scholarly journals C-reactive protein, obesity, atopy and asthma symptoms in middle-aged adults

2008 ◽  
Vol 32 (1) ◽  
pp. 77-84 ◽  
Author(s):  
B. K. Butland ◽  
D. P. Strachan ◽  
A. R. Rudnicka
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Danielle E. Eagan ◽  
Mitzi M. Gonzales ◽  
Takashi Tarumi ◽  
Hirofumi Tanaka ◽  
Sandra Stautberg ◽  
...  

C-reactive protein (CRP), a systemic marker of inflammation, is a risk factor for late life cognitive impairment and dementia, yet the mechanisms that link elevated CRP to cognitive decline are not fully understood. In this study we examined the relationship between CRP and markers of neuronal integrity and cerebral metabolism in middle-aged adults with intact cognitive function, using proton magnetic resonance spectrocospy. We hypothesized that increased levels of circulating CRP would correlate with changes in brain metabolites indicative of early brain vulnerability. Thirty-six individuals, aged 40 to 60, underwent neuropsychological assessment, a blood draw for CRP quantification, and 1H MRS examining N-acetyl-aspartate, myo-inositol, creatine, choline, and glutamate concentrations in occipito-parietal grey matter. Independent of age, sex and education, serum CRP was significantly related to higher cerebral myo-inositol/creatine ratio (F(4,31)=4.74,  P=0.004), a relationship which remained unchanged after adjustment for cardiovascular risk (F(5,30)=4.356, CRP β = 0.322, P=0.045). Because these biomarkers are detectable in midlife they may serve as useful indicators of brain vulnerability during the preclinical period when mitigating intervention is still possible.


Thorax ◽  
2010 ◽  
Vol 65 (6) ◽  
pp. 523-527 ◽  
Author(s):  
I. Muraki ◽  
T. Tanigawa ◽  
K. Yamagishi ◽  
S. Sakurai ◽  
T. Ohira ◽  
...  

2011 ◽  
Vol 32 (6) ◽  
pp. 327 ◽  
Author(s):  
Kiwoong Yu ◽  
Cheolhwan Kim ◽  
Eunju Sung ◽  
Hocheol Shin ◽  
Hyewon Lee

Diabetologia ◽  
2004 ◽  
Vol 47 (8) ◽  
Author(s):  
D.E. Laaksonen ◽  
L. Niskanen ◽  
K. Nyyss�nen ◽  
K. Punnonen ◽  
T.-P. Tuomainen ◽  
...  

2006 ◽  
Vol 7 (3) ◽  
pp. 290
Author(s):  
H.R. Nakhai Pour ◽  
D.E. Grobbe ◽  
M. Muller ◽  
Y.T. Van Der Schouw

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