Longitudinal Analysis of Body Mass and Composition in Survivors of Pediatric Hematological Malignancies After Allogeneic Hematopoietic Stem Cell Transplantation

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 1991-1991
Author(s):  
Hiroto Inaba ◽  
Jie Yang ◽  
Sue Kaste ◽  
Christine Hartford ◽  
Megan S Motosue ◽  
...  
Keyword(s):  
Body Mass ◽  
Body Fat ◽  
Lean Mass ◽  
Z Score ◽  
Hematopoietic Stem ◽  
Total Body Fat ◽  
Z Scores ◽  
The Mean ◽  
Total Body

Abstract Abstract 1991 Background: Body mass and composition have been well studied in survivors of childhood cancers, but little is known about these factors in those who have undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: We prospectively and longitudinally evaluated changes in body mass index (BMI), changes in the proportion of fat and lean body mass, and associated clinical factors in 179 survivors of pediatric hematologic malignancies after allo-HSCT. BMI was analyzed as an ordinal variable (four percentile categories: underweight, healthy weight, overweight, and obese) and as a continuous variable (Z-score); dual-energy X-ray absorptiometry data were used to derive Z-scores for percent total body fat and lean mass/height2 ratio. Results: With a median follow-up of 6.6 years (range, 1.0–17.7 years), BMI decreased significantly over time (mean Z-score, 0.32 pre-HSCT and −0.60 at 10 years post-HSCT) (Figure; p<0.001). These longitudinal changes differed among pre-HSCT BMI categories (p<0.001). BMI Z-scores of patients who were underweight before HSCT increased over the first 4 years after HSCT and then declined, while those of patients in the other three pre-HSCT BMI categories continuously declined. Although the mean Z-scores for percent fat mass were higher or similar to those of the general population during follow-up (0.305 at 1 year, −0.272 at 10 years), the mean Z-scores of lean mass/height2 ratio remained below that of healthy controls and diminished significantly over time (-0.296 at 1 year, −1.256 at 10 years post-HSCT) (p=0.002). Pre-HSCT BMI categories were strongly associated with post-HSCT BMI values (p<0.001) and with Z-scores of percent total body fat and lean mass/height2 ratio (both p<0.001). Patients who had extensive chronic graft-versus-host disease were significantly more likely to be in the underweight BMI category (p=0.021) and to have a low Z-scores for lean mass/height2 ratio (p<0.001). Younger patients (less than the median age, 11.3 years, at HSCT) had a higher BMI after HSCT than older patients (p<0.001), and female survivors had higher Z-scores of percent total body fat (p=0.005) and lower Z-scores of lean mass/height2 ratio (p=0.025) than male survivors. Conclusions: The finding of a significant decline of BMI and severe loss of lean mass after HSCT indicates a critical need for nutritional education and early intervention for these survivors. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Ethnic Variation in Fat and Lean Body Mass and the Association with Insulin Resistance

2009 ◽  
Vol 94 (12) ◽  
pp. 4696-4702 ◽  
Author(s):  
Scott A. Lear ◽  
Simi Kohli ◽  
Gregory P. Bondy ◽  
André Tchernof ◽  
Allan D. Sniderman
Keyword(s):  
Insulin Resistance ◽  
Ethnic Groups ◽  
Body Mass ◽  
Body Fat ◽  
South Asian ◽  
Lean Mass ◽  
South Asians ◽  
Model Assessment ◽  
Total Body Fat ◽  
Total Body

