scholarly journals Clinical relevance of SARS-CoV-2 infection in late pregnancy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Marta Ruggiero ◽  
Edgardo Somigliana ◽  
Beatrice Tassis ◽  
Letizia Li Piani ◽  
Sara Uceda Renteria ◽  
...  
Keyword(s):  
Intensive Care ◽  
Pregnancy Outcome ◽  
Late Pregnancy ◽  
Nasopharyngeal Swab ◽  
Historical Time ◽  
Recall Bias ◽  
Time Period ◽  
Different Types ◽  
The Impact ◽  
In Pregnancy

Abstract Background Evidence on the outcome of SARS-CoV-2 infection in pregnancy is generally reassuring but yet not definitive. Methods To specifically assess the impact of SARS-CoV-2 infection in late pregnancy, we prospectively recruited 315 consecutive women delivering in a referral hospital located in Lombardy, Italy in the early phase of the epidemic. Restriction of the recruitment to this peculiar historical time period allowed to exclude infections occurring early in pregnancy and to limit the recall bias. All recruited subjects underwent a nasopharyngeal swab to assess the presence of Sars-Cov-2 using Real-time PCR. In addition, two different types of antibodies for the virus were evaluated in peripheral blood, those against the spike proteins S1 and S2 of the envelope and those against the nucleoprotein of the nucleocapsid. Women were considered to have had SARS-CoV-2 infection in pregnancy if at least one of the three assessments was positive. Results Overall, 28 women had a diagnosis of SARS-CoV-2 infection in pregnancy (8.9%). Women diagnosed with the infection were more likely to report one or more episodes of symptoms suggestive for Covid-19 (n = 11, 39.3%) compared to unaffected women (n = 39, 13.6%). The corresponding OR was 4.11 (95%CI: 1.79–9.44). Symptoms significantly associated with Covid-19 in pregnancy included fever, cough, dyspnea and anosmia. Only one woman necessitated intensive care. Pregnancy outcome in women with and without SARS-CoV-2 infection did not also differ. Conclusions SARS-CoV-2 infection is asymptomatic in three out of five women in late pregnancy and is rarely severe. In addition, pregnancy outcome may not be markedly affected.

scholarly journals Clinical Relevance of Covid-19 in the Second Half of Pregnancy

2021 ◽  
Author(s):  
Marta RUGGIERO ◽  
Edgardo Somigliana ◽  
Beatrice TASSIS ◽  
Letizia LI PIANI ◽  
Sara Uceda Renteria ◽  
...  
Keyword(s):  
Intensive Care ◽  
Pregnancy Outcome ◽  
Real Time Pcr ◽  
Nasopharyngeal Swab ◽  
Historical Time ◽  
Recall Bias ◽  
Time Period ◽  
Different Types ◽  
The Impact ◽  
In Pregnancy

Abstract Background: Evidence on the outcome of Covid-19 in pregnancy is generally reassuring but yet not definitive. Methods: To specifically assess the impact of Covid-19 in the second half of pregnancy, we prospectively recruited 315 consecutive women delivering in a referral hospital located in Lombardy, Italy in the early phase of the epidemic. Restriction of the recruitment to this peculiar historical time period allowed to exclude infections occurring early in pregnancy and to limit the recall bias. All recruited subjects underwent a nasopharyngeal swab to assess the presence of Sars-Cov-2 using Real-time PCR. In addition, two different types of antibodies for the virus were evaluated in peripheral blood, those against the spike proteins S1 and S2 of the envelope and those against the nucleoprotein of the nucleocapsid. Women were considered to have had Covid-19 in pregnancy if at least one of the three assessments was positive. Results: Overall, 28 women had a diagnosis of Covid-19 in pregnancy (8.9%). Women diagnosed with the infection were more likely to report one or more episodes of symptoms suggestive for Covid-19 (n=11, 39.3%) compared to unaffected women (n=39, 13.6%). The corresponding OR was 4.11 (95%CI: 1.79-9.44). Symptoms significantly associated with Covid-19 in pregnancy included fever, cough, dyspnea and anosmia. Only one woman necessitated intensive care. Pregnancy outcome in women with and without Covid-19 did not also differ. Conclusions: Covid-19 is asymptomatic in three out of five women in the second half of pregnancy and is rarely severe. In addition, pregnancy outcome may not be significantly affected.

