scholarly journals 0026. Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

2014 ◽  
Vol 2 (Suppl 1) ◽  
pp. O2
Author(s):  
M Kox ◽  
LT van Eijk ◽  
J Zwaag ◽  
J van den Wildenberg ◽  
FCJG Sweep ◽  
...  
Keyword(s):  
Immune Response ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Voluntary Activation ◽  
Sympathetic Nervous

scholarly journals Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

2014 ◽  
Vol 111 (20) ◽  
pp. 7379-7384 ◽  
Author(s):  
M. Kox ◽  
L. T. van Eijk ◽  
J. Zwaag ◽  
J. van den Wildenberg ◽  
F. C. G. J. Sweep ◽  
...  
Keyword(s):  
Immune Response ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Voluntary Activation ◽  
Sympathetic Nervous

Sympathetic immunoregulation: difference between high- and low-responder animals

1982 ◽  
Vol 242 (1) ◽  
pp. R30-R33 ◽  
Author(s):  
A. del Rey ◽  
H. O. Besedovsky ◽  
E. Sorkin ◽  
M. Da Prada ◽  
G. P. Bondiolotti
Keyword(s):  
Immune Response ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Quantitative Relationship ◽  
Spleen Weight ◽  
Low Responder ◽  
Sympathetic Nervous ◽  
High Responders

A quantitative relationship is reported between the magnitude of the immune response of rats to sheep red blood cells and diminution of splenic norepinephrine (NE). A decrease in concentration and content of NE in the spleen on day 3 after immunization was evident in both high- and low-responder animals, whereas a diminished concentration of NE persisted only in the high responders. This continuing NE diminution in high-responder animals is associated with increase in spleen weight, probably attributable to blood accumulation. These findings are consonant with the concept that the sympathetic nervous system is involved in immunoregulation.

scholarly journals Antimicrobial peptides signal need for sleep from peripheral wounds to the nervous system

2020 ◽  
Author(s):  
Marina Sinner ◽  
Florentin Masurat ◽  
Jonathan Ewbank ◽  
Nathalie Pujol ◽  
Henrik Bringmann
Keyword(s):  
Immune Response ◽  
Innate Immunity ◽  
Nervous System ◽  
Antimicrobial Peptides ◽  
Antimicrobial Peptide ◽  
Long Range ◽  
Innate Immune Response ◽  
Innate Immune ◽  
List Type ◽  
Active Neuron

AbstractWounding triggers a protective innate immune response that includes the production of antimicrobial peptides and increased sleep. Little is known, however, about how peripheral wounds signal need for sleep to the nervous system. We found that during C. elegans larval molting, a tolloid/BMP-1-like protein promotes sleep through an epidermal innate immune pathway and the expression of more than a dozen antimicrobial peptide (AMP) genes. In the adult, epidermal injury activates innate immunity and turns up AMP production to trigger sleep. We show for one AMP, NLP-29, that it acts through the neuropeptide receptor NPR-12 in neurons that depolarize the sleep-active RIS neuron to induce sleep. Sleep in turn increases the chance of surviving injury. Thus, we found a novel mechanism by which peripheral wounds signal to the nervous system to increase protective sleep. Such a long-range somnogen signaling function of AMPs might also boost sleep in other animals including humans.Highlights- Gain-of-function mutation in the tolloid/BMP-1-like NAS-38 protein increases sleep- NAS-38 activates innate immunity pathways to ramp up STAT-dependent antimicrobial peptide (AMP) expression- Wounding increases sleep through the innate immune response and AMPs- Antimicrobial peptides are long-range somnogens that act through neuronal neuropeptide receptors to depolarize a sleep-active neuron- Sleep increases the chance to survive injuryGraphical Abstract

scholarly journals Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system

2003 ◽  
Vol 162 (2) ◽  
pp. 257-268 ◽  
Author(s):  
Denis Soulet ◽  
Serge Rivest
Keyword(s):  
Central Nervous System ◽  
Immune Response ◽  
Nervous System ◽  
Innate Immune Response ◽  
Transcriptional Activation ◽  
Critical Role ◽  
Innate Immune ◽  
Genes Encoding ◽  
Factor Α ◽  
Mouse Central Nervous System

The present work investigated whether polyamines play a role in the control of the innate immune response in the brain. The first evidence that these molecules may be involved in such a process was based on the robust increase in the expression of the first and rate-limiting enzyme of biosynthesis of polyamines during immune stimuli. Indeed, systemic lipopolysaccharide (LPS) administration increased ornithine decarboxylase (ODC) mRNA and protein within neurons and microglia across the mouse central nervous system (CNS). This treatment was also associated with a robust and transient transcriptional activation of genes encoding pro-inflammatory cytokines and toll-like receptor 2 (TLR2) in microglial cells. The endotoxin increased the cerebral activity of ODC, which was abolished by a suicide inhibitor of ODC. The decrease in putrescine levels largely prevented the ability of LPS to trigger tumor necrosis factor α and TLR2 gene transcription in the mouse brain. In contrast, expression of both transcripts was clearly exacerbated in response to intracerebral spermine infusion. Finally, inhibition of polyamine synthesis abolished neurodegeneration and increased the survival rate of mice exposed to a model of severe innate immune reaction in the CNS. Thus, polyamines have a major impact on the neuronal integrity and cerebral homeostasis during immune insults.

scholarly journals Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous System

2015 ◽  
Vol 33 (1) ◽  
pp. 213-221 ◽  
Author(s):  
Martín Humberto Muñoz-Ortega ◽  
Daniel Cervantes-García ◽  
Andrés Quintanar-Stephano ◽  
María del Rosario Campos-Esparza ◽  
Mario García-Lorenzana ◽  
...  
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Liver Abscess ◽  
Immune Modulation ◽  
Innate Immune ◽  
Morphological Evidence ◽  
Amebic Liver Abscess ◽  
Sympathetic Nervous
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