Oxygenation and electromyographic responses of the quadriceps during the 1-minute sit-to-stand in patients with severe COPD and healthy controls

2021 ◽  
Author(s):  
Sarah Gephine ◽  
Patrick Mucci ◽  
Mickael Martin ◽  
Didier Saey ◽  
François Maltais
Keyword(s):  
Healthy Controls ◽  
Sit To Stand ◽  
Severe Copd

scholarly journals Quadriceps Physiological Response During the 1-minute Sit-to-stand Test in People with Severe COPD and Healthy Controls

2021 ◽  
Author(s):  
Sarah Gephine ◽  
Patrick Mucci ◽  
Mathieu Bielmann ◽  
Mickael Martin ◽  
Laurent Bouyer ◽  
...  
Keyword(s):  
Physiological Response ◽  
Near Infrared ◽  
Healthy Controls ◽  
Total Work ◽  
Time Duration ◽  
Contraction Pattern ◽  
Sit To Stand ◽  
Cardiorespiratory Response ◽  
Severe Copd ◽  
Semg Signals

Abstract We compared quadriceps oxygenation and surface electromyography (sEMG) responses during the 1-min sit-to-stand (1STS) in 14 people with severe COPD and 12 controls, in whom cardiorespiratory response, near-infrared spectroscopy signals (oxy [Hb-Mb], deoxy [Hb-Mb], total [Hb-Mb], and SmO2) and sEMG signals of the quadriceps were recorded. Time duration of each sit-to-stand cycle and the total work performed during the 1STS were measured. The quadriceps oxygenation parameters were normalized by reporting their values according to the total work during 1STS. The rate of sit-to-stand maneuvers decelerated in people with COPD leading to smaller total work compared with controls. The pattern of quadriceps oxygenation response during 1STS was similar between groups. However, in COPD, the recovery after 1STS was characterized by larger overshoots in oxy [Hb-Mb], total [Hb-Mb], and SmO2. When corrected for the cumulative total work, the increase in muscle O2 extraction (deoxy [Hb-Mb]) during the first 30 seconds of recovery was greater in people with COPD compared to controls. Quadriceps sEMG changes suggestive of a fatiguing contraction pattern was observed only in people with COPD. All together, these results highlighted physiological misadaptation of people with severe COPD to the 1STS.

scholarly journals Paraoxonase 1 and Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1891
Author(s):  
Jun Watanabe ◽  
Kazuhiko Kotani ◽  
Alejandro Gugliucci
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Chronic Obstructive ◽  
Healthy Controls ◽  
Obstructive Pulmonary Disease ◽  
Paraoxonase Activity ◽  
Severe Copd

Oxidative stress is a driving factor in the pathophysiology of chronic obstructive pulmonary disease (COPD). While paraoxonase 1 (PON1) is an antioxidant enzyme and a potential biomarker of this disease, data regarding the status of PON-1 in COPD are inconclusive. In this regard, to shed light on this issue, we performed a meta-analysis of data on PON1 activity in COPD. Electronic databases (MEDLINE, Embase and CENTRAL) were searched for available studies on PON1 activity in patients with stable COPD published before October 2021. A meta-analysis was performed using random-effects models. Twelve studies (12 studies on paraoxonase and three on arylesterase) were identified. Patients with COPD had lower levels of paraoxonase activity (standard mean difference [SMD] −0.77, 95% confidence interval [CI] −1.35 to −0.18) and arylesterase activity (SMD −1.15, 95% CI −1.95 to −0.36) in comparison to healthy controls. In subgroup analyses, paraoxonase activity was lower in patients of studies as consisted of mainly non-severe COPD (SMD −1.42, 95% CI −2.04 to −0.79) and, by contrast, slightly higher in patients of studies including severe COPD (SMD 0.33, 95% CI 0.02 to 0.64) in comparison to healthy controls. Arylesterase activity showed a similar trend. Overall, PON1 activity was lower in patients with COPD, suggesting that PON1-related antioxidant defense is impaired in COPD. Future studies are warranted.

