scholarly journals Sleep disordered breathing and autonomic function in overweight and obese children and adolescents

2016 ◽  
Vol 2 (4) ◽  
pp. 00038-2016 ◽  
Author(s):  
Annelies Van Eyck ◽  
Kim Van Hoorenbeeck ◽  
Benedicte Y. De Winter ◽  
Luc Van Gaal ◽  
Wilfried De Backer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Frequency Band ◽  
High Frequency ◽  
Urinary Free Cortisol ◽  
High Frequency Band ◽  
Band Ratio ◽  
Rr Interval ◽  
Free Cortisol ◽  
Mean Heart Rate

Obstructive sleep apnoea (OSA), common in children with obesity, is associated with cardiovascular morbidity. Autonomic dysfunction has been suggested to be a key player in the development of these complications. We investigated the relationship between obesity, OSA and sympathetic activity in children.191 children with obesity were included and distributed into two groups: 131 controls and 60 with OSA. Beat-to-beat RR interval data were extracted from polysomnography for heart rate variability analysis. Urinary free cortisol levels were determined.Urinary free cortisol did not differ between groups and was not associated with OSA, independent of the level of obesity. Differences in heart rate variability measures were found: mean RR interval decreased with OSA, while low/high-frequency band ratio and mean heart rate increased with OSA. Heart rate variability measures correlated with OSA, independent of obesity parameters and age: oxygen desaturation index correlated with mean heart rate (r=0.19, p=0.009) and mean RR interval (r= −0.18, p=0.02), while high-frequency bands and low/high-frequency band ratio correlated with arterial oxygen saturation measured by pulse oximetry (SpO2) (r= −0.20, p=0.008 and r= −0.16, p=0.04) andSpO2nadir (r=0.23, p=0.003 and r= −0.19, p=0.02).These results suggest that sympathetic heart activity is increased in children with obesity and OSA. Measures of hypoxia were related to increased sympathetic tone, suggesting that intermittent hypoxia is involved in autonomic dysfunction.

The relationship between chemotherapy-induced peripheral neuropathy and heart rate variability.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 820-820
Author(s):  
Aelee Jang ◽  
Dong Uk Kim
Keyword(s):  
Quality Of Life ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Peripheral Neuropathy ◽  
Frequency Band ◽  
High Frequency ◽  
Chemotherapeutic Agents ◽  
High Frequency Band ◽  
The Relationship

820 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication related to chemotherapeutic agents and dose accumulation. Initial symptoms are known to be sensory including numbness and pain whereas autonomic symptoms are the latest. Autonomic dysfunction is related to heart rate variability (HRV) change which may precede the symptoms. But, the relationship between CIPN and heart rate variability is not fully evaluated. Therefore, we aimed to evaluate the HRV with CIPN-related questionnaires in patients underwent chemotherapy. Methods: Fifty-five patients with gastrointestinal cancers were enrolled in this cross-sectional cohort study. Patients have received chemotherapeutic agents such as paclitaxel, cisplatin, and oxaliplatin. CIPN was diagnosed using National Cancer Institute Common Toxicity Criteria for Adverse Event (NCI-CTCAE version 4.03). We evaluated the quality of life, CIPN symptom scale, and HRV. Results: Forty-two patients were male (76.4%) and mean age was 63.2 years old. Thirty-nine patients (71.0%) had CIPN of more than grade I according to NCI-CTCAE. Patients with CIPN represented lower physical and role functions. The standard deviation of all normal R-R intervals (SDNN) was decreased in the CIPN group. Parasympathetic tone (high frequency band) were decreased, but sympathetic activity (low frequency band/high frequency band) were increased in CIPN. Conclusions: CIPN affected the quality of life in gastrointestinal cancer patients underwent chemotherapy. HRV was related to CIPN. Further study may be needed to check the feasibility of HRV as early biomarkers for detecting CIPN. [Table: see text]

Effect of fingolimod on cardiac autonomic regulation in patients with multiple sclerosis

2015 ◽  
Vol 22 (8) ◽  
pp. 1080-1085 ◽  
Author(s):  
Sakari Simula ◽  
Tomi Laitinen ◽  
Tiina M Laitinen ◽  
Tuula Tarkiainen ◽  
Päivi Hartikainen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
High Frequency ◽  
Frequency Ratio ◽  
Low Frequency ◽  
Autonomic Regulation ◽  
Rr Interval ◽  
Cardiac Autonomic Regulation ◽  
Multiple Sclerosis Patients