scholarly journals Covid-19 in the second half of pregnancy: prevalence and clinical relevance

2020 ◽  
Author(s):  
Marta RUGGIERO ◽  
Edgardo SOMIGLIANA ◽  
Beatrice TASSIS ◽  
Letizia LI PIANI ◽  
Sara UCEDA RENTERIA ◽  
...  
Keyword(s):  
Intensive Care ◽  
General Population ◽  
Real Time ◽  
Pregnancy Outcome ◽  
Real Time Pcr ◽  
Peripheral Blood ◽  
Clinical Relevance ◽  
Nasopharyngeal Swab ◽  
Maternal Deaths ◽  
In Pregnancy

Abstract Evidence on the prevalence and outcome of Covid-19 in pregnancy is yet inconclusive. To draw more information on this issue, we prospectively recruited 315 consecutive women delivering in a referral hospital located in Lombardy, Italy and evaluated the proportion of women who had Covid-19 in pregnancy. All recruited subjects underwent a nasopharyngeal swab to assess the presence of Sars-Cov-2 using Real-time PCR. In addition, two different type of antibodies for the virus were evaluated in peripheral blood, those against the spike proteins S1 and S2 of the envelope and those against the nucleoprotein of the nucleocapsid. Women were considered to have had Covid-19 in pregnancy if at least one of the assessment was positive. Overall, 28 women had a diagnosis of Covid-19 in pregnancy (8.9%, 95%CI: 6.2-12.5%), in line with the local general population. Women diagnosed with the infection were more likely to report one or more episodes of symptoms suggestive for Covid-19 (n=11, 39.3%) compared to unaffected women (n=39, 13.6%). The corresponding OR was 4.11 (95%CI: 1.79-9.44). Symptoms significantly associated with Covid-19 in pregnancy included fever, cough, dyspnea and anosmia. Only one woman necessitated intensive care. No maternal deaths occurred. Pregnancy outcome in women with and without Covid-19 did not also differ. In conclusion, women in the second half of pregnancy do not appear to be more susceptible to Covid-19 and its complications. In addition, the study suggests that pregnancy outcome may not be significantly affected.

The impact of low back and pelvic pain in pregnancy on the pregnancy outcome

1991 ◽  
Vol 70 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Hans C. Oätgaard ◽  
Gunnar B. J. Andersson ◽  
Margareta Wennergren
Keyword(s):  
Pregnancy Outcome ◽  
Pelvic Pain ◽  
Low Back ◽  
The Impact ◽  
In Pregnancy

scholarly journals The Role of Thrombophilia in Pregnancy

Thrombosis ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Elisabeth M. Battinelli ◽  
Ariela Marshall ◽  
Jean M. Connors
Keyword(s):  
Pregnancy Outcome ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulants ◽  
Thrombotic Disease ◽  
Therapeutic Anticoagulation ◽  
Physical Changes ◽  
The Impact ◽  
Physiologic Changes Of Pregnancy ◽  
In Pregnancy

Thrombotic disease is a major cause of peripartum morbidity and mortality worldwide. Development of thrombosis in pregnancy is multifactorial due to the physiologic changes of pregnancy—which induce a relative hypercoagulable state—as well as physical changes leading to increased stasis and also the effects of both the inherited and the acquired thrombophilias. In this review, we discuss the impact of each of these factors on the development of thrombosis as well as the evidence for the impact of pregnancy-associated thrombosis on pregnancy outcome. We then discuss the use of both prophylactic and therapeutic anticoagulation during pregnancy and the puerperium. We review the indications and dosing recommendations for administration of anticoagulation in a context of discussing the evidence including the lack of evidence and formal guidelines in this area. We briefly address the role of the new oral anticoagulants in pregnancy and conclude that significant further research in women with thrombophilias and pregnancy-associated thrombosis may help clarify the management of this condition in the future.

scholarly journals The hero's journey: tracing the history of the myth to the celebrity

2021 ◽  
Author(s):  
Lisa Goldberg
Keyword(s):  
Communication Technology ◽  
Oral Tradition ◽  
Hero's Journey ◽  
Historical Time ◽  
Review Of The Literature ◽  
Time Period ◽  
Different Types ◽  
History Of ◽  
Theoretical Analyses

