scholarly journals Immunoediting: evidence of the multifaceted role of the immune system in self-metastatic tumor growth

2012 ◽  
Vol 9 (1) ◽  
pp. 31 ◽  
Author(s):  
Heiko Enderling ◽  
Lynn Hlatky ◽  
Philip Hahnfeldt
Keyword(s):  
Immune System ◽  
Tumor Growth ◽  
Metastatic Tumor

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 ◽  
Vol 18 (5) ◽  
pp. 1135-1135 ◽  
Author(s):  
Amy R. Nelson ◽  
Barbara Fingleton ◽  
Mace L. Rothenberg ◽  
Lynn M. Matrisian
Keyword(s):  
Matrix Metalloproteinases ◽  
Tumor Growth ◽  
Tumor Progression ◽  
Metastatic Tumor ◽  
The Body ◽  
Genetic Changes ◽  
Biologic Activity ◽  
The Matrix ◽  
Degradative Enzymes

ABSTRACT: Tumor progression is a complex, multistage process by which a normal cell undergoes genetic changes that result in phenotypic alterations and the acquisition of the ability to spread and colonize distant sites in the body. Although many factors regulate malignant tumor growth and spread, interactions between a tumor and its surrounding microenvironment result in the production of important protein products that are crucial to each step of tumor progression. The matrix metalloproteinases (MMPs) are a family of degradative enzymes with clear links to malignancy. These enzymes are associated with tumor cell invasion of the basement membrane and stroma, blood vessel penetration, and metastasis. They have more recently been implicated in primary and metastatic tumor growth and angiogenesis, and they may even have a role in tumor promotion. This review outlines our current understanding of the MMP family, including the association of particular MMPs with malignant phenotypes and the role of MMPs in specific steps of the metastatic cascade. As scientific understanding of the MMPs has advanced, therapeutic strategies that capitalize on blocking the enzymes have rapidly developed. The preclinical and clinical evolution of the synthetic MMP inhibitors (MMPIs) is also examined, with the discussion encompassing important methodologic issues associated with determining clinical efficacy of MMPIs and other novel therapeutic agents.

scholarly journals Role of mTOR and VEGFR Inhibition in Prevention of Metastatic Tumor Growth in the Spine

2020 ◽  
Vol 10 ◽  
Author(s):  
Tobias Kratzsch ◽  
Andras Piffko ◽  
Thomas Broggini ◽  
Marcus Czabanka ◽  
Peter Vajkoczy
Keyword(s):  
Tumor Growth ◽  
Metastatic Tumor

scholarly journals The role of effective energy restriction on metastatic tumor growth

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Tapasree Roy Sarkar ◽  
Nathalie Sphyris ◽  
Emily Schmitt ◽  
Garhett Wyatt ◽  
Steven Wall ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Metastatic Tumor ◽  
Energy Restriction ◽  
Effective Energy

Role of the Immune System in the Growth of an Isotransplanted Urethan-Induced Lymphosarcoma

1969 ◽  
Vol 55 (4) ◽  
pp. 189-195 ◽  
Author(s):  
Giorgio Parmiani ◽  
Giusi Carbone
Keyword(s):  
Immune System ◽  
Tumor Growth ◽  
Inhibitory Action ◽  
Cell Suspensions ◽  
Neoplastic Cells ◽  
Thymic Lymphoma ◽  
Hybrid Combination

Two groups of (SWR×C57BL)F1 mice were injected subcutaneously with two quantitatively different cell suspensions from a uretan-induced thymic lymphoma of the same hybrid combination. Each of these groups was divided before the neoplastic isograft into the following sub-groups: controls, cyclophosphamide injected, X-irradiated and BCG injected mice. Percentage of takes, tumor diameters and mortality provided the parameters for the evaluation of the tumor growth. With the higher inoculum of neoplastic cells (5×105) only cyclophosphamide was effective in enhancing the take percentage 10 days after the isograft. With the smaller inoculum (5 × 103) all treatments were effective on tumor growth although the inhibitory action of BCG was not as strong as the enhancing action of the immune depressive treatments. The results are interpreted as evidence of a specific antigenicity of urethan-induced lymphoma.

