scholarly journals Association of high sensitive C-reactive protein with coronary heart disease: a Mendelian randomization study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Qian Zhuang ◽  
Chong Shen ◽  
Yanchun Chen ◽  
Xianghai Zhao ◽  
Pengfei Wei ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Regression Model ◽  
Mendelian Randomization ◽  
Cox Regression ◽  
Causal Effect ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Abstract Objectives Whether high sensitivity C-reactive protein (hs-CRP) has a causal effect on coronary heart disease (CHD) is unclear. This study investigated the causal effect of hs-CRP on CHD risk using Mendelian Randomization (MR) analysis. Methods A total of 3802 subjects were recruited in the follow-up study. Linear regression model was used to evaluate the relationship between CRP polymorphisms and hs-CRP. Survival receiver operator characteristic curve method was used to explore the cut-off of hs-CRP on CHD incidence. Cox regression model was applied to detect the association of hs-CRP with CHD by calculating the hazard ratio (HR) and 95% confidence interval (CI). Rs1205 and rs876537 in CRP were selected as instrumental variables in MR analysis. Results During a median follow-up time of 5.01 years, 98 CHD incidence was identified (47.03/104 person-years). Hs-CRP was significantly increased among rs1205 and rs876537 genotypes with r values of 0.064 and 0.066, respectively. Hs-CRP 1.08 mg/L was identified as the cut-off value with a maximum value of sensitivity and specificity on prediction of CHD. Participants with ≥1.08 mg/L of hs-CRP has a higher risk of CHD incidence than that of participants with < 1.08 mg/L, the adjusted HR (95% CI) was 1.69 (1.11–2.60) with a P value of 0.016. No significant casual association was observed between hs-CRP and CHD with a P value of 0.777. Conclusions The association between hs-CRP and CHD is unlikely to be causal, hs-CRP might be a predictor for incidence of CHD in general population.

scholarly journals Relationship Between gamma-Glutamyltransferase (gamma-GT) with High Sensitive C-Reactive Protein (hs-CRP), Oxidized (Ox-LDL) and Glutathione Peroxidase (GPx) on Coronary Heart Disease (CHD) Patient

2009 ◽  
Vol 1 (2) ◽  
pp. 51 ◽  
Author(s):  
Marissa Arifin ◽  
Marsetio Donosepoetro ◽  
Sutomo Kasiman
Keyword(s):  
Oxidative Stress ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Glutathione Peroxidase ◽  
Medical Center ◽  
Oxidized Ldl ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Hs Crp

BACKGROUND: Recent clinical studies have suggested that γ-glutamyltransferase (γ-GT) can trigger oxidative stress within the plaque. This study aimed to investigate whether serum γ-GT might be as a risk factor of coronary heart disease (CHD), and measure the associations of serum γ-GT with high sensitive C-Reactive Protein (hs-CRP), Oxidized LDL (Ox-LDL) and Glutathione Peroxidase (GPx).METHODS: This study recruited 48 patients aged 30-70 year who underwent coronary angiography at Haji Adam Malik Medical Center at Medan between February and April 2008 and who presented at least one coronary stenosis of > 50% of the luminar diameter. The sample subjects were consecutively selected.RESULTS: γ-Glutamyltransferase was positively associated (r = 0.546) with hs-CRP as a marker of chronic inflammation after careful adjustment for other established risk factors in CHD patient. But, there was no significant difference between γ-GT in male and female patients. Further, there were no correlations between γ-GT and Ox-LDL and GPx. Ratio of γ-GT/GPx was measured as well, and it was associated with hs-CRP.CONCLUSIONS: Ratio of γ-GT/GPx was associated with inflammation process in coronary heart disease patients.KEYWORDS: γ-glutamyltransferase (γ-GT), inflammation, oxidative stress, coronary heart disease

Non-Fasting Changes of Hs-CRP Level in Chinese Patients With Coronary Heart Disease After A Daily Meal

2021 ◽  
Author(s):  
Ling Liu ◽  
Qiu-Zhen Lin ◽  
Xue-Yan Zang ◽  
Yan Fu ◽  
Xingyu Wen ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
High Sensitivity ◽  
Chinese Patients ◽  
Inflammatory Factor ◽  
Fasting State ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Atherosclerotic Cardiovascular Diseases

