scholarly journals Long-term persistence of Chikungunya virus neutralizing antibodies in human populations of North Eastern Thailand

2014 ◽  
Vol 11 (1) ◽  
pp. 183 ◽  
Author(s):  
Narong Nitatpattana ◽  
Kobkan Kanjanopas ◽  
Sutee Yoksan ◽  
Wichai Satimai ◽  
Narong Vongba ◽  
...  
Oryx ◽  
2012 ◽  
Vol 46 (2) ◽  
pp. 308-311 ◽  
Author(s):  
Narayan Sharma ◽  
M. D. Madhusudan ◽  
Prabal Sarkar ◽  
Mayur Bawri ◽  
Anindya Sinha

AbstractThe historical deforestation of the Upper Brahmaputra Valley in the Indian state of Assam has resulted in the transformation of its once-contiguous lowland rainforests into many isolated forest fragments that are still rich in species, including primates. We report the recent history and current status of six diurnal primates in one large (2,098 ha) and three small (<500 ha) fragments of the Upper Brahmaputra Valley. We censused primates in the small fragments during 2002, 2005, 2009, in the large fragment in 2008, and used other published census data to derive population trends. We also used key informant surveys to obtain historical occurrence data for these populations. Our analyses reveal the recent extinction of some populations and the simultaneous long-term persistence of others in these fragments over 16 years. Most populations appeared to have declined in the small fragments but primate abundance has increased significantly in the largest fragment over the last decade. Addressing the biomass needs of the local human populations, which appears to drive habitat degradation, and better protection of these forests, will be crucial in ensuring the future survival of this diverse and unique primate assemblage in the last rainforest fragments of the human-dominated Upper Brahmaputra Valley.


Pathogens ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 231 ◽  
Author(s):  
Rafael Kroon Campos ◽  
Lorena Preciado-Llanes ◽  
Sasha R. Azar ◽  
Cesar Lopez-Camacho ◽  
Arturo Reyes-Sandoval ◽  
...  

The mosquito-borne chikungunya virus (CHIKV) has become a major global health problem. Upon infection, chikungunya fever (CHIKF) can result in long-term joint pain and arthritis, and despite intense research, no licensed vaccine for CHIKV is available. We have developed two recombinant chimpanzee adenovirus-vectored vaccines (ChAdOx1) that induce swift and robust anti-CHIKV immune responses with a single dose, without the need for adjuvants or booster vaccines. Here, we report the vaccines’ protective efficacies against CHIKV infection in a lethal A129 mouse model. Our results indicate that a single, un-adjuvanted ChAdOx1 Chik or ChAdOx1 Chik ΔCap dose provided complete protection against a lethal virus challenge and prevented CHIKV-associated severe inflammation. These candidate vaccines supported survival equal to the attenuated 181/25 CHIKV reference vaccine but without the vaccine-related side effects, such as weight loss. Vaccination with either ChAdOx1 Chik or ChAdOx1 Chik ΔCap resulted in high titers of neutralizing antibodies that are associated with protection, indicating that the presence of the capsid within the vaccine construct may not be essential to afford protection under the conditions tested. We conclude that both replication-deficient ChAdOx1 Chik vaccines are safe even when used in A129 mice and afford complete protection from a lethal challenge.


2020 ◽  
Vol 20 (5) ◽  
pp. 321-332
Author(s):  
Yunbo Liu ◽  
Xu Zhang ◽  
Lin Yang

Adeno-associated virus (AAV) is a promising vector for in vivo gene therapy because of its excellent safety profile and ability to mediate stable gene expression in human subjects. However, there are still numerous challenges that need to be resolved before this gene delivery vehicle is used in clinical applications, such as the inability of AAV to effectively target specific tissues, preexisting neutralizing antibodies in human populations, and a limited AAV packaging capacity. Over the past two decades, much genetic modification work has been performed with the AAV capsid gene, resulting in a large number of variants with modified characteristics, rendering AAV a versatile vector for more efficient gene therapy applications for different genetic diseases.


2019 ◽  
Vol 11 (4) ◽  
pp. 315-328
Author(s):  
Sergey Aleksandrovich Mikhailov

This article deals with the issue of North-Eastern India, its current social and economic problems in the context of long-term demonstrations of the ethnic separatism. The main aim of the research implies systematic analysis and identification of key factors and reasons perpetuating separatism in NER as well as resource search which determines Indian strategy in solving this problem. The first part of the article is devoted to separatism peculiarities in the region which remains withdrawn and underexplored in many respects. Apart from this, the author provides a quite detailed analysis of negative mentality of the certain part of NER population which justifiably reproaches New Delhi for “discrimination” and inability to solve many problems of the region. Then the author paid the detailed attention to these problems of NER modern society (ethnic, demographic, economic, transport, social etc.) as well as measures undertaken by the Indian government for its settlement.


Author(s):  
Juan P. Wisnivesky ◽  
Kimberly Stone ◽  
Emilia Bagiella ◽  
Molly Doernberg ◽  
Damodara Rao Mendu ◽  
...  

2017 ◽  
Vol 15 ◽  
pp. 8-22 ◽  
Author(s):  
Mariëlle van Aalst ◽  
Charlotte Marieke Nelen ◽  
Abraham Goorhuis ◽  
Cornelis Stijnis ◽  
Martin Peter Grobusch

2019 ◽  
Vol 128 (3) ◽  
pp. 583-591
Author(s):  
Leo Joseph ◽  
Alex Drew ◽  
Ian J Mason ◽  
Jeffrey L Peters

Abstract We reassessed whether two parapatric non-sister Australian honeyeater species (Aves: Meliphagidae), varied and mangrove honeyeaters (Gavicalis versicolor and G. fasciogularis, respectively), that diverged from a common ancestor c. 2.5 Mya intergrade in the Townsville area of north-eastern Queensland. Consistent with a previous specimen-based study, by using genomics methods we show one-way gene flow for autosomal but not Z-linked markers from varied into mangrove honeyeaters. Introgression barely extends south of the area of parapatry in and around the city of Townsville. While demonstrating the long-term porosity of species boundaries over several million years, our data also suggest a clear role of sex chromosomes in maintaining reproductive isolation.


Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 404 ◽  
Author(s):  
Daniel E. Speiser ◽  
Martin F. Bachmann

Vaccines are needed to protect from SARS-CoV-2, the virus causing COVID-19. Vaccines that induce large quantities of high affinity virus-neutralizing antibodies may optimally prevent infection and avoid unfavorable effects. Vaccination trials require precise clinical management, complemented with detailed evaluation of safety and immune responses. Here, we review the pros and cons of available vaccine platforms and options to accelerate vaccine development towards the safe immunization of the world’s population against SARS-CoV-2. Favorable vaccines, used in well-designed vaccination strategies, may be critical for limiting harm and promoting trust and a long-term return to normal public life and economy.


2013 ◽  
Vol 7 (3) ◽  
pp. e2137 ◽  
Author(s):  
Clémentine Schilte ◽  
Frédérik Staikovsky ◽  
Thérèse Couderc ◽  
Yoann Madec ◽  
Florence Carpentier ◽  
...  

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