scholarly journals Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa

2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Guy-Roger Ndong-Atome ◽  
Maria Makuwa ◽  
Richard Njouom ◽  
Michel Branger ◽  
Francoise Brun-Vézinet ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Pregnant Women ◽  
Central Africa ◽  
Virus Prevalence

A Phase One Pharmacokinetic Study of Ledipasvir/Sofosbuvir in Pregnant Women with Hepatitis C Virus

2020 ◽  
Author(s):  
Catherine Chappell ◽  
Kimberly K. Scarsi ◽  
Brian J. Kirby ◽  
Vithika Suri ◽  
Anuj Gaggar ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Pregnant Women ◽  
Pharmacokinetic Study

scholarly journals Genetic diversity and evolution of hepatitis C virus – 15 years on

2004 ◽  
Vol 85 (11) ◽  
pp. 3173-3188 ◽  
Author(s):  
Peter Simmonds
Keyword(s):  
Genetic Diversity ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Liver ◽  
Large Population ◽  
Sequence Divergence ◽  
Selection Pressures ◽  
Host Interactions ◽  
Persistent Viruses ◽  
The Face

In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about its role as a major causative agent of human liver disease and its ability to persist in the face of host-cell defences and the immune system. This review describes what is known about the diversity of HCV, the current classification of HCV genotypes within the family Flaviviridae and how this genetic diversity contributes to its pathogenesis. On one hand, diversification of HCV has been constrained by its intimate adaptation to its host. Despite the >30 % nucleotide sequence divergence between genotypes, HCV variants nevertheless remain remarkably similar in their transmission dynamics, persistence and disease development. Nowhere is this more evident than in the evolutionary conservation of numerous evasion methods to counteract the cell's innate antiviral defence pathways; this series of highly complex virus–host interactions may represent key components in establishing its ‘ecological niche’ in the human liver. On the other hand, the mutability and large population size of HCV enables it to respond very rapidly to new selection pressures, manifested by immune-driven changes in T- and B-cell epitopes that are encountered on transmission between individuals with different antigen-recognition repertoires. If human immunodeficiency virus type 1 is a precedent, future therapies that target virus protease or polymerase enzymes may also select very rapidly for antiviral-resistant mutants. These contrasting aspects of conservatism and adaptability provide a fascinating paradigm in which to explore the complex selection pressures that underlie the evolution of HCV and other persistent viruses.

scholarly journals Seroepidemiological survey of hepatitis C virus among commercial sex workers and pregnant women in Kinshasa, Democratic Republic of Congo

2001 ◽  
Vol 30 (4) ◽  
pp. 872-877 ◽  
Author(s):  
C Laurent ◽  
D Henzel ◽  
C Mulanga-Kabeya ◽  
G Maertens ◽  
B Larouzé ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Pregnant Women ◽  
Sex Workers ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Commercial Sex ◽  
Republic Of Congo ◽  
Commercial Sex Workers

Hepatitis C virus infection among pregnant women in Yaounde, Cameroon: Prevalence, viremia, and genotypes

2003 ◽  
Vol 69 (3) ◽  
pp. 384-390 ◽  
Author(s):  
Richard Njouom ◽  
Christophe Pasquier ◽  
Ahidjo Ayouba ◽  
Karine Sandres-Sauné ◽  
Jermie Mfoupouendoun ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Pregnant Women ◽  
Hepatitis C Virus Infection

scholarly journals Frequency and the risk factors of hepatitis C virus in pregnant women; A hospital based descriptive study in Gadap Town Karachi

2017 ◽  
Vol 33 (5) ◽  
Author(s):  
Kausar Jilani ◽  
Bushra Zulfiqar ◽  
Qadir Bux Memon ◽  
Muhammad Faisal Fahim
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Pregnant Women ◽  
Descriptive Study

scholarly journals Genetic Diversity of Near Genome-Wide Hepatitis C Virus Sequences during Chronic Infection: Evidence for Protein Structural Conservation Over Time

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e19562 ◽  
Author(s):  
Hui Li ◽  
Austin L. Hughes ◽  
Nazneen Bano ◽  
Susan McArdle ◽  
Stephen Livingston ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Infection ◽  
Genome Wide ◽  
Structural Conservation ◽  
Over Time

Hepatitis C Virus in Women of Childbearing Age, Pregnant Women, and Children

2018 ◽  
Vol 55 (5) ◽  
pp. 633-641 ◽  
Author(s):  
Sarah F. Schillie ◽  
Lauren Canary ◽  
Alaya Koneru ◽  
Noele P. Nelson ◽  
Wade Tanico ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Pregnant Women ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Women And Children

scholarly journals Hepatitis C virus infection among pregnant women in Slovenia: study on 31,849 samples obtained in four screening rounds during 1999, 2003, 2009 and 2013

2015 ◽  
Vol 20 (22) ◽  
Author(s):  
B Kopilović ◽  
M Poljak ◽  
K Seme ◽  
I Klavs
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Pregnant Women ◽  
Hepatitis C Virus Infection ◽  
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