Abstract High-sensitivity C-reactive protein (hs-CRP) is a key inflammatory factor in atherosclerotic cardiovascular diseases. In Chinese patients with coronary heart disease (CHD), the changes in hs-CRP levels after a daily meal and the effect of statins on those were never explored. A total of 300 inpatients with CHD were included. Hs-CRP levels were measured in fasting and non-fasting state at 2 hour (h) and 4h after a daily breakfast. Group with fasting hs-CRP ≤ 3mg/L had significantly higher percentage of patients with statins using ≥ 1 month (m) than that with fasting hs-CRP > 3mg/L (51.4% vs. 23.9%, P < 0.05). Hs-CRP levels were significantly higher in non-fasting state (P < 0.05). Interestingly, the hs-CRP didn’t elevate significantly in inpatients with statins using ≥ 1m in hs-CRP > 3mg/L group, but it elevated significantly after meal in inpatients without and with statins using < 1m (P < 0.05). About 32% of patients with non-fasting hs-CRP > 3mg/L came from those with fasting hs-CRP ≤ 3mg/L. In conclusion, hs-CRP levels increased significantly in CHD patients after a daily meal. When fasting hs-CRP > 3mg/L but not ≤ 3mg/L, statins work partly in reducing hs-CRP elevation in non-fasting state.

scholarly journals Study on Role of Nitric Oxide and High Sensitive C - reactive protein in subjects with Coronary Heart Disease

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 3068-3072
Author(s):  
Keerthi Karini ◽  
Thirunavukkarasu Jaishankar ◽  
Kasthuri Natarajan ◽  
Balasubramanian Kannan
Keyword(s):  
Nitric Oxide ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lipid Profile ◽  
Research Centre ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Mean ◽  
Hs Crp

Nitric Oxide (NO) where produced by endothelial nitric oxide synthase (eNOS) enzyme which are inhibited by C-reactive protein (CRP) which causes endothelial dysfunction and cardiovascular events. In the current study, we evaluated the association of NO with hs-CRP in subjects with coronary heart disease. This Case-Control study was conducted 60 CHD patients and 60 healthy controls in age group of 30 to 55 years at SRM Medical College Hospital and Research Centre on subjects attending the Cardiology and medicine OP. Blood samples were collected after overnight fasting for analysis of Lipid Profile, High sensitive C-reactive protein. Nitric Oxide and High sensitive C-reactive protein is measured by ELISA method and Lipid Profile is measured using Auto Analyzer AU480. Statistical analysis was done using Student ‘t’ test and Pearson correlation analysis used to the variable between two groups. The mean level of LDL-C (161.9±27.46) and hs-CRP (6.80±1.35) were significantly elevated in CHD subjects when compared to the normal healthy controls. And the mean level of Nitric Oxide (12.97±1.20) were decreased significantly in CHD group when compared to controls. Increased oxidative stress associated with low grade inflammation lead to diminished bioavailability of nitric oxide.

Abstract MP11: Elevated High Sensitivity C-Reactive Protein as a Risk Marker of the Attenuated Relationship Between Serum Cholesterol and Coronary Heart Disease at Older Age - Atherosclerosis Risk in Communities Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Seamus Whelton ◽  
Probal Roy ◽  
Brad Astor ◽  
Lin Zhang ◽  
Ron Hoogeveen ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Total Cholesterol ◽  
Serum Cholesterol ◽  
High Sensitivity ◽  
Older Individuals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Chd Risk ◽  
Hs Crp