The terms "hero," "heroism," and, more recently, "heroine," are broad, wide ranging, and contested terms prominent within academia yet there remains a general consensus that heroes are, historically, an essential component to society. This paper will identify that there are diverse Western cultural conceptions surrounding the hero. It is therefore important to trace the meaning behind the concept and draw conclusions as to whether or not the hero narrative has developed or shifted over time. Through an intensive review of the literature on the "hero," this research paper critically identifies the historical constructions, empirical observations, and theoretical analyses in order to explore and understand how the hero narrative has changed or retained timeless qualities of meaning or myth. As the hero developed from the Classical times to the present, through the periods of oral tradition to electronic media, those who are identified as a "hero" became more and more far-reaching. This paper constructs several empirical tables that identify similarities and differences concerning how Western society's classification of heroes has developed. By taking into account the different types of heroic figures that have existed across time, including Greek gods, soldiers, community workers, and celebrities, this paper establishes whether or not the conception of the "hero" changes depending on war, gender, race, popular culture, historical time period, and changes in communication technology.

Rethinking Physiologic Stability: Touch and Intracranial Pressure

1999 ◽  
Vol 1 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Pamela H. Mitchell ◽  
Barbara Habermann
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Intracranial Pressure ◽  
Parental Care ◽  
Intracranial Hypertension ◽  
Pediatric Intensive Care Unit ◽  
Pediatric Intensive Care ◽  
Time Period ◽  
The Stability ◽  
The Impact

The purpose of this research was to examine the contingent nature of physiologic stability with respect to the impact of nursing and parental care touch on intracranial pressure (ICP) in children. Data were reanalyzed from those previously collected in eight children in a pediatric intensive care unit who had intracranial hypertension from a variety of causes and whose ICP was invasively monitored. One hundred forty-nine clusters of spontaneous touch/talking were available for analysis after those occurring close in time to procedures and drugs affecting ICP were dropped. Twenty-three episodes of investigator touch (without talking) were also analyzed. ICP stability was defined as any tracing over a defined time period in which the peak-to-trough amplitude did not exceed twice the calculated resting variability. Such an approach allowed classification and counting of stable versus unstable baselines, and stable versus unstable responses to touch. Therefore, ICP stability was examined by comparing the stability of the ICP tracing the last minute prior to a cluster of nonprocedural touch (baseline) with the first minute after the cluster. Clusters of spontaneous touch were nearly always associated with talking to the child and rarely were followed by change in level of ICP greater than that child’s ICP variability at rest. Investigator stroking without talking never was followed by a significant change in level of ICP. There was a contingent relationship between stability of the ICP tracing prior to a cluster of touching/talking such that the probability of ICP becoming more stable when the touch/talk occurred on an unstable baseline was twice that of touch/talk occurring on an stable baseline.

scholarly journals Could Sotrovimab, a monoclonal antibody, be helpful in COVID-19 symptoms in cats and ferrets?

2021 ◽  
Author(s):  
Sayıner Serkan
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Intensive Care ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Early Stages ◽  
Different Types ◽  
The Impact

Although the types of coronaviruses seen in animals differ, recent studies have also shown that they are affected by COVID-19, known as SARS-CoV-2. The impact of COVID-19 on animals is a factor that should be followed carefully, especially since different variants appear in humans every day and this disease is transmitted from human to animal. Thanks to vaccination, animals are less affected by different types of coronaviruses. Cats and ferrets are especially affected much more in COVID-19, causing damage to the lungs and other organs. Recently, it has been shown that the use of monoclonal antibodies, especially in the early stages of COVID-19, by people with chronic diseases, positively affects the course of the disease, reduces the frequency of hospitalization and the possibility of falling into intensive care. Sotrovimab is a pan-sarbecovirus monoclonal antibody, and 12-13 studies to date have shown that individuals with chronic disease are less affected when given in the early stages of the disease when the symptoms are mild. We also think that if especially old cats and ferrets are treated with Sotrovimab in the early stages of the disease when they contract COVID-19, it will positively affect the prognosis of the disease.

scholarly journals The hero's journey: tracing the history of the myth to the celebrity

2021 ◽  
Author(s):  
Lisa Goldberg
Keyword(s):  
Communication Technology ◽  
Oral Tradition ◽  
Hero's Journey ◽  
Historical Time ◽  
Review Of The Literature ◽  
Time Period ◽  
Different Types ◽  
History Of ◽  
Theoretical Analyses

