scholarly journals Urinary amylase / urinary creatinine ratio (uAm/uCr) - a less-invasive parameter for management of hyperamylasemia

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Keita Terui ◽  
Tomoro Hishiki ◽  
Takeshi Saito ◽  
Tetsuya Mitsunaga ◽  
Mitsuyuki Nakata ◽  
...  
Keyword(s):  
Creatinine Ratio ◽  
Urinary Creatinine ◽  
Urinary Amylase ◽  
Less Invasive

Enzymuria as a Marker of Renal Injury and Disease: Studies of N-Acetyl-βglucosaminidase in the General Population and in Patients with Renal Disease

PEDIATRICS ◽  
1978 ◽  
Vol 62 (5) ◽  
pp. 751-760
Author(s):  
Calvin M. Kunin ◽  
Russell W. Chesney ◽  
William A. Craig ◽  
Albert C. England ◽  
Catherine DeAngelis
Keyword(s):  
Renal Disease ◽  
Small Body ◽  
Adult Life ◽  
Creatinine Ratio ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Close Relationship ◽  
The Mean ◽  
Urine Specimens ◽  
Urinary Creatinine Excretion

Urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) was shown to be reproducible in random urine specimens when expressed as the ratio of NAG to milligrams of urinary creatinine. The enzyme/creatinine ratio in 815 healthy people was relatively constant throughout childhood and adult life except for the first two years after birth and in individuals 56 years or greater. High ratios in the young children may be explained by low urinary creatinine excretion probably related to small body mass and reduced glomerular filtration rate at this age. The ratio was increased in adult uremic patients and children and adults with a variety of neurologic and obstructive lesions of the voiding mechanism. The presence of bacteriuria did not appear to increase the ratio. Significant enzymuria (> 2 SD above the mean for age and sex) was detected in 38 of 81 children with well-characterized renal disease. Among patients with predominantly glomerular disorders there was a close relationship between activity of the disease and enzymuria. In patients with tubulointerstitial disease enzymuria was frequent even in the absence of proteinuria. One of the highest enzyme/creatinine ratios was observed in a child with cystinosis. These studies indicate that NAG enzymuria is a sensitive indicator of activity of renal disease and may prove to be a suitable screening test for significant renal disease or injury in childhood.

Association of sodium intake with insulin resistance in Korean children and adolescents: the Korea National Health and Nutrition Examination Survey 2010

2018 ◽  
Vol 31 (2) ◽  
pp. 117-125 ◽  
Author(s):  
Yong Min Kim ◽  
So Hyun Kim ◽  
Young Suk Shim
Keyword(s):  
Insulin Resistance ◽  
Children And Adolescents ◽  
National Health ◽  
Sodium Intake ◽  
Urinary Sodium ◽  
Nutrition Examination Survey ◽  
Creatinine Ratio ◽  
Korean Children ◽  
Urinary Creatinine ◽  
Health And Nutrition

Abstract Background: This study aimed to evaluate the relationship between sodium intake and insulin resistance indices. Methods: A total of 718 Korean children and adolescents (411 boys) aged 10–18 years who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) were included in the study. The urinary sodium to urinary creatinine ratio was used as a surrogate for sodium intake. The homeostatic model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI) were used as indices of insulin resistance. Results: The mean urinary sodium to urinary creatinine ratio was 11.34 in males and 10.17 in females. The urinary sodium to urinary creatinine ratio was significantly positively correlated with HOMA-IR (r=0.165, p<0.001) and inversely correlated with QUICKI (r=−0.181, p<0.001) in Pearson’s correlation analyses. In a multivariate linear regression analysis, the urinary sodium to urinary creatinine ratio was independently and significantly positively associated with HOMA-IR (β=0.073, p=0.018) and significantly inversely associated with QUICKI (β=−0.080, p=0.007) after adjustment for possible confounders. HOMA-IR was independently and significantly positively associated with the urinary sodium to urinary creatinine ratio (β=0.087, p=0.018), whereas QUICKI was independently and significantly negatively associated with the urinary sodium to urinary creatinine ratio (β=−0.097, p=0.009) after controlling for confounders. Conclusions: Our results suggest that sodium intake, as estimated by the urinary sodium to urinary creatinine ratio, may be independently associated with insulin resistance in children and adolescents.

