IPC use in non-malignant effusions

AbstractOur aim was to investigate the diagnostic yield of rapid T1-mapping for the differentiation of malignant and non-malignant effusions in an ex-vivo set up. T1-mapping was performed with a fast modified Look-Locker inversion-recovery (MOLLI) acquisition and a combined turbo spin-echo and inversion-recovery sequence (TMIX) as reference. A total of 13 titrated albumin-solutions as well as 48 samples (29 ascites/pleural effusions from patients with malignancy; 19 from patients without malignancy) were examined. Samples were classified as malignant-positive histology, malignant-negative histology and non-malignant negative histology. In phantom analysis both mapping techniques correlated with albumin-content (MOLLI: r = − 0.97, TMIX: r = − 0.98). MOLLI T1 relaxation times were shorter in malignancy-positive histology fluids (2237 ± 137 ms) than in malignancy-negative histology fluids (2423 ± 357 ms) as well as than in non-malignant-negative histology fluids (2651 ± 139 ms); post hoc test for all intergroup comparisons: < 0.05. ROC analysis for differentiation between malignant and non-malignant effusions (malignant positive histology vs. all other) showed an (AUC) of 0.89 (95% CI 0.77–0.96). T1 mapping allows for non-invasive differentiation of malignant and non-malignant effusions in an ex-vivo set up.

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A TUNNELED PLEURAL CATHETER ACCESS PORT DRAINAGE SYSTEM FOR THE MANAGEMENT OF MALIGNANT EFFUSIONS

CHEST Journal ◽

10.1378/chest.132.4_meetingabstracts.619 ◽

2007 ◽

Vol 132 (4) ◽

pp. 619A

Author(s):

Ken Y. Yoneda ◽

Wayne Monsky ◽

John McMillan

Keyword(s):

Drainage System ◽

Access Port ◽

Malignant Effusions ◽

Pleural Catheter

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Assessment of a panel of tumor markers for the differential diagnosis of benign and malignant effusions by well-based reverse phase protein array

Diagnostic Pathology ◽

10.1186/s13000-015-0290-4 ◽

2015 ◽

Vol 10 (1) ◽

Cited By ~ 3

Author(s):

Till Braunschweig ◽

Joon-Yong Chung ◽

Chel Hun Choi ◽

Hanbyoul Cho ◽

Qing-Rong Chen ◽

...

Keyword(s):

Differential Diagnosis ◽

Tumor Markers ◽

Protein Array ◽

Reverse Phase Protein Array ◽

Reverse Phase ◽

Phase Protein ◽

Malignant Effusions

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Biochemical Analysis of Neoplastic Versus Nonneoplastic Abdominal Effusions in Dogs

Journal of the American Animal Hospital Association ◽

10.5326/0400372 ◽

2004 ◽

Vol 40 (5) ◽

pp. 372-375 ◽

Cited By ~ 15

Author(s):

Derek D. Nestor ◽

Sheila M. McCullough ◽

David J. Schaeffer

Keyword(s):

Prospective Study ◽

Biochemical Parameters ◽

Biochemical Analysis ◽

Lower Glucose ◽

Low Glucose ◽

Malignant Effusions ◽

Lactate Levels ◽

High Lactate

This prospective study of 15 dogs evaluated biochemical parameters in abdominal effusions of neoplastic and nonneoplastic origin in an attempt to identify markers for malignant effusions. Dogs in the neoplastic group had statistically significant lower glucose concentrations (mean, 72.6 mg/dL versus 110.0 mg/dL; P=0.0431) and higher lactate levels (mean, 3.81 mmol/L versus 1.68 mmol/L; P=0.0377) in their abdominal fluid than did dogs in the nonneoplastic group, indicating that low glucose and high lactate in abdominal effusions may be markers for neoplasia.

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Hyaluronic acid levels are increased in complicated parapneumonic pleural effusions

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2011.217 ◽

2015 ◽

Vol 75 (3) ◽

Cited By ~ 1

Author(s):

T. Zaga ◽

D. Makris ◽

I. Tsilioni ◽

T. Kiropoulos ◽

S. Oikonomidi ◽

...

Keyword(s):

Heart Failure ◽

Extracellular Matrix ◽

Congestive Heart Failure ◽

Hyaluronic Acid ◽

Pleural Fluid ◽

Inflammatory Process ◽

Serum Levels ◽

Pleural Effusions ◽

Tnf Α ◽

Malignant Effusions

Background and Aim. Hyaluronic acid (HA) is a component of extracellular matrix and may play a role in the pleural inflammation which is implicated in parapneumonic effusions.The aim of the current study was to investigate HA levels in serum and pleura in patients with parapneumonic effusions. Methods. We prospectively studied pleural and serum levels of HA in 58 patients with pleural effusions due to infection (complicated and uncomplicated parapneumonic effusions), malignant effusions and transudative effusions due to congestive heart failure. In addition to HA, TNF-α and IL-1β levels were determined in pleural fluid and serum by ELISA. Results. The median±SD HA levels (pg/ml) in pleural fluid of patients with complicated effusions (39.058±11.208) were significantly increased (p<0.005), compared to those with uncomplicated parapneumonic effusions (11.230±1.969), malignant effusions (10.837±4.803) or congestive heart failure (5.392±3.133). There was no correlation between pleural fluid and serum HA values. Pleural fluid TNF-α levels (146±127 pg/mL) and IL-1β levels (133.4±156 pg/mL) were significantly higher in patients with complicated parapneumonic effusions compared to patients with other types of effusion (p<0.05). No significant association between HA and TNF-α or IL-1β was found. Conclusions. HA may play a significant role in the inflammatory process which characterises exudative infectious pleuritis. Further investigation might reveal whether HA is a useful marker in the management of parapneumonic effusions.

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