Decrease in pulmonary function and oxygenation after lung resection

Respiratory deficits are common following curative intent lung cancer surgery and may reduce the patient's ability to be physically active. We evaluated the influence of surgery on pulmonary function, respiratory muscle strength and physical performance after lung resection.Pulmonary function, respiratory muscle strength (maximal inspiratory/expiratory pressure) and 6-min walk test (6MWT) were assessed pre-operatively, 2 weeks post-operatively and 6 months post-operatively in 80 patients (age 68±9 years).Video-assisted thoracoscopic surgery was performed in 58% of cases. Two weeks post-operatively, we found a significant decline in pulmonary function (forced vital capacity −0.6±0.6 L and forced expiratory volume in 1 s −0.43±0.4 L; both p<0.0001), 6MWT (−37.6±74.8 m; p<0.0001) and oxygenation (−2.9±4.7 units; p<0.001), while maximal inspiratory and maximal expiratory pressure were unaffected. At 6 months post-operatively, pulmonary function and oxygenation remained significantly decreased (p<0.001), whereas 6MWT was recovered.We conclude that lung resection has a significant short- and long-term impact on pulmonary function and oxygenation, but not on respiratory muscle strength. Future research should focus on mechanisms negatively influencing post-operative pulmonary function other than impaired respiratory muscle strength.

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Relationship between respiratory muscle function and age, sex, and other factors

Journal of Applied Physiology ◽

10.1152/jappl.1989.66.2.943 ◽

1989 ◽

Vol 66 (2) ◽

pp. 943-948 ◽

Cited By ~ 90

Author(s):

H. I. Chen ◽

C. S. Kuo

Keyword(s):

Muscle Strength ◽

Pulmonary Function ◽

Duty Cycle ◽

Muscle Function ◽

Respiratory Muscle ◽

Forced Expiratory Volume ◽

Inspiratory Muscle ◽

Muscle Endurance ◽

Respiratory Muscle Strength ◽

Respiratory Muscle Function

To investigate the effects of gender and age on respiratory muscle function, 160 healthy volunteers (80 males, 80 females) were divided into four age groups. Twenty-eight of the male subjects were smokers. After the subjects were familiarized with the experimental procedure, respiratory muscle strength, inspiratory muscle endurance, and spirometric function, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, tidal volume, breathing rate, and duty cycle, were measured. The respiratory muscle strength was indicated by the maximal static inspiratory and expiratory pressures (PImmax and PEmmax). Inspiratory muscle endurance was determined by the time the subject was able to sustain breathing against an inspiratory pressure load on a modified Nickerson-Keens device. The results showed that 1) except for inspiratory muscle endurance and FEV1/FVC, men had greater respiratory muscle and pulmonary functions than women, 2) respiratory muscle function and pulmonary function decreased with age, 3) smoking tended to lower duty cycle and FEV1/FVC and to enhance PE,mmax, and 4) inspiratory muscle endurance was greater in men who were physically active than in those who were sedentary. Therefore we conclude that there are sexual and age differences in respiratory muscle strength and pulmonary function and that smoking or physical activity may affect respiratory muscle function.

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Effects of transcutaneous electrical nerve stimulation on pain, pulmonary function, and respiratory muscle strength in the postoperative period of thoracic surgery in an intensive care unit

Journal of Critical Care ◽

10.1016/j.jcrc.2017.09.141 ◽

2017 ◽

Vol 42 ◽

pp. 414

Author(s):

Hermann Heinrich Husch ◽

Pauline Lopes Carvalho ◽

Camila da Cunha Niedermeyer ◽

Adriana Kessler ◽

Graciele Sbruzzi

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Muscle Strength ◽

Thoracic Surgery ◽

Pulmonary Function ◽

Postoperative Period ◽

Transcutaneous Electrical Nerve Stimulation ◽

Respiratory Muscle ◽

Respiratory Muscle Strength ◽

Electrical Nerve Stimulation

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Monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosis

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2013000300004 ◽

2013 ◽

Vol 71 (3) ◽

pp. 146-152 ◽

Cited By ~ 6

Author(s):

Guilherme Fregonezi ◽

Palomma Russelly Saldanha Araújo ◽

Tathiana Lindemberg Ferreira Macêdo ◽

Mario Emilio Dourado Junior ◽

Vanessa Regiane Resqueti ◽

...

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Muscle Strength ◽

Early Diagnosis ◽

Pulmonary Function ◽

Healthy Subjects ◽

Respiratory Muscle ◽

Function Evaluation ◽

Respiratory Muscle Strength ◽

Respiratory Dysfunction ◽

Lateral Sclerosis

ObjectiveIt was study the relationship between respiratory muscle strength and forced vital capacity (FVC) in patients with amyotrophic lateral sclerosis (ALS) versus healthy subjects.MethodsPulmonary function and respiratory muscle strength [maximal inspiratory (PImax), maximal expiratory (PEmax) and sniff nasal inspiratory pressure (SNIP)] were assessed in patients with ALS and healthy subjects, matched using cutoffs established in the literature for impaired pulmonary function and respiratory muscle weakness.ResultsTwenty-eight ALS patients and 28 healthy subjects were studied. We found sensitivity and specificity for PImax, PEmax and SNIP of 75/58%, 81/67% and 75/67%. The Receiver Operating Characteristic curve (ROC curve) indicated that the variables PImax, PEmax and SNIP can identify differences in respiratory muscle strength between ALS and healthy individuals at 0.89, 0.9 and 0.82, respectively. A positive correlation was recorded between FVC (%) versus SNIP, PImax and PEmax.ConclusionIn ALS, monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of FVC.

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Influence of a Six-Week Swimming Training with Added Respiratory Dead Space on Respiratory Muscle Strength and Pulmonary Function in Recreational Swimmers

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17165743 ◽

2020 ◽

Vol 17 (16) ◽

pp. 5743 ◽

Cited By ~ 1

Author(s):

Stefan Szczepan ◽

Natalia Danek ◽

Kamil Michalik ◽

Zofia Wróblewska ◽

Krystyna Zatoń

Keyword(s):

Muscle Strength ◽

Pulmonary Function ◽

Dead Space ◽

Respiratory Muscle ◽

Moderate Intensity ◽

Respiratory Muscle Strength ◽

Swimming Training ◽

Respiratory Muscle Fatigue ◽

Front Crawl ◽

Respiratory Dead Space

The avoidance of respiratory muscle fatigue and its repercussions may play an important role in swimmers’ health and physical performance. Thus, the aim of this study was to investigate whether a six-week moderate-intensity swimming intervention with added respiratory dead space (ARDS) resulted in any differences in respiratory muscle variables and pulmonary function in recreational swimmers. A sample of 22 individuals (recreational swimmers) were divided into an experimental (E) and a control (C) group, observed for maximal oxygen uptake (VO2max). The intervention involved 50 min of front crawl swimming performed at 60% VO2max twice weekly for six weeks. Added respiratory dead space was induced via tube breathing (1000 mL) in group E during each intervention session. Respiratory muscle strength variables and pulmonary and respiratory variables were measured before and after the intervention. The training did not increase the inspiratory or expiratory muscle strength or improve spirometric parameters in any group. Only in group E, maximal tidal volume increased by 6.3% (p = 0.01). The ARDS volume of 1000 mL with the diameter of 2.5 cm applied in moderate-intensity swimming training constituted too weak a stimulus to develop respiratory muscles and lung function measured in the spirometry test.

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