Urinary Protein/Creatinine Ratio Weighted by Estimated Urinary Creatinine Improves the Accuracy of Predicting Daily Proteinuria

2015 ◽  
Vol 349 (6) ◽  
pp. 477-487 ◽  
Author(s):  
Chun-Fan Chen ◽  
Wu-Chang Yang ◽  
Chih-Yu Yang ◽  
Szu-Yuan Li ◽  
Shuo-Ming Ou ◽  
...  
Keyword(s):  
Urinary Protein ◽  
Creatinine Ratio ◽  
Urinary Creatinine

scholarly journals Urinary uric acid or urinary creatinine ratio as a non-invasive marker for perinatal asphyxia

2020 ◽  
Vol 7 (6) ◽  
pp. 1378
Author(s):  
Siddharth . ◽  
Preeti Lata Rai ◽  
P. L. Prasad
Keyword(s):  
Uric Acid ◽  
Early Recognition ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Neonatal Morbidity ◽  
Cerebral Injury ◽  
Creatinine Ratio ◽  
Urinary Creatinine ◽  
Spot Urine ◽  
Non Invasive

Background: Perinatal asphyxia is amongst the common problem of neonates and there exists a significant contribution to the neonatal morbidity and mortality. It is observed as a common and a vital cause of the preventable cerebral injury. The prediction of the perinatal asphyxial outcome is very important but dreadful. There is a limited role for APGAR score to predict the immediate outcome, like HIE and the long-term neurological sequelae observational error may happen in APGAR. But the biochemical parameters can truly be relied upon. This study was done to assess urinary uric acid/urinary creatinine ratio (UA/Cr) as a non-invasive marker for perinatal asphyxia and co-relate its absolute value to the degree of the perinatal asphyxia.Methods: In this prospective case control study conducted in the Pediatrics Department of Shri Ram Murti Smarak Institute of Medical Sciences between Nov 2017 to May 2019, 42 asphyxiated and 42 non-asphyxiated newborns were included. Detailed history and assessment were for all the enrolled newborns. Spot urine samples were sent for the uric acid and creatinine estimation. Results were documented, and statistical analysis was performed.Results: Urinary uric acid to creatinine ratio used as additional non-invasive, early and easy biochemical marker of the birth asphyxia that biochemically supports severity grading and clinical diagnosis of the asphyxia by APGAR score.Conclusions: The ratio of the urinary uric acid and creatinine enables rapid and early recognition of asphyxial injury and also the evaluation of its severity and potential for short-term morbidity or death.

Decrease in urinary creatinine in acute kidney injury influences diagnostic value of urinary biomarker-to-creatinine ratio in rats

Toxicology ◽  
2011 ◽  
Vol 290 (2-3) ◽  
pp. 241-248 ◽  
Author(s):  
Yutaka Tonomura ◽  
Takeki Uehara ◽  
Emi Yamamoto ◽  
Mikinori Torii ◽  
Mitsunobu Matsubara
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Diagnostic Value ◽  
Creatinine Ratio ◽  
Urinary Biomarker ◽  
Urinary Creatinine

scholarly journals Urinalysis and Urinary GGT-to-Urinary Creatinine Ratio in Dogs with Acute Pancreatitis

2019 ◽  
Vol 6 (1) ◽  
pp. 27 ◽  
Author(s):  
Eleonora Gori ◽  
Alessio Pierini ◽  
Ilaria Lippi ◽  
Noemi Boffa ◽  
Francesca Perondi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Prognostic Factor ◽  
Odds Ratio ◽  
Kidney Injury ◽  
Outcome Data ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Statistical Software ◽  
Urinary Creatinine ◽  
Negative Prognostic Factor

In acute pancreatitis (AP), kidney injury (KI) can occur. Urinalysis and some urinary biomarkers have been proposed as prognostic tools in human AP. The aim of the study was to evaluate urinalysis and urinary GGT-to-urinary creatinine (uGGT/uCr) in canine AP and their association with possible outcomes. AP diagnosis was based on clinical and laboratory parameters, abnormal SNAP® cPL™ test and compatible imaging. Urinary KI (uKI) was defined if dogs had urinary casts and/or proteinuria. Dogs (n = 70) were divided in survivors and non-survivors according to the 15-day outcome. Data were analyzed using statistical software. Seventy dogs were retrospectively included, of which 24 dogs (34%) died. uKI was detected in 36 dogs (37%) which was associated with mortality (p = 0.01, Odds ratio (OR) 3.9, 95% CI 1.3–11.56). Non-survivors showed higher dipstick bilirubin levels than survivors (p = 0.0022). By excluding active sediments, urine protein-to-creatinine ratio (UPC) ≥2 was associated with mortality (p = 0.001, OR 47.5, 95% CI 4–571.9). The uGGT/uCr was available in 40 dogs, although no association of this factor with any outcome was found. The UPC ≥2 can be a negative prognostic factor in canine AP and further studies on uGGT/uCr are warranted.

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