Introduction: The relationship between serum cholesterol and coronary heart disease (CHD) risk is attenuated at older age, making it difficult to estimate risk in this age group. Hypothesis: We hypothesized that high sensitivity C-reactive protein (hs-CRP) would identify two subgroups of older individuals (≥65 years): one in whom cholesterol is less predictive of CHD and one in whom it is equally predictive compared to younger individuals. Methods: We calculated crude incident rates per 1,000 person-years and used adjusted Cox proportional hazards models to analyze cholesterol as a predictor of CHD in 8,947 participants with no known history of CHD who were stratified by age (53-64 or 65-75 years) and hs-CRP level (<2 or ≥2 mg/L) at baseline. Results: Among younger participants, total serum cholesterol was significantly associated with an increased risk of CHD regardless of hs-CRP group HR 1.39 (95% CI 1.20-1.61) for hs-CRP <2 mg/L and HR 1.37 (95% CI 1.22-1.53) for hs-CRP ≥2 mg/L. Among older participants with a low hs-CRP, total cholesterol had a similar association with CHD, HR 1.46 (95% CI 1.24-1.71), as in younger individuals. In contrast, among older individuals with higher hs-CRP, the association of CHD with total cholesterol was attenuated, HR 1.14 (95% CI 1.00-1.29), p-value for interaction = 0.02. Similar trends were observed between age groups and hs-CRP categories for LDL cholesterol. Conclusions: Among individuals aged 65-75 years, the association of cholesterol with CHD was strong in those with a low hs-CRP and weak in those with an elevated hs-CRP. Thus, in addition to its use as a risk factor, an elevated hs-CRP could be useful for stratifying the elderly population to aid in the interpretation of serum cholesterol in the prediction of subsequent CHD risk.

Depression, inflammation and coronary heart disease: prognostical value of c reactive protein and depressive symptoms

2011 ◽  
Vol 26 (S2) ◽  
pp. 611-611
Author(s):  
A. Bruschi ◽  
M. Mazza ◽  
D. Harnic ◽  
P. Grandinetti ◽  
C. Battaglia ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Depressive Symptoms ◽  
Statistical Significance ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cardiac Events ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp

IntroductionThe aim of this preliminary study is to assess, in a sample of patients with Coronary Heart Disease (CHD), the specific association between depressive symptoms and systemic inflammation.MethodsSixty-One inpatients with CHD, 31 Unstable Angina and 28 Myocardial Infarction, participated in the study. The plasma levels of C Reactive Protein were measured using Dade Behring’s High Sensitivity CRP assay (hs-CRP) at T0, T30 and T90.At the same timings, they were tested by an examiner, unaware of their diagnosis, with a psychometric battery (SCL90-R, HDRS, MADRS, BDI, QlesQ).ResultsThe elevation of hs-CRP occurs during the whole observation period, with maximum significance at T90 (p = 0,031).A multivariate analysis at T0 indicates a statistical correlation between SCL90-R scores and hs-CRP levels (p = 0.02).The SCL90-R is also associated with the risk of further cardiac events (p = 0.013).Also the BDI could be useful as a prognostic factor (p = 0.026).We found a trend towards correlation between CRP values and depressive symptoms, but it never reaches statistical significance for the other scales.ConclusionsThe feelings of loss and the fear of death, related to the environmental and emotional situation of the hospitalization, may prevail in the acute phase of CHDs.Some patients may overcome this reactive depression, while others may exhibit a biological depression, related to the high level of CRP and thus to an increased risk of re-infarction and other coronary events.

scholarly journals Compare and correlate the levels of lipoprotein (a) and high-sensitive C-reactive protein in coronary heart disease with control

2019 ◽  
Vol 6 (3) ◽  
pp. 691
Author(s):  
Kamal Lochan Behera ◽  
Ashok Vankayala ◽  
Suresh Babu Sayana ◽  
D. S. S. K. Raju
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Inflammatory Marker ◽  
Case Control ◽  
C Reactive Protein ◽  
Lipoprotein A ◽  
Reactive Protein ◽  
Patients With Diabetes ◽  
Hs Crp

