The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations

1. Increased concentrations of plasma polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease. However, it is not known whether there are corresponding changes in circulating phospholipids - the major source of fatty acids in the plasma. 2. Fasting plasma samples were obtained from 17 control subjects and 13 patients with active Crohn's disease [Simple Index of Crohn's Disease Activity (SICDA) >6] before, and 2 and 8 weeks after, treatment with either a peptide diet or oral prednisolone. 3. Before treatment, the Crohn's disease patients had mildly active disease (SICDA 9.9 ± 0.8, erythrocyte sedimentation rate 26.4 ± 6.5 mm/h, serum C-reactive protein 2.8 ± 0.4 mg/l). The proportions of the polyunsaturated phosphatidylcholine species, 16:0–20:4 (10.0 ± 0.7%) and 16:0–22:6 (7.1 ± 0.8%), were both significantly higher than those in healthy controls (7.6 ± 0.5%, P < 0.01 and 5.3 ± 0.5%, P < 0.05 respectively). 4. After 2 weeks treatment, the SICDA in the Crohn's disease patients decreased to 3.2 ± 0.6 (P < 0.0001 compared with the pretreatment value), and there were corresponding falls in the erythrocyte sedimentation rate (to 12.6 ± 2.7 mm/h, P < 0.05) and C-reactive protein concentration (to 1.7 ± 0.3 mg/l, P < 0.05)—these improvements being maintained at 8 weeks. There was also a fall to normal values in 16:0–20:4 (to 7.7 ± 0.6%, P < 0.01 compared with the pretreatment value) and in 16:0–22:6 (to 5.7 ± 0.5%, P not significant), by week 8. 5. The proportions of polyunsaturated phosphatidylcholine molecular species were increased in the plasma of patients with active Crohn's disease, but fell to normal levels during disease remission. These observations are consistent with the theory that, in active Crohn's disease, the mucosal phospholipids containing polyunsaturated fatty acids are increased, contribute to eicosanoid synthesis and ‘spill’ into the plasma.

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Efficacy of Polyunsaturated Fatty Acids on Inflammatory Markers in Patients Undergoing Dialysis: A Systematic Review with Network Meta-Analysis of Randomized Clinical Trials

International Journal of Molecular Sciences ◽

10.3390/ijms20153645 ◽

2019 ◽

Vol 20 (15) ◽

pp. 3645 ◽

Cited By ~ 1

Author(s):

Po-Kuan Wu ◽

Shu-Ching Yeh ◽

Shan-Jen Li ◽

Yi-No Kang

Keyword(s):

Fatty Acids ◽

Clinical Trials ◽

Vitamin E ◽

Polyunsaturated Fatty Acids ◽

Inflammatory Markers ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

The effects of polyunsaturated fatty acids (PUFAs) on inflammatory markers among patients receiving dialysis have been discussed for a long time, but previous syntheses made controversial conclusion because of highly conceptual heterogeneity in their synthesis. Thus, to further understanding of this topic, we comprehensively gathered relevant randomized clinical trials (RCTs) before April 2019, and two authors independently extracted data of C-reactive protein (CRP), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) for conducting network meta-analysis. Eighteen eligible RCTs with 962 patients undergoing dialysis were included in our study. The result showed that with placebo as the reference, PUFAs was the only treatment showing significantly lower CRP (weighted mean difference (WMD): −0.37, 95% confidence interval (CI): −0.07 to −0.68), but the CRP in PUFAs group was not significantly lower than vitamin E, PUFAs plus vitamin E, or medium-chain triglyceride. Although no significant changes were noted for hs-CRP and IL-6 levels, PUFAs showed the best ranking among treatments according to surface under the cumulative ranking. Therefore, PUFAs could be a protective option for patients receiving dialysis in clinical practice.

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Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men

European Journal of Clinical Nutrition ◽

10.1038/ejcn.2011.195 ◽

2011 ◽

Vol 66 (6) ◽

pp. 736-741 ◽

Cited By ~ 34

Author(s):

I Reinders ◽

J K Virtanen ◽

I A Brouwer ◽

T-P Tuomainen

Keyword(s):

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

C Reactive Protein ◽

Reactive Protein

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Activities of Daily Living Decrease Serum Levels of C-Reactive Protein in Elderly Adults but Not in Young and Middle-Aged Adults

Journal of the American Geriatrics Society ◽

10.1111/jgs.14046 ◽

2016 ◽

Vol 64 (4) ◽

pp. 883-884

Author(s):

Katarzyna Wesolowska ◽

Bożena Czarkowska-Paczek ◽

Agnieszka Wirkowska

Keyword(s):

Activities Of Daily Living ◽

Daily Living ◽

Serum Levels ◽

Elderly Adults ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Middle Aged Adults