Background: Fingolimod modulates sphingosine-1-phosphate receptors that are also found in cardiovascular tissue. Objective: To investigate the effects of fingolimod on cardiac autonomic regulation prospectively. Methods: Twenty-seven relapsing–remitting multiple sclerosis patients underwent 24-hour electrocardiogram recording before, at the first day of fingolimod treatment (1d) and after three months of continuous dosing (3mo). The time interval between two consecutive R-peaks (RR-interval) was measured. Cardiac autonomic regulation was assessed by the various parameters of heart rate variability. Parasympathetic stimulation prolongs the RR-interval and increases heart rate variability while the effects of sympathetic stimulation are mainly the opposite. The low frequency/high frequency ratio reflects sympathovagal balance. Results: From baseline to 1d, a prolongation of the RR-interval ( P<0.001), an increase in the values of various heart rate variability parameters ( P<0.05 to P<0.001) and a decrease in the low frequency/high frequency ratio ( P<0.05) were demonstrated. At 3mo, although the RR-interval remained longer ( P<0.01), the values of various heart rate variability parameters were lower ( P<0.01 to P<0.001) as compared to baseline. At 3mo, the low frequency/high frequency ratio ( P<0.05) was higher in men than in women although no such difference was found at baseline or at 1d. Conclusions: After an initial increase in parasympathetic regulation, continuous fingolimod dosing shifts cardiac autonomic regulation towards sympathetic predominance, especially in men. Careful follow-up of fingolimod-treated relapsing–remitting multiple sclerosis patients is warranted as sympathetic predominance associates generally with impaired outcome. ClinicalTrials.cov: NCT01704183

Heart rate at 4 s after the onset of exercise in endurance-trained men

2014 ◽  
Vol 92 (6) ◽  
pp. 476-480 ◽  
Author(s):  
Divanei Zaniqueli ◽  
Elis Aguiar Morra ◽  
Eduardo Miranda Dantas ◽  
Marcelo Perim Baldo ◽  
Luciana Carletti ◽  
...  
Keyword(s):  
Heart Rate ◽  
Frequency Spectrum ◽  
High Frequency ◽  
Sinus Node ◽  
Low Frequency ◽  
Spectral Indices ◽  
High Frequency Band ◽  
Band Ratio ◽  
Endurance Runners ◽  
Vagal Influence

It has been suggested that the increase in heart rate (HR) at the onset of exercise is caused by vagal withdrawal. In fact, endurance runners show a lower HR in maximum aerobic tests. However, it is still unknown whether endurance runners have a lower HR at 4 s after the onset of exercise (4th-sec-HR). We sought to measure the HR at the onset of the 4 s exercise test (4-sET), clarifying its relationship to heart rate variability (HRV), spectral indices, and cardiac vagal index (CVI) in endurance runners (ER) and healthy untrained controls (CON). HR at 4th-sec-HR, CVI, and percent HR increase during exercise were analyzed in the 4-sET. High frequency spectrum (HF-nu), low frequency spectrum (LF-nu), and low frequency/high frequency band ratio (LF/HF) were analyzed from the HRV. ER showed a significantly higher HF, and both a lower LF and LF/HF ratio compared with the CON. ER presented a significantly lower 4th-sec-HR, although neither CVI nor HR increases during exercise were statistically different from the CON. In conclusion, ER presented a lower 4th-sec-HR secondary to increased vagal influence over the sinus node. CVI seems to be too weak to use for discriminating individuals with respect to the magnitude of HR vagal control.

Heart rate variability and dissociation in panic disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 147-147
Author(s):  
T. Diveky ◽  
D. Kamaradova ◽  
A. Grambal ◽  
K. Latalova ◽  
J. Prasko ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Panic Disorder ◽  
Frequency Band ◽  
High Frequency ◽  
Power Spectra ◽  
Low Frequency ◽  
Very Low Frequency ◽  
Significant Difference ◽  
Before And After

The aim of our study is to measure very low frequency band (VLF), low frequency band (LF) and high frequency band (HF) components of R-R interval during orthostatic experiment in panic disorder patients before and after treatment.MethodsWe assessed heart rate variability in 19 patients with panic disorder before and after 6-weeks treatment with antidepressants combined with CBT and 18 healthy controls. They were regularly assessed on the CGI, BAI and BDI. Heart rate variability was assessed during 5 min standing, 5 min supine and 5 min standing positions before and after the treatment. Power spectra were computed using a fast Fourier transformation for very low frequency - VLF (0.0033 - 0.04 Hz), low-frequency - LF (0.04-0.15 Hz) and high frequency - HF (0.15-0.40 Hz) powers.Results19 panic disorder patients entered a 6-week open-label treatment study with combination of SSRI and cognitive behavioral therapy. A combination of CBT and pharmacotherapy proved to be the effective treatment of patients. They significantly improved in all rating scales. There were highly statistical significant differences between panic patients and control group in all components of power spectral analysis in 2nd and in two component of 3rd (LF and HF in standing) positions. There was also statistically significant difference between these two groups in LF/HF ratio in supine position (2nd). During therapy there was tendency to increasing values in all three positions in components of HRV power spectra, but there was only statistically significant increasing in HF1 component.Supported by project IGA MZ ČR NS 10301-3/2009

scholarly journals Heart Rate Variability during Face Cooling in Concussed Adolescents