Background: The incidence of ischemic heart disease/ myocardial infarction is rapidly increasing in India. However, the traditional risk factors alone could not explain this excess of Coronary Heart Disease (CHD). So, we are in need of a tool to assess the severity and prognosis of these acute coronary syndromes. Lipoprotein (a) [Lp(a)] and High Sensitive C-Reactive Protein (hs-CRP) have been recognised as independent risk factors for CHD in many retrospective case control studies. As the data shows inconsistency in the prediction of risk by Lp(a) and hs-CRP, the study is carried out to compare and correlate the levels of Lp(a) and hs-CRP in coronary heart disease patients with controls.Methods: An observational case control study was conducted at Maharaja’s Institute of Medical Sciences, Nellimarla, with 120 participants. 80 admitted with CHD were categorised as type 2 diabetic and non-diabetic. Remaining 40 participants were age matched controls, who have attended the OP for general health check-up. Samples collected from the participants were analysed for Lp(a), hs-CRP and HbA1c.Results: Lp(a) levels were significantly elevated in CHD patients with diabetes (69.2±27.5) and non-significant in CHD patients without diabetes (50.4±24.3) as compared to their controls (36.6±22.5). There was significant correlation and elevation of hs-CRP in CHD patients with diabetes (6.0±2.6) and without diabetes (3.7±2.0) as compared to their controls (0.7±0.4).Conclusions: The present study shows a lack of association of Lp(a) levels in CHD patients with and without diabetes. A strong correlation of the inflammatory marker, hs-CRP was observed between the CHD patients with and without diabetes and even as compared to their controls. It may be concluded that hs-CRP is a better and independent marker than Lp(a) in patients with CHD.

scholarly journals Prognostic value of C-reactive protein in adults with congenital heart disease

Heart ◽  
2020 ◽  
pp. heartjnl-2020-316813
Author(s):  
Laurie W Geenen ◽  
Vivan J M Baggen ◽  
Annemien E van den Bosch ◽  
Jannet A Eindhoven ◽  
Robert M Kauling ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Prognostic Value ◽  
Congenital Heart ◽  
Cox Regression ◽  
Troponin T ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Risk Of Death ◽  
Hs Crp

BackgroundHigh-sensitivity C reactive protein (hs-CRP) has been associated with outcomes in adult congenital heart disease (ACHD). However, its prognostic value beyond N-terminal pro B type natriuretic peptide (NT-proBNP) or troponin T remains unknown. We studied the temporal evolution of hs-CRP, as well as the relation between hs-CRP and adverse clinical outcomes independent of NT-proBNP and troponin T in patients with ACHD.MethodsIn this prospective cohort study, we enrolled 602 patients with ACHD (2011–2013) who underwent baseline and thereafter annual blood sampling during 4 years. Hs-CRP, hs-troponin T and NT-proBNP were measured. The primary endpoint was composed of death or heart failure (HF). Cox regression and Joint Modelling was used to relate 2log hs-CRP levels with the endpoint, with adjustment for baseline characteristics and (repeated) hs-troponin T and NT-proBNP measurements.ResultsHs-CRP was measured at baseline in 591 patients, median age 33 years, 58% men, 90% New York Heart Association I with an average of 4.3 measurements per patient. Median follow-up was 5.9 (IQR 5.3–6.3) years (99.2% complete) and 69 patients met the endpoint. Higher baseline hs-CRP was independently associated with higher risk of death or HF (HR 1.36, 95% CI 1.19 to 1.55). Hs-CRP increased over time prior to death or HF, and repeated hs-CRP measurements were associated with the endpoint, independent of repeated NT-proBNP and hs-troponin T (HR 1.54, 95% CI 1.24 to 1.98).ConclusionsHs-CRP carries incremental prognostic value for the risk of death or HF, beyond NT-proBNP and hs-troponin T. Hs-CRP increased prior to the occurrence of HF or death, supporting the role of inflammation in the clinical deterioration of patients with ACHD.

scholarly journals The Role Of hs-CRP In Predicting The Likelihood Of Coronary Heart Disease

2020 ◽  
Vol 3 (1) ◽  
pp. 51-61
Author(s):  
Nadroh Br Sitepu ◽  
Urip Harahap
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Strong Predictor ◽  
High Sensitivity ◽  
Vascular Risk ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Atherosclerotic Lesions ◽  
Hs Crp

Coronary Heart Disease (CHD) is a disorder of the cardiovascular system, characterized by atherosclerotic lesions. Inflammation is a strong predictor for coronary heart disease. High sensitivity C-Reactive Protein (hs-CRP) is an important biomarker, synthesized in the liver, can predict the severity of CHD. If the hs-CRP level is found to be low 3 mg / L, a person has the potential for severe vascular risk. Therefore, hs-CRP can be used as a predictor of primary CHD prevention, especially if the hs-CRP level is still low.

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