Antibody fragment and targeted colorectal cancer therapy: A global systematic review

2021 ◽  
Vol 22 ◽  
Author(s):  
Sepideh Ghani ◽  
Niloofar Deravi ◽  
Marzieh Pirzadeh ◽  
Behnam Rafiee ◽  
Zahra Rezanejad Gatabi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Immune System ◽  
Tumor Growth ◽  
Cancer Treatment ◽  
Antibody Fragment ◽  
Antibody Fragments ◽  
Great Promise ◽  
Single Chain

Background and aims: Antibody-based therapeutics have been evidenced promising for the treatment of colorectal cancer patients. However, the size and long circulating half-lives of antibodies can limit their reproducible manufacture in clinical studies. Consequently, in novel therapeutic approaches conventional antibodies are minimized and engineered to produce fragments like Fab, scFv, nanobody, bifunctional antibody, bispecific antibody, minibody and diabody to preserve their high affinity and specificity to target pharmaceutical nanoparticle conjugates. This systematic review for the first time aimed to elucidate the role of various antibody fragments in colorectal cancer treatment. Method: A systematic literature search in web of sciences, PubMed, Scopus, Google scholar and ProQuest was conducted. Reference lists of the articles were reviewed to identify the relevant papers. The full text search included articles published in English during 1990–2021. Results: Most the 53 included studies were conducted in vitro and in most conducted studies single-chain antibodies were among the most used antibody fragments. Most antibodies targeted CEA in the treatment of colorectal cancer. Moreover, a large number of studies observed apoptosis induction and tumor growth inhibition. In addition, few studies implicated the role of the innate immune system as an indirect mechanisms of tumor growth by enhancing NK-cell killing. Conclusion: Antibody-based therapy was demonstrated to be of a great promise in the treatment of colorectal cancer rather than common treatments such as radiotherapy, chemotherapy, and surgical operations. This type of specified cancer treatment can also induce the activation of innate and specific immune system to eradicate tumor cells.

Role of Protein kinase D2 in pancreatic tumor growth and tumor angiogenesis

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
N Azoitei ◽  
GV Pusapati ◽  
A Kleger ◽  
C Brunner ◽  
F Genze ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tumor Growth ◽  
Tumor Angiogenesis ◽  
Pancreatic Tumor

PERAN IBU DALAM PENINGKATAN SISTEM IMUN ANAK DENGAN INFEKSI SALURAN PERNAFASAN AKUT

2019 ◽  
Vol 11 (2) ◽  
pp. 79-86
Author(s):  
Cindy Ayustin Noya ◽  
Angkit Kinasih ◽  
Venti Agustina ◽  
R.Rr Maria Dyah Kurniasari
Keyword(s):  
Immune System ◽  
Acute Respiratory Infection ◽  
Lower Respiratory Tract ◽  
Research Method ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Clean Environment ◽  
History Of ◽  
Qualitative Descriptive

Infeksi saluran pernafasan akut atau yang sering disebut ISPA merupakan infeksi pada saluran pernafasan baik saluran pernafasan atas atau bawah.ISPA juga kebanyakan terjadi pada anak balita karena daya tahan tubuh mereka tidak kuat dalam menghadapi penyakit ISPA. ISPA mengakibatkan kematiansekitar15%-20% per tahun pada usia balita di Negara berkembang. Tujuan penelitian ini adalah untuk mengetahui dan menganalisa peran ibu dalam meningkatkan sistem imun anak dengan ISPA.Metode penelitian yang digunakan dalam penelitian ini adalah kualitatif deskriptif dengan sampel purposive sampling.Populasi dan sampel penelitian ini adalah ibu yang mempunyai anak dengan riwayat dan saat ini menderita penyakit ISPA di Batu Gajah Kota Ambon.Partisipan dalam penelitian ini berjumlah 5 orang. Hasil dari penelitian mendapati 4 kategori yaitu pemberian nutrisi pada anak untuk memenuhi kebutuhan agar sistem imunnya terjaga, kebersihan lingkungan, peran ibu dalam melakukan pencegahan pada anaknya yang mengalami ISPA, dan  peran ibu dalam menjaga dan mempertahankan kesehatan anaknya.   Kata kunci: peran ibu, sistem imun, ispa THE ROLE OF MOTHERS IN INCREASING IMMUNE SYSTEM OF CHILDREN WITH ACUTE RESPIRATORY INFECTION    ABSTRACT Acute respiratory infections or often called ARI is an infection of the upper or lower respiratory tract. ARI occurs mostly in children under the age of five because their endurance is not strong in dealing with ARI. ARI results in deaths of around 15%-20% per year at the age of under-five in developing countries. The purpose of this study was to determine and analyze the role of mothers in improving the immune system of children against ARI. The research method used in this study was qualitative descriptive with a purposive sampling sample. Respondents and samples of this study were five mothers who had children with a history of ARI and currently suffering from the disease in Batu Gajah, Ambon City. The results of the study found 4 categories, namely providing nutrition to children to meet their needs so that their immune systems are maintained, clean environment, mother's role in preventing children with ARI, and mother's role to preserve and maintain the health of their children. The findings indicated that in terms of coping or improving the immune system of a child to avoid ARI, it is necessary to have role the of mothers in providing nutrition so that the immune system is boosted, besides that the mother can prevent and protect her child from various diseases, especially ARI. Keywords: role of mothers, immune system, acute respiratory infections

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