Neurology ◽  
2019 ◽  
Vol 93 (14 Supplement 1) ◽  
pp. S8.1-S8
Author(s):  
Mohammad Haider ◽  
Charles Wilber ◽  
Kaitlin Viera ◽  
Itai Bezherano ◽  
John Leddy
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
High Frequency ◽  
Low Frequency ◽  
High Frequency Power ◽  
Clinical Recovery ◽  
Face Cooling ◽  
Ratio Measure ◽  
Frequency Power ◽  
Mean Heart Rate

ObjectiveWe measured heart rate variability (HRV) during physiological stimuli in acutely concussed adolescents (CX) and after clinical recovery, and compared with healthy controls (HC).BackgroundConcussion is associated with autonomic dysfunction. Face Cooling (FC) triggers the trigeminal nerve to evoke transient increases in cardiac parasympathetic (PNS) activity.Design/Methods11 CX (14.8 ± 0.9 years, 6 male, 7 days since injury) and 11 HC (16.1 ± 1.1 years, 9 male) participated. We calculated mean heart rate (HR), standard deviation of root mean square (RMSSD, measure of PNS tone) and low-frequency to high-frequency power ratio (LF/HF ratio, measure of sympathetic [SNS] tone) at rest and 3-minute FC test.ResultsCX at Visit 1 and 2 had significantly lesser increase in HR (p = 0.02) and RMSSD (p = 0.038) than HC on FC.ConclusionsThese data show that acutely concussed participants have an attenuated PNS response to physiological stimuli which continues after clinical recovery.

scholarly journals Maternal, fetal and neonatal heart rate and heart rate variability in Holstein cattle

2019 ◽  
Vol 39 (4) ◽  
pp. 286-291
Author(s):  
Dario A.C. Quevedo ◽  
Maria Lucia G. Lourenço ◽  
Carmen D. Bolaños ◽  
Angélica Alfonso ◽  
Carla M.V. Ulian ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Frequency Domain ◽  
High Frequency ◽  
Low Frequency ◽  
Perinatal Period ◽  
Rr Interval ◽  
Neonatal Heart ◽  
Neonatal Heart Rate ◽  
The Time Domain

ABSTRACT: The aim of this study was to describe the normal values for maternal, fetal and neonatal heart rate (HR) and heart rate variability (HRV) indexes in the time domain (standard deviation of beat-to-beat interval - SDNN; root mean square of successive beat-to-beat differences - RMSSD) and the frequency domain (low frequency - LF; high frequency - HF; relationship between low and high frequency - LF/HF) in 23 Holstein cows, 23 fetuses and 18 neonates during the perinatal period. HR and HRV were calculated by fetomaternal electrocardiography (ECG). Fetomaternal measurements were taken six times prepartum (between days 234 and 279 of pregnancy) and measurements were taken in neonates six times after calving (after birth and five times weekly). HR, time and frequency domain were analyzed. No significant changes in maternal, fetal beat-to-beat interval (RR interval) or HR were found. In maternal variables, SDNN decreased significantly from 38.08±2.6ms (day 14 before calving) to 23.7±2.5ms (day 1 after calving) (p<0.05), but the RMSSD did not change significantly. HR and RR interval of calf differed statistically from the day before delivery (163±7.5bpm; 381±24.2ms) to the day after calving (131±5bpm; 472±16.2ms). Time variables (SDNN and RMSSD) and the frequency-domain variables (LF and HF) were significantly different (p<0.05) between fetal and neonatal stages. Reductions in the values of SDNN and RMSSD can reflect a sympathetic dominance. After calving, the increase in HF and decrease in LF variables can indicate activation of the vagal nerve followed by heart and respiratory modulation.

Association between RR interval and high-frequency heart rate variability acquired during short-term, resting recordings with free and paced breathing

2008 ◽  
Vol 29 (7) ◽  
pp. 795-802 ◽  
Author(s):  
Gavin Sandercock ◽  
Valerie Gladwell ◽  
Samantha Dawson ◽  
David Nunan ◽  
David Brodie ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
High Frequency ◽  
Short Term ◽  
Paced Breathing ◽  
Rr Interval

scholarly journals Objective Measures of Disordered Sleep in Fibromyalgia

2009 ◽  
Vol 36 (9) ◽  
pp. 2009-2016 ◽  
Author(s):  
RONALD D. CHERVIN ◽  
MIHAELA TEODORESCU ◽  
RAMESH KUSHWAHA ◽  
ANDREA M. DELINE ◽  
CHRISTINE B. BRUCKSCH ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sympathetic Activity ◽  
Sleep Latency ◽  
Urinary Free Cortisol ◽  
Control Subjects ◽  
Free Cortisol ◽  
Eeg Power ◽  
And Control ◽  
Multiple Sleep Latency

