cells ◽  
Peripheral Blood ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Stem And Progenitor Cells ◽  
Stimulating Factor ◽  
Mobilized Peripheral Blood

Key Points G-CSF mobilizes dormant HSCs without proliferation. Transplantation defects of mobilized peripheral blood-derived hematopoietic stem and progenitor cells are divisional history independent.

scholarly journals Successful Treatment of Cisplatin Overdose with Plasma Exchange

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Yasuhiro Yamada ◽  
Yoshiaki Ikuta ◽  
Kisato Nosaka ◽  
Nobutomo Miyanari ◽  
Naoko Hayashi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adjuvant Therapy ◽  
Supportive Care ◽  
Plasma Exchange ◽  
Bone Marrow Suppression ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Subtotal Esophagectomy ◽  
Intravenous Hydration ◽  
Stimulating Factor

Accidental cisplatin overdose has been occurring with an increasing frequency due to expanding usage of the agent. However, the optimal strategy to treat such patients remains to be established. Here, we report a case of large cisplatin overdose, successfully managed by plasma exchange, intravenous hydration, granulocyte colony-stimulating factor (G-CSF) administration, and other supportive care. A 67-year-old man with esophageal carcinoma received a large cisplatin overdose of 240 , when he received adjuvant therapy following subtotal esophagectomy. On day 4, he experienced frank cisplatin toxicities and emergency plasma exchange was initiated. With 7 cycles of plasma exchange, the cisplatin concentration decreased from 2,350 to 110 ng/mL. Severe bone marrow suppression with high fever ensued on day 10, which was successfully treated with G-CSF and antibiotics. Despite moderate hearing sense reduction, he recovered without significant complications. Immediate plasma exchange with hydration and other care was efficacious in quickly lowering cisplatin concentrations.

Sign in / Sign up

Export Citation Format

Share Document