Pathogenesis of B cell lymphoma in a patient with AIDS

Lymphoma occurs at increased frequency in patients with the acquired immunodeficiency syndrome (AIDS). We studied, using serologic and molecular techniques, one such lymphoma for (a) evidence of infection with human T lymphotropic virus, type III (HTLV-III), and Epstein-Barr virus (EBV), (b) monoclonal rearrangement of immunoglobulin and T cell receptor genes, and (c) rearrangement of the c-myc oncogene. Immunoglobulin and T cell receptor gene studies demonstrated that the tumor was of monoclonal B cell origin. Similar to cases of Burkitt's lymphoma unrelated to AIDS, there were DNA sequences in the lymphoma that hybridized to EBV-specific probes and demonstrated evidence of c- myc rearrangement. HTLV-III sequences were not detected in the malignant B cells. The pathogenesis of some B cell neoplasms in patients with the syndrome may involve transformation by EBV and deregulation of oncogene expression without direct infection of the malignant B cells by HTLV-III.

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Pathogenesis of B cell lymphoma in a patient with AIDS

Blood ◽

10.1182/blood.v67.3.612.612 ◽

1986 ◽

Vol 67 (3) ◽

pp. 612-615 ◽

Cited By ~ 100

Author(s):

JE Groopman ◽

JL Sullivan ◽

C Mulder ◽

D Ginsburg ◽

SH Orkin ◽

...

Keyword(s):

T Cell ◽

B Cells ◽

B Cell ◽

T Cell Receptor ◽

Dna Sequences ◽

Receptor Gene ◽

B Cell Lymphoma ◽

Cell Receptor ◽

Molecular Techniques ◽

Barr Virus

Abstract Lymphoma occurs at increased frequency in patients with the acquired immunodeficiency syndrome (AIDS). We studied, using serologic and molecular techniques, one such lymphoma for (a) evidence of infection with human T lymphotropic virus, type III (HTLV-III), and Epstein-Barr virus (EBV), (b) monoclonal rearrangement of immunoglobulin and T cell receptor genes, and (c) rearrangement of the c-myc oncogene. Immunoglobulin and T cell receptor gene studies demonstrated that the tumor was of monoclonal B cell origin. Similar to cases of Burkitt's lymphoma unrelated to AIDS, there were DNA sequences in the lymphoma that hybridized to EBV-specific probes and demonstrated evidence of c- myc rearrangement. HTLV-III sequences were not detected in the malignant B cells. The pathogenesis of some B cell neoplasms in patients with the syndrome may involve transformation by EBV and deregulation of oncogene expression without direct infection of the malignant B cells by HTLV-III.

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Abstract A003: Safety and preliminary efficacy of ACTR707, autologous T lymphocytes expressing an antibody-coupled T-cell receptor, in combination with rituximab in subjects with relapsed or refractory CD20-positive B-cell lymphoma

10.1158/2326-6074.cricimteatiaacr18-a003 ◽

2019 ◽

Author(s):

Veronika Bachanova ◽

Jonathon Cohen ◽

Luke Akard ◽

Samantha Jaglowski ◽

Jessica Sachs ◽

...

Keyword(s):

T Cell ◽

T Lymphocytes ◽

B Cell ◽

T Cell Receptor ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Cell Receptor

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Granulomatosis linfomatoide cerebral, con clonalidad del receptor de células T. A propósito de un caso.

Archivos de Patologia ◽

10.47579/ap.20.05.0030 ◽

2020 ◽

Vol 1 (5) ◽

Author(s):

Dr. Raúl Rodríguez ◽

Dra. Esther Nimchinsky ◽

Dr. James K Liu ◽

Dra. Ada Baisre de León

Keyword(s):

