Zinc deficiency in Japanese children with idiopathic short stature

2019 ◽  
Vol 32 (10) ◽  
pp. 1083-1087 ◽  
Author(s):  
Kei Yoshida ◽  
Tatsuhiko Urakami ◽  
Remi Kuwabara ◽  
Ichiro Morioka
Keyword(s):  
Short Stature ◽  
Zinc Deficiency ◽  
Serum Insulin ◽  
Serum Zinc ◽  
Zinc Level ◽  
Idiopathic Short Stature ◽  
Japanese Children ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background and methods We investigated the frequency of zinc deficiency in Japanese children with idiopathic short stature, and evaluated whether serum zinc levels correlated with background factors, including age and standard deviation scores (SDSs) for height and serum insulin-like growth factor (IGF)-1 levels. The study subjects consisted of 89 Japanese children. Results The mean serum zinc level was 79 ± 12 (49–108) μg/dL. Of all the children, 48.3% had a low zinc level, in the 60–80 μg/dL range, and 6.7% had zinc deficiency with a zinc level below 60 μg/dL. The majority with a low zinc level and zinc deficiency were asymptomatic other than for short stature. We found no significant correlations of serum zinc with age, or the SDSs for height and serum IGF-1 levels, in either the entire subject population or those with a zinc level below 80 μg/dL. Conclusions We found a low zinc level to be common in Japanese children with idiopathic short stature, whereas actual zinc deficiency was rare. However, other as yet unknown mechanisms not associated with the growth hormone (GH)-IGF-1 axis could be involved in growth retardation in idiopathic short stature.

scholarly journals Dysgeusia Due to Zinc Deficiency After Pancreaticoduodenectomy Requiring Continuous Intravenous Zinc Supplementation: a Case Report and Literature Review

2021 ◽  
Author(s):  
Hironobu Hata ◽  
Yojiro Ota ◽  
Katsuhiko Uesaka ◽  
Yutaka Yamazaki ◽  
Tsubasa Murata ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Oral Surgery ◽  
Oral Care ◽  
Serum Zinc ◽  
Zinc Level ◽  
Normal Serum ◽  
Acrodermatitis Enteropathica ◽  
Proximal Jejunum ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background: Zinc is mainly absorbed in the duodenum and proximal jejunum, which are removed during pancreaticoduodenectomy (PD). Little is known about the adverse oral events and skin disorders caused by zinc deficiency after PD. Herein, we reviewed studies regarding the development of zinc deficiency after PD and presented the case of a patient with zinc deficiency after PD, who required home intravenous zinc replacement.Case presentation: A 73-year-old woman with glossitis, taste disorder, and acrodermatitis enteropathica-like eruption on her fingers presented to the Division of Dentistry and Oral Surgery 69 days after PD. Her serum zinc level markedly decreased to 30 μg/dL. Oral zinc administration was inadequate to treat hypozincemia after PD; therefore, multi-trace elements were injected intravenously under readmission. Her serum zinc levels recovered, and the lesions gradually improved. Furthermore, a central venous port was implanted to maintain normal serum zinc levels, and she continued self-injecting zinc at home.Conclusion: Zinc deficiency after PD rarely occurs. The clinical oncologist community, including dentists responsible for the oral care of cancer patients, should be aware of dysgeusia associated with zinc deficiency after cancer surgery, as well as that induced by chemotherapy or head and neck radiation therapy.

scholarly journals Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4114
Author(s):  
Hirofumi Matsuyama ◽  
Keita Matsuura ◽  
Hidehiro Ishikawa ◽  
Yoshinori Hirata ◽  
Natsuko Kato ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Zinc Deficiency ◽  
Clinical Symptoms ◽  
Psychiatric Symptoms ◽  
Serum Zinc ◽  
Dosing Frequency ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson’s disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage, and symptoms of zinc deficiency in PD patients. We measured serum zinc levels and analyzed correlations between serum zinc levels, the levodopa oral administration period, dosage, dosing frequency, and zinc deficiency symptoms including taste disorders. Data analyses were performed using Spearman’s rank correlation coefficient. The mean serum zinc level was 60.5 ± 11.6 μg/dL. The mean administration period for levodopa was 8.0 ± 5.5 years, mean administration frequency 3.4 ± 0.9 times/d, and mean administration dose 420.6 ± 237.1 mg/d. Negative correlations between zinc levels and levodopa dosage and dosing frequency were found. Multiple regression analysis showed a significant correlation with the frequency of levodopa (β = −0.360, p = 0.007). No significant change in clinical symptoms was observed after zinc administration, but anxiety tended to improve. Our results indicated that frequent levodopa administration strongly influenced serum zinc levels which may have alleviating effects on psychiatric symptoms; therefore, preventing zinc deficiency can be important during PD treatment.

scholarly journals A study of zinc level in cord blood of neonates and its relationship with antropometric measurements in the neonates: a descriptive cross-sectional study