Context: Body fat distribution varies among different ethnic groups, yet less is known regarding differences in lean mass and how this may affect insulin resistance. Objective: Our objective was to compare total body fat to lean mass ratio (F:LM) in Aboriginal, Chinese, European, and South Asian individuals with differences in insulin resistance. Participants, Design, and Setting: Aboriginal (196), Chinese (222), European (202), and South Asian (208) individuals were recruited across a range of body mass index to participate in this cross-sectional community study. Main Outcome Measures: Total body fat, lean mass, and insulin resistance were assessed using homeostasis model assessment (HOMA). Results: After adjustment for confounders and at a given body fat, South Asian men had less lean mass than Aboriginal [3.42 kg less; 95% confidence interval (CI) = 1.55–5.29], Chinese (3.01 kg less; 95% CI = 1.33–4.70), and European (3.57 kg less; 95% CI = 1.82–5.33) men, whereas South Asian women had less lean mass than Aboriginal (1.98 kg less; 95% CI = 0.45–3.50), Chinese (2.24 kg less; 95% CI = 0.81–3.68), and European (2.97 kg less; 95% CI = 1.67–4.27) women. In adjusted models, F:LM was higher in South Asian compared with Chinese and European men and higher in South Asian compared with Aboriginal, Chinese, and European women (P &lt; 0.01 for all). Insulin and HOMA were greatest in South Asians after adjustment; however, these differences were no longer apparent when F:LM was considered. Conclusions: South Asians have a phenotype of high fat mass and low lean mass, which may account for greater levels of insulin and HOMA compared with other ethnic groups.

scholarly journals Childhood Craniopharyngioma: A 22-Year Challenging Follow-Up in a Single Center

2018 ◽  
Vol 50 (09) ◽  
pp. 675-682 ◽  
Author(s):  
Patrícia Tosta-Hernandez ◽  
Adriana Siviero-Miachon ◽  
Nasjla da Silva ◽  
Andrea Cappellano ◽  
Marcelo Pinheiro ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Growth Hormone ◽  
Body Mass ◽  
Body Fat ◽  
Human Growth Hormone ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Z Score ◽  
Total Body Fat ◽  
Total Body

AbstractCraniopharyngioma is a sellar/suprasellar benign tumor whose aggressiveness may imply in endocrine disturbances (hypothalamic obesity and hormone deficiencies). Fifty-seven patients were evaluated according to clinical characteristics, hypothalamic involvement, type of treatment, anthropometric variables, adiposity indexes (body mass index Z score category at diagnosis and post-treatment, total body fat, visceral adipose tissue, and metabolic syndrome components) and analyzed through multiple regression and logistic models. Patients were stratified according to growth hormone deficiency and recombinant human growth hormone use. Mean ages at diagnosis and at study evaluation were 9.6 and 16.6 years old, respectively. A set of 43/57 (75.4%) patients presented with important hypothalamic involvement, 24/57 (42.1%) received surgical treatment and cranial radiotherapy, and 8/57 (14%) interferon-α exclusively. Fifty-five patients (96.5%) were considered growth hormone deficient, and 26/57 (45.6%) grew despite no recombinant human growth hormone replacement therapy. At diagnosis, 12/57 (21%) patients were obese, and 33/57 (57.9%) at study evaluation, and after 3.2 years (median) post first therapy. There was no influence of height Z score on body mass index Z score. Body mass index Z score at diagnosis positively influenced body mass index Z score, total body fat, waist circumference and the presence of the metabolic syndrome post-treatment. Replacement of recombinant human growth hormone decreased total body fat and visceral adipose tissue. Craniopharyngioma patients worsened body mass index Z score category 3.2 years (median) after first treatment. Body mass index Z score increased due to real weight gain, without height decrease. Replacement of recombinant human growth hormone had beneficial effect on adiposity.

scholarly journals Longitudinal Changes in Body Mass and Composition in Survivors of Childhood Hematologic Malignancies After Allogeneic Hematopoietic Stem-Cell Transplantation

2012 ◽  
Vol 30 (32) ◽  
pp. 3991-3997 ◽  
Author(s):  
Hiroto Inaba ◽  
Jie Yang ◽  
Sue C. Kaste ◽  
Christine M. Hartford ◽  
Megan S. Motosue ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Body Mass ◽  
Fat Mass ◽  
Lean Mass ◽  
Hematologic Malignancies ◽  
Z Score ◽  
Hematopoietic Stem ◽  
Z Scores