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Seafood intake, polyunsaturated fatty acids, blood mercury, and serum C-reactive protein in US National Health and Nutrition Examination Survey (2005–2006)

International Journal of Environmental Health Research ◽

10.1080/09603123.2017.1292495 ◽

2017 ◽

Vol 27 (2) ◽

pp. 136-143

Author(s):

Erin Emanuele ◽

Jaymie Meliker

Keyword(s):

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

National Health ◽

Nutrition Examination Survey ◽

C Reactive Protein ◽

Reactive Protein ◽

Health And Nutrition ◽

Blood Mercury

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A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527317666180625101643 ◽

2018 ◽

Vol 17 (6) ◽

pp. 430-438 ◽

Cited By ~ 16

Author(s):

Mina Abdolahi ◽

Payam Sarraf ◽

Mohammad Hassan Javanbakht ◽

Niyaz Mohammadzadeh Honarvar ◽

Mahsa Hatami ◽

...

Keyword(s):

Gene Expression ◽

Fatty Acids ◽

Mononuclear Cells ◽

Serum Levels ◽

Combination Group ◽

C Reactive Protein ◽

Neuroprotective Effects ◽

Peripheral Blood Mononuclear ◽

Reactive Protein ◽

Hs Crp

Background: Migraine is a disabling neuroinflammatory condition characterized by increasing the levels of interleukin (IL)-6, a proinflammatory cytokine and C-reactive protein (CRP) which considered as a vascular inflammatory mediator, disrupting the integrity of blood-brain barrier and contributing to neurogenic inflammation, and disease progression. Curcumin and ω-3 fatty acids can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels. The aim of present study is the evaluation of combined effects of ω-3 fatty acids and nano-curcumin supplementation on IL-6 gene expression and serum level and hs-CRP levels in migraine patients. Methods: Eighty episodic migraine patients enrolled in the trial and were divided into four groups as 1) combination of ω-3 fatty acids (2500 mg) plus nano-curcumin (80 mg), 2) ω-3 (2500 mg), 3) nanocurcumin (80 mg), and 4) the control (ω-3 and nano-curcumin placebo included oral paraffin oil) over a two-month period. At the beginning and the end of the study, the expression of IL-6 from peripheral blood mononuclear cells and IL-6 and hs-CRP serum levels were measured, using a real-time PCR and ELISA methods, respectively. Results: The results showed that both of ω-3 and nano-curcumin down-regulated IL-6 mRAN and significantly decreased the serum concentration. hs-CRP serum levels significantly decrease in combination and nano-curcumin within groups (P<0.05). An additive greater reduction of IL-6 and hs-CRP was observed in the combination group suggested a possible synergetic relation. Conclusion: It seems that ω-3 fatty acids and curcumin supplementation can be considered a new promising target in migraine prevention.

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Plasma Trans Fatty Acid Levels, Cardiovascular Risk Factors and Lifestyle: Results from the Akershus Cardiac Examination 1950 Study

Nutrients ◽

10.3390/nu12051419 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1419

Author(s):

Anupam Chandra ◽

Magnus Nakrem Lyngbakken ◽

Ivar Anders Eide ◽

Helge Røsjø ◽

Thea Vigen ◽

...

Keyword(s):

Risk Factors ◽

Fatty Acids ◽

Trans Fatty Acids ◽

High Plasma ◽

Cross Sectional Study ◽

C Reactive Protein ◽

Serum Triglycerides ◽

Cross Sectional ◽

Reactive Protein ◽

The Relationship

Intake of industrially produced trans fatty acids (iTFAs) has previously been associated with dyslipidemia, insulin resistance, hypertension and inflammation, as well as increased cardiovascular (CV) morbidity and mortality. iTFA intake declined in Norway after the introduction of legislative bans against iTFA consumption. However, the relationship between the current iTFA intake and CV health is unclear. The aim of the present study was to investigate the association between current iTFA intake, reflected by plasma iTFA levels, and established CV risk factors. We also examined the associations between plasma ruminant TFA levels and CV risk factors. In this cross-sectional study, we included 3706 participants from a Norwegian general population, born in 1950 and residing in Akershus County, Norway. The statistical method was multivariable linear regression. Plasma iTFA levels were inversely associated with serum triglycerides (p < 0.001), fasting plasma glucose (p < 0.001), body mass index (p < 0.001), systolic and diastolic blood pressure (p = 0.001 and p = 0.03) and C-reactive protein (p = 0.001). Furthermore, high plasma iTFA levels were associated with higher education and less smoking and alcohol consumption. We found that plasma ruminant trans fatty acids (rTFA) levels were favorably associated with CV risk factors. Furthermore, plasma iTFA levels were inversely associated with CV risk factors. However, our results might have been driven by lifestyle factors. Overall, our findings suggest that the current low intake of iTFAs in Norway does not constitute a threat to CV health.

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