2019 ◽  
Vol 6 (2) ◽  
pp. 722
Author(s):  
Syed Mohamed ◽  
Santosh Kumar ◽  
J. Kumutha
Keyword(s):  
Cord Blood ◽  
Growth Parameters ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Cross Sectional ◽  
Medical College ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: During pregnancy, fast growth and cell differentiation takes place in both mother and foetus. Maternal nutritional factors play an important role in the growth of the neonate. Among the micronutrient zinc is an important micronutrient whose deficiency is associated with poor pregnancy outcomes. The objective the current study was to evaluate the relationship of serum zinc concentration of the maternal blood and the neonatal cord blood with that of the infant’s anthropometric measurements.Methods: A descriptive cross-sectional study was performed under the Department of Neonatology, Saveetha medical college. Duration of the study was from April 2017 to June 2018. The study included 82 singleton mother baby dyads born in Saveetha medical college. Anthropometric measurements such as birth weight, head circumference, neonate length apart from other clinical features of both the mother and neonates were recorded for statistical analysis. Serum zinc levels were estimated using 2-(5-bromo-2-pyridylazo)-5-(N-Propyl-N-sulfopropylamino)-phenol (5-Br-PAPS) protocol.Results: The mean maternal age of the study population is 25.3±2.3 years. Majority of the mother had natural mode of delivery (57%). The mean cord serum zinc level was found to be 94.0±1.6microgram /dl and the mother’s serum zinc level was 93.8±30.7microgram /dl (range from 49 to 171microgram /dl) which was not found to be statistically significant. Serum zinc levels of the cord was compared with the child anthropometrics and mother’s serum zinc levels to assess for the significance, but there was no correlation observed between the umbilical cord, and the birth weight (r=0.03), length of the child (r=-0.02), head circumference (r=-0.07) and mothers serum zinc levels (r=-0.002).Conclusions: According to our results authors were unable to establish a relationship between Neonates growth parameters and zinc levels in neonates cord blood and zinc levels in the mother. Further studies with a larger sample size and prospective design would establish a causal relationship between zinc and growth parameters in the neonate.

scholarly journals Decreasing Zinc Levels in Stunting Toddlers in Lampung Province, Indonesia

2019 ◽  
Vol 12 (1) ◽  
pp. 239-243
Author(s):  
Khairun Nisa Berawi ◽  
Maya Nurul Hidayati ◽  
Susianti Susianti ◽  
Roro Rukmi W. Perdami ◽  
Tiwuk Susantiningsih ◽  
...  
Keyword(s):  
Univariate Analysis ◽  
Serum Zinc ◽  
Zinc Content ◽  
Zinc Level ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Stunting is a condition of chronic malnutrition in children that causes the posture is not optimal and triggers other disorders such as deacreasing of immunity and intelligence. The level of adequacy of zinc is one of the factors that influence the incidence of stunting. Zinc is needed to activate and begin the synthesis of Growth Hormone (GH) so that children with zinc deficiency cause GH receptors to be disrupted and GH production to be resistant. This study aims to examine the decrease in zinc levels by looking at the difference in mean zinc levels in stunting and non-stunting toddlers. The research method was carried out observational analytic with a cross sectional approach used in this study. The study sample was 40 toddlers aged 24-60 months with 18 stunting toddlers and 22 non-stunting toddlers in Gunung Sugih District, Central Lampung Regency. The results of univariate analysis revealed that the average zinc level of toddlers serum was 52.60 ug / dl with the largest value of 76 ug / dl and the lowest value was 24 ug / dl. The results of bivariate analysis showed that there were significant differences in the mean zinc levels of stunting and non-stunting children (p = 0.01). The mean zinc content of stunting infants was 45.06 ± 12.21 lower than the mean zinc level of non-stunting infants 58.77 ± 12.98. There is a decrease in serum zinc levels in stunting toddlers compared to non stunting toddlers.

scholarly journals Prevalence of Zinc Deficiency in Japanese Patients on Peritoneal Dialysis: Comparative Study in Patients on Hemodialysis

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 764 ◽  
Author(s):  
Satoshi Shimizu ◽  
Ritsukou Tei ◽  
Masahiro Okamura ◽  
Nobuteru Takao ◽  
Yoshihiro Nakamura ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Zinc Deficiency ◽  
Serum Albumin Level ◽  
Serum Zinc ◽  
Japanese Patients ◽  
Zinc Level ◽  
Albumin Level ◽  
Zinc Levels ◽  
Inadequate Dietary Intake ◽  
Serum Zinc Levels

Background: It is known that patients on hemodialysis (HD) are prone to developing zinc deficiency due to removal of zinc by HD, inadequate dietary intake, and reduced gastrointestinal zinc absorption. However, the prevalence of zinc deficiency in patients on peritoneal dialysis (PD) has not been well established. Methods: Serum zinc levels were compared between 47 patients on PD and 47 patients on HD matched for age, sex, and duration of dialysis. A serum zinc level < 60 μg/dL was defined as clinical zinc deficiency and a level of 60–80 μg/dL as subclinical zinc deficiency. The prevalence of zinc deficiency and associated clinical factors were determined in both groups. Results: Clinical zinc deficiency was found in 59.6% of the PD group and 70.2% of the HD group (p = 0.391). Subclinical zinc deficiency was found in 40.4% of the PD group and 29.8% of the HD group. Age, body mass index, and serum albumin level were identified as independent predictors of zinc deficiency in the PD group by multivariate analysis. Conclusions: A higher prevalence of clinical and subclinical zinc deficiency was found in patients on PD. The rates were comparable between patients on PD and those on HD after adjustment for confounding factors.