T Cell ◽

B Cell ◽

Dna Analysis ◽

Receptor Gene ◽

Brain Mri ◽

B Cell Lymphoma ◽

Cell Receptor ◽

Lymphomatoid Granulomatosis ◽

T Cell Clonality ◽

Cell Clonality

Lymphomatoid granulomatosis (LG) is a rare, angioinvasive and angiodestructive, EBV-associated B cell lymphoproliferative disorder, which occurs in the setting of immunosuppression. We present the peculiar case of a 67-year-old lady, with systemic lupus erythematous (SLE) and lupus nephritis, on immunosuppressant therapy, who developed a new onset of seizures and was found to have multiple ring enhancing lesions on brain MRI. A biopsy of one of the lesions revealed lymphomatoid granulomatosis, grade I. DNA analysis of the neoplasm, showed T-cell receptor gene rearrangement (TRG) and no evidence of B-cell rearrangement, which is an unusual finding. On further examination several lung nodules were identified on a CT scan of the chest, a characteristic of LG. Key words: Cerebral lymphomatoid granulomatosis, T cell clonality, Epstein Bar virus, Immunodeficiency associated B-cell lymphoma

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An (8;14)(q24;q11) translocation involving the T-cell receptor α-chain gene and theMYC oncogene 3′ region in a B-cell lymphoma

Genes Chromosomes and Cancer ◽

10.1002/gcc.2870010105 ◽

1989 ◽

Vol 1 (1) ◽

pp. 15-22 ◽

Cited By ~ 14

Author(s):

James K. Park ◽

Timothy W. McKeithan ◽

Michelle M. le Beau ◽

Mitchell A. Bitter ◽

Wilbur A. Franklin ◽

...

Keyword(s):

T Cell ◽

B Cell ◽

T Cell Receptor ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Cell Receptor ◽

Chain Gene ◽

Α Chain

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Rearrangement of the genes for the beta and gamma chains of the T cell receptor is rarely observed in adult B cell lymphoma and chronic lymphocytic leukemia.

Journal of Clinical Investigation ◽

10.1172/jci113182 ◽

1987 ◽

Vol 80 (4) ◽

pp. 1209-1214 ◽

Cited By ~ 14

Author(s):

A C Aisenberg ◽

B M Wilkes ◽

J O Jacobson

Keyword(s):

T Cell ◽

Chronic Lymphocytic Leukemia ◽

B Cell ◽

T Cell Receptor ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Cell Receptor ◽

Lymphocytic Leukemia

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Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.

Journal of Clinical Oncology ◽

10.1200/jco.1990.8.3.431 ◽

1990 ◽

Vol 8 (3) ◽

pp. 431-442 ◽

Cited By ~ 63

Author(s):

C A Felix ◽

D G Poplack ◽

G H Reaman ◽

S M Steinberg ◽

D E Cole ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

B Cell ◽

T Cell Receptor ◽

Lymphoblastic Leukemia ◽

Receptor Gene ◽

Cell Receptor ◽

Leukemic Cells ◽

Cell Precursor

Immunoglobulin (Ig) and T-cell receptor (TCR) genes were examined in the lymphoblasts of 70 children with immunophenotypically defined B-cell precursor acute lymphoblastic leukemia (ALL). The most frequent genes to rearrange were Ig heavy (H) chain (93%) and TCR delta (79%), followed by TCR gamma (49%), Ig kappa and/or lambda light (L) chain (46%), TCR alpha (46%), and TCR beta (29%). Thus, despite their putative "B-cell precursor" lineage, these leukemias manifest a remarkably high incidence of TCR gene rearrangements. While certain patterns predominate, there is considerable heterogeneity in Ig and TCR genotypes in this disease. No significant associations were found between Ig and TCR genotype and commonly used prognostic factors including age, sex, race, WBC, French-American-British (FAB) subtype, or cytogenetics. However, the lymphoblasts of three of six patients who failed to achieve initial remission had germline patterns of every Ig and TCR gene, a genotype not observed in the leukemic cells from any of the 64 patients who achieved complete remission (p2 = .0007). This study suggests that particular Ig and TCR genotypes may be of clinical relevance in childhood B-cell precursor ALL. The finding of rearranged TCR genes in a large proportion of cases raises fundamental questions about early lineage commitment and lymphocyte differentiation along B-cell and T-cell pathways.

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