Objective.Patients with fibromyalgia syndrome (FM) complain of inadequate sleep, which could contribute to common symptoms including sleepiness, fatigue, or pain. However, measures that consistently and objectively distinguish FM patients remain elusive.Methods.Fifteen women with FM and 15 age- and gender-matched controls underwent 3 nights of polysomnography; Multiple Sleep Latency Tests to assess sleepiness; testing of auditory arousal thresholds during non-REM stage 2 and stage 4 sleep; overnight assessment of urinary free cortisol; and analysis of 24-hour heart rate variability.Results.On the second night of polysomnography, women with FM in comparison to controls showed more stage shifts (p = 0.04) but did not differ significantly on any other standard polysomnographic measure or on the Multiple Sleep Latency Tests. Alpha EEG power during deep non-REM sleep, alone or as a proportion of alpha power during remaining sleep stages, also failed to distinguish the groups, as did auditory arousal thresholds. Urinary free cortisol did not differ between FM and control subjects in a consistent manner. However, decreased short-term heart rate variability (HRV) and especially ratio-based HRV among FM subjects suggested diminished parasympathetic and increased sympathetic activity, respectively. Other HRV measures suggested decreased complexity of HRV among the FM subjects.Conclusion.Standard measures of sleep, a gold-standard measure of sleepiness, quantified alpha-delta EEG power, auditory arousal thresholds, and urinary free cortisol largely failed to distinguish FM and control subjects. However, HRV analyses showed more promise, as they suggested both increased sympathetic activity and decreased complexity of autonomic nervous system function in FM.

scholarly journals Relationship of Thyroid Hormones with Heart Rate Variability

1970 ◽  
Vol 5 (1) ◽  
pp. 20-26
Author(s):  
Rassel Kabir ◽  
Noorzahan Begum ◽  
Sultana Ferdousi ◽  
Shelina Begum ◽  
Taskina Ali
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Negative Correlation ◽  
Nervous Activity ◽  
Antithyroid Drugs ◽  
Cross Sectional ◽  
Rr Interval ◽  
Group A ◽  
Serum Tsh ◽  
Mean Heart Rate

Background: Altered thyroid functions are associated with variation in autonomic regulation ofcardiovascular activity. Cardiac Autonomic Nervous Activity (CANA) can be assessed quantitativelyby analysis of Heart Rate Variability (HRV). Objective: To observe the relationship between CANAwith altered TSH and FT4. Methods: This cross sectional study was carried out in the Department ofPhysiology, BSMMU, Dhaka between1st July 2007 and 30th June 2008 on 60 patients with excessthyroid hormone (group B, aged 30-50 years). Based on treatment, 30 untreated newly diagnosedpatients were designated as group B1 and 30 patients under treatment with antithyroid drugs for atleast 2 months were included into group B2 in order to observe the effect of treatment. All thesepatients were selected from the Out Patient Department of Endocrinology wing of Department ofMedicine, BSMMU, Dhaka. Sociodemographically matched 20 apparently healthy euthyroid personswere selected for comparison (group A). To confirm thyroid status, serum TSH and serum FT4 levelswere measured by AxSym system and some of the spectral HRV parameters i.e.mean R-R interval,mean heart rate, variance, LF n.u, HF n.u and LF/HF ratio were assessed by recordings of ECG for 5minute (short term) with a polyrite. For statistical analysis Pearson’s correlation coefficient (r) test wasused. Results: With serum TSH level, the LF n.u. power and LF/HF ratio showed significant (p<0.05)positive correlations but HF n.u. power showed significant (p<0.05) negative correlation in group B1.But these three parameters showed non significant correlations with TSH in the other two groups (A,B2). Similarly with serum TSH level, variance and mean R-R interval showed negative and mean HRshowed positive correlation in group B1. In group A, all these parameters were positively correlatedwhereas in group B2, RR interval and variance were positively and mean HR was negatively correlated.All these correlations were statistically non significant. With serum FT4 levels, mean R-R and HF n.u.were negatively and mean heart rate, LFnu, LF/HF were positively correlated in all three groups butvariance showed positive in group A and negative correlation in B1 and B2. All these correlations werestatistically non significant. Conclusion: From this study it can be concluded that changes in autonomicnervous regulation are related to altered serum level of TSH and FT4 in hyperthyroids.Key words: HRV; LF; HF; RR interval; HyperthyroidDOI: 10.3329/jbsp.v5i1.5414J Bangladesh Soc Physiol. 2010 June; 5(1): 20-26

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