scholarly journals Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Majid Rostami Mogaddam ◽  
Nastaran Safavi Ardabili ◽  
Nasrollah Maleki ◽  
Maedeh Soflaee
Keyword(s):  
Acne Vulgaris ◽  
Serum Zinc ◽  
Atomic Absorption Spectrophotometry ◽  
Zinc Level ◽  
Healthy Controls ◽  
Serum Zinc Level ◽  
Absorption Spectrophotometry ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant (P=0.598). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.

scholarly journals Retrospective study revealed that Zn relate to improvement of swallowing function in the older adults

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yumika Seki ◽  
Kota Ishizawa ◽  
Tetsuya Akaishi ◽  
Michiaki Abe ◽  
Koji Okamoto ◽  
...  
Keyword(s):  
Older Adults ◽  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Swallowing Function ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In older adults patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before. Methods A total of 52 older adults subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured. Results At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = − 0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the older adults who had comorbid dysphagia and zinc deficiency. Conclusions Zinc deficiency is associated with compromised swallowing function in older adults patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in older adults patients with zinc deficiency even though this is a retrospective study. Further study will be needed to confirm this positive effect.

scholarly journals Improved Swallowing Function after Zinc Supplementation in the Elderly

2020 ◽  
Author(s):  
Yumika Seki ◽  
Kota Ishizawa ◽  
Tetsuya Akaishi ◽  
Michiaki Abe ◽  
Okamoto Koji ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
The Elderly ◽  
Zinc Level ◽  
Swallowing Function ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background: Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In elderly patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before.Methods: A total of 52 elderly subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured.Results: At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = -0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the elderly who had comorbid dysphagia and zinc deficiency.Conclusions: Zinc deficiency is associated with compromised swallowing function in elderly patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in elderly patients with zinc deficiency.

scholarly journals Investigation of Serum Zinc Level in Patients with Hearing Loss and its Association with Tinnitus

2020 ◽  
Author(s):  
V Zand ◽  
P Hosseinpoor ◽  
MH Baradaranfar ◽  
M Meybodian ◽  
M Mandegari ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Correlation Coefficient ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Study Results ◽  
Significant Difference ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Introduction: This study aims to determine the serum zinc level in patients with hearing loss and its relation with tinnitus.  Materials & Methods: In this Cross-Sectional study, 110 patients older than 20 years old with Complaining of hearing loss and tinnitus were involved. Participating patients were first visited by an ear, nose, and throat specialist with a history and physical examination, and were assessed for standard hearing loss as well as the intensity and frequency of tinnitus by standard audiometric tests. Then, fasting blood samples were taken to check serum zinc levels. Results:The mean serum level was 85.32 ± 27 27.62, and the mean frequency of tinnitus was 4.94 ± 2.76, both of which had significant differences between different groups (P = 0.001). The mean intensity of tinnitus was 7.77 ± 4.56, and there was no significant difference between different groups (P = 0.677). Serum zinc level and tinnitus frequency were associated with a correlation coefficient of 0.205 (P = 0.032), and serum zinc level and tinnitus severity were associated with a correlation coefficient of 0.249 (P = 0.009). Conclusion: According to the present study results, the positive effect of serum zinc levels on the severity and frequency of tinnitus has been determined so that with decreasing serum zinc levels, tinnitus occurs at lower frequencies.

scholarly journals Serum zinc levels in children with simple febrile seizures

2019 ◽  
Vol 6 (4) ◽  
pp. 1480
Author(s):  
Malavika P. Santappanawar ◽  
Habeeb U. Khan ◽  
Jaidev M. Devdas ◽  
Sujonitha John ◽  
Pavan Hegde
Keyword(s):  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Nutritional Deficiencies ◽  
Control Group ◽  
Serum Zinc Level ◽  
Chi Square ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common seizures in childhood and are often associated with nutritional deficiencies. The present study was done to find any correlation of serum zinc levels in children with simple febrile seizures.Methods: This study was a hospital based prospective case control study, involving 60 children (30 cases and 30 controls) aged between 6 months to 60 months. Serum zinc level was measured in all subjects by atomic absorption spectrophotometer. Data was analysed by using frequency, percentage and Pearson’s chi square test..Results: Most cases (80%) had serum zinc levels <90 mcg/dl, in comparison with children in the control group where only 30% had serum zinc levels <90 mcg/dl. The mean serum zinc level was 78.9±14.26 mcg/dl in cases with simple febrile seizures and 96.7±12.12 mcg/dl in the control group.Conclusions: The mean serum zinc level was significantly lower in children with simple febrile seizures in comparison with controls.

Sign in / Sign up

Export Citation Format

Share Document