Purpose To measure longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation (HSCT). Patients and Methods Body mass index (BMI) was analyzed in 179 survivors by category (underweight, healthy-weight, overweight, and obese) and by z score. Fat and lean body mass measured by dual-energy x-ray absorptiometry was analyzed as z scores. Results Over a median 6.6 years of follow-up, BMI z scores diminished significantly (0.32 pre-HSCT v −0.60 at 10 years post-HSCT; P < .001). Mean z scores for fat mass stayed within population norms, but those for lean mass remained below normal levels and diminished significantly over time (P = .018). Pre-HSCT BMI category and/or z score were strongly predictive of post-HSCT BMI (P < .001) and of fat and lean mass z scores (both P < .001). Survivors with extensive chronic graft-versus-host disease were more likely than others to have low BMI (P = .004) and low lean mass (P < .001) post-HSCT. Older age at HSCT (P = .015) and T-cell–depleted graft (P = .018) were predictive of lower post-HSCT BMI. Female patients had higher body fat (P = .002) and lower lean mass (P = .013) z scores than male patients, and black patients had higher fat mass z scores than white patients (P = .026). Conclusion BMI declines significantly after allogeneic HSCT for childhood hematologic malignancies, reflecting primarily a substantial decrease in lean mass but not fat mass. Monitoring and preservation of BMI and lean mass are vital, especially in those with the identified risk factors.

scholarly journals Body mass index and waist circumference are better predictors of insulin resistance than total body fat percentage in middle-aged and elderly Taiwanese

Medicine ◽  
2017 ◽  
Vol 96 (39) ◽  
pp. e8126 ◽  
Author(s):  
Yiu-Hua Cheng ◽  
Yu-Chung Tsao ◽  
I-Shiang Tzeng ◽  
Hai-Hua Chuang ◽  
Wen-Cheng Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Middle Aged ◽  
Fat Percentage ◽  
Total Body Fat ◽  
Total Body

scholarly journals Relationship between dietary patterns, lifestyle habits and Total body fat composition among university students

2019 ◽  
Vol 10 (SPL1) ◽  
Author(s):  
Wan Hafizah W Jusof ◽  
Nuqman Mursyid Ramli
Keyword(s):  
Body Fat ◽  
Dietary Patterns ◽  
Male Students ◽  
Young Generation ◽  
Lifestyle Habits ◽  
Total Body Fat ◽  
Fat Composition ◽  
The Mean ◽  
Total Body ◽  
Main Meal

The prevalence of obesity has increased worldwide, leading to an increased risk of many serious illnesses, including diabetes, heart disease, and certain cancers. The changes of dietary patterns and lifestyle habits especially among young generation may contribute to this problem. This study was conducted to investigate the impacts of dietary patterns and lifestyle habits on total body fat composition among UniKL RCMP students.The self-administered questionnaires were distributed among 71 students (42.3% male and 57.7% female) by convenience sampling method to identify their dietary pattern and lifestyle habits. Bioelectrical Impedance Analysis Method was used to assess body fat composition. The results showed that most of the students (52.1%) consumed 2 meals daily, which contained carbohydrates, proteins, fatty foods, and beverages, but a low intake of fruits and vegetables. The majority of the students skipped breakfast and ate lunch as their main meal. For lifestyle habits, 77.5% of students preferred to do inactive activity during leisure time, while only 2.8% preferred to do exercise. The mean body fat percentage (% BF) for male students was 21.13 + 1.30, which is classified as high, while for females, the mean % BF was 26.71 + 1.25, which is classified as normal. The majority of the students did not practice healthy eating and lifestyle habits, and these factors may have contributed to the high body fat composition in male students. Therefore, the university is suggested to provide more programs such as good lifestyle habits and nutrition educations campaigns to increase awareness among the students.

Seasonal patterns in food intake, live mass, and body composition of mature female fallow deer ( Dama dama)

1998 ◽  
Vol 76 (6) ◽  
pp. 1141-1152 ◽  
Author(s):  
M L Weber ◽  
J M Thompson
Keyword(s):  
Body Composition ◽  
Food Intake ◽  
Body Mass ◽  
Body Fat ◽  
Low Energy ◽  
Body Tissue ◽  
Seasonal Patterns ◽  
Total Body Fat ◽  
Total Body ◽  
Seasonal Oscillations