The terms "hero," "heroism," and, more recently, "heroine," are broad, wide ranging, and contested terms prominent within academia yet there remains a general consensus that heroes are, historically, an essential component to society. This paper will identify that there are diverse Western cultural conceptions surrounding the hero. It is therefore important to trace the meaning behind the concept and draw conclusions as to whether or not the hero narrative has developed or shifted over time. Through an intensive review of the literature on the "hero," this research paper critically identifies the historical constructions, empirical observations, and theoretical analyses in order to explore and understand how the hero narrative has changed or retained timeless qualities of meaning or myth. As the hero developed from the Classical times to the present, through the periods of oral tradition to electronic media, those who are identified as a "hero" became more and more far-reaching. This paper constructs several empirical tables that identify similarities and differences concerning how Western society's classification of heroes has developed. By taking into account the different types of heroic figures that have existed across time, including Greek gods, soldiers, community workers, and celebrities, this paper establishes whether or not the conception of the "hero" changes depending on war, gender, race, popular culture, historical time period, and changes in communication technology.

scholarly journals Investigation of the wind generator blades material resistance to the lightning current action

2018 ◽  
Vol 245 ◽  
pp. 15001 ◽  
Author(s):  
Yuri Adamyan ◽  
Sergey Krivosheev ◽  
Tatyana Minevich
Keyword(s):  
Current Pulse ◽  
Fiber Composite ◽  
Experimental Studies ◽  
Carbon Fiber Composite ◽  
Long Tail ◽  
Wind Generator ◽  
Lightning Current ◽  
Time Period ◽  
Different Types ◽  
The Impact

This paper is devoted to the problems of lightning protection of composite materials of wind generator blades. The results of experimental studies for carbon fibers under different types of lightning current pulse effects are provided. A significant increase in the degree of destruction of materials is shown for the pulse approximating field experiment results as compared with the standard lightning current pulse. We show that under the impact of the standard current pulse there is no significant material destruction, and the release of the discharge products is also insignificant. Also we shown that under the impact of the current pulse having a long «tail» time period (the current pulse close to the real one) there is an ignition of the carbon fiber composite material near the edges of the feeding electrode. With this the burning process doesn’t end after the end of the current pulse. The description of the pulse current generator created for experiments is given.

scholarly journals Augmented EDHF signaling in rat uteroplacental vasculature during late pregnancy

2010 ◽  
Vol 299 (5) ◽  
pp. H1642-H1652 ◽  
Author(s):  
N. I. Gokina ◽  
O. Y. Kuzina ◽  
A. M. Vance
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Combined Treatment ◽  
Late Pregnancy ◽  
Successful Pregnancy ◽  
High K ◽  
The Impact ◽  
Prostacyclin Production ◽  
In Pregnancy

A successful pregnancy outcome relies on extensive maternal cardiovascular adaptation, including enhanced uteroplacental vasodilator mechanisms. The objective of the present study was to determine the contribution of the endothelium-derived hyperpolarizing factor (EDHF) signaling in pregnancy-enhanced uterine vasodilation, to define the role of Ca2+-activated K+ channels in mediating EDHF effects, and to explore the impact of endothelial Ca2+ signaling in pregnancy-specific upregulation of EDHF. Fura 2-based measurements of smooth muscle cell (SMC) and endothelial cell cytosolic Ca2+ concentration ([Ca2+]i) were performed simultaneously with measurements of the diameter of uterine radial arteries from nonpregnant (NP) and late pregnant (LP) rats. Changes in SMC membrane potential of pressurized arteries from LP rats were assessed using glass microelectrodes. After blockade of nitric oxide and prostacyclin production, a cumulative application of ACh induced rapid and effective dilatation of uterine vessels from both NP and LP rats. This vasodilation was associated with SMC hyperpolarization and SMC [Ca2+]i reduction and was abolished by a high-K+ solution, demonstrating that NG-nitro-l-arginine (l-NNA)- and indomethacin-resistant responses are attributable to EDHF. Pregnancy significantly potentiates EDHF-mediated vasodilation in part due to enhanced endothelial Ca2+ signaling. l-NNA- and indomethacin-resistant responses were insensitive to iberiotoxin but abolished by a combined treatment with apamin and charybdotoxin, supporting the key role of small- and intermediate-conductance K+ channels in mediating EDHF signaling in the maternal uterine resistance vasculature.

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