Impact of Fibromyalgia in the Sit-to-Stand-to-Sit Performance Compared With Healthy Controls

PM&R ◽  
2016 ◽  
Vol 9 (6) ◽  
pp. 588-595 ◽  
Author(s):  
Daniel Collado-Mateo ◽  
Jose C. Adsuar ◽  
Francisco J. Dominguez-Muñoz ◽  
Pedro R. Olivares ◽  
Narcis Gusi
Keyword(s):  
Healthy Controls ◽  
Sit To Stand

Preserved muscle metaboreflex in chronic obstructive pulmonary disease

2011 ◽  
Vol 36 (6) ◽  
pp. 821-830 ◽  
Author(s):  
Megan F.B. Sherman ◽  
Jeremy D. Road ◽  
Donald C. McKenzie ◽  
A. William Sheel
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Heart Rate ◽  
Blood Flow ◽  
Pulmonary Disease ◽  
Exercise Capacity ◽  
Chronic Obstructive ◽  
Healthy Controls ◽  
Obstructive Pulmonary Disease ◽  
Muscle Metaboreflex ◽  
Severe Copd

The objective of this study was to measure the magnitude of the muscle metaboreflex in people with chronic obstructive pulmonary disease (COPD) compared with healthy controls and to assess the relationships between disease severity, exercise capacity, and the magnitude of the muscle metaboreflex. Nine people with mild-to-severe COPD and 11 age- and gender-matched healthy controls performed isometric handgrip exercise (IHG), followed by postexercise circulatory occlusion (PECO) while hemodynamic changes were measured. Continuous measures of heart rate, arterial pressure, leg blood flow, leg vascular resistance, and total peripheral resistance were obtained. Participants then performed a cycle test to exhaustion. Heart rate, blood pressure, and blood flow responses during IHG and PECO were similar between the COPD group and healthy controls (p > 0.05). There was no association between disease severity or exercise capacity and the magnitude of the muscle metaboreflex. We observed a preserved muscle metaboreflex in mild-to-severe COPD, suggesting the metaboreflex is not a contributing factor to the development of exercise intolerance in this population.

Intra- and interrater reproducibility of 30-seconds sit-to-stand test in patients with severe and very severe COPD

2018 ◽  
Author(s):  
Henrik Hansen ◽  
Nina Beyer ◽  
Anne Frølich ◽  
Nina Godtfredsen ◽  
Theresa Bieler
Keyword(s):  
Stand Test ◽  
Sit To Stand ◽  
Severe Copd

scholarly journals Biomechanical Alterations during Sit-to-Stand Transfer Are Caused by a Synergy between Knee Osteoarthritis and Obesity

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Loek Verlaan ◽  
Ramon J. Boekesteijn ◽  
Pieter W. Oomen ◽  
Wai-Yan Liu ◽  
Marloes J. M. Peters ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Reaction Force ◽  
Three Dimensional ◽  
Movement Analysis ◽  
Healthy Controls ◽  
Compensatory Mechanisms ◽  
Vertical Ground Reaction Force ◽  
Knee Oa ◽  
Sit To Stand ◽  
Current Prevalence

Osteoarthritis is one of the major causes of immobility and its current prevalence in elderly (>60 years) is 18% in women and 9.6% in men. Patients with osteoarthritis display altered movement patterns to avoid pain and overcome movement limitations in activities of daily life, such as sit-to-stand transfers. Currently, there is a lack of evidence that distinguishes effects of knee osteoarthritis on sit-to-stand performance in patients with and without obesity. The purpose of this study was therefore to investigate differences in knee and hip kinetics during sit-to-stand movement between healthy controls and lean and obese knee osteoarthritis patients. Fifty-five subjects were included in this study, distributed over three groups: healthy controls (n=22), lean knee osteoarthritis (n=14), and obese knee OA patients (n=19). All subjects were instructed to perform sit-to-stand transfers at self-selected, comfortable speed. A three-dimensional movement analysis was performed to investigate compensatory mechanisms and knee and hip kinetics during sit-to-stand movement. No difference in sit-to-stand speed was found between lean knee OA patients and healthy controls. Obese knee osteoarthritis patients, however, have reduced hip and knee range of motion, which is associated with reduced peak hip and knee moments. Reduced vertical ground reaction force in terms of body weight and increased medial ground reaction forces indicates use of compensatory mechanisms to unload the affected knee in the obese knee osteoarthritis patients. We believe that an interplay between obesity and knee osteoarthritis leads to altered biomechanics during sit-to-stand movement, rather than knee osteoarthritis alone. From this perspective, obesity might be an important target to restore healthy sit-to-stand biomechanics in obese knee OA patients.