Seasonal oscillations in food intake, live mass, and body component masses were investigated in two groups, each of 4 mature fallow does, which were fed high and low energy density diets ad libitum over a 17-month period. The aim of the experiment was to quantify seasonal patterns of food intake, live mass, and body tissue masses and to assess the effect of high- and low-energy diets on these patterns. Total body fat, muscle, and viscera masses were estimated on 10 occasions using computer-aided tomography. When food intake was expressed in megajoules of metabolisable energy per day, there was little difference between the groups fed the high- and low-energy diets. Food intake showed a clear deviation from a regular annual oscillation during the summer, when intake by both groups was reduced. Seasonal oscillations were apparent in live mass, empty body mass, muscle mass, and total body fat mass, with maximum values in autumn and minimum values in spring. Viscera mass did not show a seasonal pattern but was closely related to food intake. There was a lag phase of 6-7 weeks in the correlation between food intake and live mass and body tissue masses, suggesting that the changes in food intake were a precursor of subsequent changes in live mass and body composition. Further oscillations in muscle and fat masses persisted independently of changes in empty body mass, which indicated a differential change in these components according to season.

Annual Changes in Total Body Fat and Fat-free Mass in Children from 8 to 18 Years in Relation to Changes in Body Mass Index: The Fels Longitudinal Study

2006 ◽  
Vol 904 (1) ◽  
pp. 420-423 ◽  
Author(s):  
ROGER M. SIERVOGEL ◽  
L. MICHELE MAYNARD ◽  
WAYNE A. WISEMANDLE ◽  
ALEX F. ROCHE ◽  
SHUMEI S. GUO ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Longitudinal Study ◽  
Body Mass ◽  
Body Fat ◽  
Fat Free Mass ◽  
Total Body Fat ◽  
Annual Changes ◽  
Total Body

scholarly journals Associations of blood glucose levels with some diabetes risk factors (body mass index, blood pressure and total body fat) in inhabitants of Ho Municipality, Ghana: A cross-sectional survey

2021 ◽  
Vol 21` (01) ◽  
pp. 17365-17378
Author(s):  
Nii Korley Kortei ◽  
◽  
A Koryo-Dabrah ◽  
SK Angmorterh ◽  
D Adedia ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Risk Factor ◽  
Blood Glucose ◽  
Correlation Analysis ◽  
Body Mass ◽  
Body Fat ◽  
Lifestyle Modification ◽  
Total Body Fat ◽  
Total Body

One complex metabolic disorder that can unenviably affect the normal human physiology is diabetes mellitus(DM). It is indeed one of the commonest non-communicable diseases that has heightened to an epidemic level worldwide. For diseases like DM, hypertension, cardiovascular disease, type II DM, and other chronic diseases, body mass index (BMI) is identified as a positive and independent risk factor associated with morbidity and mortality. The objective of the study was to determine the relationships between BMI,blood pressure, and total body fat among inhabitants of peri-urban Ho, Ghana. Across-sectional survey was carried out between May and June,2018,among 132 inhabitants of Ho to determine the prevalence and associations among DM risk factors.The participants were selected by systematic random sampling. Standardized international protocols were used to measure BMI, blood pressure, blood glucose, and total body fat. Out of 132 respondents, majority 96 (72.7%) were female and the most common age group was 54-60 (31.1%). From the BMI classifications, 65 (49.2%) people were of normal weight while 6 (4.5%) were underweight. Total body fat (%) and blood pressure, likewise total body fat and BMI recorded significant associations of values (0.299, p<0.001-systolic; 0.298, p=0.001-diastolic), and 0.585(p<0.001),respectively. On the contrary, there were insignificant associations found between blood glucose and diastolic blood pressure and also blood glucose and systolic blood pressure(0.100, p=0.253)and (0.057. p=0.514),respectively using the Spearman’s correlation analysis. Lastly,the test of association of socio-demographics and anthropometrics revealed there was a significant (p<0.001)correlation between total body fat and BMI using Pearson’s correlation analysis. BMI is closely related to total body fat and blood pressure;hence,education on lifestyle modification needs to be intensified to create awareness among the inhabitants of Ho municipality of Ghana.It is imperative to educate Ghanaians and beyond about the risk factor associations that predispose an individual to DM.

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