Knee efforts and weight-bearing asymmetry during sit-to-stand tasks in individuals with hemiparesis and healthy controls

2013 ◽  
Vol 23 (2) ◽  
pp. 508-515 ◽  
Author(s):  
Anabèle Brière ◽  
Sylvie Nadeau ◽  
Séléna Lauzière ◽  
Denis Gravel ◽  
Patrick Dehail
Keyword(s):  
Weight Bearing ◽  
Healthy Controls ◽  
Sit To Stand

Influence of sex gap on muscle strength and functional mobility in patients with cystic fibrosis

2020 ◽  
Vol 45 (4) ◽  
pp. 387-392 ◽  
Author(s):  
María del M. Martínez-García ◽  
Juan J. Rodríguez-Juan ◽  
Juan D. Ruiz-Cárdenas
Keyword(s):  
Cystic Fibrosis ◽  
Muscle Strength ◽  
Lung Function ◽  
Muscle Weakness ◽  
Walking Speed ◽  
Handgrip Strength ◽  
Pancreatic Insufficiency ◽  
Functional Mobility ◽  
Healthy Controls ◽  
Sit To Stand

The objectives of this study were to determine whether there were differences in handgrip strength and functional mobility between patients with cystic fibrosis (CF) and healthy controls with regard to sex and to ascertain whether these differences were related to lung function. Thirty-eight patients with CF (21 women) and 38 healthy controls aged 18–65 years were included. Muscle weakness and functional mobility were assessed through handgrip strength; walking speed; and time, velocity, and power derived from a single sit-to-stand (STS) test. Patients with CF showed differences for STS variables and walking speed but not for handgrip strength, compared with healthy controls. Considering sex differences, female patients showed differences for all variables analyzed while males with CF only exhibited differences for STS variables, compared with healthy controls. Females with CF showed moderate relationship between muscle weakness, functional mobility, and lung function (|r| = 0.45–0.49; p ≤ 0.05) whereas no relationships were observed for males with CF. The influence of chronic infection with Pseudomonas aeruginosa and pancreatic insufficiency on muscle weakness and functional mobility was similar in both sexes. Differences in muscle strength and functional mobility were predominantly observed in females with CF. These results suggest an important effect of sex gap on muscle weakness and functional mobility in patients with CF. Novelty The influence of sex gap on muscle weakness in CF has been shown. Muscle weakness was predominantly observed in females with CF.

scholarly journals Glucose and pyruvate metabolism in severe chronic obstructive pulmonary disease

2012 ◽  
Vol 112 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Christina C. Kao ◽  
Jean W.-C. Hsu ◽  
Venkata Bandi ◽  
Nicola A. Hanania ◽  
Farrah Kheradmand ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Glucose Metabolism ◽  
Pulmonary Disease ◽  
Body Mass ◽  
Lactate Production ◽  
Glucose Production ◽  
Chronic Obstructive ◽  
Healthy Controls ◽  
Obstructive Pulmonary Disease ◽  
Severe Copd

The mechanisms leading to weight loss in patients with chronic obstructive pulmonary disease (COPD) are poorly understood but may involve alterations in macronutrient metabolism. Changes in muscle oxidative capacity and lactate production during exercise suggest glucose metabolism may be altered in COPD subjects. The objective of this study was to determine differences in the rates of glucose production and clearance, the rate of glycolysis (pyruvate production), and oxidative and nonoxidative pyruvate disposal in subjects with severe COPD compared with healthy controls. The in vivo rates of glucose production and clearance were measured in 14 stable outpatients with severe COPD (seven with low and seven with preserved body mass indexes) and 7 healthy controls using an intravenous infusion of [2H2]glucose. Additionally, pyruvate production and oxidative and non-oxidative pyruvate disposal were measured using intravenous infusions of [13C]bicarbonate and [13C]pyruvate. Endogenous glucose flux and glucose clearance were significantly faster in the combined COPD subjects ( P = 0.002 and P < 0.001, respectively). This difference remained significant when COPD subjects were separated by body mass index. Pyruvate flux and oxidation were significantly higher in the combined COPD subjects than controls ( P = 0.02 for both), but there was no difference in nonoxidative pyruvate disposal or plasma lactate concentrations between the two groups. In subjects with severe COPD, there are alterations in glucose metabolism leading to increased glucose production and faster glucose metabolism by glycolysis and oxidation compared with controls. However, no difference in glucose conversion to lactate via pyruvate reduction is observed.

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